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Composition : ERLOTINIB-100MG
Dose Form : TABLET
Description : ERLONAT 100MG TAB
Route Of Administration : ORAL
Pack : 10


Drug Ingredient Information



Information for patients
Drug Information Erlotinib is a medicine used to treat cancer by preventing the activity of a protein called epidermal growth factor receptor (EGFR). This protein is known to be involved in the growth and spread of cancer cells. This medicine can be prescribed to you if you have non-small cell lung cancer at an advanced stage. It can be prescribed as initial therapy if your cancer cells have specific EGFR mutations. It can also be prescribed if your disease remains largely unchanged after initial chemotherapy, or if previous chemotherapy has not helped to stop your disease. This medicine can also be prescribed to you in combination with another treatment called gemcitabine if you have cancer of the pancreas at a metastatic stage.
Drug Alert
Alert •if you are allergic (hypersensitive) to erlotinib or to any of the ingredients of Erlotinib .
Before Consuming the Medicine
Avoid Drug •if you are allergic (hypersensitive) to erlotinib or to any of the ingredients of Erlotinib .
Drug Special Care •if you are taking other medicines that may increase or decrease the amount of erlotinib in your blood (for example antifungals like ketoconazole, protease inhibitors, erythromycin, clarithromycin, phenytoin, carbamazepine, barbiturates, rifampicin, ciprofloxacin, omeprazole, ranitidine or St. John’s Wort). In some cases these medicines may reduce the efficacy or increase the side effects of Erlotinib and your doctor may need to adjust your treatment. Your doctor might avoid treating you with these medicines while you are receiving Erlotinib. •if you are taking anticoagulants (a medicine which helps to prevent thrombosis or blood clotting e.g. warfarin), Erlotinib may increase your tendency to bleed and your doctor will need to regularly monitor you with some blood tests. •if you are taking statins (medicines to lower your blood cholesterol), Erlotinib may increase the risk of statin related muscle problems, which on rare occasions can lead to serious muscle breakdown (rhabdomyolysis) resulting in kidney damage. •if you use contact lenses and/or have a history of eye problems such as severe dry eyes, inflammation of the front part of the eye (cornea) or ulcers involving the front part of the eye, tell your doctor. You should tell your doctor: •if you have sudden difficulty in breathing associated with cough or fever because your doctor may need to treat you with other medicines and interrupt your Erlotinib treatment; •if you have diarrhoea because your doctor may need to treat you with anti-diarrhoeal (for example loperamide); •immediately, if you have severe or persistent diarrhoea, nausea, loss of appetite, or vomiting because your doctor may need to interrupt your Erlotinib treatment and may need to treat you in the hospital; •if you have severe pain in the abdomen, severe blistering or peeling of skin. Your doctor may need to interrupt or stop your treatment; •if you develop acute or worsening redness and pain in the eye, increased eye watering, blurred vision and/or sensitivity to light, please tell your doctor or nurse immediately as you may need urgent treatment. •if you are also taking a statin and experience unexplained muscle pain, tenderness, weakness or cramps. Your doctor may need to interrupt or stop your treatment. It is not known whether Erlotinib has a different effect if your liver or kidneys are not functioning normally. The treatment with this medicine is not recommended if you have a severe liver disease or severe kidney disease. Your doctor must treat you with caution if you have a glucuronidation disorder like Gilbert’s syndrome.You are advised to stop smoking if you are treated with Erlotinib as smoking could decrease the amount of your medicine in the blood. Children and adolescents Erlotinib has not been studied in patients under the age of 18 years. The treatment with this medicine is not recommended for children and adolescents.
Drug Drug Interactions Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines,including medicines obtained without a prescription.
Drug Pregnancy Interaction Avoid pregnancy while being treated with Erlotinib . If you could become pregnant, use adequate contraception during treatment, and for at least 2 weeks after taking the last .If you become pregnant while you are being treated with Erlotinib , immediately inform your doctor who will decide if the treatment should be continued. Ask your doctor or pharmacist for advice before taking any medicine.
Drug Breast feeding Interaction Do not breast-feed if you are being treated with Erlotinib .
Drug Machinery Interaction Erlotinib has not been studied for its possible effects on the ability to drive and use machines but it is very unlikely that your treatment will affect this ability.
Drug More Information Do not take Erlotinib with food.
How to take the Medicine
Consumption Info
Drug quanitty The usual dose is one of Erlotinib 150 mg each day if you have non-small cell lung cancer. The usual dose is one of Erlotinib 100 mg each day if you have metastatic pancreatic cancer. Erlotinib is given in combination with gemcitabine treatment. Your doctor may adjust your dose in 50 mg steps. For the different dose regimens Erlotinib is available in strengths of 25 mg, 100 mg or 150 mg.
Drug Dose Always take Erlotinib exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. The should be taken at least one hour before or two hours after the ingestion of food.
Excess Drug Consumption Contact your doctor or pharmacist immediately.You may have increased side effects and your doctor may interrupt your treatment.
Forgot Drug Consumption If you miss one or more doses of Erlotinib , contact your doctor or pharmacist as soon as possible. Do not take a double dose to make up for a forgotten dose.
Stop Drug Consumption It is important to keep taking Erlotinib every day, as long as your doctor prescribes it for you. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Possible Side Effects
General Information •Rash which may occur or worsen in sun exposed areas. If you are exposed to sun, protective clothing, and/or use of sun screen (e.g. mineral-containing) may be advisable •Infection •Loss of appetite, decreased weight •Depression •Headache, altered skin sensation or numbness in the extremities •Difficulty in breathing, cough •Nausea •Mouth irritation •Stomach pain, indigestion and flatulence •Abnormal blood tests for the liver function •Itching, dry skin and loss of hair •Tiredness, fever, rigors
Common Drug Side Effects •Bleeding from the nose •Bleeding from the stomach or the intestines •Inflammatory reactions around the fingernail •Cracked skin (skin fissures)
Rare Drug Side Effects •Eyelash changes •Excess body and facial hair of a male distribution pattern •Eyebrow changes •Brittle and loose nails
Very Rare Drug Side Effects •Cases of perforation or ulceration of the cornea •Severe blistering or peeling of skin (suggestive of Stevens-Johnson syndrome)
Drug Side Effects Symptoms •Diarrhoea and vomiting (very common). Persistent and severe diarrhoea may lead to low blood potassium and kidney failure, particularly if you receive other chemotherapy treatments at the same time. If you experience more severe or persistent diarrhoea contact your doctor immediately as your doctor may need to treat you in the hospital. •Eye irritation due to conjunctivitis/keratoconjunctivitis (very common) and keratitis (common). •Rare form of lung irritation called interstitial lung disease (uncommon). This disease can also be linked to the natural progression of your medical condition and can have a fatal outcome in some cases. If you develop symptoms such as sudden difficulty in breathing associated with cough or fever contact your doctor immediately as you could suffer from this disease. Your doctor may decide to permanently stop your treatment with Erlotinib . •Gastrointestinal perforations (uncommon) have been observed. Tell your doctor if you have severe pain in your abdomen. Also, tell your doctor if you had peptic ulcers or diverticular disease in the past, as this may increase this risk. •In rare cases liver failure was observed (rare). If your blood tests indicate severe changes in your liver function, your doctor may need to interrupt your treatment.
How to Store the Medicine
How to Store the Medicine Keep out of the reach and sight of children. Do not use Erlotinib after the expiry date which is stated on the blister and the carton after EXP. The expiry date refers to the last day of that month.This medicine does not require any special storage conditions. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

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