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  3. Trombonat 25 Tablet 7's

Trombonat 25 Tablet 7's, Pack of 7 TabletS
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Synonym :

ELTROMBOPAGUM

Composition :

ELTROMBOPAG-25MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Trombonat 25 Tablet

Trombonat 25 Tablet is used to treat low blood platelet count in patients with idiopathic thrombocytopenic purpura (ITP) and hepatitis C virus (HCV) infections. Trombonat 25 Tablet is also used to treat severe aplastic anemia (SAA) in adults. Idiopathic thrombocytopenic purpura is an immune condition associated with low levels of platelets. Hepatitis C is an infection and inflammation of the liver caused by the hepatitis C virus. Severe aplastic anemia is a condition in which the bone marrow doesn't make enough blood cells.

Trombonat 25 Tablet contains Eltrombopag, which belongs to the class of 'thrombopoietin receptor agonists. Thrombopoietin is a glycoprotein hormone that stimulates the formation of megakaryocytes (large bone marrow cells) and further regulates platelet production. Trombonat 25 Tablet works by increasing these large bone marrow cells responsible for the production of platelets. Thus, Trombonat 25 Tablet helps increase these bone marrow cells, thereby stimulating the number of platelets, which further lowers the risk of bleeding.

Take Trombonat 25 Tablet as prescribed by your doctor. In some cases, Trombonat 25 Tablet can cause common side effects like nausea, diarrhea, headache, muscle pain, tiredness, loss of appetite, fever, anemia (lack of blood cells), cough, and tingling numbness. These side effects are not familiar to everyone who takes Trombonat 25 Tablet and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you have any allergic reactions to Trombonat 25 Tablet or any other medicines before starting Trombonat 25 Tablet. It is essential to inform your doctor if you have any heart, kidney, or liver problems, blood disorders, blood clotting problems, or cataracts before starting Trombonat 25 Tablet. Consult the doctor if you are pregnant or planning to conceive. Trombonat 25 Tablet is not indicated for use in breastfeeding since it passes into the breast milk. Trombonat 25 Tablet may make you dizzy hence, drive or operate machinery only when you are mentally alert.

Uses of Trombonat 25 Tablet

Trombonat 25 Tablet is used to treat low platelet count and severe aplastic anemia (SAA). The detailed uses of Trombonat 25 Tablet are as follows:<br/>• Chronic immune thrombocytopenia (ITP): Trombonat 25 Tablet helps prevent excessive bleeding in patients with low platelet counts.<br/>• Severe aplastic anemia: Trombonat 25 Tablet is used to treat severe aplastic anemia when other tratments have failed.<br/>• Chronic hepatitis C-related thrombocytopenia: Trombonat 25 Tablet helps maintain platelet levels before and during interferon therapy.<br/>

Directions for Use

• Trombonat 25 Tablet can be taken with or without food.• Follow your doctor's instructions on the dosage and timing of this medication.• Measure the prescribed dose using a measuring cup and administer it orally.• Avoid using regular household spoons, as they may not measure the dose correctly. Shake well before use.

Medicinal Benefits

Trombonat 25 Tablet contains 'Eltrombopag,' which belongs to the class of 'thrombopoietin receptor agonists' used to treat low blood platelet count in patients with immune (idiopathic) thrombocytopenic purpura (ITP), hepatitis C virus (HCV) infections, and severe aplastic anemia (SAA). Trombonat 25 Tablet works by increasing megakaryocytes, the large bone marrow cells responsible for the production of platelets. The increase in these bone marrow cells stimulates the production of platelets. Thus, Trombonat 25 Tablet prevents bleeding episodes by increasing the number of platelets in the blood.

How Trombonat 25 Tablet Works

Trombonat 25 Tablet contains Eltrombopag, which belongs to the class of 'thrombopoietin receptor agonists. Thrombopoietin is a glycoprotein hormone that stimulates the formation of megakaryocytes (large bone marrow cells) and further regulates platelet production. Trombonat 25 Tablet works by increasing these large bone marrow cells responsible for the production of platelets. Thus, Trombonat 25 Tablet helps increase these bone marrow cells, stimulating the number of platelets and further lowering the risk of bleeding.
Side effects of Trombonat 25 Tablet
  • Get plenty of rest and sleep.
  • Keep your body warm.
  • Drink plenty of fluids to stay hydrated.
  • Avoid strenuous activities.
  • Maintain good hygiene to prevent flu from spreading.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.

