How does Difizma Capsule (Inhalation Powder) work?

Difizma Capsule (Inhalation Powder) works by relaxing the muscles of the small airways in the lungs and reducing inflammation (swelling and irritation). Thus, it helps ease breathing problems gradually and prevent asthma attacks.

Can I stop using Difizma Capsule (Inhalation Powder) if IÃ¢â‚¬â„¢m feeling well?

Do not stop using Difizma Capsule (Inhalation Powder) if you feel well. You are advised to use Difizma Capsule (Inhalation Powder) every day and not only when you have breathing problems or other asthma symptoms to ensure it controls your asthma properly.

Does Difizma Capsule (Inhalation Powder) relieve sudden asthma attack?

Difizma Capsule (Inhalation Powder) does not relieve a sudden asthma attack. Therefore, it is advised always to carry a rescue inhaler to treat sudden asthma symptoms.

What is Difizma Capsule (Inhalation Powder) powder for inhalation?

Difizma Capsule (Inhalation Powder) powder for inhalation is a triple-therapy medication that combines Glycopyrronium, Indacaterol, and Mometasone Furoate. It is used for the maintenance treatment of Chronic Obstructive Pulmonary Disease (COPD) and Asthma, helping to improve lung function, reduce symptoms, and enhance quality of life.

Can I smoke if I have been prescribed Difizma Capsule (Inhalation Powder) ?

It is strictly advised not to smoke while using Difizma Capsule (Inhalation Powder) . Difizma Capsule (Inhalation Powder) helps in managing asthma by improving lung function, but smoking makes these benefits useless as smoking can worsen asthma symptoms.

Being a diabetic, what should I remember while taking Difizma Capsule (Inhalation Powder) ?

If you have diabetes and are taking Difizma Capsule (Inhalation Powder) , monitor your blood sugar and rinse your mouth after use to prevent infection. If you notice any significant changes in your blood sugar levels, consult your healthcare provider for advice and adjustments to your treatment plan.

Do I still need to take Difizma Capsule (Inhalation Powder) even when I am feeling better?

Yes, it is essential to continue taking Difizma Capsule (Inhalation Powder) even if you start feeling better and complete the entire treatment course. Stopping too soon can lead to incomplete recovery and the return of symptoms. Instead, report your progress to your doctor and follow their advice. They will guide you on how to safely taper off the medication if necessary, monitor for any potential side effects, and ensure your health is fully cleared.

How much Difizma Capsule (Inhalation Powder) is recommended for inhalation?

The recommended dose of Difizma Capsule (Inhalation Powder) for inhalation depends on factors like age, sex, and disease condition. Generally, one capsule is recommended for a day. However, follow your doctor's instructions for optimal results.

What if my symptoms do not improve even after using Difizma Capsule (Inhalation Powder) ?

If your symptoms persist or fail to improve, consult your doctor. Please note that it may take some time to fully heal your condition, as the treatment process can be gradual. However, if you don't see improvement, your doctor may need to reassess your condition, adjust the dosage, or consider alternative treatments. Don't hesitate to consult your doctor with concerns or questions about your progress.

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Written By Veda Maddala , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Difizma Capsule (Inhalation Powder) is indicated as a maintenance treatment for asthma in adults. It combines three drugs: Glycopyrronium Bromide and Indacaterol (bronchodilators), and mometasone furoate (corticosteroids). Glycopyrronium Bromide and Indacaterol relax the muscles of the small airways in the lungs, which helps open the airways and makes it easier for air to get in and out. Mometasone Furoate reduces the inflammation (swelling and irritation) in the small airways in the lungs. This gradually eases breathing problems and also helps to prevent asthma attacks.

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About Difizma Capsule (Inhalation Powder)

Difizma Capsule (Inhalation Powder) is indicated as a maintenance treatment of asthma in adults. Asthma is a long-term lung disease where the muscles around the smaller airways become tight (bronchoconstriction) and inflamed, leading to difficulty in breathing.

Difizma Capsule (Inhalation Powder) is a combination of three drugs: Glycopyrronium Bromide and Indacaterol (bronchodilators), and Mometasone Furoate (corticosteroids). Glycopyrronium Bromide and Indacaterol relax the muscles of the small airways in the lungs, which helps open the airways and makes it easier for air to get in and out. Mometasone Furoate reduces the inflammation (swelling and irritation) in the small airways in the lungs. This gradually eases breathing problems and also helps to prevent asthma attacks.

Difizma Capsule (Inhalation Powder) is for inhalation only. Do not swallow Difizma Capsule (Inhalation Powder) . Use Difizma Capsule (Inhalation Powder) as prescribed by your doctor. You are advised to use Difizma Capsule (Inhalation Powder) for as long as your doctor has advised it based on your medical condition. Difizma Capsule (Inhalation Powder) may cause common side effects such as runny nose, sore throat, sudden difficulty breathing and chest tightness with coughing or wheezing, oral thrush (a fungal infection in the mouth), headache or fast heartbeat. Most of these side effects of Difizma Capsule (Inhalation Powder) do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to mometasone furoate, indacaterol, glycopyrronium bromide, or any other ingredients of Difizma Capsule (Inhalation Powder) , please tell your doctor. Difizma Capsule (Inhalation Powder) is not recommended for children below 18 years. If you are pregnant or breastfeeding, take your doctor’s advice before using Difizma Capsule (Inhalation Powder) . If you have chest tightness, wheezing, coughing or breathlessness immediately after using Difizma Capsule (Inhalation Powder) , stop using it and consult a doctor right away as these may be signs of unexpected airways tightening.

