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  3. CARBOPLATIN 450MG INJECTION 45ML

CARBOPLATIN 450MG INJECTION 45ML, Pack of 1 INJECTION
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Composition :

CARBOPLATIN-450MG

Manufacturer/Marketer :

Pharmacia & Upjohn India Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About CARBOPLATIN 450MG INJECTION

CARBOPLATIN 450MG INJECTION belongs to a group of anti-cancer medicines used for the treatment of ovarian cancer and small-cell lung cancer. It may sometimes be used to treat other cancers. Cancer forms in tissues of the ovary (one of a pair of female reproductive glands in which the ova, or eggs, are formed). Small-cell lung cancer is a disease in which malignant (cancer) cells form in the tissues of the lung.

CARBOPLATIN 450MG INJECTION contains 'Carboplatin'. Carboplatin acts by penetrating the cell wall and binding to the cell's DNA, stopping the cell from naturally dividing and functioning, ultimately destroying the cell. These medicines target cancer cells because they often affect rapidly dividing cells.

CARBOPLATIN 450MG INJECTION is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection. You may experience nausea, diarrhoea, vomiting, thrombocytopenia (a low platelet count), peripheral neuropathy (nerves malfunction), nephrotoxicity at high doses and electrolyte disturbances. Most of these side effects of CARBOPLATIN 450MG INJECTION do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

To treat your condition effectually, continue taking CARBOPLATIN 450MG INJECTION for as long as your doctor has prescribed. Do not stop the CARBOPLATIN 450MG INJECTION midway. Talk to your doctor before taking CARBOPLATIN 450MG INJECTION if you have severe allergic reactions to CARBOPLATIN 450MG INJECTION or other platinum-containing compounds or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. CARBOPLATIN 450MG INJECTION should not be employed in patients with severe bone marrow depression or significant bleeding. Avoid taking CARBOPLATIN 450MG INJECTION if you are pregnant or breastfeeding because this CARBOPLATIN 450MG INJECTION can cause harmful effects on the unborn baby. Both women and men using this CARBOPLATIN 450MG INJECTION should use birth control to avoid pregnancy.

Uses of CARBOPLATIN 450MG INJECTION

Treatment of Ovarian cancer and Small cell lung cancer

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• CARBOPLATIN 450MG INJECTION will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

CARBOPLATIN 450MG INJECTION contains 'Carboplatin' which belongs to a group of anti-cancer medicines used to treat ovarian cancer and small cell lung cancer. It works by damaging the genetic material (DNA) of the cancer cells, which stops their growth and multiplication. It can be used alone or with other chemotherapy drugs depending on your cancer type.

How CARBOPLATIN 450MG INJECTION Works

CARBOPLATIN 450MG INJECTION contains 'Carboplatin'. Carboplatin acts by penetrating the cell wall and binding to the cell's DNA, stopping the cell from naturally dividing and functioning, ultimately destroying the cell. These medicines target cancer cells because they often affect rapidly dividing cells.

Storage

Store in a cool and dry place away from sunlight
Side effects of Carboplatin 450mg Injection 45ml
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Limit the intake of alcohol consumption.
  • Get vaccinated against hepatitis B and C.
  • Maintain a healthy weight through diet and exercise.
  • Eat healthy diet containing fruits, vegetables, whole grains, and lean proteins.
  • Include vitamin D in your diet.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.

What if I have taken an overdose of CARBOPLATIN 450MG INJECTION

It is unlikely to overdose on parenteral medication as it is administered by a healthcare professional. However, seek medical attention if you experience symptoms of overdose such as black/tarry/bloody stools, bloody vomit or vomited material that looks like coffee grounds, unusual bruising or bleeding, decreased urination, pain, burning, or tingling in the hands or feet, ringing in ears and difficulty hearing.

Drug Warnings

CARBOPLATIN 450MG INJECTION should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking CARBOPLATIN 450MG INJECTION. To treat your condition effectually, continue taking CARBOPLATIN 450MG INJECTION for as long as your doctor has prescribed. Do not stop the CARBOPLATIN 450MG INJECTION midway. Talk to your doctor before taking CARBOPLATIN 450MG INJECTION if you have severe allergic reactions to CARBOPLATIN 450MG INJECTION or other platinum-containing compounds or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. CARBOPLATIN 450MG INJECTION should not be employed in patients with severe bone marrow depression or significant bleeding. Avoid taking CARBOPLATIN 450MG INJECTION if you are pregnant or breastfeeding because this CARBOPLATIN 450MG INJECTION can cause harmful effects on the unborn baby. Both women and men using this CARBOPLATIN 450MG INJECTION should use birth control to avoid pregnancy. Peripheral blood counts should be frequently monitored during CARBOPLATIN 450MG INJECTION treatment and appropriate until recovery is achieved.

