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  3. Peg Doxozest 50 Injection 25 ml

Peg Doxozest 50 Injection 25 ml, Pack of 1
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Synonym :

DOXORUBICIN HYDROCHLORIDE

Composition :

DOXORUBICIN-2MG/ML

Manufacturer/Marketer :

Zee Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Peg Doxozest 50 Injection 25 ml

Peg Doxozest 50 Injection 25 ml is an anti-cancer medicine used in the treatment of cancer. Cancer is a disease where the cells grow abnormally and divide uncontrollably. Peg Doxozest 50 Injection 25 ml is primarily used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer (abnormal growth in the cells of the breast). It is also used to treat neuroblastoma (cancer that starts in nerve cells and primarily affects children) and Wilms' tumor (a form of kidney cancer that affects children).

Peg Doxozest 50 Injection 25 ml contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis.

Peg Doxozest 50 Injection 25 ml may cause certain side effects such as nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, red discoloration of urine, diarrhea, and pain at the site of injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. A trained healthcare doctor will administer Peg Doxozest 50 Injection 25 ml. So, do not self-administer. Your doctor will decide the dose of the medicine based on your health condition.

Peg Doxozest 50 Injection 25 ml should be avoided if you are allergic to it or any other components of this medicine. It is contraindicated in patients having severe myocardial insufficiency, a recent history of myocardial infarction (MI), severe persistent drug-induced myelosuppression, and severe liver disease. Hence, if you have any such conditions, inform your doctor. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any CYP3A4 or CYP2D6 inducers medication, as it can cause adverse effects. Peg Doxozest 50 Injection 25 ml is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of Peg Doxozest 50 Injection 25 ml

Peg Doxozest 50 Injection 25 ml is used to treat various types of cancer. The detailed uses of Peg Doxozest 50 Injection 25 ml are as follows:<br/>• Treats solid tumors: Peg Doxozest 50 Injection 25 ml is used alone or with other medicines to manage bladder, breast, lung, stomach, ovarian, and thyroid cancers, as well as certain soft tissue and bone sarcomas.<br/>• Treats blood cancers: Peg Doxozest 50 Injection 25 ml helps treat Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, and certain types of leukemia, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML, ANLL).<br/>• Manages childhood cancers: Peg Doxozest 50 Injection 25 ml is also used to treat neuroblastoma and Wilms’ tumor (a kidney cancer in children).<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.• Peg Doxozest 50 Injection 25 ml will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

Peg Doxozest 50 Injection 25 ml contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. Peg Doxozest 50 Injection 25 ml is also used in the treatment of acute lymphoblastic leukaemia, acute myeloblastic leukaemia, Hodgkin lymphoma, Non-Hodgkin lymphoma, metastatic breast cancer, metastatic Wilms’ tumour, metastatic neuroblastoma, metastatic soft tissue sarcoma, metastatic bone sarcomas, metastatic ovarian carcinoma, metastatic transitional cell bladder carcinoma, metastatic thyroid carcinoma, metastatic gastric carcinoma, metastatic bronchogenic carcinoma.

How Peg Doxozest 50 Injection 25 ml Works

Peg Doxozest 50 Injection 25 ml contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis.

Storage

Store in a cool and dry place away from sunlight
Side effects of Peg Doxozest 50 Injection 25 ml
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Using a cold compress may help relieve itching and inflammation associated with conjunctivitis.
  • A warm compress and washing the eyes with water can help with crusting on the eyelids.
  • Avoid wearing contact lens until you feel better; use spectacles instead.
  • Do not rub the eyes.
  • Practise good hand hygiene and avoid touching the eyes to prevent the spread of infection.

What if I have taken an overdose of Peg Doxozest 50 Injection 25 ml

Since Peg Doxozest 50 Injection 25 ml is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly. Overdose of Peg Doxozest 50 Injection 25 ml may cause sores in the mouth and throat, fever, sore throat, chills, or other signs of infection, unusual bleeding or bruising, black and tarry stools, red blood in stools, and bloody vomit or vomited material that looks like coffee grounds.

Drug Warnings

Peg Doxozest 50 Injection 25 ml should be avoided if you are allergic to it. It is contraindicated in patients having severe myocardial insufficiency, a recent history of myocardial infarction (MI), severe persistent drug-induced myelosuppression and severe liver disease. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any CYP3A4 or CYP2D6 inducers medication, as it can cause serious adverse effects. Peg Doxozest 50 Injection 25 ml is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. Do not stop receiving Peg Doxozest 50 Injection 25 ml without a doctor’s advice, as it can cause serious health conditions. Peg Doxozest 50 Injection 25 ml is known to cause secondary malignancies, tissue necrosis, cardiomyopathy and septic shock in some patients. Hence careful monitoring of the patient is needed while receiving the medicine.

Drug-Drug Interactions

verifiedApollotooltip
DoxorubicinZiprasidone
Critical
DoxorubicinSotalol
Severe

Drug-Drug Interactions

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DoxorubicinZiprasidone
Critical
How does the drug interact with Peg Doxozest 50 Injection 25 ml:
Coadministration of Peg Doxozest 50 Injection 25 ml with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Peg Doxozest 50 Injection 25 ml is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
DoxorubicinSotalol
Severe
How does the drug interact with Peg Doxozest 50 Injection 25 ml:
Using Peg Doxozest 50 Injection 25 ml together with sotalol can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Peg Doxozest 50 Injection 25 ml, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
DoxorubicinEscitalopram
Severe
How does the drug interact with Peg Doxozest 50 Injection 25 ml:
When Peg Doxozest 50 Injection 25 ml is taken with Escitalopram, the amount of Peg Doxozest 50 Injection 25 ml in the blood can go up.

