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Ethisone 5mg Tablet is used to treat heavy, painful, or irregular periods, premenstrual syndrome (PMS), and endometriosis. Additionally, it may be used in the treatment of breast cancer. It contains Norethisterone, which works by restoring the hormone levels in the body. In some cases, this medicine may cause side effects such as unusual vaginal bleeding or spotting, dizziness, dry mouth, constipation, nausea, and diarrhoea. Let the doctor know if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-Drug Interactions: Ethisone 5mg Tablet may interact with anticonvulsants (carbamazepine, phenytoin), antiviral drugs (nelfinavir, ritonavir), a medicine used to treat Cushing’s syndrome (aminoglutethimide), antibiotics (co-trimoxazole, rifampicin, tetracycline), immunosuppressant (ciclosporin).

Drug-Food Interaction: Ethisone 5mg Tablet may interact with St. John’s wort (herbal medicine used to treat depression). Also, limit the intake of grapefruit juice with Ethisone 5mg Tablet as it may increase the levels of Ethisone 5mg Tablet in the blood.  

Drug-Disease Interactions: Avoid taking Ethisone 5mg Tablet if you have vaginal bleeding, blood clots, severe itching, porphyria (blood disorder), liver problems, angina (chest pain), or if you ever had a heart attack, jaundice, or pemphigoid gestationis (an itchy rash that develops into blisters). If you have asthma, migraine headaches, epilepsy (fits), kidney or heart problems, inform your doctor before taking Ethisone 5mg Tablet.

Drug-Drug Interactions

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How does the drug interact with Ethisone 5mg Tablet:
Coadministration of Phenytoin and Ethisone 5mg Tablet may decrease the blood levels of Ethisone 5mg Tablet, which may make Ethisone 5mg Tablet less effective.

How to manage the interaction:
Although taking Phenytoin and Ethisone 5mg Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. If you experience any symptoms, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Ethisone 5mg Tablet:
Co-administration of Ethisone 5mg Tablet with Bosentan can reduce the blood levels and effects of norethindrone.

How to manage the interaction:
Taking Ethisone 5mg Tablet with Bosentan together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Ethisone 5mg Tablet:
The combined use of Ethisone 5mg Tablet and phenobarbital can reduce the blood levels and effects of Ethisone 5mg Tablet.

How to manage the interaction:
Although taking phenobarbital and Ethisone 5mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience any symptoms like abnormal bleeding, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
NorethisteroneAmprenavir
Severe
How does the drug interact with Ethisone 5mg Tablet:
Coadministration of Amprenavir and Ethisone 5mg Tablet together may reduce amprenavir effects.

How to manage the interaction:
Combining Amprenavir with Ethisone 5mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ethisone 5mg Tablet:
Coadministration of Ethisone 5mg Tablet and Mycophenolic acid can decrease the levels and effects of Ethisone 5mg Tablet.

How to manage the interaction:
There could be a possible interaction between Mycophenolic acid and Ethisone 5mg Tablet, but they can be taken together if your doctor has prescribed them. However, if you experience hot flashes, vaginal dryness, or abnormal bleeding consult a doctor. Do not discontinue any medications without a doctor's advice.
NorethisteroneTelaprevir
Severe
How does the drug interact with Ethisone 5mg Tablet:
Using Telaprevir and Ethisone 5mg Tablet together can increase risk of unintended pregnancy and decrease the effectiveness of norethindrone.

How to manage the interaction:
Combining Telaprevir with Ethisone 5mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ethisone 5mg Tablet:
Taking carbamazepine and Ethisone 5mg Tablet may possibly reduce the effects of Ethisone 5mg Tablet which may result in higher risk of breakthrough bleeding and unexpected pregnancy.

How to manage the interaction:
Although taking carbamazepine and Ethisone 5mg Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. Contact your doctor if you experience hot flashes, vaginal dryness, or uncontrolled bleeding. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ethisone 5mg Tablet:
Coadministration of Ethisone 5mg Tablet and primidone can reduce the blood levels and effects of Ethisone 5mg Tablet and increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Ethisone 5mg Tablet and Primidone, they can be taken together if prescribed by a doctor. However, if you experience abnormal bleeding, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NorethisteroneFosphenytoin
Severe
How does the drug interact with Ethisone 5mg Tablet:
Coadministration of Ethisone 5mg Tablet with Fosphenytoin can reduces the blood levels and effects of Ethisone 5mg Tablet .

How to manage the interaction:
Taking Ethisone 5mg Tablet with Fosphenytoin together can result in an interaction, but it can be taken if your doctor has advised it. If you experience symptoms of abnormal bleeding while using birth control, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ethisone 5mg Tablet:
Coadministration of Ethisone 5mg Tablet with Oxcarbazepine can reduce the blood levels and effects of norethindrone. This increases the risk of severe bleeding and unintended pregnancy.

How to manage the interaction:
Although taking oxcarbazepine and Ethisone 5mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience any symptoms like abnormal bleeding, consult the doctor immediately Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Consuming Grapefruit juice may increase the blood levels of Ethisone 5mg Tablet. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Ethisone 5mg Tablet dose. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Ethisone 5mg Tablet dose.

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