Drug Ingredient Information
Naproxen belongs to a group of medicines called non-steriodal anti-inflammatory drugs (NSAIDs), which are used to reduce inflammation and pain in joints and muscles. Naproxen are used to treat:
•diseases of joints such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis. Naproxen cannot cure arthritis but is used to give relief of some symptoms such as inflammation, swelling, stiffness and joint pain.
•attacks of gout
•muscle and bone disorders such as cervical spondylitis, low back pain, strains and sprains, muscular pain and stiffness (fibrositis) and inflammation of tendons (tenosynovitis).
||•Medicines such as naproxen may be associated with a small increased risk of heart attack (myocardial infaraction) or stroke. Any risk is more likely with high doses and prolonged treatment. Do not exceed the recommended dose or duration of treatment.
•If you have heart problems, previous stroke or think that you might be at risk of these conditions (for example if you have high blood pressure, diabetes or high cholesterol or are a smoker) you should discuss your treatment with your doctor or pharmacist.
•If you are elderly or frail, you have a higher risk of getting side effects, especially from the stomach. If you experience any unusual symptoms from the stomach you must tell your doctor about it.
•Naproxen may hide the symptoms of an infection.
||•are in the last three months of pregnancy or if you are breast -feeding
•are allergic to naproxen or to any of the other ingredients of Naproxen.
•are allergic to aspirin or other non-steroidal anti-inflammatory medicines (NSAIDs), or you have developed signs of asthma (wheezing), runny nose, swelling of the skin or rash when taking these medicines
•have or have had stomach or duodenum (gut) ulcers, bleeding in the stomach or intestines (gastrointestinal bleeding) or have had two or more episodes of peptic ulcers, stomach bleeding or perforation
•have severe liver, kidney (not receiving dialysis) or heart failure.If you are not sure about any of the above conditions, please ask your doctor.
|Drug Special Care
||•use other non-steroidal anti-inflammatory medicines (NSAIDs) or any medication which may cause bleeding or ulcers in the stomach
•have a history of gastrointestinal disease e.g. ulcerative colitis, Crohn’s disease
•have or have had high blood pressure or any liver, kidney or heart problems
•have or have had bronchial asthma or allergic disease
•have systemic lupus erythematosus or other connective tissue disorders
•have a blood clotting disorder
•are a women trying to become pregnant or undergoing investigation of infertility.
|Drug Drug Interactions
||•other NSAIDs such as aspirin or COX II inhibitors
•medicines which thin the blood or which prevent blood clotting such as warfarin
•diuretics (“water ”) (e.g. furosemide)
•medicines to treat high blood pressure (e.g. captopril, ramipril, propranolol, losartan or candesartan)
•ciclosporin or tacrolimus
•mifepristone – do not take NSAIDs 8-12 days after mifepristone
•colestyramine (take naproxen 1 hour before or 4 to 6 hours after colestyramine to avoid interference with absorption)
•hydantoins (e.g. phenytoin)
•cardiac glycosides (e.g. digoxin or digitoxin).
|Drug Pregnancy Interaction
||Naproxen may make it more difficult to become pregnant. You should inform your doctor if you are planning to become pregnant or if you have problems becoming pregnant. You should not take Naproxen in the first 6 months of pregnancy and must not take Naproxen in the last 3 months of pregnancy or during labour.
|Drug Breast feeding Interaction
||If you are breast-feeding, you should not take Naproxen .
|Drug Machinery Interaction
||Naproxen may make you feel dizzy, drowsy or tired and may cause blurred vision. Make sure you are not affected before you drive or operate machinery.
|Drug More Information
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine, as it contains lactose.
If you need any blood or urine tests tell your doctor you are taking Naproxen. The may need to be stopped 48 hours before a test, as they may interefere with the results.
|How to take the
Your doctor should prescribe as low a dose as possible. This will reduce any side effects you may experience.
•Rheumatoid arthritis, osteoarthritis and ankylosing spondylitis Initially a dose of 750mg-1g may be given then 500mg-1g a day in two doses at twelve hour intervals, or as one dose taken in either the morning or evening.
•Attack of gout
Initially 750mg as a single dose then 250mg every 8 hours until the attack has passed.
•Muscle and bone disorders
Initially 500mg as a single dose then 250mg every 6-8 hours as necessary. Up to a maximum of 1250mg a day may be given after the first day.
