Octreotide is a long-acting injection, often called a ‘depot’ injection because the active ingredient is released into the body slowly. This means that you don’t have to have an injection every day. Octreotide contains the active ingredient octreotide (as the acetate). Octreotide is a synthetic form of the natural hormone, somatostatin. It helps stop the release of some hormones, including growth hormone, in the body. Octreotide can be used for two conditions.
1.To treat acromegaly
Acromegaly is a condition where the body produces too much growth hormone. The level of growth hormone controls the growth of tissues, organs and bones. Too much hormone means the size of bones and tissues, especially in the hands and feet, is ger than normal. The symptoms of acromegaly include headache, excessive perspiration, numb hands and feet, tiredness, and joint pain. In most cases, the overproduction of growth hormone is caused by an engement in the pituitary gland (a pituitary adenoma).Octreotide is used to treat people with acromegaly;
•when daily treatment with Octreotide injection given subcutaneously (under the skin) has been proved to be satisfactory; (Switching to Octreotide means that the injections will be much less frequent.)
•when other types of treatment for acromegaly (surgery or radiotherapy) are not suitable or haven’t worked;
•after radiotherapy, to cover the interim period until the radiotherapy becomes fully effective;
•before surgery on the pituitary gland.
||Overproduction of specific hormones and other related natural substances can be caused by some rare conditions of the stomach, bowels or pancreas. This upsets the natural hormonal balance of the body, and results in a variety of symptoms, such as flushing, diarrhoea, low blood pressure, rash, and weight loss. Treatment with Octreotide helps to control these symptoms. It is generally given to people who have already responded well to treatment with daily Octreotide injections
||•You think you may be allergic to octreotide or to any of the other ingredients of Octreotide .
•You are breastfeeding.
|Drug Special Care
||•Are you pregnant ?
•Do you have diabetes?
•Do you have thyroid problems, or have you had a disease which may have affected your thyroid?
•Do you have any problems with your liver, or have you had a disease which may have affected your liver?
•Have you ever suffered from gallstones or other stomach problems?
•Do you have a history of Vitamin B12 deficiency?
If the answer to any of these questions is YES, tell your doctor or nurse because Octreotide might not be the right medicine for you.
|Drug Drug Interactions
||Octreotide interacts with a ge number of other medicines. Tell your doctor or nurse if you are taking any of the following:
Insulin, or other drugs for diabetes
Medicines to control blood pressure (beta-blockers or calcium channel blockers) or agents to control fluid and electrolyte balance (diuretics)
Medicines metabolised by the liver for example carbamazepine, digoxin and warfarin and terfenadine.
Always tell your doctor or pharmacist about all the medicines you are taking. This means medicines you have bought yourself as well as medicines on prescription from your doctor
|Drug Pregnancy Interaction
|Drug Breast feeding Interaction
|Drug Machinery Interaction
||No problems have been reported
|Drug More Information
|How to take the
||•Your doctor may want to give you a check up from time to time while you are being treated with Octreotide .
•Growth hormone secreting pituitary tumours may sometimes expand and cause problems. Tell your doctor if you experience any problems with your eyes or sight.
•Tell your doctor if your stomach or bowel problems get worse.
•There is very little experience of using Octreotide in children.
•Octreotide should only be used during pregnancy if clearly needed. Tell your doctor if you are pregnant or want to become pregnant.
•Women of child bearing potential must use an effective contraceptive method during treatment with Octreotide
||Your doctor will work out the correct dose for you.
For all adults the starting dose is usually 20 mg Octreotide , which is given at 4-week intervals. After about the first 3 months of treatment with Octreotide , your doctor will probably want to reassess your treatment. This may involve measuring the levels of growth hormone or other hormones in your blood. Depending on these results, and on how you are feeling, the dose of Octreotide may need to be changed. The dose given in each injection can be reduced to 10 mg or, if the treatment is not fully effective, it can be increased to 30 mg. After the most suitable dose for you has been found, your doctor will probably want to
reassess your treatment about every 6 months.Octreotide must be injected into the gluteal muscles in your buttocks. For repeat injections the doctor or nurse will use the left and right buttocks alternately.If you have had no problems with Octreotide injected subcutaneously, you can immediately be changed over to Octreotide . If you haven’t had Octreotide before, the doctor will give you a test dose to see how you react, before switching to Octreotide , if appropriate. Depending on why you are having Octreotide , you may need to continue having subcutaneous Octreotide for about two weeks after your first injection of Octreotide until it becomes fully effective. You might also occasionally need to use subcutaneous Sandostation as
well when your symptoms are troublesome.When Octreotide is being used prior to surgery on the pituitary gland, you must have the last dose at least 3 to 4 weeks before the surgery.Ask your doctor or pharmacist if you are unsure about how much medicine you are being given or how often you are being given it.
|Excess Drug Consumption
||If you think you have been given the wrong dose talk to the nurse or doctor.
|Forgot Drug Consumption
||If you forget to go for your appointment for your injection, you should contact your doctor as soon as possible to arrange another appointment.
|Stop Drug Consumption
||•Your face becomes flushed or swollen or you develop spots or a rash
•Your chest feels tight, you become short of breath or wheezy
•You feel faint, possibly as a result of a fall in blood pressure.
These might be the result of an allergic reaction.
If you develop any of the following see your doctor immediately:
•Prolonged/troublesome bloating of the stomach with pain
•Nausea/vomiting associated with drowsiness
•Feeling restless or giddy
•Yellowing of skin or the whites of your eyes
•Acute pancreatitis (sudden, severe pains in the lower stomach). This may happen within the first few hours or days of treatment and resolves itself upon drug withdrawal
|Common Drug Side Effects
||•Local pain at the site of the injection
•Stomach ache, nausea, wind, diarrhoea or constipation
•Changes in blood sugar levels (Hyperglycaemia)
|Rare Drug Side Effects
||•Slow heart beat
•Shortness of breath
•Loss of appetite
•Changes in blood sugar levels (Hypoglycaemia)
•Impaired glucose tolerance
•Stomach discomfort after a meal
•Loose faeces (stools)
•Discolouration of faeces
•Fat in your faeces (pale and fatty loose stools)
•Inflammation of the gallbladder
•Yellow skin and eyes
•Abnormal liver function test results
•Changes in activity of the thyroid gland (hypothyroidism) causing changes in heart rate, appetite or weight, tiredness, feeling cold or sweating too much, anxiety or swelling at the front of the neck
|Very Rare Drug Side Effects
•Fast heart beat
|Drug Side Effects Symptoms
||•Anaphylaxis (a type of allergic reaction which causes difficulty in breathing or dizziness),allergy/hypersensitivity reactions
•Inflammation of the pancreas
•Liver inflammation (hepatitis); symptoms may include yellowing of the skin and eyes (jaundice), nausea, vomiting, loss of appetite, generally feeling unwell, itching, light-coloured urine
•Irregu heart beat
|How to Store the
|How to Store the Medicine
||Keep all medicines out of the reach and sight of children. Octreotide should be stored in the fridge (between 2°C and 8°C). Keep in the original packaging to protect it from light. Octreotide can be kept below 25°C on the day of injection, but it must be kept in the outer carton to protect it from light. The suspension must only be prepared immediately before injection.Do not use Octreotide after the expiry date which is printed on the outside of the pack.