Composition : FOSPHENYTOIN-75MG
Description : NEOFOST 2ML INJ
Route Of Administration : PARENTERAL
Pack : 1
Out of stock
Composition : FOSPHENYTOIN-75MG
Description : NEOFOST 2ML INJ
Route Of Administration : PARENTERAL
Pack : 1

Drug Ingredient Information



Information for patients
Drug Information Fosphenytoin is one of a group of medicines called anti-epileptic drugs; these medicines are used to treat epilepsy. Fosphenytoin is used to treat severe epileptic seizure or fits (status epilepticus). It can also be used to control or prevent seizures during or after brain surgery and/or severe head injury. Fosphenytoin is also used to control or prevent seizures for short periods of time when antiepileptic drugs cannot be taken by mouth. You should consult your doctor if you are unsure why you have been given Fosphenytoin.
Drug Alert
Alert no data available
Before Consuming the Medicine
Avoid Drug If you are allergic (hypersensitive) to fosphenytoin sodium, phenytoin or any of the other ingredients of Fosphenytoin. If you suffer from a condition affecting your heart rhythm. If you suffer from a disorder of red blood cell formation (acute intermittent porphyria).
Drug Special Care A small number of people being treated with anti-epileptics such as fosphenytoin have had thoughts of harming or killing themselves. If at any time you have these thoughts, immediately contact your doctor. Serious skin side effects can rarely occur during treatment with Fosphenytoin. This risk may be associated with a variant in genes in a subject with Chinese origin. If you are of such origin and have been tested previously carrying this genetic variant (HLA-B*1502), discuss this with your doctor before taking Fosphenytoin. Medicines are not always suitable for everyone. Your doctor needs to know before you take Fosphenytoin if you suffer from or have suffered in the past from any of the following conditions: Liver disease. Heart disease or stroke. Low blood pressure or heart failure. Kidney disease. Low protein (albumin) in your blood. Diabetes. Special diet which restricts your phosphate intake.
Drug Drug Interactions Some medicines can affect the way Fosphenytoin works, or Fosphenytoin itself can reduce the effectiveness of other medicines taken at the same time. These include: Medicines used for heart and circulation problems (felbamate, digoxin, amiodarone, furosemide, quinidine, , warfarin, and calcium channel blockers e.g. diltiazem and nifedipine, nicardipine, nimodipine, verapamil, diazoxide). Medicines used for epilepsy (carbamazepine, lamotrigine, phenobarbital, sodium valproate and valproic acid, succinimides e.g. ethosuximide and vigabatrin). Medicines used to treat fungal infections (e.g. amphotericin B, fluconazole, itraconazole, ketoconazole and miconazole). Medicines used to treat viral infections (nelfinavir) Medicines used for tuberculosis and other infections (chloramphenicol, isoniazid, rifampicin, praziquantel, sulphonamides, erythromycin, doxycycline and ciprofloxacin, tetracycline,). Medicines used for stomach ulcers (omeprazole, sucralfate, the medicines known as H2 antagonists e.g. cimetidine, ranitidine, famotidine and some antacids). Medicines used for asthma and bronchitis (theophylline). Medicines used for pain and inflammation (phenylbutazone, salicylates e.g. azapropazone, ticlopidine, aspirin and steroids). Medicines used for sleeplessness, depression and psychiatric disorders (chlordiazepoxide, clozapine, diazepam, disulfiram, fluoxetine,fluvoxamine, sertraline, methadone, methylphenidate, paroxetine, phenothiazines, trazodone, St John’s Wort, tricyclic antidepressants and viloxazine). Medicines used for diabetes (tolbutamide), chlorpropamide, , glibenclamide. Some hormone replacement therapies (oestrogens), oral contraceptives (the birth control pill). Medicines used for organ and tissue transplants, to prevent rejection (ciclosporin), corticosteroids. Medicines used for cancer (antineoplastic agents), teniposide. Muscle relaxants used for surgery (neuromuscular blockers), some anaesthetic medicines (halothane) pancuronium, vecuronium. Some products available without a prescription (folic acid, theophylline, vitamin D). Your doctor may need to test the amount of phenytoin in your blood to help decide if any of these medicines are affecting your treatment. Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. The herbal preparation St John’s wort (Hypericum perforatum) should not be taken at the same time as this medicine. If you already take St John’s wort, consult your doctor before stopping the St John’s wort preparation. Fosphenytoin may also interfere with certain laboratory tests that you may be given.
