Drug Ingredient Information
GLIMEPIRIDE-1MG+METFORMIN-500MG
GLIMEPIRIDE
| Information for
patients
|
| Drug Information |
Glimepiride is a medicine taken by mouth to help lower blood
sugar. It belongs to a group of medicines called
sulfonylureas.
Glimepiride works by increasing the amount of insulin released
from your pancreas. The insulin then lowers your blood
sugar levels.
What Glimepiride is used for:
• Glimepiride is used to treat a certain form of diabetes (type 2
diabetes mellitus) when diet, physical exercise and weight
reduction alone have not been able to control your blood
sugar levels |
| Drug Alert |
| Alert |
You are allergic (hypersensitive) to: Glimepiride or other
sulfonylureas (medicines used to lower your blood
sugar such as glibenclamide) or sulfonamides
(medicines for bacterial infections such as
sulfamethoxazole) or any of the other ingredients of
Glimepiride (listed in Section 6 What Glimepiride contains)
• You have insulin dependent diabetes (type 1 diabetes
mellitus) |
| Before Consuming
the Medicine
|
| Avoid Drug |
You are allergic (hypersensitive) to: Glimepiride or other
sulfonylureas (medicines used to lower your blood
sugar such as glibenclamide) or sulfonamides
(medicines for bacterial infections such as
sulfamethoxazole) or any of the other ingredients of
Glimepiride (listed in Section 6 What Glimepiride contains)
• You have insulin dependent diabetes (type 1 diabetes
mellitus)
• You have diabetic ketoacidosis (a complication of diabetes
when your acid level is raised in your body and you may
have some of the following signs: fatigue, feeling sick
(nausea), frequent urination and muscular stiffness)
• You are in a diabetic coma
• You have severe kidney disease
• You have a severe liver disease
Do not take this medicine if any of the above apply to you.
If you are not sure, talk to your doctor or pharmacist
before taking Glimepiride |
| Drug Special Care |
Check with your doctor or pharmacist before taking
your medicine if:
• You are recovering from an injury, operation, infections
with fever, or from other forms of stress, inform your
doctor as temporary change of treatment may be
necessary
• You have a severe liver or kidney disorder
If you are not sure if any of these apply to you, talk to
your doctor or pharmacist before taking Glimepiride.
Lowering of the haemoglobin level and breakdown of red
blood cells (haemolytic anemia) can occur in patients
missing the enzyme glucose-6-phosphate dehydrogenase.
The information available on the use of Glimepiride in people
under 18 years of age is limited. Therefore, its use in
these patients is not recommende |
| Drug Drug Interactions |
Please tell your doctor or pharmacist if you are taking or
have recently taken any other medicines, including
medicines obtained without a prescription.
Your doctor may wish to change your dose of Glimepiride if
you are taking other medicines, which may weaken or
strengthen the effect of Glimepiride on the level of sugar in
your blood.
