Gemfibrozil belongs to a group of medicines commonly known as fibrates. These medicines are used to lower the level of fats (lipids) in the blood. For example the fats known as triglycerides.Gemfibrozil is used, alongside a low fat diet and other non-medical treatment such as exercise and weight loss, to lower levels of fat in the blood. Gemfibrozil can be used when other medicines (statins) are unsuitable, to reduce the occurrence of heart problems in men who are at high risk and who have increased ‘bad cholesterol’. Gemfibrozil may also be prescribed to people who cannot be prescribed other lipid-lowering medicines for lowering blood cholesterol levels.
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||if you are hypersensitive to gemfibrozil or any of the other ingredients of Gemfibrozil
if you have liver disease
if you have severe kidney disease
if you have a history of gall stones, bile and gall bladder disease (biliary tract disease)
if in the past you have had photoallergy or a phototoxicity reaction (allergic reaction triggered by exposure to sunlight) during treatment with fibrates
if you are currently taking a drug called repaglinide (a drug used to reduce blood sugar levels in diabetes)
|Drug Special Care
||Tell your doctor if you have any of the following conditions to help decide if Gemfibrozil is suitable for you: high risk of muscle breakdown (rhabdomyolysis): risk factors include kidney impairment; under-active thyroid; over 70 years; excessive use of alcohol; previous history of muscular pain and weakness (muscular toxicity) with another fibrate or statin; a history of inherited muscular disorders; use of Gemfibrozil in combination with statins
mild or moderate kidney disease
|Drug Drug Interactions
||anti-diabetic medication particularly rosiglitazone or repaglinide (used to help reduce blood sugar levels)
anticoagulants like warfarin (used to thin the blood)
statins used to lower bad cholesterol and triglycerides, and increase good cholesterol such as atorvastatin, simavastatin, lovastatin, pravastatin, and rosuvastatin
Colestipol resin granules for the treatment of high levels of fat (cholesterol) in your blood
bexarotene medication for the treatment of skin cancer.
|Drug Pregnancy Interaction
||It is recommended that you do not take Gemfibrozil during pregnancy unless it is necessary. Tell your doctor if you are pregnant or trying to become pregnant.
|Drug Breast feeding Interaction
||It is recommended that you do not take Gemfibrozil while you breastfeed. Ask your doctor or pharmacist for advice before taking any medicine.
|Drug Machinery Interaction
||In rare cases Gemfibrozil may cause dizziness and affect your eyesight, if this happens, do not drive or operate machinery. You can drive or operate machinery as long as you feel well.
|Drug More Information
||Taking Gemfibrozil with food and drink
Gemfibrozil should be taken half an hour before meals.
|How to take the
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||Adults and elderly
The usual starting dose is between 900mg and 1200mg daily. Your doctor will decide the best dose for you, follow the instructions given on the label. If you are advised to take a 1200mg dose, one 600mg tablet will need to be taken, half an hour before your breakfast and a second 600mg tablet will need to be taken half an hour before your evening meal.If you are advised to take a 900mg dose, you will need to take the dose (3 x 300mg capsules) half an hour before your evening meal.
Adults with mild or moderate kidney disease:
Your doctor will assess your condition before and during your treatment with Gemfibrozil. Your treatment will start at 900mg daily and may be increased up to 1200mg depending on your response. Gemfibrozil should not be used in patients with severe kidney disease.
Gemfibrozil is not recommended for children
||Always take Gemfibrozil exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.Your blood lipid levels will be closely monitored and regularly assessed before and during your treatment with Gemfibrozil. If you are diabetic or have problems with your thyroid, your doctor will try to treat these conditions before you start treatment. Your doctor will also give you advice about eating the correct diet, exercising, giving up smoking, cutting down on alcohol and if necessary, losing weight. Gemfibrozil should be taken orally. It is recommended that the capsules or tablets be swallowed with a glass of water as the tablets taste unpleasant if you break them.
|Excess Drug Consumption
||If you accidentally take too much Gemfibrozil contact your doctor at once or go to the nearest hospital accident and emergency department. Always take the labelled medicine package with you, whether there is any Gemfibrozil left or not. Signs of overdose may be abdominal cramps, diarrhoea, joint and muscle pain, nausea and vomiting.
|Forgot Drug Consumption
||If you forget to take a dose, do not worry. Simply miss that dose and take your next dose at the right time. Do not take two doses at the same time.
|Stop Drug Consumption
||Do not stop taking Gemfibrozil unless your doctor tells you to. It is recommended that you follow all the advice given while you are taking Gemfibrozil so as to gain the full benefit of the treatment.
||Any sudden wheeziness, difficulty in breathing or dizziness, swelling of the eyelids, face, lips or throat
Peeling and blistering of the skin, mouth, eyes and genitals
Rash affecting your whole body
Muscle weakness or weakness accompanied by dark urine, fever, rapid heart rate (palpitations), nausea, vomiting and facial swelling.
|Common Drug Side Effects
||-sense of spinning or swaying (vertigo)
-eczema, rash (particularly an itchy or puffy rash)
|Rare Drug Side Effects
||-reduction or increase in white blood cells (leucopenia, eosinophilia), bone marrow disease (bone marrow failure)
-reduction of blood platelets (thrombocytopenia)
-allergic reaction in which the face, tongue or throat may start to swell up, causing difficulty in breathing (angioedema)
-inflammation of the nerves (peripheral neuropathy),
-unusual bruising or bleeding due to a reduction in blood platelets (thombocytopaenia)
-painful muscles or muscle breakdown (rhabdomyolysis)
-loss of feeling and a tingling sensation (paraesthesia)
-jaundice (yellowing of the skin ), disturbed liver function
-inflammation of the liver (hepatitis)
-gallstones (cholelithiasis), inflammation of the gall bladder (cholecystitis)
-painful joints and extremities
-muscle disease (myopathy) muscle weakness,
-inflammation of the skin or inflamed skin which flakes or falls off
-inflammation of the muscles (myositis)
-inflammation of the synovial membrane (synovitis)
-persistent lack of energy
-photosensitivity (a sensitivity to light that can cause skin discolouration or a rash)
-red, itchy raised areas of skin
|Very Rare Drug Side Effects
|Drug Side Effects Symptoms
||no data available
|How to Store the
|How to Store the Medicine
||Keep out of the reach and sight of children.Do not use Gemfibrozil after the expiry date which is stated on the carton label and blister foil after EXP. The expiry date refers to the last day of that month. Gemfibrozil hard capsules: Store below 25ºC in the original package in order to protect from moisture Gemfibrozil film-coated tablets: Store below 25ºC Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment