NEORECORMON 5000IU PFS INJECTION

Manufacturer : ROC-ROCHE PRODUCTS LTD
Composition : EPOETIN ALFA-5000I.U
Dose Form : INJECTION
Description : NEORECORMON 5000IU PFS
Route Of Administration : PARENTERAL
Pack : 1
Out of stock
SKU
NEO0295
₹1,393.00
Manufacturer : ROC-ROCHE PRODUCTS LTD
Composition : EPOETIN ALFA-5000I.U
Dose Form : INJECTION
Description : NEORECORMON 5000IU PFS
Route Of Administration : PARENTERAL
Pack : 1

Drug Ingredient Information

EPOETIN ALFA-5000I.U

EPOETIN ALFA

Information for patients
Drug Information EPOETIN ALFA contains epoetin alfa - a protein that stimulates the bone marrow to produce more red blood cells which carry haemoglobin (a substance that transports oxygen). Epoetin alfa is a copy of the human protein erythropoietin (ee-rith-roe-po-eh-tin) and acts in the same way. EPOETIN ALFA is used to treat symptomatic anaemia caused by kidney disease in children on haemodialysis in adults on haemodialysis or peritoneal dialysis in severely anaemic adults not yet undergoing dialysis. If you have kidney disease, you may be short of red blood cells if your kidney does not produce enough erythropoietin (necessary for red cell production). EPOETIN ALFA is prescribed to stimulate your bone marrow to produce more red blood cells. EPOETIN ALFA is used to treat anaemia if you are receiving chemotherapy for solid tumours, malignant lymphoma or multiple myeloma (bone marrow cancer) and your doctor decides you may have a high need for a blood transfusion. EPOETIN ALFA can reduce the need for a blood transfusion. EPOETIN ALFA is used in moderately anaemic people who donate some of their blood before surgery, so that it can be given back to them during or after the operation. Because EPOETIN ALFA stimulates the production of red blood cells, doctors can take more blood from these people. EPOETIN ALFA can be used in moderately anaemic adults about to have major orthopaedic surgery (for example hip or knee replacement operations), to reduce the need for potential blood transfusions.
Drug Alert
Alert If you have been diagnosed with Pure Red Cell Aplasia (the bone marrow cannot produce enough red blood cells) after previous treatment with any product that stimulates red blood cell production (including EPOETIN ALFA). To stimulate the production of your red blood cells (so that doctors can take more blood from you) if you cannot have transfusions with your own blood during or after surgery.
Before Consuming the Medicine
Avoid Drug If you have high blood pressure not properly controlled with medicines. If you are allergic (hypersensitive) to epoetin alfa or any of the other ingredients of EPOETIN ALFA. If you are due to have major orthopaedic surgery (such as hip or knee surgery), and you: have severe heart disease have severe disorders of the veins and arteries have recently had a heart attack or stroke can’t take medicines to thin the blood EPOETIN ALFA may not be suitable for you. Please discuss with your doctor. While on EPOETIN ALFA, some people need medicines to reduce the risk of blood clots. If you can’t take medicines that prevent blood clotting, you must not have EPOETIN ALFA.
Drug Special Care It is important to tell your doctor if any of the following apply to you. You may still be able to use EPOETIN ALFA, but discuss it with your doctor first. If you know you suffer, or have suffered, from: heart disease, including angina; high blood pressure; blood clots, or you are at a higher risk for developing blood clots, (for example if you are overweight, have diabetes or you are off your feet for a long time because of surgery or illness). epileptic seizures or fits anaemia from other causes liver disease porphyria (a rare blood disorder). If you are a cancer patient be aware that products that stimulate red blood cell production (like EPOETIN ALFA) may act as a growth factor and therefore in theory may affect the progression of your cancer. Depending on your individual situation a blood transfusion may be preferable. Please discuss this with your doctor. Take special care with other products that stimulate red blood cell production: EPOETIN ALFA is one of a group of products that stimulate the production of red blood cells like the human protein erythropoietin does. Please ensure that it exactly documented which product you are using. If you are given a product in this group other than EPOETIN ALFA during your treatment, speak to your doctor or pharmacist before using it.
Drug Drug Interactions EPOETIN ALFA does not normally react with other medicines but please tell your doctor if you are using (or have recently used) any other medicines – including medicines obtained without a prescription. If you are taking a drug called ciclosporin (used e.g. after kidney transplants), your doctor may order blood tests to check the level of ciclosporin while you are taking EPOETIN ALFA. Iron supplements and other blood stimulants may increase the effectiveness of EPOETIN ALFA. Your doctor will decide if it is right for you to take them. If you visit a hospital, clinic or family doctor, tell them you are having EPOETIN ALFA treatment. It may affect other treatments or test results.