The following medicines can increase the blood sugar
lowering effect of Glimepiride. This can lead to a risk of
hypoglycaemia (low blood sugar):
• Other medicines to treat diabetes mellitus (such as
insulin or metformin)
• Medicines to treat pain and inflammation
(phenylbutazone, azopropazone, oxyphenbutazone,
aspirin-like medicines)
• Medicines to treat urinary infections (such as some long
acting sulfonamides)
• Medicines to treat bacterial and fungal infections
(tetracyclines, chloramphenicol, fluconazole,
miconazole, quinolones, clarithromycin)
• Medicines to inhibit blood clotting (coumarin
derivatives such as warfarin)
• Medicines supporting muscle build up (anabolics)
• Medicines used for male sex hormone replacement
therapy
• Medicines to treat depression (fluoxetine, MAO-
inhibitors)
• Medicines lowering high cholesterol level (fibrates)
• Medicines lowering high blood pressure (ACE inhibitors)
• Medicines called anti-arrhythmic agents used to control
abnormal heart beat (disopyramide)
• Medicines to treat gout (allopurinol, probenecid,
sulfinpyrazone)
• Medicines to treat cancer (cyclophosphamide,
ifosfamide, trofosfamide)
• Medicines used to reduce weight (fenfluramine)
• Medicines to increase circulation when given in a high
dose intravenous infusion (pentoxifylline)
• Medicines to treat nasal allergies such as hay fever
(tritoqualine)
• Medicines called sympatholytics to treat high blood
pressure, heart failure, or prostate symptoms
The following medicines may decrease the blood sugar
lowering effect of Glimepiride. This can lead to a risk of
hyperglycaemia (high blood sugar level):
• Medicines containing female sex hormones (oestrogens,
progestogens)
• Medicines to treat high blood pressure called thiazide
diuretics (water tablets)
• Medicines used to stimulate the thyroid gland (such as
levothyroxine)
• Medicines to treat allergies and inflammation
(glucocorticoids)
• Medicines to treat severe mental disorders
(chlorpromazine and other phenothiazine derivatives)
• Medicines used to raise heart beat, to treat asthma or
nasal congestion, coughs and colds, used to reduce
weight, or used in life-threatening emergencies
(adrenaline and sympathomimetics)
• Medicines to treat high cholesterol level (nicotinic acid)
• Medicines to treat constipation when they are used long
term (laxatives)
• Medicines to treat fits (phenytoin)
• Medicines to treat nervousness and sleep problems
(barbiturates)
• Medicines to treat increased pressure in the eye
(azetazolamide)
• Medicines to treat high blood pressure or lowering
blood sugar (diazoxide)
• Medicines to treat infections, tuberculosis (rifampicine)
• Medicines to treat severe low blood sugar levels
(glucagon)
The following medicines can increase or decrease the
blood sugar lowering effect of Glimepiride:
• Medicines to treat stomach ulcers (called H2
antagonists)
• Medicines to treat high blood pressure or heart failure
such as beta-blockers, clonidine, guanethidine and
reserpine. These can also hide the signs of
hypoglycaemia, so special care is needed when taking
these medicines
Glimepiride may either increase or weaken the effects of the
following medicines:
• Medicines inhibiting blood clotting (coumarin
derivatives such as warfarin) |
| Drug Pregnancy Interaction |
Glimepiride should not be taken during pregnancy. Tell your
doctor if you are, you think you might be or are planning
to become pregnant |
| Drug Breast feeding Interaction |
Glimepiride may pass into breast milk. Glimepiride should not be
taken during breast feeeding.
Ask your doctor or pharmacist for advice before taking
any medicine |
| Drug Machinery Interaction |
your blood sugar is lowered (hypoglycaemia), or raised
(hyperglycaemia) or if you develop visual problems as a
result of such conditions. Bear in mind that you could
endanger yourself or others (e.g. when driving a car or
using machines). Please ask your doctor whether you can
drive a car if you:
• have frequent episodes of hypoglycaemia,
• have fewer or no warning signals of hypoglycaemia |
| Drug More Information |
Important information about hypoglycaemia (low
blood sugar)
When you take Glimepiride, you may get hypoglycaemia (low
blood sugar). Please see below for additional information
about hypoglycaemia, its signs and treatment.
Following factors could increase the risk of you
getting hypoglycaemia:
• Undernourishment, irregular meal time, missed or
delayed meal or period of fasting
• Changes to your diet
• Taking more Glimepiride than needed
• Having kidneys that do not work properly
• Having severe liver disease
• If you suffer from particular hormone-induced
disorders (disorders of the thyroid glands, of the
pituitary gland or adrenal cortex)
• Drinking alcohol (especially when you skip a meal)
• Taking certain other medicines (See Taking other
medicines below)
• If you increase the amount of exercise you do and you
don''t eat enough food or eat food containing less
carbohydrate than usual.
