Metosartan CH 50 contains chlorthalidone, telmisartan, and metoprolol, which are commonly used to treat high blood pressure. Dolo 650 contains paracetamol and is generally considered safe to take with Metosartan CH 50 at the recommended dose. There are no major harmful interactions between these medicines. Zerodol contains aceclofenac, a pain-relieving anti-inflammatory medicine. Taking Zerodol with Metosartan CH 50 may increase the risk of kidney problems, especially in older adults or people who already have kidney disease, dehydration, or diabetes. Aceclofenac can also reduce the blood pressure-lowering effect of telmisartan and chlorthalidone, making blood pressure harder to control. In some cases, it may also cause swelling or fluid retention. If pain relief is needed for a short time, paracetamol is usually a safer option than aceclofenac for patients taking blood pressure medicines. Always consult your doctor before starting any new pain medication to ensure your heart and kidneys remain protected.