Drug Pregnancy Interaction If you are pregnant, or think you may be pregnant.
Drug Breast feeding Interaction If you are breast feeding.
Drug Machinery Interaction no data available
Drug More Information no data available
How to take the Medicine
Consumption Info You should discuss this with your doctor because a combination of epoetin alfa with interferon and ribavirin has lead to a loss of effect and development of a condition called pure red cell aplasia (PRCA), a severe form of anemia, in rare cases. EPOETIN ALFA is not approved in the management of anaemia associated with hepatitis C.
Drug quanitty Your doctor has carried out blood tests and decided you need EPOETIN ALFA. EPOETIN ALFA may be given by injection: Either into a vein or a tube that goes into a vein (intravenously) Or under the skin (subcutaneously). Your doctor will decide how EPOETIN ALFA will be injected. Usually the injections will be given to you by a doctor, nurse or other health care professional. Some people, depending on why they need EPOETIN ALFA treatment, may later learn how to inject themselves under the skin: EPOETIN ALFA should not be used: after the expiry date on the label and outer carton if you know, or think that it may have been accidentally frozen, or if there has been a refrigerator failure. The dose of EPOETIN ALFA you receive is based on your bodyweight in kilograms. The cause of your anaemia is also a factor in your doctor deciding the correct dose. Your doctor will monitor your blood pressure regularly while you are using EPOETIN ALFA. People with kidney disease Your doctor will maintain your haemoglobin level between 10 and 12 g/dl as a high haemoglobin level may increase the risk of blood clots and death. The usual starting dose of EPOETIN ALFA for adults and children is 50 International Units (IU) per kilogram (/kg) of bodyweight given three times a week. For patients on peritoneal dialysis EPOETIN ALFA is given twice a week. For adults and children EPOETIN ALFA is given as an injection either into a vein or a tube that goes into a vein. When this access (via a vein or tube) is not readily available, your Doctor may decide that EPOETIN ALFA should be injected under the skin (subcutaneously). This includes patients on peritoneal dialysis. Your doctor will order regular blood tests to see how your anaemia is responding and may adjust the dose, usually every four weeks. Once your anaemia has been corrected, your doctor will continue to regularly check your blood and your dose may be further adjusted to maintain your response to treatment. You may be given iron supplements before and during EPOETIN ALFA treatment to make it more effective. If you are having dialysis treatment when you begin treatment with EPOETIN ALFA, your dialysis regime may need to be adjusted. Your doctor will decide this. Adults on chemotherapy Your doctor may initiate treatment with EPOETIN ALFA if your haemoglobin is 10g/dl or less. Your doctor will maintain your haemoglobin level between 10 and 12 g/dl as a high haemoglobin level may increase the risk of blood clots and death. The starting dose is either 150 IU per kilogram bodyweight three times a week or 450 IU per kilogram bodyweight once a week.EPOETIN ALFA is given by injection under the skin. Your doctor will order blood tests, and may adjust the dose, depending on how your anaemia responds to EPOETIN ALFA treatment. You may be given iron supplements before and during EPOETIN ALFA treatment to make it more effective. You will usually continue EPOETIN ALFA treatment for one month after the end of chemotherapy. Adults donating their own blood The usual dose is 600 IU per kilogram bodyweight twice a week. EPOETIN ALFA is given by injection into a vein, for 3 weeks before your surgery, after you have donated blood. You may be given iron supplements before and during EPOETIN ALFA treatment to make it more effective. Adults scheduled for major orthopaedic surgery The recommended dose is 600 IU per kilogram bodyweight once a week. EPOETIN ALFA is given by injection under the skin for three weeks before surgery and on the day of surgery. If there is a medical need to reduce the time before your operation, you will be given a daily dose of 300 IU/kg for up to ten days before surgery, on the day of surgery and for four days immediately afterwards. If blood tests show your haemoglobin is too high before the operation, the treatment will be stopped. You may be given iron supplements before and during EPOETIN ALFA treatment to make it more effective.