Signs of hypoglycaemia include:
• Hunger pangs, headache, nausea, vomiting,
sluggishness, sleepiness, problems sleeping,
restlessness, aggression, problems with concentration,
reduced alertness and reaction time, depression,
confusion, problems with your speech and
sight, slurred speech, shakiness, partial
paralysis, dizziness, helplessness
• The following signs may also occur: sweating, clammy
skin, anxiety, fast or increased heart beat, high blood
pressure, awareness of your heart beat, sudden strong
pain in the breast that may radiate into neighbouring
areas (angina pectoris and cardiac arrhythmias)
If blood sugar levels continue to drop you may suffer
from considerable confusion (delirium), develop fits,
lose self control, breathing may be shallow and your
heart beat slowed down, you may fall into
unconsciousness. The clinical picture of a severe
reduced blood sugar level may resemble that of a
stroke.
Treating hypoglycaemia:
In most cases the signs of reduced blood sugar vanish
very quickly when you consume some form of sugar,
e.g. sugar cubes, sweet juice, sweetened tea.
You should therefore always take some form of sugar
with you (e.g. sugar cubes). Remember that artificial
sweeteners are not effective. Please contact your doctor
or go to the hospital if taking sugar does not help or if
the symptoms recur.
Laboratory Tests
The level of sugar in your blood or urine should be
checked regularly. Your doctor may also take blood tests
to monitor your blood cell levels and liver function. |
| How to take the
Medicine
|
| Consumption Info |
Glimepiride contains lactose. If you have been told by your
doctor that you cannot tolerate some sugars, contact your
doctor before taking this medicinal product.
Alcohol intake may increase or decrease the blood sugar
lowering action of Glimepiride in an unpredictable way. |
| Drug quanitty |
The dose of Glimepiride depends on your needs, condition
and results of blood and urine sugar tests and is
determined by your doctor. Do not take more tablets
than your doctor has prescribed.
• The usual starting dose is one Glimepiride 1 mg tablet once
a day
• If necessary, your doctor may increase the dose after
each 1 - 2 weeks of treatment
• The maximum recommended dose is 6 mg Glimepiride per day
• A combination therapy of glimepiride plus metformin
or of glimepiride plus insulin may be started. In such a
case your doctor will determine the proper doses of
glimepiride, metformin or insulin individually for you
• Your dose of Glimepiride may need to be adjusted if you
change weight, change your lifestyle, or if you are
under a lot of stress. Please speak to your doctor if any of these situations apply to you
• If you feel the effect of your medicine is too weak or
too strong do not change the dose yourself, but ask
your doctor |
| Drug Dose |
• Take this medicine by mouth, just before or with the
first main meal of the day (usually breakfast). If you do
not have breakfast you should take the product on
schedule as prescribed by your doctor. It is important
not to leave out any meal when you are on Glimepiride
• Swallow the tablets whole with at least half glass of
water. Do not crush or chew the tablets |
| Excess Drug Consumption |
If you happen to have taken too much Glimepiride or an
additional dose there is a danger of hypoglycaemia (signs
of hypoglycaemia see Section 2 - Take special care with
Glimepiride) and therefore you should instantly consume
enough sugar (e.g. a small bar of sugar cubes, sweet
juice, sweetened tea) and inform a doctor immediately.
When treating hypoglycaemia due to accidental intake in
children, the quantity of sugar given must be carefully
controlled to avoid the possibility of producing dangerous
hyperglycaemia. Persons in a state of unconsciousness
must not be given food or drink.
Since the state of hypoglycaemia may last for some time
it is very important that the patient is carefully
monitored until there is no more danger. Admission into
hospital may be necessary, also as a measure of
precaution. Show the doctor the package or remaining
tablets, so the doctor knows what has been taken.
