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  3. Lith-450 PR Tablet 10's

Lith-450 PR Tablet 10's, Pack of 10 TabletS
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Composition :

LITHIUM CARBONATE-450MG

Manufacturer/Marketer :

Savin Pharma

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Lith-450 PR Tablet

Lith-450 PR Tablet belongs to a psychological class of drugs called 'anti-manic agents' or 'mood stabilizers' primarily used to prevent and treat mood disorders like mania and bipolar disorder. Mania is a mental condition that causes intense excitement, high energy, and delusions (misbeliefs). Bipolar disorder is a mental condition associated with extreme mood swings ranging from the hyper stage of mania to low mood depression.

Lith-450 PR Tablet contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Take Lith-450 PR Tablet as prescribed. Your doctor will advise you on how often you need to take Lith-450 PR Tablet based on your medical condition. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Most of these side effects of Lith-450 PR Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Lith-450 PR Tablet or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Lith-450 PR Tablet . Regular blood tests are recommended while taking Lith-450 PR Tablet to monitor the levels of lithium in blood. If you have fits, kidney or heart problems, thyroid, persistent headache, vision problems, and if you are planning or had weight loss surgery, please inform your doctor before taking Lith-450 PR Tablet .

Uses of Lith-450 PR Tablet

Treatment of Bipolar disorder and Mania

Directions for Use

• Take Lith-450 PR Tablet with food for better absorption or take it as advised by the doctor.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow it as a whole with a glass of water.• Do not crush, chew or break it.

Medicinal Benefits

Lith-450 PR Tablet is a mood stabilizer that is used to prevent and treat mood disorders such as mania and bipolar disorder. Lith-450 PR Tablet contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood. Thus, Lith-450 PR Tablet relaxes nerves and calms the mood, which helps in having a better social life and enables to do daily activities comfortably.

How Lith-450 PR Tablet Works

Lith-450 PR Tablet contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Storage

Store in a cool and dry place away from sunlight
Side effects of Lith-450 PR Tablet
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
  • Reduce fluid intake 2-3 hours prior to bedtime.
  • Limit alcohol and caffeine as they can increase urination and affect bladder health.
  • Maintain sleep hygiene.
  • Eat a low-salt and healthy diet.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Limit or eliminate caffeine and alcohol from your diet, as these substances can worsen hand trembling.
  • Practice relaxation techniques like deep breathing, yoga, or mindfulness meditation to reduce stress-induced tremors.
  • Engage in regular exercise to improve muscle control and coordination.
  • Ensure adequate sleep (7-8 hours) to prevent fatigue, which can worsen tremors.
  • Identify and minimize triggers that cause tremors, such as stress or certain activities.
  • Consider occupational therapy for tailored exercises and adaptive tools to manage daily tasks with trembling hands.
  • Consult a doctor if hand trembling interferes with your daily activities or is accompanied by other concerning neurological symptoms such as weakness, numbness, or speech difficulties.

What if I have taken an overdose of Lith-450 PR Tablet

Take Lith-450 PR Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include vomiting, diarrhoea, muscular weakness, drowsiness, and lack of coordination. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Regular blood tests are recommended while taking Lith-450 PR Tablet to check lithium levels in the blood. If you are pregnant or breastfeeding, please inform your doctor before taking Lith-450 PR Tablet . If you have hypothyroidism (underactive thyroid gland), please inform your doctor before taking Lith-450 PR Tablet as it may cause low thyroid levels. If you notice decreased amount of urine, dark, reddish urine, muscle pain or weakness, inform your doctor immediately as it may be due to a serious condition called rhabdomyolysis (muscle tissue breakdown) which may lead to kidney problems.

Drug-Drug Interactions

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LithiumCisapride
Critical
LithiumCidofovir
Critical

Drug-Drug Interactions

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LithiumCisapride
Critical
How does the drug interact with Lith-450 PR Tablet:
Taking Cisapride with Lith-450 PR Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Lith-450 PR Tablet with Cisapride is not recommended as it can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
LithiumCidofovir
Critical
How does the drug interact with Lith-450 PR Tablet:
Cidofovir can cause higher levels of Lith-450 PR Tablet carbonate in the blood which increases risk of kidney problems.

How to manage the interaction:
Taking Lith-450 PR Tablet with Cidofovir is not recommended, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
LithiumOlmesartan medoxomil
Severe
How does the drug interact with Lith-450 PR Tablet:
Taking Lith-450 PR Tablet with olmesartan medoxomil may significantly increase the blood levels of Lith-450 PR Tablet .