Children under 16 years
Naproxen should not be used in children under 16 years of age.
Dosage may be reduced in the elderly.
||Always take Naproxen exactly as your doctor has told you. If you are not sure, check with your doctor or pharmacist. Swallow with or after food.
|Excess Drug Consumption
||It is important not to take too many . Contact your doctor, pharmacist or nearest hospital casualty department immediately if you have taken more than you should.
Symptoms of overdose are headache, feeling or being sick, heartburn, diarrhoea, disorientation, bleeding of the stomach or intestines, unconsciousness, drowsiness, dizziness, ringing or buzzing in the ears, fainting, fits and excitation.
|Forgot Drug Consumption
||If you forget to take your , take your next dose as soon as you remember, unless it is nearly time for your next dose. Do not take a double dose to make up for one you have missed.
|Stop Drug Consumption
||depression, irregular heartbeat (palpitations), abnormal dreams, forgetfulness, difficulty concentrating, sensitivity of the skin to light (may cause blistering), difficulty sleeping.
•indigestion, heartburn, pains in your stomach or other abnormal stomach symptoms, feeling or being sick (you may have an ulcer or inflammation in the stomach or gut)
•pass blood in your faeces (stools/motions) or black tarry looking stools
•vomit any blood or dark particles that look like coffee grounds
•have an allergic reaction:
-swelling of the face, mouth, tongue, airways or body
-skin reactions including: hives (pale/red raised skin with severe itching), blistered skin, itchy skin rash, blood spots, bruising or discolouring of the skin, raised purple rashes red skin patches, a severe rash with reddening, peeling and swelling of the skin that resembles burns, bumpy, rashes, blisters, dermatitis (skin shedding, itching, swelling)
-difficulty breathing or wheezing, coughing up blood.
|Common Drug Side Effects
||confusion, headache, ringing in the ears, changes in vision (you should go for an eye test if you notice changes in vision), tiredness, drowsiness, dizziness, rashes, heart failure, diarrhoea, being sick, water retention (may cause swelling in the limbs). feeling sick, constipation.
|Rare Drug Side Effects
||high blood potassium levels (causing irregular, slow heart beat, feeling sick), hair loss, jaundice (yellow skin or eyes), hearing difficulties, inflammation of blood vessels (causing fever, swelling and general unwellness), worsening of asthma, muscle weakness/pain, ulcers on the inner cheeks, gums and tongue, hepatitis (symptoms include feeling tired, loss of appetite, feeling or being sick and pale coloured stools) resulting in death.
|Very Rare Drug Side Effects
||changes in the numbers and types of blood cells (if you develop sore throats, nose bleeds or infections consult your doctor), anaemia (may cause fainting, chest pain, breathlessness), fits, aseptic meningitis (may cause fever, feeling or being sick, disorientation, headache, neck stiffness and sensitivity to light), severe skin rash with flushing, blisters or ulcers (Stevens-Johnson syndrome), blisters or sores on the skin, kidney damage or infection (may cause blood in the urine, decrease in amount of urine passed, feeling or being sick), inflammation of the pancreas; pancreatitis (causing fever, stomach pain, sickness). Medicines such as naproxen may be associated with a small increased risk of heart attack (myocardial infarction) or stroke.
|Drug Side Effects Symptoms
||(frequency cannot be estimated from the available data) low amounts of white cells in the blood (may cause fever or frequent
infections), runny nose, lowered female fertility, sensing things that are not there, high blood creatinine levels seen in blood tests, kidney disease or failure (may cause changes in the need to or amount of urine), thirst, fever, inflammation in the eye (causing eye pain or changes in vision), tingling or “pins and needles”, a spinning sensation, high blood pressure, abnormal liver function seen in tests, wind, worsening of colitis and Crohn’s disease, worsening of Parkinson’s disease, general feeling of discomfort and illness, swelling of the hands and feet, swelling in the eye (causing headaches or blurred vision), hepatitis (feeling tired, loss of appetite, feeling or being sick and pale coloured stools). If any of the side effects get worse, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
|How to Store the
|How to Store the Medicine
||Keep out of the reach and sight of children. Store below 25ºC in a dry place. Protect from light. Do not use Naproxen after the expiry date which is stated on the label/carton/bottle. The expiry date refers to the last day of that month. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.