Severe cases of hypoglycaemia accompanied by loss of
consciousness and coma are cases of medical emergency
requiring immediate medical treatment and admission
into hospital. It may be helpful to tell your family and
friends to call a doctor immediately if this happens to
you |
| Forgot Drug Consumption |
If you forget to take a dose, do not take a double dose to
make up for forgotten doses |
| Stop Drug Consumption |
If you interrupt or stop the treatment you should be
aware that the desired blood sugar lowering effect is not
achieved or that the disease will get worse again. Keep
taking Glimepiride until your doctor tells you to stop. |
| Possible Side
Effects
|
| General Information |
• Allergic reactions (including inflammation of blood
vessels, often with skin rash) which may develop into
serious reactions with difficulty in breathing, fall in
blood pressure and sometimes progressing to shock
• Abnormal liver function including yellowing of the skin
and eyes (jaundice), problems with the bile flow
(cholestasis), inflammation of the liver (hepatitis) or
liver failure
• Allergy (hypersensitivity) of the skin such as itching,
rash, hives and increased sensitivity to sun.
Some mild allergic reactions may develop into serious reactions
• Severe hypoglycaemia including loss of consciousness,
seizures or coma
Some patients experienced the following side effects
whilst taking |
| Common Drug Side Effects |
• Allergy (hypersensitivity) of the skin may occur such as
itching, rash, hives and increased sensitivity to sun.
Some mild allergic reactions may develop into serious
reactions with swallowing or breathing problems,
swelling of your lips, throat or tongue. Therefore in the
event of one of these side effects, tell your doctor
immediately
• Allergic reactions with sulfonylureas, sulfonamides, or
related drugs may occur
• Problems with your sight may occur when beginning
treatment with Glimepiride. This is due to changes in blood
sugar levels and should soon improve
• Increased liver enzymes
If any of the side effects gets serious, or if you notice
any side effects not listed in this leaflet, please tell
your doctor or pharmacist |
| Rare Drug Side Effects |
• Lower blood sugar than normal (hypoglycaemia)
(See Section 2 - Take special care with Glimepiride)
• Decrease in the number of blood cells:
• Blood platelets (which increases risk of bleeding or
bruising)
• White blood cells (which makes infections more likely)
• Red blood cells (which can make the skin pale and
cause weakness or breathlessness)
These problems generally get better after you stop taking
Glimepiride |
| Very Rare Drug Side Effects |
• Allergic reactions (including inflammation of blood
vessels, often with skin rash) which may develop into
serious reactions with difficulty in breathing, fall in
blood pressure and sometimes progressing to shock. If
you experience any of these symptoms, tell your
doctor immediately
• Abnormal liver function including yellowing of the skin
and eyes (jaundice), impairment of the bile flow
(cholestasis), inflammation of the liver (hepatitis) or
liver failure. If you experience any of these symptoms,
tell your doctor immediately
• Feeling or being sick, diarrhoea, feeling full or bloated,
and abdominal pain
• Decrease in the amount of sodium level in your blood
(shown by blood tests) |
| Drug Side Effects Symptoms |
|
| How to Store the
Medicine
|
| How to Store the Medicine |
Keep out of the reach and sight of children.
Do not use Glimepiride after the expiry date which is stated
after ‘EXP’ on the blister and carton. The expiry date
refers to the last day of that month.
Glimepiride 1 mg, 2 mg, 3 mg, and 4 mg tablets: do not store
above 30°C.
Store in the original package in order to protect from moisture Do not use Glimepiride if you notice visible signs of
deterioration.
