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  3. Zerodol-MR Tablet 10's

Zerodol-MR Tablet 10's, Pack of 10
Zerodol-MR Tablet 10's, Pack of 10
Zerodol-MR Tablet 10's, Pack of 10
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy

Zerodol-MR Tablet is used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, tooth pain, bone and joint pain, and headache. It works on the centres of the spinal cord and brain and blocks the effect of chemical messengers, which cause pain and inflammation. This helps relieve muscle stiffness, pain, and inflammation, and improves muscle movements.

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Composition :

ACECLOFENAC-100MG + TIZANIDINE-2MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Zerodol-MR Tablet

Zerodol-MR Tablet is a combination medicine used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, tooth pain, bone and joint pain, and headache. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable.
 
Zerodol-MR Tablet contains Tizanidine (muscle relaxant) and Aceclofenac (NSAID). Tizanidine works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Aceclofenac works by blocking the effect of prostaglandins, which cause pain and inflammation. Thus, it reduces mild to moderate pain and inflammation. Together, Zerodol-MR Tablet helps in relieving pain due to muscle spasms.
 
You are advised to take Zerodol-MR Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience common side effects such as nausea, vomiting, stomach pain, loss of appetite, heartburn, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. Zerodol-MR Tablet may cause drowsiness and dizziness, so drive with caution. Zerodol-MR Tablet is not recommended for children as safety and efficacy have not been established. Avoid consuming alcohol with Zerodol-MR Tablet as it could lead to increased drowsiness and dizziness; it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any interactions.

Uses of Zerodol-MR Tablet

Zerodol-MR Tablet is used to treat pain and inflammation associated with musculoskeletal and joint disorders. The detailed uses of Zerodol-MR Tablet are as follows:

  • Pain Relief: Zerodol-MR Tablet is used to manage moderate to severe pain, including injuries, post-surgical pain, and various medical conditions.
  • Anti-Inflammatory: It helps reduce inflammation associated with conditions like osteoarthritis, rheumatoid arthritis by blocking chemicals in the body that cause swelling.
  • Headache: Zerodol-MR Tablet helps to ease migraine pain and provides relief from symptoms like headaches.
  • Menstrual Pain: Zerodol-MR Tablet provides relief from period pain and cramps, helping to ease the discomfort of dysmenorrhea.
  • Postoperative Pain: Zerodol-MR Tablet can be prescribed to manage pain following a surgical procedure as it is a combination of an NSAID and a muscle relaxant to ease post-surgery pain, swelling, and stiffness, supporting a smoother recovery.

Directions for Use

• Zerodol-MR Tablet can be taken with food to avoid stomach upset. • It is usually taken twice daily or as prescribed by your doctor. • Swallow Zerodol-MR Tablet as a whole with a glass of water. • Do not break, chew, or crush it.

Medicinal Benefits

Zerodol-MR Tablet is a combination of two drugs: Tizanidine and Aceclofenac. Zerodol-MR Tablet is a combination medicine used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, tooth pain, bone and joint pain, and headache. Tizanidine is a muscle relaxant that works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Aceclofenac is an analgesic that works by blocking the effect of a chemical messenger known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandins, which are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Together, Zerodol-MR Tablet helps in relieving pain due to muscle spasms.

How Zerodol-MR Tablet Works

Zerodol-MR Tablet contains Tizanidine (muscle relaxant) and Aceclofenac (NSAID). Tizanidine works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Aceclofenac works by blocking the effect of prostaglandins, which cause pain and inflammation. Thus, it reduces mild to moderate pain and inflammation. Together, Zerodol-MR Tablet helps in relieving pain due to muscle spasms.

Storage

• Store in a cool and dry place away from sunlight.• Keep Zerodol-MR Tablet out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Zerodol-MR Tablet
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

What if I have taken an overdose of Zerodol-MR Tablet

Take Zerodol-MR Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Zerodol-MR Tablet if you are allergic to any of its components. Inform your doctor if you have/ had high blood pressure, heart problems, stomach ulcer or perforation, bleeding problems such as bleeding from the stomach, intestine or brain, bypass surgery, heart attack, blood circulation problems, or inflammation of the intestine, high cholesterol, diabetes, asthma, inflammatory bowel disease, liver or kidney problems. Consult your doctor if you are pregnant or breastfeeding. Zerodol-MR Tablet may cause drowsiness and dizziness, so drive only if you are alert. Zerodol-MR Tablet is not recommended for children as safety and effectiveness have not been established. Stop taking Zerodol-MR Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools.