What if I have taken an overdose of Trombonat 25 Tablet

Take Trombonat 25 Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include rash, slowed heartbeat, and excessive tiredness. It may also cause life-threatening blood clots. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

If you are known to be allergic to Trombonat 25 Tablet or other medicines, please inform your doctor in advance. Brief your medical history if you have blood clots, clotting disorders (Factor V Leiden), blood disorders like blood cancer, myelodysplastic syndrome, cataracts, liver or kidney diseases before starting Trombonat 25 Tablet. Take Trombonat 25 Tablet at least two hours before or four hours after consuming antacids, mineral and vitamin supplements (iron, calcium, magnesium, aluminium, selenium and zinc), dairy products, calcium-enriched foods and fortified juices since they interfere with the absorption of Trombonat 25 Tablet. It is not recommended during pregnancy since it may have harmful effects on the foetus. Consult your doctor before using Trombonat 25 Tablet if you are a breastfeeding mother. Do not drive or operate machinery since Trombonat 25 Tablet may cause side effects like dizziness and tiredness, affecting your ability to concentrate and drive. Avoid or limit alcohol consumption with Trombonat 25 Tablet as it may affect the efficacy of Trombonat 25 Tablet. It is not recommended for children less than one year of age in ITP and children less than two years of age in SAA.

Drug-Drug Interactions

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EltrombopagMagnesium oxide
Critical
EltrombopagAluminium hydroxide
Critical

Drug-Drug Interactions

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EltrombopagMagnesium oxide
Critical
How does the drug interact with Trombonat 25 Tablet:
Coadministration of Magnesium oxide with Trombonat 25 Tablet can impair the absorption of Trombonat 25 Tablet which leads to increased levels in the blood. This can increase the risk and severity of side effects.

How to manage the interaction:
Taking Magnesium oxide with Trombonat 25 Tablet together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any body aches or pain, chills, cough, difficulty in breathing, fever, headache, or loss of voice you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
EltrombopagAluminium hydroxide
Critical
How does the drug interact with Trombonat 25 Tablet:
Coadministration of Trombonat 25 Tablet and aluminum hydroxide may interfere with the absorption of Trombonat 25 Tablet and reduce its effectiveness.

How to manage the interaction:
Taking Trombonat 25 Tablet with aluminum hydroxide is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.
EltrombopagCalcium chloride
Critical
How does the drug interact with Trombonat 25 Tablet:
When Trombonat 25 Tablet is mixed with Calcium chloride, the amount of Trombonat 25 Tablet in the blood can decrease. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Trombonat 25 Tablet with calcium chloride is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
EltrombopagMagnesium citrate
Critical
How does the drug interact with Trombonat 25 Tablet:
Taking magnesium citrate with Trombonat 25 Tablet can make it less effective by reducing its absorption and lowering its concentration in the blood.

How to manage the interaction:
Taking Magnesium citrate with Trombonat 25 Tablet is not recommended as it can result in an interaction. It can be taken if your doctor has advised it. You should take Trombonat 25 Tablet on an empty stomach at least 2 hours before or 4 hours after magnesium citrate. Do not discontinue any medication without consulting a doctor.
EltrombopagFerric maltol
Critical
How does the drug interact with Trombonat 25 Tablet:
Ferric maltol can make Trombonat 25 Tablet less effective by reducing its absorption and lowering its concentration in the blood. This can lead to poor treatment outcomes.

How to manage the interaction:
Taking Ferric maltol with Trombonat 25 Tablet is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. You should take Trombonat 25 Tablet on an empty stomach at least 2 hours before or 4 hours after ferric maltol. Do not discontinue any medication without consulting a doctor.
EltrombopagFerrous gluconate
Critical
How does the drug interact with Trombonat 25 Tablet:
Ferrous gluconate can make Trombonat 25 Tablet less effective by reducing its absorption in the body. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Trombonat 25 Tablet with Ferrous gluconate is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. You should take Trombonat 25 Tablet on an empty stomach at least 2 hours before or 4 hours after ferrous gluconate. Do not discontinue any medication without consulting a doctor.
EltrombopagInterferon alfa-n1
Severe
How does the drug interact with Trombonat 25 Tablet:
Coadministration of Trombonat 25 Tablet and Interferon alfa-n1 can increase the risk or severity of liver damage.

How to manage the interaction:
Although taking Trombonat 25 Tablet and Interferon alfa-n1 together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes it's important to call a doctor right away. Do not stop using any medications without talking to a doctor.
EltrombopagLenalidomide
Severe
How does the drug interact with Trombonat 25 Tablet:
Coadministration of Trombonat 25 Tablet with lenalidomide can increase the risk or severity of blood clots.