Drug Pregnancy Interaction If you think you might be pregnant, or are planning to get pregnant, tell your doctor before you take Fosphenytoin. You should not take Fosphenytoin if you are breast-feeding.
Drug Breast feeding Interaction If you think you might be pregnant, or are planning to get pregnant, tell your doctor before you take Fosphenytoin. You should not take Fosphenytoin if you are breast-feeding.
Drug Machinery Interaction Fosphenytoin may cause dizziness or drowsiness, especially during the first few weeks of treatment. If you experience these symptoms, do not drive or use any tools or machinery.
Drug More Information Drinking a lot of alcohol can also affect the concentration of Fosphenytoin in your blood.
How to take the Medicine
Consumption Info no data available
Drug quanitty Adults Severe epileptic seizure or fits (Status epilepticus) Fosphenytoin is usually given after treatment with either diazepam or lorazepam injection.The usual first dose (loading dose) of Fosphenytoin to treat severe or continuous seizures (status epilepticus) is 15 mg PE per kilogram of your body weight injected into your vein (this is called a loading dose). This is followed by more doses of Fosphenytoin given into your vein or into your muscle or by doses of phenytoin given by mouth (these are called maintenance doses).If Fosphenytoin does not stop your seizures, other treatments will be tried. Brain surgery or head trauma If your seizures are less severe or Fosphenytoin is used to treat or prevent seizures occurring during or following brain surgery or trauma to the head, the usual first dose (loading dose) of Fosphenytoin may be between 10 and 15 mg PE per kilogram of your body weight. This may be injected either into your vein or into your muscle. This is followed by more doses (these are called maintenance doses) of Fosphenytoin given into your vein or into your muscle or by doses of phenytoin given by mouth. Maintenance doses The usual maintenance dose of Fosphenytoin is 4 to 5 mg PE per kilogram of your body weight per day. Your doctor may take a sample of your blood to help decide the right dose for you. If your doctor decides that you need to continue treatment, you will be transferred to treatment by mouth as soon as possible. This will be with phenytoin because Fosphenytoin cannot be taken by mouth. Replacement of oral phenytoin treatment If you are given Fosphenytoin because you cannot take phenytoin by mouth, you will not need a loading dose and the dose you are given will be the same as your dose of phenytoin. Because the dose of Fosphenytoin is given in PE (phenytoin sodium equivalents), the number of mg PE of Fosphenytoin you are given should be the same as the number of mg of phenytoin sodium you take by mouth. Children The doses of Fosphenytoin per kilogram of body weight are the same for children as for adults. Fosphenytoin is given to children by a drip (infusion) into the vein (intravenous) only. Elderly patients over 65 years, the very ill and patients with kidney or liver disease. The dose of Fosphenytoin may be reduced or the injection given into the vein at a slower rate. Always take Fosphenytoin exactly as you doctor has told you. You should check with your doctor or pharmacist if you are still not sure.
Drug Dose You will be in hospital when you are given Fosphenytoin. Fosphenytoin will be either injected into one of your large veins (intravenously) or into your muscle (intramuscularly). When given intravenously, Fosphenytoin must be diluted. The dose and concentration of the solution of Fosphenytoin you are given will be decided by your doctor and will be written as the equivalent dose of phenytoin sodium (PE). The dose will be as mg per dose if given as an injection or mg per ml of solution if given as an infusion.