Drug-Drug Interactions

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TizanidineDronedarone
Critical
TizanidineSaquinavir
Critical

Drug-Drug Interactions

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TizanidineDronedarone
Critical
How does the drug interact with Zerodol-MR Tablet:
Coadministration of Zerodol-MR Tablet with Dronedarone can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Zerodol-MR Tablet with Dronedarone is generally avoided as it can result in an interaction, it can be taken when prescribed by a doctor. If you experience sudden dizziness, shortness of breath, palpitations, or chest pain, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
TizanidineSaquinavir
Critical
How does the drug interact with Zerodol-MR Tablet:
Combining Zerodol-MR Tablet with Saquinavir can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Zerodol-MR Tablet with Saquinavir is not recommended, as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhoea or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TizanidineCisapride
Critical
How does the drug interact with Zerodol-MR Tablet:
Coadministration of Zerodol-MR Tablet with Cisapride can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Zerodol-MR Tablet with Cisapride is avoided as it can result in an interaction, it can be taken if your doctor has advised it. Contact your doctor immediately if you experience sudden dizziness, shortness of breath, palpitations, or vomiting. Do not discontinue any medications without consulting your doctor.
TizanidineFluvoxamine
Critical
How does the drug interact with Zerodol-MR Tablet:
Taking Fluvoxamine with Zerodol-MR Tablet it can increases the risk of side effects.

How to manage the interaction:
Although Fluvoxamine with Zerodol-MR Tablet is not recommended, but can be taken together if prescribed by a doctor. However, if you experience drowsiness, dizziness, low blood pressure, slurred speech, confusion, or severe weakness, contact your doctor immediately. Do not stop using any medications without consulting a doctor.
TizanidineCiprofloxacin
Critical
How does the drug interact with Zerodol-MR Tablet:
Coadministration of Ciprofloxacin and Zerodol-MR Tablet together can increase the risk of side effects.

How to manage the interaction:
Using Ciprofloxacin and Zerodol-MR Tablet together is avoided, as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience drowsiness, weakness, sweating, or palpitations contact the doctor immediately. Do not discontinue any medications without consulting the doctor.
TizanidineZiprasidone
Critical
How does the drug interact with Zerodol-MR Tablet:
Co-administration of Zerodol-MR Tablet with Ziprasidone can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Zerodol-MR Tablet with Ziprasidone is not recommended, as it can result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
AceclofenacAtenolol
Severe
How does the drug interact with Zerodol-MR Tablet:
Co-administration of Atenolol with Zerodol-MR Tablet could increase the risk of low blood pressure.

How to manage the interaction:
Although there is a possible interaction between Atenolol and Zerodol-MR Tablet, you can take these medicines together if prescribed by a doctor. Consult a doctor if you experience excessive sweating, shortness of breath, palpitations, or chest discomfort. Do not discontinue any medications without consulting a doctor.
TizanidineNimodipine
Severe
How does the drug interact with Zerodol-MR Tablet:
Taking Nimodipine and Zerodol-MR Tablet when taken together may lower the blood pressure which may lead to side effects.

How to manage the interaction:
Although taking Nimodipine and Zerodol-MR Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience lightheadedness, dizziness, headaches, fainting, or irregular heart rate, consult a doctor. Do not stop taking any medications without consulting a doctor.
TizanidineFamotidine
Severe
How does the drug interact with Zerodol-MR Tablet:
When Zerodol-MR Tablet with Famotidine, famotidine can considerably raise the blood levels and effects of Zerodol-MR Tablet. This could result in a sudden decrease in blood pressure.

How to manage the interaction:
Taking Famotidine with Zerodol-MR Tablet together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience dizziness, fainting, and irregular heart rhythm, consult your doctor immediately. Do not stop using any medications without talking to a doctor.
TizanidineValsartan
Severe
How does the drug interact with Zerodol-MR Tablet:
Coadministration of Zerodol-MR Tablet and Valsartan may increase the risk of low blood pressure.

How to manage the interaction:
Although taking Zerodol-MR Tablet together with Valsartan may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate, contact a doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Massages can also be helpful.
  • Rest well, get plenty of sleep.
  • To avoid developing pressure sores, change your position at least every two hours.
  • Hot or cold therapy can help treat muscle spasms. Apply an ice-pack or hot-pack on the muscle for 15-20minutes.
  • Stay hydrated, drink plenty of water.

Habit Forming

No

Therapeutic Class

ANALGESICS

Zerodol-MR Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Zerodol-MR Tablet as it may cause increased drowsiness. It may also increase the risk of stomach bleeding.

bannner image

Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor if you are breastfeeding; your doctor will decide whether Zerodol-MR Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

Zerodol-MR Tablet may cause dizziness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have liver problems or any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney problems or any concerns regarding this.

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Children

Unsafe

Zerodol-MR Tablet is not recommended for children as safety and effectiveness are not established.

Have a query?

FAQs

Zerodol-MR Tablet is used to treat pain and inflammation associated with musculoskeletal and joint disorders.

Zerodol-MR Tablet contains Tizanidine and Aceclofenac. Tizanidine works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Aceclofenac works by blocking the effect of prostaglandins, thereby reduces mild to moderate pain and inflammation.

Zerodol-MR Tablet is used to reduce and relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Arthritis is the tenderness and swelling in the joints.

Diarrhoea might be a side-effect of Zerodol-MR Tablet . Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Dry mouth could be a side-effect of Zerodol-MR Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevents drying of the mouth.