Medicines should not be disposed of via wastewater or
household waste. Ask your pharmacist how to dispose of
medicines no longer required. These measures will help
to protect the environment. |
METFORMIN
| Information for
patients
|
| Drug Information |
Metformin is used alone or with other medications, including insulin, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Metformin helps to control the amount of glucose (sugar) in your blood. It decreases the amount of glucose you absorb from your food and the amount of glucose made by your liver. Metformin also increases your body's response to insulin, a natural substance that controls the amount of glucose in the blood. Metformin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). |
| Drug Alert |
| Alert |
no data available |
| Before Consuming
the Medicine
|
| Avoid Drug |
Tell your doctor if you regularly drink alcohol or sometimes drink large amounts of alcohol in a short time (binge drinking). Drinking alcohol increases your risk of developing lactic acidosis or may cause a decrease in blood sugar. Ask your doctor how much alcohol is safe to drink while you are taking metformin. |
| Drug Special Care |
Before taking metformin,
tell your doctor and pharmacist if you are allergic to metformin or any other medications.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: amiloride (Midamor, Moduretic); antihistamines; beta-blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Lexxel, Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular), and verapamil (Calan, Isoptin, Verelan); cimetidine (Tagamet); digoxin (Lanoxin, Lanoxicaps); furosemide (Lasix); hormone replacement therapy; insulin or other medications for diabetes; isoniazid (INH, Nydrazid); medications for asthma and colds; medications for mental illness and nausea such as fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), promethazine (Phenergan), thioridazine (Mellaril), thiothixene (Navane), trifluoperazine (Stelazine), and triflupromazine (Vesprin); medications for thyroid disease; morphine (MS Contin, Roxanol, others); nicotinic acid; oral contraceptives ('birth control pills'); oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); phenytoin (Dilantin, Phenytek); procainamide (Procanbid); quinidine (Quinidex); quinine; ranitidine (Zantac); triamterene (Dyazide, Maxzide, others); or trimethoprim (Proloprim, Trimpex). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor if you have or have ever had any medical condition, especially those mentioned in the IMPORTANT WARNING section.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking metformin, call your doctor.
if you are using the extended-release tablets, you should know that sometimes the tablet shell may appear in your stool. If this occurs, it is not harmful and will not affect the way the medication works.
tell your doctor if you eat less or exercise more than usual. This can affect your blood sugar. Your doctor will give you instructions if this happens. |
| Drug Drug Interactions |
acyclovir (Zovirax); acetaminophen (Tylenol); aminoglycoside antibiotics such as amikacin (Amikin), gentamicin (Garamycin), Kanamycin (Kantrex), Neomycin (Neo-Fradin, Neo-Rx), netilmicin (Netromycin), paromomycin (Humatin), streptomycin and tobramycin (Nebcin, Tobi); amphotericin B (Abelcet, Amphocin, others); angiotensin converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinvil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); cancer chemotherapy medications; cyclosporine (Sandimmune, Neoral); dapsone (Avlosulfon); diuretics (water pills); foscarnet (Foscavir); gold compounds such as auranofin (Ridaura), aurothioglucose (Aurolate, Solganol), and gold sodium thiomalate (Myochrysine); hydralazine (Hydra-Zide); lithium (Eskalith, Lithobid); medications to treat human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS); methicillin (Staphcillin); nitrates; penicillin and sulfa antibiotics; penicillamine (Cuprimine, Depen); primaquine; propranolol (Inderal); rifampin (Rifadin, Rimactane); tacrolimus (Prograf); vancomycin (Vancocin); or if you have ever taken the Chinese weight-loss herb Aristolochia. |
| Drug Pregnancy Interaction |
no data available |
| Drug Breast feeding Interaction |
no data available |
| Drug Machinery Interaction |
no data available |
| Drug More Information |
In addition to describing the cardiovascular risks, the drug labels have been revised to state that rosiglitazone and rosiglitazone-containing medicines should only be used:
In patients already being treated with these medicines
In patients whose blood sugar cannot be controlled with other anti-diabetic medicines and who, after consulting with their healthcare professional, do not wish to use pioglitazone-containing medicines |
| How to take the
Medicine
|
| Consumption Info |
If you are having surgery, including dental surgery, any x-ray procedure in which dye is injected, or any major medical procedure, tell the doctor that you are taking metformin. You may need to stop taking metformin before the procedure and wait 48 hours to restart treatment. Your doctor will tell you exactly when you should stop taking metformin and when you should start taking it again. |
| Drug quanitty |
no data available |
| Drug Dose |
Metformin comes as a liquid, a tablet and an extended-release (long-acting) tablet to take by mouth. The liquid is usually taken with meals one or two times a day. The regular tablet is usually taken with meals two or three times a day. The extended-release tablet is usually taken once daily with the evening meal. To help you remember to take metformin, take it around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take metformin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow metformin extended-release tablets whole; do not split, chew, or crush them.