How to manage the interaction:
Although taking olmesartan medoxomil alongside Lith-450 PR Tablet can lead to interaction, they can be taken if prescribed by a doctor. However, if you develop sleepiness, dizziness, confusion, loose stools, vomiting, muscular weakness, muscle incoordination, a shaking sensation, blurred vision, ringing in the ears, excessive thirst, and/or increased urination, consult a doctor. Do not stop using any medications without talking to a doctor.
LithiumGatifloxacin
Severe
How does the drug interact with Lith-450 PR Tablet:
Taking Gatifloxacin with Lith-450 PR Tablet can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Gatifloxacin with Lith-450 PR Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or unusual memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LithiumTenofovir disoproxil
Severe
How does the drug interact with Lith-450 PR Tablet:
Co-administration of Lith-450 PR Tablet carbonate with Tenofovir Disoproxil can increase the risk of developing kidney problems.

How to manage the interaction:
Although there is a possible interaction between Tenofovir disoproxil and Lith-450 PR Tablet, you can take these medicines when prescribed by your doctor. Consult the doctor immediately if you experience symptoms such as vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, shortness of breath, muscle cramps, or weakness. Do not discontinue any medications without consulting a doctor.
LithiumOndansetron
Severe
How does the drug interact with Lith-450 PR Tablet:
Taking ondansetron with Lith-450 PR Tablet can increase the risk of serotonin syndrome a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Although taking ondansetron along with Lith-450 PR Tablet can result in an interaction but can be taken together if prescribed by a doctor. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools, or fast or rapid heartbeats during therapy, consult a doctor. Do not stop using any medications without talking to a doctor.
LithiumTramadol
Severe
How does the drug interact with Lith-450 PR Tablet:
Taking tramadol with Lith-450 PR Tablet can increase the risk of seizures(fits).

How to manage the interaction:
Co-administration of tramadol along with Lith-450 PR Tablet can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience any unusual symptoms like staring, stiffening of the legs and hands, stiffening of body, loss of consciousness, breathing difficulties , lack of urinary or bowel control, and Falling suddenly for no apparent reason, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
LithiumMifepristone
Severe
How does the drug interact with Lith-450 PR Tablet:
Co-administration of Lith-450 PR Tablet with mifepristone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Lith-450 PR Tablet with mifepristone together is avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, shortness of breath, or irregular heartbeat. Do not discontinue any medications without consulting a doctor.
LithiumIndometacin
Severe
How does the drug interact with Lith-450 PR Tablet:
Taking Lith-450 PR Tablet with indomethacin may significantly increase the blood levels of Lith-450 PR Tablet.

How to manage the interaction:
Taking Indometacin with Lith-450 PR Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience drowsiness, dizziness, confusion, diarrhoea, vomiting, muscle weakness, muscle incoordination, shaking of hands and legs, blurred vision, ringing in the ear, excessive thirst, and increased urination consult a doctor. Do not stop using any medications without a doctor's advice.
LithiumAmiodarone
Severe
How does the drug interact with Lith-450 PR Tablet:
Co-administration of Amiodarone together with Lith-450 PR Tablet may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Even though Amiodarone and Lith-450 PR Tablet interact, they can be used if prescribed by a doctor. If you have heart problems or electrolyte imbalances, you may be at greater risk. If you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical attention. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a constant sodium diet as it may affect lithium levels in the blood and cause adverse effects.
  • Limit the intake of caffeine as it may reduce the effectiveness of Lith-450 PR Tablet .
  • Do regular exercise and maintain a stable weight as Lith-450 PR Tablet may cause weight gain.
  • Drink plenty of water to avoid dehydration and try to drink the same amount of water every day as any major changes in quantity may affect lithium levels.
  • Avoid consumption of alcohol as it may increase drowsiness.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

Lith-450 PR Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Lith-450 PR Tablet as it may increase the risk of side effects such as drowsiness, dizziness or difficulty in concentrating.

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Pregnancy

Unsafe

Lith-450 PR Tablet is a Category D pregnancy drug and is not recommended for use during pregnancy as it may cause harm to the unborn baby.

bannner image

Breast Feeding

Unsafe

Avoid breastfeeding while taking Lith-450 PR Tablet as it may be excreted in breast milk and cause adverse effects in the baby.

bannner image

Driving

Unsafe

Lith-450 PR Tablet may cause dizziness, drowsiness or other severe adverse effects. Therefore, avoid driving if you feel drowsy or dizzy after taking Lith-450 PR Tablet .

bannner image

Liver

Safe if prescribed

Lith-450 PR Tablet is safe to use in patients with liver diseases/conditions if prescribed by a doctor.

bannner image

Kidney

Caution

Take Lith-450 PR Tablet with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required. Lith-450 PR Tablet is not recommended for patients with severe kidney problems.

bannner image

Children

Caution

Lith-450 PR Tablet is generally not recommended for children below 12 years. However, Lith-450 PR Tablet may be used in children above 7 years for treating bipolar disorder only if prescribed by a doctor.