Taking Zerodol-MR Tablet can elevate symptoms of gastric ulcer and bleeding. So, talk to your doctor before taking Zerodol-MR Tablet if you have gastrointestinal bleeding or other bleeding problems like haemophilia before using Zerodol-MR Tablet .

Zerodol-MR Tablet and Hifenac-MR are similar, as they relieve pain and inflammation but differ in their active components.

Yes, Zerodol-MR Tablet is a painkiller. However, it is not meant for every kind of pain. Use it as prescribed to avoid side effects.

You are not recommended to take Zerodol-MR Tablet with other painkillers, particularly NSAIDs, as it can increase the risk of side effects like stomach irritation or bleeding. If you are allergic to painkillers or NSAIDs, you should avoid using Zerodol-MR Tablet . Always check with your doctor before taking Zerodol-MR Tablet with other medicines.

Take Zerodol-MR Tablet only as prescribed by your doctor. Do not adjust the dose without consulting them. If the pain persists, consult your doctor for further guidance.

Zerodol-MR Tablet contains Aceclofenac, and Tizanidine, making it effective for pain relief and muscle relaxation. Zerodol-SP, on the other hand, includes Aceclofenac, Paracetamol, and Serratiopeptidase, which helps reduce pain, inflammation, and swelling. Both should be used as directed by a doctor.

Diabetic patients can use Zerodol-MR Tablet , but it should be taken with caution as it may impact blood sugar levels. Therefore, please consult a doctor before using Zerodol-MR Tablet to ensure its safety for your condition. Regular monitoring of blood sugar is recommended.

You are recommended to consult a doctor before taking Zerodol-MR Tablet with paracetamol or other medicines to avoid potential interactions.

Zerodol-MR Tablet may cause drowsiness as it is one of its common side effects. However, please consult a doctor if this side effect persists for longer durations.

Yes, the use of Zerodol-MR Tablet can cause nausea and vomiting. Take it with milk, food, or antacids to avoid nausea. Avoid intake of fried or fatty food along with Zerodol-MR Tablet . If vomiting occurs, drink plenty of water or other fluids by taking small frequent sips. If vomiting persists, consult your doctor.

You are advised to take Zerodol-MR Tablet preferably after meals to minimize the risk of stomach discomfort. However, always follow your doctor's instructions.

Zerodol-MR Tablet usually starts working within 20-30 minutes of taking it, though the onset may vary depending on individual health conditions.

Zerodol-MR Tablet contains aceclofenac and tizanidine as its active components.

Do not take higher than the recommended dose of Zerodol-MR Tablet as it can lead to increased side effects. Therefore, do not exceed the recommended dose. If your symptoms worsen, please consult your doctor.

Store Zerodol-MR Tablet at room temperature in a cool and dry place as advised on the label. Protect from light and moisture. Keep it out of reach of children.

Zerodol-MR Tablet is safe when used as per the dose and duration advised by a doctor.

Zerodol-MR Tablet is contraindicated in individuals with known allergies to its ingredients, or patients with high blood pressure, heart problems, stomach ulcers, bleeding disorders, inflammatory bowel disease, high cholesterol, diabetes, asthma, or liver and kidney issues. Zerodol-MR Tablet is not recommended for children, and you should consult your doctor if you are pregnant or breastfeeding.

You are recommended not to stop taking Zerodol-MR Tablet without consulting your doctor as stopping it suddenly can cause adverse effects. Therefore, continue taking Zerodol-MR Tablet for the duration prescribed and if you experience any difficulty while taking Zerodol-MR Tablet , consult your doctor so that the dose may be reduced gradually.

Take Zerodol-MR Tablet as directed by your doctor. Swallow Zerodol-MR Tablet whole with a glass of water; do not crush, chew, or break it.

You are recommended to avoid alcohol while taking Zerodol-MR Tablet , as it may cause excessive drowsiness and increase the risk of stomach bleeding. Please, consult the doctor if you have any concerns.

Pregnant women should consult a doctor before taking Zerodol-MR Tablet . Your doctor prescribes Zerodol-MR Tablet only when the benefits outweigh the risks. Do not self-medicate.

If you miss a dose of Zerodol-MR Tablet , take it as soon as you remember and if it is the time for the next dose, skip the missed dose and continue with the regular dose. Avoid taking double dose to make up for the missed one.

Zerodol-MR Tablet may cause side effects such as nausea, vomiting, stomach pain, diarrhoea, loss of appetite, and heartburn. These do not require any medical treatment as they will gradually reduce over time. Consult a doctor if these side effects persist for longer durations.

Country of origin

India

Manufacturer/Marketer address

142 AB, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra
Other Info - ZER0001

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Aug 5, 2025 | 11:45 AM IST

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Reference

  1. https://www.hpra.ie/img/uploaded/swedocuments/2188598.PPA0465_168_001.a8263158-055a-45a9-a0c4-78a88025a375.000001Zanaflex%20Combined%20PIL.170214.pdf
  2. https://www.medicines.org.uk/emc/files/pil.4240.pdf
  3. https://www.drugs.com/tizanidine.html

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