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Composition : LETROZOLE-2.5MG
Dose Form : TABLET
Description : LETROZ TAB 2.5MG
Route Of Administration : ORAL
Pack : 5

Drug Ingredient Information



Information for patients
Drug Information Letrozole contain an active substance called letrozole. It belongs to a group of medicines called aromatase inhibitors. It is a hormonal (or “endocrine”) breast cancer treatment.Letrozole are used to prevent breast cancer happening again. It can be used as a first treatment after breast surgery or following five years of treatment with tamoxifen. Letrozole are also used to prevent breast tumour spreading to other parts of the body in patients with advanced breast cancer. Letrozole should only be used for: •oestrogen receptor-positive breast cancer and •only in women after menopause i.e. cessation of periods. Growth of breast cancer is frequently stimulated by oestrogens, which are female sex hormones. Letrozole reduce the amount of oestrogen by blocking an enzyme (“aromatase”) involved in the production of oestrogens. As a consequence tumour cells slow or stop the growing and/or spreading to other parts of the body. You should only take this medicine under strict medical supervision. Your doctor will regularly monitor your condition to check if the treatment is having the right effect. Letrozole may cause thinning or wasting of your bones (osteoporosis) due to the reduction of oestrogens in your body. This means that doctor may decide to measure your bone density (a way of monitoring for osteoporosis) before, during and after treatment.If you have any questions about how Letrozole work or why this medicine has been prescribed for you, ask your doctor.
Drug Alert
Before Consuming the Medicine
Avoid Drug •are allergic (hypersensitive) to letrozole or any of the other ingredients of Letrozole. •still have periods, i.e. if you have not yet gone through the menopause. •are pregnant •are breast-feeding If any of these conditions apply to you, do not take this medicine tell your doctor.
Drug Special Care •have a severe kidney disease •have severe liver disease •have a history of osteoporosis or bone fractures. If any of these conditions apply to you, tell your doctor. Your doctor will take this into account during your treatment with Letrozole .
Drug Drug Interactions Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Other medicines may be affected by letrozole. They, in turn may affect how well letrozole works. Children and adolescents (below 18 years) Children and adolescents should not use this medicine.
Drug Pregnancy Interaction Ask your doctor or pharmacist for advice before taking any medicine. You must not take Letrozole if you are pregnant or breast feeding as it may harm your baby. However, since Letrozole are only recommended for postmenopausal women, pregnancy and breast-feeding restrictions most likely will not apply to you. If you recently became postmenopausal or if you are perimenopausal, your doctor should discuss with you the necessity of a pregnancy test before taking Letrozole and of contraception as you might have the potential to become pregnant.
Drug Breast feeding Interaction You must not take Letrozole if you are pregnant or breast feeding as it may harm your baby.
Drug Machinery Interaction If you feel dizzy, tired, drowsy or generally unwell, do not drive or operate any tools or machines until you feel normal again.
Drug More Information
How to take the Medicine
Consumption Info
Drug quanitty
Drug Dose Always take Letrozole exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. How much Letrozole to take The usual dose for adults, including elderly people (aged 65 years and over) is one Letrozole tablet to be taken once a day. Taking Letrozole at the same time each day will help you remember when to take your tablet. How to take Letrozole The tablet should be swallowed whole with a glass of water or another liquid. How long to take Letrozole Continue taking Letrozole every day for as long as your doctor tells you. You may need to take it for months or even years. If you have any questions about how long to keep taking Letrozole, talk to your doctor.
Excess Drug Consumption If you have taken too much Letrozole, or if someone else accidentally takes your, contact your doctor or hospital for advice immediately. Show them the pack of . Medical treatment may be necessary.
Forgot Drug Consumption •Do not take a double dose to make up for a forgotten tablet. •If it is almost time for the next dose (e.g. within 2 or 3 hours) skip the missed dose and take the next tablet at the usual time •Otherwise, take the dose as soon as you remember, and then take the next tablet as you would normally.
Stop Drug Consumption Do not stop taking Letrozole even if you are feeling well, unless your doctor tells you. If you have any further questions on the use of this Letrozole , ask your doctor or pharmacist.
Possible Side Effects
General Information •hot flushes •fatigue •increased sweating •pain in joints (arthralgia)
Common Drug Side Effects •generally feeling unwell (malaise) •skin rash •headache •dizziness •gastrointestinal disorders such as nausea, vomiting, indigestion, constipation, diarrhoea •increase in or loss of appetite •pain in muscles or bones •thinning or wasting of your bones (osteoporosis), leading to bone fractures in some cases •swelling of arms, hands, feet, ankles (peripheral oedema) •sad mood (depression) •weight increase •hair loss
Rare Drug Side Effects •nervous disorders such as anxiety, nervousness, irritability, drowsiness, memory problems •sleep problems (sleepiness or difficulty in sleeping) •impairment of sensation, especially that of touch •eye disorders such as blurred vision, eye irritation, cataract (loss of transparency of the lens of the eye) •raised blood pressure (hypertension) •palpitations, rapid heart rate, angina and heart attack •stroke (a blockage or haemorrhage of the blood vessel leading to the brain) •inflamed blood vessels •skin disorders such as itching (urticaria), dry skin •vaginal disorders such as bleeding, discharge or dryness •joint stiffness (arthritis) •abdominal pain •breast pain •tumour pain •fever •thirst, taste disorder, dry mouth inflammation of the mucosa in the mouth •mucosal dryness •general swelling due to fluid retention •weight loss •urinary tract infection, increased frequency of urination •decreased white blood cells which can lead to infections (leucopenia) •cough, breathlessness
Very Rare Drug Side Effects •clotting in the blood vessels e.g. legs (thrombosis) •blood clots in the lungs (pulmonary embolism) You may also have some blood test disorders while taking letrozole, i.e. high level of cholesterol
Drug Side Effects Symptoms •experience weakness, paralysis or loss of feeling in an arm or leg or any other part of the body, loss of coordination, nausea, or difficulty in speaking or breathing (sign of a brain disorder, e.g. stroke). •have sudden oppressive chest pain (sign of a heart disorder). •experience difficulty in breathing, chest pain, fainting, rapid heart rate, bluish skin discoloration, or sudden arm or leg (foot) pain (signs that a blood clot may have formed). •experience swelling and redness along a vein which is extremely tender and possibly painful when touched. •get severe fever, chills or mouth ulcers due to infections (lack of white blood cells). •get severe persistent blurred vision. Some patients experienced swelling mainly of the face and throat during treatment with letrozole.
How to Store the Medicine
How to Store the Medicine Keep out of the reach and sight of children. This medicinal product does not require any special storage conditions. Do not use Letrozole after the expiry date which is stated on the carton after EXP. The expiry date refers to the last day of that month. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

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