Uses of Difizma Capsule (Inhalation Powder)

Difizma Capsule (Inhalation Powder) is used in the treatment of Asthma. The detailed uses of Difizma Capsule (Inhalation Powder) are as follows:<br/>• Improve lung function: Difizma Capsule (Inhalation Powder) reduces airway secretions and helps keep the airways open and improve lung function.<br/>• Reduce asthma symptoms: Difizma Capsule (Inhalation Powder) reduces asthma symptoms like wheezing, coughing, and breathlessness.<br/>• Decrease the frequency of asthma attacks: Difizma Capsule (Inhalation Powder) reduces inflammation in the lungs, easing breathing and preventing asthma flare-ups.<br/>

Directions for Use

• Difizma Capsule (Inhalation Powder) is recommended to be inhaled once daily at the same time each day or as advised by your doctor.• Check the label for instructions before using this medication.• It is for inhalation only. Do not swallow the capsule.• Remove one capsule from the package and place it into the inhaler device. Close the inhaler and pierce the capsule by twisting or clicking the device. • Place the mouthpiece into your mouth and seal your lips around it. Inhale deeply and slowly through the mouthpiece, hold your breath for 2-3 seconds, and then exhale slowly. • Rinse your mouth with water and spit it out after using Difizma Capsule (Inhalation Powder) to avoid fungal infections in the mouth and throat.

Medicinal Benefits

Difizma Capsule (Inhalation Powder) belongs to the class of respiratory stimulants. It contains Glycopyrronium Bromide, Indacaterol and Mometasone Furoate. Difizma Capsule (Inhalation Powder) is used as a maintenance treatment of asthma in adults not adequately controlled with a maintenance combination of a long-acting beta2-agonist and a high dose of an inhaled corticosteroid who experienced one or more asthma flare-ups in the previous year. Difizma Capsule (Inhalation Powder) relaxes the muscles of the small airways in the lungs and reduces inflammation (swelling and irritation). This gradually eases breathing problems and also helps to prevent asthma attacks.

How Difizma Capsule (Inhalation Powder) Works

Difizma Capsule (Inhalation Powder) is a combination of three drugs: Glycopyrronium Bromide and Indacaterol (bronchodilators), and Mometasone Furoate (corticosteroids). Glycopyrronium Bromide and Indacaterol relax the muscles of the small airways in the lungs, which helps open the airways and makes it easier for air to get in and out. Mometasone Furoate reduces the inflammation (swelling and irritation) in the small airways in the lungs. This gradually eases breathing problems and also helps to prevent asthma attacks.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Difizma Capsule (Inhalation Powder)

An overdose of Difizma Capsule (Inhalation Powder) can cause tachycardia, tremor, palpitations, headache, nausea, vomiting, drowsiness, ventricular arrhythmias, metabolic acidosis, hypokalaemia, hyperglycaemia, increased intraocular pressure (causing pain, vision disturbances or reddening of the eye), constipation or difficulties in voiding, suppression of hypothalamic pituitary adrenal axis function. If you encounter these symptoms or think you might have taken too much, get medical help immediately.

Drug Warnings

If you are allergic to mometasone furoate, indacaterol, glycopyrronium bromide, or any other ingredients of Difizma Capsule (Inhalation Powder) , please tell your doctor. Difizma Capsule (Inhalation Powder) is not recommended for children below 18 years. If you are pregnant or breastfeeding, take your doctor’s advice before using Difizma Capsule (Inhalation Powder) . If you have chest tightness, wheezing, coughing or breathlessness immediately after using Difizma Capsule (Inhalation Powder) , stop using it and consult a doctor right away as these may be signs of unexpected airways tightening. If you have eye pain or discomfort, visual haloes (seeing bright circles around lights), temporary blurring of vision, or coloured images in association with red eyes, contact your doctor, as these may be signs of an attack of angle-closure glaucoma. If your asthma is not getting better or if it worsens after you have started using Difizma Capsule (Inhalation Powder) , talk to your doctor.

Drug-Drug Interactions

MometasoneMifepristone

Critical

Glycopyrronium bromidePotassium chloride

Severe

Drug-Drug Interactions

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MometasoneMifepristone

Critical

How does the drug interact with Difizma Capsule (Inhalation Powder):
Co-administration of Difizma Capsule (Inhalation Powder) with Mifepristone may make Difizma Capsule (Inhalation Powder) less effective as a therapy.

How to manage the interaction:
Taking Difizma Capsule (Inhalation Powder) with Mifepristone is generally avoided as it can result in an interaction, it can be taken only when a doctor has advised it. Do not stop using any medications without talking to a doctor.