How to manage the interaction:
There may be a possibility of interaction between Escitalopram and Peg Doxozest 50 Injection 25 ml, but it can be taken if prescribed by a doctor. This can make the side effects of Peg Doxozest 50 Injection 25 ml worse. If you notice any of these symptoms - feeling dizzy, lightheaded, or faint, having a fast or irregular heartbeat, feeling short of breath, or having prolonged diarrhea or vomiting - contact your doctor immediately. Do not stop using any medications without a doctor's advice.
DoxorubicinClozapine
Severe
How does the drug interact with Peg Doxozest 50 Injection 25 ml:
Taking Peg Doxozest 50 Injection 25 ml and clozapine may increase the risk of neutropenia.

How to manage the interaction:
Co-administration of Peg Doxozest 50 Injection 25 ml with Clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - like a severe infection, fever, diarrhea, sore throat, muscle pain, or difficulty breathing - it's important to call your doctor right away." Do not discontinue any medications without first consulting your doctor.
DoxorubicinMoxifloxacin
Severe
How does the drug interact with Peg Doxozest 50 Injection 25 ml:
Using Moxifloxacin together with Peg Doxozest 50 Injection 25 ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Peg Doxozest 50 Injection 25 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience dizziness, shortness of breath, or irregular heartbeat, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
DoxorubicinHydroxychloroquine
Severe
How does the drug interact with Peg Doxozest 50 Injection 25 ml:
The combined use of Peg Doxozest 50 Injection 25 ml and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Peg Doxozest 50 Injection 25 ml and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DoxorubicinAmisulpride
Severe
How does the drug interact with Peg Doxozest 50 Injection 25 ml:
Using Amisulpride together with Peg Doxozest 50 Injection 25 ml can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Although taking Peg Doxozest 50 Injection 25 ml and Amisulpride together can cause an interaction, it can be taken if a doctor has suggested it. If you're having any of these symptoms like an irregular heart rhythm, sudden dizziness, or severe diarrhea, it's important to contact the doctor right away. Do not stop using any medications without a doctor's advice.
DoxorubicinDisopyramide
Severe
How does the drug interact with Peg Doxozest 50 Injection 25 ml:
The combined use of Peg Doxozest 50 Injection 25 ml and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Peg Doxozest 50 Injection 25 ml and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DoxorubicinEtanercept
Severe
How does the drug interact with Peg Doxozest 50 Injection 25 ml:
When Etanercept is used with Peg Doxozest 50 Injection 25 ml, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Peg Doxozest 50 Injection 25 ml can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult your doctor immediately. Do not discontinue any medications without a doctor's advice.
DoxorubicinTofacitinib
Severe
How does the drug interact with Peg Doxozest 50 Injection 25 ml:
Taking Tofacitinib with Peg Doxozest 50 Injection 25 ml may increase the risk of serious infection.

How to manage the interaction:
Although taking Tofacitinib and Peg Doxozest 50 Injection 25 ml together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. It is important to keep a close eye on your condition. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Peg Doxozest 50 Injection 25 ml Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Alcohol consumption is not recommended.

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Pregnancy

Unsafe

Peg Doxozest 50 Injection 25 ml is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Peg Doxozest 50 Injection 25 ml. Use reliable methods of birth control while on treatment with Peg Doxozest 50 Injection 25 ml.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Peg Doxozest 50 Injection 25 ml. Your doctor may suggest you stop feeding while on treatment with this medicine.

bannner image

Driving

Caution

Peg Doxozest 50 Injection 25 ml may cause dizziness and tiredness; therefore, avoid driving vehicles or operating machinery until you return to normal.

bannner image

Liver

Caution

Peg Doxozest 50 Injection 25 ml should be used with caution in patients with liver impairment. However, this medicine is contraindicated in patients with severe liver disease. If you have a pre-existing or a history of liver disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

bannner image

Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative, if necessary, based on your condition.

bannner image

Children

Consult your doctor

Peg Doxozest 50 Injection 25 ml is used to treat neuroblastoma (cancer that starts in nerve cells and primarily affects children) and Wilms' tumor (a form of kidney cancer that affects children). Your doctor may recommend a suitable dosage based on your child's condition.

Have a query?

FAQs

Peg Doxozest 50 Injection 25 ml is used to treat Breast Cancer.

Peg Doxozest 50 Injection 25 ml contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

Peg Doxozest 50 Injection 25 ml can disrupt a woman&amp;#039;s natural menstrual cycle (period) and inhibit sperm production in men. However, you should not presume that you cannot become pregnant or that you cannot make someone else pregnant. It may also harm your foetus. Use reliable methods of birth control while on treatment with Peg Doxozest 50 Injection 25 ml.

Yes, Peg Doxozest 50 Injection 25 ml is considered a vesicant. This means it may cause tissue blistering and damage if it leaks out of the vein during administration in some individuals. Hence, this medication must be administered by a trained healthcare professional to reduce the risk of this complication.

The common side effects of Peg Doxozest 50 Injection 25 ml may include nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, red discoloration of urine, diarrhoea, and pain at the injection site. Most of these side effects are mild and temporary, and they often resolve on their own over time. However, if you experience persistent, severe, or worsening side effects, it's crucial to consult your doctor.

It is not recommended for use in breastfeeding women as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before prescribing Peg Doxozest 50 Injection 25 ml.

Peg Doxozest 50 Injection 25 ml is an anti-cancer medication used to treat various types of cancer. It belongs to the class of anthracycline topoisomerase inhibitors.

Alcohol intake might increase the risk of stomach or intestine bleeding. Alcohol consumption is not recommended during the treatment.

Country of origin

India

Manufacturer/Marketer address

Uchani, G.T. Road, Karnal-132001 Haryana (INDIA).
Other Info - PEG0166

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 7:04 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/050467s078,050629s030lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a682221.html#side-effects
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