Excess Drug Consumption Dail 1066. OR Contact doctor immediately
Forgot Drug Consumption Contact Your doctor
Stop Drug Consumption Fosphenytoin is dangerous in overdose. If you think you have been given too much Fosphenytoin, contact your doctor immediately.If you have any further questions on how to take this product, ask your doctor or pharmacist.
Possible Side Effects
General Information • If you notice bruising, fever, you are looking pale or a severe sore throat. These may be the first signs of an abnormality of the blood, including decreases in the number of red cells, white cells or platelets. Your doctor may take regular blood samples to test for these effects. • Skin rash and fever with swollen glands, yellow skin and eyes, particularly in the first two months of treatment, as these may be signs of a hypersensitivity reaction. If these are severe and you also experience pain and inflammation of the joints this could be related to a condition called systemic lupus erythematosus. • If you experience a state of confusion or severe mental illness, as this may be a sign that you have high amounts of Fosphenytoin in your blood. On rare occasions, when the amount of phenytoin in the blood remains high, irreversible brain injury has occurred. Your doctor may test your blood to see how much Fosphenytoin is in the blood and may change your dose. • Sudden wheeziness, difficulty in breathing, swelling of eyelids, face or lips, rash or itching (especially affecting the whole body) as this may be a sign of a hypersensitivity reaction.
Common Drug Side Effects Effects on your nervous system: Unusual eye movements, unsteadiness, difficulty in controlling movements, shaking, abnormal or uncoordinated movements, slurred speech, confusion, loss of sensation in the tongue, pins and needles or numbness, drowsiness, dizziness, vertigo, sleeplessness, nervousness, twitching muscles, headaches, convulsions, abnormal/irrational thoughts, mood swings. Effects on your skin: skin rash including measles-like reactions which are mild. Effects on your stomach and intestines: feeling sick, being sick, constipation, change in appetite, dry mouth. Effects on your blood and lymph system: swelling of the lymph glands, Effects on your liver and kidney: inflammation of the kidneys and liver, liver damage (seen as yellowing of the skin and whites of the eye). Effects on your hands, face and body: changes in the hands with difficulty in straightening the fingers, changes in facial features, enlarged lips or gums, increased or abnormal body or facial hair, loss of energy or strength, chills, painful muscles or muscle weakness. Effects on your eyes and ears: ringing in the ears, loss of hearing, double vision, blurred vision. Effects on medical tests: Increased levels of blood sugar, or decreased levels of blood calcium, folic acid and vitamin D. If you also do not get enough vitamin D in your diet or from exposure to sunlight, you may suffer from bone pain or fractures. Effects on your respiratory system: problems breathing, inflammation of the lining of the lung. Effects on your immune system: problems with the body’s defence against infection, inflammation of the wall of the arteries. Effect on your heart and circulation: low blood pressure, enlargement of blood vessels, slowing of your heart beat. Your blood pressure may also become very low when Fosphenytoin is injected into your vein too quickly or at too high a dose. Effects of the injection: Pain or reaction at the site of injection, temporary itching, burning, warmth or tingling in the groin may sometimes occur during or shortly after injection of Fosphenytoin into your vein. Your doctor may reduce the rate at which Fosphenytoin is injected or temporarily stop injecting Fosphenytoin if you feel these sensations.
Rare Drug Side Effects no data available
Very Rare Drug Side Effects no data available
Drug Side Effects Symptoms no data available
How to Store the Medicine
How to Store the Medicine The storage of Fosphenytoin will not be your responsibility Keep out of the reach and sight of children. Store in a refrigerator at 2oC to 8oC. The undiluted product may be stored at room temperature (8oC to 25oC) for up to 24 hours. Do not use Fosphenytoin after the expiry date which is stamped on the pack. The expiry date refers to the last day of that month. Medicines should not be disposed of via wastewater of household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Substitute Drugs

Write Your Own Review
You're reviewing:NEOFOST INJECTION 2ML
Your Rating