Have a query?

FAQs

Lith-450 PR Tablet belongs to a psychological class of drugs called 'anti-manic agents' or 'mood stabilizers' primarily used to prevent and treat mood disorders like mania and bipolar disorder.

Lith-450 PR Tablet helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Lith-450 PR Tablet is not recommended for hypothyroid (underactive thyroid gland) patients as it may increase the risk of low levels of thyroid hormone. Therefore, if you have hypothyroidism, please inform your doctor before taking Lith-450 PR Tablet .

Lith-450 PR Tablet may cause weight gain but it is not necessary for everyone taking Lith-450 PR Tablet to experience this side effect. However, in order to avoid gaining weight while taking Lith-450 PR Tablet , you are advised to do regular exercise and avoid high-calorie drinks. Instead take non-alcoholic drinks, herbal tea and lemon water.

It is advised to inform your doctor if you are planning or had weight loss surgery as the dose may be adjusted accordingly based on lithium levels in blood.

Lith-450 PR Tablet may cause dehydration especially if you have low sodium levels in the body or consume too much alcohol. However, if you notice dark, strong-smelling urine or a decrease in urination, it indicates that you are dehydrated, and this may affect lithium levels in the blood. Therefore, you are recommended to drink plenty of fluids while taking Lith-450 PR Tablet to avoid dehydration.

You are not recommended to stop taking Lith-450 PR Tablet without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Lith-450 PR Tablet for as long as your doctor has prescribed it and if you experience any difficulty while taking Lith-450 PR Tablet , please consult your doctor so that the dose may be gradually reduced.

You are not recommended to take Lith-450 PR Tablet with fluoxetine or other antidepressants such as paroxetine and sertraline as co-administration of these medicines may increase the risk of a rare and serious condition known as serotonin syndrome. If you experience blurred vision, increased heart rate, hallucination, fits, confusion, muscle stiffness or spasm, vomiting, nausea, diarrhoea, excessive sweating, stomach cramps, fever, shaking, or shivering, please consult a doctor immediately. However, before using Lith-450 PR Tablet with any other medicines, you are advised to contact your doctor.

The effects of Lith-450 PR Tablet can vary from person to person, but it generally takes 1-3 weeks for you to see the full benefits. However, it's important to continue taking the Lith-450 PR Tablet regularly as prescribed by your doctor to maintain its effectiveness.

It's important to inform your doctor about your hypertension and the medications you're taking for it as Lith-450 PR Tablet can interact with certain blood pressure medications, and your doctor may need to adjust your treatment plan to ensure your safety.

No, you should not increase the dose of Lith-450 PR Tablet on your own. It can take 1-3 weeks to feel the full effects, and increasing the dose without medical advice can be dangerous and may lead to adverse effects. However consult your doctor if you have any concerns.

Yes, Lith-450 PR Tablet can cause sleepiness as a side effect. It's important to be cautious when performing activities that require alertness, such as driving or operating heavy machinery, until you know how the medication affects you.

Yes, Lith-450 PR Tablet can affect the kidneys. Long-term use of lithium can lead to kidney problems, and regular monitoring of kidney function is necessary during treatment. It's important to inform your doctor if you have any pre-existing kidney conditions or if you experience any symptoms of kidney problems while taking Lith-450 PR Tablet .

Lith-450 PR Tablet should only be started if adequate facilities for assessing Lith-450 PR Tablet levels are available. Because elevated levels of Lith-450 PR Tablet are linked to Lith-450 PR Tablet toxicity. Lith-450 PR Tablet toxicity can even occur at dose which is effective for treatment. Therefore, your doctor may closely monitor your Lith-450 PR Tablet levels weekly until stabilization is achieved, then weekly for one month and then at monthly intervals thereafter.

Lith-450 PR Tablet should be taken as prescribed by your doctor. It is recommended to take with food to reduce nausea. Lith-450 PR Tablet may be taken before or after meals. Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Certain medications which decrease the levels of Lith-450 PR Tablet in blood include carbonic anhydrase inhibitors, chlorpromazine, sodium-containing preparations, theophylline, urea and herbal medicines. Therefore, before starting Lith-450 PR Tablet , inform your doctor about all the medicines you are taking.

The common side effects of Lith-450 PR Tablet are loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Tamil nadu , India
Other Info - LIT0246

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 18, 2025 | 6:59 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.10828.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/017812s033,018421s032,018558s027lbl.pdf
  3. https://www.drugs.com/lithium.html
  4. https://www.nhs.uk/medicines/lithium/

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