Drug-Drug Interactions

verifiedApollotooltip
CarboplatinSorafenib
Critical
CarboplatinTopotecan
Severe

Drug-Drug Interactions

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CarboplatinSorafenib
Critical
How does the drug interact with Carboplatin 450mg Injection 45ml 450mg Injection 45ml:
Co-administration of Sorafenib with Carboplatin 450mg Injection 45ml can increase the risk or severity of serious side effects.

How to manage the interaction:
Taking Sorafenib with Carboplatin 450mg Injection 45ml together is not recommended as it can cause an interaction, consult a doctor before taking it. However if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without consulting a doctor.
CarboplatinTopotecan
Severe
How does the drug interact with Carboplatin 450mg Injection 45ml 450mg Injection 45ml:
When Carboplatin 450mg Injection 45ml is used with topotecan, it may increase the risk of side effects.

How to manage the interaction:
Co-administration of Carboplatin 450mg Injection 45ml with clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without consulting your doctor.
CarboplatinCidofovir
Severe
How does the drug interact with Carboplatin 450mg Injection 45ml 450mg Injection 45ml:
Taking cidofovir with Carboplatin 450mg Injection 45ml can increase the risk of kidney problems.

How to manage the interaction:
Although taking Carboplatin 450mg Injection 45ml and cidofovir together can possibly cause an interaction, it can be taken if your doctor has suggested it. However, if you experience loss of hunger, increased or decreased urination, swelling, shortness of breath, bone pain, muscle cramps, irregular heart rhythm, consult a doctor immediately. It is advised to wait at least for 7 days after stopping Carboplatin 450mg Injection 45ml, before taking Cidofovir. Do not stop using any medications without talking to a doctor.
CarboplatinNatalizumab
Severe
How does the drug interact with Carboplatin 450mg Injection 45ml 450mg Injection 45ml:
Taking Carboplatin 450mg Injection 45ml with Natalizumab can increase the risk of developing serious infections. Particularly, progressive multifocal leukoencephalopathy(a rare but serious viral infection of the brain).

How to manage the interaction:
Taking Carboplatin 450mg Injection 45ml with Natalizumab together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, weakness on one side of the body, clumsiness of legs and hands, eye problems, confusion, or changes in thinking, memory and personality, consult a doctor. Do not stop using any medications without a doctor's advice.
CarboplatinAdalimumab
Severe
How does the drug interact with Carboplatin 450mg Injection 45ml 450mg Injection 45ml:
Using Adalimumab with Carboplatin 450mg Injection 45ml can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Carboplatin 450mg Injection 45ml and Adalimumab together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CarboplatinPalifermin
Severe
How does the drug interact with Carboplatin 450mg Injection 45ml 450mg Injection 45ml:
When Palifermin is used with Carboplatin 450mg Injection 45ml, may increase the risk or severity of mouth ulcers.

How to manage the interaction:
Co-administration of Carboplatin 450mg Injection 45ml with Palifermin can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have painful mouth ulcers, contact the doctor right away. It is advised to take Palifermin at least after 24 hours of stopping Carboplatin 450mg Injection 45ml. Do not stop using any medications without a doctor's advice.
CarboplatinCladribine
Severe
How does the drug interact with Carboplatin 450mg Injection 45ml 450mg Injection 45ml:
Using cladribine and Carboplatin 450mg Injection 45ml together can increase the risk of serious infections.

How to manage the interaction:
Co-administration of Carboplatin 450mg Injection 45ml and cladribine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, red or inflamed skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
CarboplatinFingolimod
Severe
How does the drug interact with Carboplatin 450mg Injection 45ml 450mg Injection 45ml:
Using Carboplatin 450mg Injection 45ml with Fingolimod can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Carboplatin 450mg Injection 45ml and Fingolimod, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CarboplatinThiotepa
Severe
How does the drug interact with Carboplatin 450mg Injection 45ml 450mg Injection 45ml:
Using Carboplatin 450mg Injection 45ml with Thiotepa can increase the risk and severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Thiotepa and Carboplatin 450mg Injection 45ml, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without talking to a doctor.
CarboplatinInfliximab
Severe
How does the drug interact with Carboplatin 450mg Injection 45ml 450mg Injection 45ml:
Taking Infliximab with Carboplatin 450mg Injection 45ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Infliximab with Carboplatin 450mg Injection 45ml can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhoea, sore throat, muscle pain, difficulty breathing, pain or burning when you pee, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs in your diet.
  • Get optimal sleep; rest well.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

CARBOPLATIN 450MG INJECTION Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking CARBOPLATIN 450MG INJECTION. It could lead to avoiding unpleasant side effects.

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Pregnancy

Unsafe

CARBOPLATIN 450MG INJECTION should not be used during pregnancy because it causes harm to the fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking CARBOPLATIN 450MG INJECTION and at least six months afterwards. Please consult your doctor about any concerns regarding this.

