While oral supplements like Glutathione and Vitamin C are commonly marketed for skin brightening, they lack strong scientific evidence and FDA approval for general skin whitening. Prescription medications like Tranexamic acid can treat specific pigmentation issues like melasma, but carry serious risks (like blood clots) and must only be taken under strict medical supervision. There is no safe, universal 'skin-lightening pill.' Instead, I recommend consulting a dermatologist. They can safely guide you toward effective topical treatments, such as Vitamin C, retinoids, niacinamide, and broad-spectrum sunscreen, which are much safer and more effective for achieving a healthy, bright complexion.