Glycopyrronium bromidePotassium chloride

Severe

How does the drug interact with Difizma Capsule (Inhalation Powder):
The use of Potassium chloride and Difizma Capsule (Inhalation Powder) can increase the irritant effects of potassium on your stomach and upper intestine.

How to manage the interaction:
Using Potassium chloride and Difizma Capsule (Inhalation Powder) together can lead to an interaction, however, it can be taken if advised by a doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.

Glycopyrronium bromideDigoxin

Severe

How does the drug interact with Difizma Capsule (Inhalation Powder):
Co-administration of Digoxin and Difizma Capsule (Inhalation Powder) may increase the serum concentration of Digoxin and increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Digoxin and Difizma Capsule (Inhalation Powder), you can take these medicines together if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, confusion, loss of appetite, nausea, vomiting, diarrhea, change in vision such as blurry or yellow vision, fatigue, and fast or irregular heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Glycopyrronium bromideLevodopa

Severe

How does the drug interact with Difizma Capsule (Inhalation Powder):
Coadministration of levodopa with Difizma Capsule (Inhalation Powder) can significantly decrease the blood levels of levodopa.

How to manage the interaction:
Although using Difizma Capsule (Inhalation Powder) and levodopa together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any unusual symptoms contact the doctor immediately. Do not stop using any medications without a doctor's advice.

Glycopyrronium bromidePramlintide

Severe

How does the drug interact with Difizma Capsule (Inhalation Powder):
Taking Pramlintide with Difizma Capsule (Inhalation Powder) can cause slow stomach emptying or slow the intestinal absorption of nutrients.

How to manage the interaction:
Although using Pramlintide and Difizma Capsule (Inhalation Powder) together can lead to an interaction, it can be taken if advised by your doctor.

Glycopyrronium bromideSecretin

Severe

How does the drug interact with Difizma Capsule (Inhalation Powder):
The combined use of secretin and Difizma Capsule (Inhalation Powder) can inhibit gastric acid secretion.

How to manage the interaction:
Although using secretin and Difizma Capsule (Inhalation Powder) together can lead to an interaction, it can be taken if advised by your doctor.

IndacaterolLabetalol

Severe

How does the drug interact with Difizma Capsule (Inhalation Powder):
Combining Labetalol and Difizma Capsule (Inhalation Powder) could decrease the medical benefits of both medications.

How to manage the interaction:
Although taking Labetalol and Difizma Capsule (Inhalation Powder) together can result in an interaction, it can be taken if a doctor has prescribed it. Do not forget to inform a doctor, if you have severe chronic obstructive pulmonary disease (COPD) or a history of asthma, as Labetalol is often not advised in these patients. Do not discontinue any medications without a doctor's advice.

IndacaterolCarvedilol

Severe

How does the drug interact with Difizma Capsule (Inhalation Powder):
Taking Carvedilol and Difizma Capsule (Inhalation Powder) may reduce the treatment outcomes.

How to manage the interaction:
There may be a possibility of interaction between Difizma Capsule (Inhalation Powder) and Carvedilol, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.

IndacaterolPropranolol

Severe

How does the drug interact with Difizma Capsule (Inhalation Powder):
Using propranolol together with Difizma Capsule (Inhalation Powder) may reduce the benefits of both medications, since they have opposing effects in the body. In addition, propranolol can cause breathing problems.

How to manage the interaction:
Although taking Propranolol together with Difizma Capsule (Inhalation Powder) can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Eat a healthy diet and exercise regularly to strengthen your breathing muscles and boost your immune system.
Avoid foods such as cabbage, beans, garlic, onions, shrimp, pickled food, dried fruits, fried foods, carbonated drinks, wine, bottled lemon, and lime juice, as they may worsen asthma symptoms.
Do meditation, deep breathing, regular exercise, and try progressive muscle relaxation techniques to get relief from stress and reduce the risk of an asthma attack.
Quit smoking as it may reduce the effectiveness of the Difizma Capsule (Inhalation Powder) and irritate the lungs, worsening breathing problems.
Learning breathing exercises will help you move more air in and out of your lungs.

Habit Forming

No

Therapeutic Class

RESPIRATORY STIMULANTS

Alcohol

Consult your doctor

The interaction of Difizma Capsule (Inhalation Powder) with alcohol is unknown. If you have any concerns, discuss them with your doctor.

Pregnancy

Consult your doctor

Difizma Capsule (Inhalation Powder) is given to pregnant women only if the doctor thinks the benefits outweigh the risks. Therefore, inform your doctor if you are pregnant before using Difizma Capsule (Inhalation Powder) .

Breast Feeding

Consult your doctor

It is unknown whether Difizma Capsule (Inhalation Powder) is excreted in human milk. Your doctor decides whether to discontinue breastfeeding or to discontinue Difizma Capsule (Inhalation Powder) , taking into account the benefit of breastfeeding for the child and the benefit of therapy for the mother. Therefore, inform your doctor if you are breastfeeding before using Difizma Capsule (Inhalation Powder) .