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Breast Feeding

Unsafe

CARBOPLATIN 450MG INJECTION should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers. Please consult your doctor about any concerns regarding this.

bannner image

Driving

Caution

CARBOPLATIN 450MG INJECTION may affect your reactions and your ability to drive. Possible side effects of chemotherapy with CARBOPLATIN 450MG INJECTION may occur, such as nausea and vomiting. If you are affected by these side effects, you should not drive and/or operate machines that require you to be alert.

bannner image

Liver

Caution

If you have had a history or evidence of any liver-related diseases, please consult the doctor before taking CARBOPLATIN 450MG INJECTION. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

bannner image

Kidney

Caution

If you have had a history or evidence of any kidney-related diseases, please consult the doctor before taking CARBOPLATIN 450MG INJECTION. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

bannner image

Children

Unsafe

Efficacy and safety have not been established. Please consult your doctor. Your doctor will weigh the benefits and potential risks before prescribing them.

Have a query?

FAQs

CARBOPLATIN 450MG INJECTION is used to treat ovarian cancer and small-cell lung cancer.

CARBOPLATIN 450MG INJECTION contains 'Carboplatin'. Carboplatin works by breaching the cellular wall and binding to the cell’s DNA, preventing the cell from dividing and functioning normally, which eventually kills the cell.

Yes, CARBOPLATIN 450MG INJECTION can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or believe you have an infection.

CARBOPLATIN 450MG INJECTION should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.

Before you receive treatment with CARBOPLATIN 450MG INJECTION, tell your doctor about all of your medical conditions. You should not receive CARBOPLATIN 450MG INJECTION if you are allergic to carboplatin or any contents in CARBOPLATIN 450MG INJECTION. It should not be employed in patients with severe bone marrow depression or significant bleeding.

If not given an inappropriate dose, CARBOPLATIN 450MG INJECTION can cause toxic effects, although not everyone gets it. So, CARBOPLATIN 450MG INJECTION is prescribed by a doctor experienced in the use of medications to treat cancer only.

Avoid taking CARBOPLATIN 450MG INJECTION if you are pregnant because CARBOPLATIN 450MG INJECTION can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of CARBOPLATIN 450MG INJECTION.

CARBOPLATIN 450MG INJECTION is administered to you through an intravenous (IV) infusion. A healthcare professional usually gives it in a medical facility.

CARBOPLATIN 450MG INJECTION is not cell cycle specific. It works by forming DNA adducts, which leads to cell death. This mechanism of action is not specific to any particular phase of the cell cycle, meaning it can affect cells at various stages of their life cycle.

Yes, CARBOPLATIN 450MG INJECTION is FDA approved. It was approved on 3 March 1989.

Yes, CARBOPLATIN 450MG INJECTION is a platinum-containing compound medication that works by stopping or slowing the growth of cancer cells.

CARBOPLATIN 450MG INJECTION may cause side effects, including neuropathy (tingling and numbness) in the hands and feet, hearing loss, temporary hair loss, and constipation. Weight gain is rare but possible. While leukemia is not typically associated with CARBOPLATIN 450MG INJECTION, the long-term use of any chemotherapy drug can increase the risk of secondary cancers. It's important to discuss any side effects with your doctor to manage them effectively.

CARBOPLATIN 450MG INJECTION is not a vesicant, and it does not cause blistering or tissue damage if it leaks out of the vein. It is also not cardio-toxic, so it does not specifically target the heart. Additionally, Carboplatin is not an anthracycline, as it does not belong to that class of platinum-containing compounds.

Yes, sometimes the doctor may suggest CARBOPLATIN 450MG INJECTION to treat breast cancer based on your health situation. It is often given in combination with other chemotherapy drugs for optimal results.

CARBOPLATIN 450MG INJECTION is not available in pill form; It is available in two primary dosage forms: injection and powder for injection.

The common side effects of the CARBOPLATIN 450MG INJECTION are nausea, vomiting, diarrhoea, constipation, sores in the mouth and throat, pain, burning, or tingling in the hands or feet, pain, itching, redness, swelling, blisters, or sores in the place where the medication was injected, hair loss, pain, weakness, loss in ability to taste food. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.

The efficacy and safety of CARBOPLATIN 450MG INJECTION have yet to be established for using children. Please consult your doctor. The doctor will help determine whether the potential benefits outweigh the possible risks and make the appropriate recommendation.

Country of origin

India

Manufacturer/Marketer address

SURVEY NO.69/2&69/3,KUNIGAL-MANGALORE HIGHWAY, NEELAMANGALA,BANGALORE DIST. NEELAMANGALA,BANGALORE DIST. KA 000000 IN
Other Info - CAR0047

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:50 AM IST

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Reference

  1. https://www.uhs.nhs.uk/Media/SUHTExtranet/Services/Chemotherapy-SOPs/Ovarian-cancer/Carboplatin(AUC5).pdf
  2. https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/carboplatin
  3. https://medlineplus.gov/druginfo/meds/a695017.html
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020452s005lbl.pdf
  5. https://www.drugs.com/mtm/carboplatin.html
  6. https://www.asbestos.com/treatment/chemotherapy/carboplatin/

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