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  3. Macrozide 1500mg Tablet 6's

Macrozide 1500mg Tablet 6's, Pack of 6 TABLETS
Macrozide 1500mg Tablet 6's, Pack of 6 TABLETS
Macrozide 1500mg Tablet 6's, Pack of 6 TABLETS
Macrozide 1500mg Tablet 6's, Pack of 6 TABLETS
Not for online sale
Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Macrozide 1500mg Tablet is used to treat and prevent tuberculosis. It contains Pyrazinamide which converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary for the survival of the TB bacteria. It may cause common side effects such as muscle/joint pain, nausea, vomiting and loss of appetite. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

PYRAZINAMIDE-1500MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Macrozide 1500mg Tablet

Macrozide 1500mg Tablet is used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine and bone marrow. Macrozide 1500mg Tablet does not work against infections caused by the virus, such as the common cold and flu.

Macrozide 1500mg Tablet contains 'Pyrazinamide'. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary for the survival of the TB bacteria.

Your doctor will decide the dose and duration based on the severity of your disease. Common side effects of Macrozide 1500mg Tablet include muscle/joint pain, nausea, vomiting and loss of appetite. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you use any prescription and non-prescription medications you are taking, including other vitamins, before starting Macrozide 1500mg Tablet. Please tell your doctor if you are allergic to Macrozide 1500mg Tablet or its components. Inform your doctor beforehand if you have a history of liver or kidney diseases, diabetes, gout, high uric acid level in the blood, alcohol use and are undergoing dialysis. It is essential to let your doctor know if you are pregnant, planning to conceive or are a breastfeeding mother. Avoid consuming alcohol along with Macrozide 1500mg Tablet as it might lead to liver problems.

Uses of Macrozide 1500mg Tablet

Treatment of Tuberculosis (TB).

Directions for Use

Swallow Macrozide 1500mg Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Macrozide 1500mg Tablet contains 'Pyrazinamide', which is used to treat and prevent tuberculosis. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary to survive the TB bacteria. It is usually given in alone or combined with other antitubercular agents to treat tuberculosis.

How Macrozide 1500mg Tablet Works

Macrozide 1500mg Tablet contains 'Pyrazinamide'. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary for the survival of the TB bacteria.

Storage

Store in a cool and dry place away from sunlight
Side effects of Macrozide 1500mg Tablet
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.
Managing Medication-Triggered malaise (Feeling Unwell): A Step-by-Step Guide:
  • If you experience persistent or severe malaise (a general feeling of discomfort, illness, or unease) after taking medication, seek medical attention immediately.
  • Inform your doctor about the medication you're taking and the symptoms you're experiencing.
  • Your treatment plan may be modified, which may include adjusting the dosage, substituting with an alternative medication, or discontinuing the medication. Additionally, certain lifestyle changes may be recommended to help manage symptoms.
  • To manage malaise symptoms, follow your doctor's advice, such as getting plenty of rest, staying hydrated, and practicing stress-reducing techniques.
  • Track your symptoms regularly and report any changes or concerns to your healthcare provider to ensure the malaise is managed effectively.
  • Painful urination can be reduced by drinking lots of water.
  • Don't hold urine, as it can worsen the pain during urination.
  • Try taking probiotics and eating garlic, which can help reduce painful urination.
  • Sleep well and give enough rest to your body.
  • Take a balanced diet and avoid bladder-irritating foods.
  • Quit smoking and intake of alcohol.
  • Practice yoga and meditation to improve inner strength and stay healthy.

What if I have taken an overdose of Macrozide 1500mg Tablet

Do not take more than the prescribed dose of Macrozide 1500mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Brief your medical history to the doctor if you have any liver or kidney diseases, diabetes, gout, high uric acid level in the blood, lactose intolerance, alcohol use and are undergoing dialysis treatment before starting Macrozide 1500mg Tablet. Let your doctor know if you are undergoing any vaccinations with live bacterial vaccines (like typhoid vaccine) since Macrozide 1500mg Tablet may affect vaccine's activity. Please consult your doctor know if you are pregnant, planning to conceive or are a breastfeeding mother before starting Macrozide 1500mg Tablet. Avoid consuming alcohol along with Macrozide 1500mg Tablet as it might lead to liver problems. Store Macrozide 1500mg Tablet below 25°C away from direct sunlight.

Drug-Drug Interactions

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PyrazinamideKetoconazole
Severe
PyrazinamideLomitapide
Severe

Drug-Drug Interactions

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PyrazinamideKetoconazole
Severe
How does the drug interact with Macrozide 1500mg Tablet:
Co-administration of Ketoconazole with Macrozide 1500mg Tablet may increase the risk or severity of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Macrozide 1500mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue the medication without consulting a doctor.
PyrazinamideLomitapide
Severe
How does the drug interact with Macrozide 1500mg Tablet:
Co-administration of Lomitapide with Macrozide 1500mg Tablet may increase in the risk or severity of liver problems.