How to manage the interaction:
Although there is an interaction between lenalidomide and Trombonat 25 Tablet, it can be taken if your doctor has advised it. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
EltrombopagInterferon alfa-2b
Severe
How does the drug interact with Trombonat 25 Tablet:
When Interferon alfa-2b is taken with Trombonat 25 Tablet, it can lower the metabolism of Trombonat 25 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Trombonat 25 Tablet and Interferon alfa-2b, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to call a doctor right away. These symptoms include chronic hepatitis C, advanced liver disease, cirrhosis, liver failure, and other liver-related problems. You should also seek medical attention if you experience confusion, fever, joint pain, swelling, or any other unusual symptoms. Do not discontinue any medications without consulting a doctor.
EltrombopagKetoconazole
Severe
How does the drug interact with Trombonat 25 Tablet:
Coadministration of Ketoconazole and Trombonat 25 Tablet may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Trombonat 25 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat natural and healthy foods by cutting down on fatty and sodium-processed foods.
  • Exercise regularly to maintain good health.
  • Avoid smoking and alcohol intake.
  • Avoid activities like contact sports and use sharp objects like nail cutters and razors to decrease bleeding risk.
  • A high-protein diet, such as lean meat, chicken, crab, turkey, beef, and fish, can help increase platelet count.
  • Eating Papayaa is the best natural remedy to increase your platelet count, and you can also use Papayaa leave's mixture.
  • Include iron-rich foods like pomegranate, beetroot, green leafy vegetables, carrots, raisins, oranges, peanuts, kidney beans, and black-eyed peas in your diet.
  • Vitamin C sources like guava, black currant, red pepper, kiwi, green peppers, orange, strawberries, pineapple, peas, mango, grapefruit , and broccoli can also boost your platelet count.

Habit Forming

No

Therapeutic Class

PLATELET STIMULATING AGENTS

Trombonat 25 Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Limit alcohol intake, along with Trombonat 25 Tablet, to attain the maximum efficacy of Trombonat 25 Tablet and rule out any possibility of worsening of side effects.

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Pregnancy

Unsafe

Trombonat 25 Tablet is not recommended in pregnancy. It may affect and harm the developing baby. Please consult your doctor if you are pregnant or planning to conceive.

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Breast Feeding

Caution

It is not known if Trombonat 25 Tablet is excreted into the breast milk. If you are a nursing mother, please consult your doctor for more information before taking Trombonat 25 Tablet.

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Driving

Caution

Trombonat 25 Tablet may cause dizziness and tiredness affecting your ability to concentrate and drive. Hence, it is recommended not to drive or operate machinery until you are mentally alert.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before taking Trombonat 25 Tablet. It may cause an increase in liver enzymes. Your doctor may start the treatment with a lower dose of Trombonat 25 Tablet based on your health condition.

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Kidney

Caution

Trombonat 25 Tablet should be used with caution in cases of renal impairment. Seeking a doctor's advice before starting Trombonat 25 Tablet if you have any kidney problems is advised.

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Children

Safe if prescribed

Trombonat 25 Tablet is not recommended for children less than one year of age in ITP and children less than two years of age in SAA.

Have a query?

FAQs

Trombonat 25 Tablet is used to treat low blood platelet count in patients with idiopathic thrombocytopenic purpura (ITP) and hepatitis C virus (HCV) infections. It is also used to treat severe aplastic anemia (SAA).

Trombonat 25 Tablet contains Eltrombopag that stimulates platelet production (helps in clotting) from megakaryocytes (bone marrow cells). Thus Trombonat 25 Tablet lowers the risk of bleeding episodes in diseases like immune (idiopathic) thrombocytopenic purpura (ITP), hepatitis C virus (HCV) infections, and severe aplastic anemia (SAA).

Do not stop using Trombonat 25 Tablet even if you feel better. It should be strictly used as advised by your doctor to avoid the recurrence of symptoms and worsening of the disease.

Trombonat 25 Tablet should be used with caution and only under doctor supervision in cases if you are having any allergic reactions, blood clots, clotting disorders (Factor V Leiden), blood disorders like blood cancer, myelodysplastic syndrome, cataracts, liver or kidney diseases.

Trombonat 25 Tablet decreases the risk of bleeding by increasing the platelet count in your body. However, you are advised to stay away from activities that may increase your risk of bleeding like contact sports and using sharp objects like razors and nail cutters.

It is advised to take Trombonat 25 Tablet on an empty stomach. Please take Trombonat 25 Tablet at least two hours before or four hours after consuming antacids, mineral and vitamin supplements (iron, calcium, magnesium, aluminium, selenium, and zinc), dairy products, calcium-enriched foods, and fortified juices since they interfere with the absorption of Trombonat 25 Tablet.

It is usually taken by mixing the prescribed amount of suspension powder in water and administering it orally immediately after ensuring perfect mixing.

Trombonat 25 Tablet should be stored in a cool and dry place away from sunlight. Keep out of sight and reach of children.

Trombonat 25 Tablet can cause or increase the risk of severe liver issues. Check with your doctor straight away if you experience nausea or vomiting, dark urine, light-coloured stools, right upper stomach pain, unusual exhaustion, or yellow eyes or skin while using this medication.

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - TRO0429

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 7:09 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/022291s037,207027s017lbl.pdf
  2. https://pmc.ncbi.nlm.nih.gov/articles/PMC5858473/#:~:text=Eltrombopag%20is%20currently%20the%20only,thrombocytopenia%20(ITP)%20in%20children
  3. https://www.webmd.com/drugs/2/drug-151606/eltrombopag-oral/details
  4. https://www.drugs.com/mtm/eltrombopag.html
  5. https://www.ema.europa.eu/en/documents/product-information/revolade-epar-product-information_en.pdf
  6. https://www.medicines.org.uk/emc/files/pil.508.pdf

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