Your doctor may start you on a low dose of metformin and gradually increase your dose not more often than once every 1 to 2 weeks. You will need to monitor your blood sugar carefully so your doctor will be able to tell how well metformin is working.
Metformin controls diabetes but does not cure it. Continue to take metformin even if you feel well. Do not stop taking metformin without talking to your doctor. |
| Excess Drug Consumption |
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
extreme tiredness
weakness
discomfort
vomiting
nausea
stomach pain
decreased appetite
deep, rapid breathing
shortness of breath
dizziness
lightheadedness
abnormally fast or slow heartbeat
flushing of the skin
muscle pain
feeling cold |
| Forgot Drug Consumption |
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. |
| Stop Drug Consumption |
Do not stop the drug untill your doctor says you to do so. |
| Possible Side
Effects
|
| General Information |
extreme tiredness, weakness, or discomfort; nausea; vomiting; stomach pain; decreased appetite; deep and rapid breathing or shortness of breath; dizziness; lightheadedness; fast or slow heartbeat; flushing of the skin; muscle pain; or feeling cold. |
| Common Drug Side Effects |
Metformin may rarely cause a serious, life-threatening condition called lactic acidosis. Tell your doctor if you have or have ever had a heart attack; stroke; high blood pressure; diabetic ketoacidosis (blood sugar that is high enough to cause severe symptoms and requires emergency medical treatment) or coma; surgery to remove part of your small intestine; anemia (not enough red blood cells), or heart, kidney, lung, or liver disease. |
| Rare Drug Side Effects |
no data available |
| Very Rare Drug Side Effects |
no data available |
| Drug Side Effects Symptoms |
This medication may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.
You may experience hypoglycemia (low blood sugar) while you are taking this medication. Your doctor will tell you what you should do if you develop hypoglycemia. He or she may tell you to check your blood sugar, eat or drink a food or beverage that contains sugar, such as hard candy or fruit juice, or get medical care. Follow these directions carefully if you have any of the following symptoms of hypoglycemia:
shakiness
dizziness or lightheadedness
sweating
nervousness or irritability
sudden changes in behavior or mood
headache
numbness or tingling around the mouth
weakness
pale skin
hunger
clumsy or jerky movements
If hypoglycemia is not treated, severe symptoms may develop. Be sure that your family, friends, and other people who spend time with you know that if you have any of the following symptoms, they should get medical treatment for you immediately:
confusion
seizures
loss of consciousness
Call your doctor immediately if you have any of the following symptoms of hyperglycemia (high blood sugar):
extreme thirst
frequent urination
extreme hunger
weakness
blurred vision
If high blood sugar is not treated, a serious, life-threatening condition called diabetic ketoacidosis could develop. Call your doctor immediately if you have any of these symptoms:
dry mouth
nausea and vomiting
shortness of breath
breath that smells fruity
decreased consciousness
Metformin may cause side effects. Tell your doctor if any of these symptoms are severe, do not go away, go away and come back, or do not begin for some time after you begin taking metformin:
diarrhea
bloating
stomach pain
gas
constipation
unpleasant metallic taste in mouth
heartburn
headache
sneezing
cough
runny nose
flushing of the skin
nail changes
muscle pain
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them or those listed in the IMPORTANT WARNING section, call your doctor immediately:
chest pain
rash
Some female laboratory animals given high doses of metformin developed non-cancerous polyps (abnormal growths of tissue) in the uterus (womb). It is not known if metformin increases the risk of polyps in humans. Talk to your doctor about the risks of taking this medication.
Metformin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. |
| How to Store the
Medicine
|
| How to Store the Medicine |
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication. |
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