How to manage the interaction:
Although taking Lomitapide and Macrozide 1500mg Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor immediately: fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, or bleeding. Do not stop using any medications without a doctor's advice. Do not discontinue the medication without consulting a doctor.
PyrazinamideLeflunomide
Severe
How does the drug interact with Macrozide 1500mg Tablet:
Co-administration of leflunomide with Macrozide 1500mg Tablet may increase the risk or severity of liver problems.

How to manage the interaction:
Although taking Leflunomide and Macrozide 1500mg Tablet together can cause an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PyrazinamideTeriflunomide
Severe
How does the drug interact with Macrozide 1500mg Tablet:
Co-administration of Teriflunomide with Macrozide 1500mg Tablet may increase the risk or severity of liver damage.

How to manage the interaction:
Although taking Teriflunomide and Macrozide 1500mg Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor immediately: fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, or bleeding. Do not stop using any medications without a doctor's advice. Do not discontinue the medication without consulting a doctor.
PyrazinamideRifampicin
Severe
How does the drug interact with Macrozide 1500mg Tablet:
Taking rifampicin together with Macrozide 1500mg Tablet can cause liver problems.

How to manage the interaction:
Although there is an interaction between Macrozide 1500mg Tablet and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience fever, rash, less desire to eat, nausea, vomiting, fatigue, right upper abdominal pain, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.

  • Foods rich in vitamin C, such as kiwi, broccoli and bell pepper, help improve the immune system.

  • Avoid processed and fried foods.

  • Warm ginger tea or warm soup can help in providing relief from the cough.

  • Avoid foods and drinks, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine and beer.

  • Quit smoking and avoid alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTI- TUBERCULOSIS
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Macrozide 1500mg Tablet. Alcohol intake, along with Macrozide 1500mg Tablet, may cause increased liver damage. Please consult your doctor for more information.

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Pregnancy

Caution

Macrozide 1500mg Tablet should be used with caution during pregnancy. Please consult your doctor before taking Macrozide 1500mg Tablet if you are pregnant or planning to conceive.

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Breast Feeding

Caution

Macrozide 1500mg Tablet is not recommended for use during breastfeeding since it is excreted into the breast milk and may harm a nursing baby. Please consult your doctor if you are a breastfeeding mother.

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Driving

Caution

It is not known if Macrozide 1500mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to drive or operate machinery.

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Liver

Caution

Macrozide 1500mg Tablet is not recommended in patients with severe liver damage. Please consult your doctor since Macrozide 1500mg Tablet should be used with caution in patients with liver impairment/liver disease. Regular monitoring of the liver with liver function tests is also advised.

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Kidney

Caution

Please consult your doctor since Macrozide 1500mg Tablet should be used with caution in patients with kidney impairment/kidney disease. Your doctor may adjust the dosage in case of renal dysfunction.

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Children

Caution

Macrozide 1500mg Tablet is recommended in children below 12 years of age only after doctor's advice.

Have a query?

FAQs

Macrozide 1500mg Tablet is used to treat and prevent tuberculosis.

Macrozide 1500mg Tablet contains 'Pyrazinamide.' It is bactericidal and works by stopping the growth of Mycobacterium tuberculosis, a bacteria that causes tuberculosis.

Macrozide 1500mg Tablet is not recommended for use in the medical history of liver or kidney diseases, diabetes, gout, high uric acid level in the blood, alcohol use and undergoing dialysis treatment. Please let your doctor know if you have any other medical problems before starting Macrozide 1500mg Tablet.

Macrozide 1500mg Tablet can affect the live vaccines like typhoid vaccine and decrease its effectiveness. Please consult a doctor before you start Macrozide 1500mg Tablet if you are undergoing any vaccinations.

It is advised to take Macrozide 1500mg Tablet 30 minutes before food or 2 hours after food. Please consult your doctor for more information.

Macrozide 1500mg Tablet gets converted in the body to Pyrazinoic acid that blocks the excretion of urates (salt form of uric acid) by the kidneys. Increased blood levels of uric acid (hyperuricemia) causes pain, swelling, redness and stiffness in joints (gout). Hence, Macrozide 1500mg Tablet should be avoided if you have a history of gout.

Macrozide 1500mg Tablet is an antibiotic that belongs to the group of anti-tuberculosis (TB) drugs. It is used for the treatment of tuberculosis which is an infectious disease that mainly affects lungs but can also impact other parts of the body.

Yes, Macrozide 1500mg Tablet is bactericidal. It works by inhibiting the growth of Mycobacterium tuberculosis, the bacteria that is responsible for causing tuberculosis.

Macrozide 1500mg Tablet causes hyperuricemia and gout by inhibiting the renal excretion of uric acid, which can lead to the precipitation or worsening of gout. It should be used with caution in individuals with hyperuricemia or a history of gout.

The side effects of Macrozide 1500mg Tablet include nausea, vomiting, muscle/joint pain, nausea and loss of appetite. Consult the doctor if any of these symptoms persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - MAC0017

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jan 1, 2025 | 2:48 PM IST

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Reference

  1. https://www.drugs.com/mtm/pyrazinamide.html
  2. https://www.webmd.com/drugs/2/drug-7398/pyrazinamide-oral/details
  3. https://www.medicines.org.uk/emc/files/pil.5273.pdf
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