Drug Dose The pre-filled syringes are fitted with a needle safety device to help prevent needle stick injuries after use. This is indicated on the packaging. - Take a syringe out of the refrigerator. The liquid needs to come to room temperature. - Check the syringe, to make sure it is the right dose, has not passed its expiry date, is not damaged, and the liquid is clear and not frozen. - Choose an injection site. Good sites are the top of the thigh and around the tummy (abdomen) but away from the navel. Vary the site from day to day. - Wash your hands. Use an antiseptic swab on the injection site, to disinfect it. - Take the cover off the syringe by holding the barrel and pulling the cover off carefully without twisting it. Don’t push the plunger, touch the needle or shake the syringe. - Push the plunger to remove any unwanted liquid from the syringe before you inject under the skin in order to only keep the amount of liquid as instructed by your doctor or nurse. - Pinch a fold of skin between your thumb and index finger. Don’t squeeze it. - Push the needle in fully. Your doctor or nurse may have shown you how to do this. - Check that you haven’t punctured a blood vessel. Pull back slightly on the plunger. If you see blood, take the syringe out and try somewhere else. - Push the plunger with your thumb as far as it will go to inject the entire amount of liquid corresponding to the correct dose to be injected. Push it slowly and evenly, keeping the skin fold pinched. When treatment starts, EPOETIN ALFA is usually injected by medical or nursing staff. Later, your doctor may suggest that you or your caregiver learn how to inject EPOETIN ALFA under the skin (subcutaneously) yourself. Do not attempt to inject yourself unless you have been trained to do so by your doctor or nurse. Always use EPOETIN ALFA exactly as instructed by your doctor or nurse. Ensure that you only inject the amount of liquid as instructed by your doctor or nurse. Only use EPOETIN ALFA if it has been stored correctly. Before use, leave the EPOETIN ALFA syringe or vial to stand until it reaches room temperature. This usually takes between 15 and 30 minutes. Use the syringe or vial within 3 days of taking it out of the refrigerator. Only take one dose of EPOETIN ALFA from each syringe or vial. If EPOETIN ALFA is injected under the skin (subcutaneously), the amount injected is not normally more than one millilitre (1 ml) in a single injection. EPOETIN ALFA is given alone and not mixed with other liquids for injection. Do not shake EPOETIN ALFA syringes or vials. Prolonged vigorous shaking may damage the product. If the product has been shaken vigorously, don’t use it. How to inject yourself using a pre-filled syringe: The pre-filled syringes are fitted with a needle safety device to help prevent needle stick injuries after use. This is indicated The needle safety device will not activate unless the entire dose is given. - When the plunger is pushed as far as it will go, take out the needle and let go of the skin. - Take your thumb off the plunger and allow the syringe to move up until the entire needle is covered by the needle safety device. - Press an antiseptic swab over the injection site for a few seconds after the injection. - Dispose of your used syringe in a safe container – see section 5, How to store EPOETIN ALFA. How to inject yourself using an injection prepared from a vial: - Take a vial out of the refrigerator. The liquid needs to come to room temperature. - Check the vial, to make sure it is the right dose, has not passed its expiry date, is not damaged, and the liquid is clear and not frozen. - Assemble the other items you will need for your injection: a syringe, needle and antiseptic swabs. - Wash your hands. - Remove the cap from the top of the vial but do not remove the rubber stopper. Clean the rubber stopper with an antiseptic swab. - Remove the needle cover from the syringe. Pull the syringe plunger out to fill the syringe with an amount of air equal to the amount of liquid prescribed by your doctor. - Put the vial on a flat surface and push the syringe needle through the rubber stopper. Push the syringe plunger down to add the air into the vial. - Turn the vial and the syringe upside down. Pull on the syringe plunger to fill the syringe with the correct amount of liquid from the vial. It is important that the needle is always in the liquid in order to prevent air bubbles forming in the syringe. - Remove the syringe and needle from the vial. Hold the syringe with the needle pointing up to see if it has any air bubbles inside. If there are air bubbles gently press the plunger until all of the air (but none of the liquid) has been removed. - Choose an injection site. Good sites are the top of the thigh and around the tummy (abdomen) but away from the navel. Vary the site from day to day. - Use an antiseptic swab on the injection site, to disinfect it. - Pinch a fold of skin between your thumb and index finger. Don’t squeeze it. - Push the syringe needle in fully. Your doctor or nurse may have shown you how to do this. - Check that you haven’t punctured a blood vessel. Pull back slightly on the plunger. If you see blood, take the syringe out and try somewhere else. - Push the plunger with your thumb as far as it will go to inject the liquid. Push it slowly and evenly, keeping the skin fold pinched. - When the plunger is pushed as far as it will go, take out the needle and let go of the skin. - Press an antiseptic swab over the injection site for a few seconds after the injection. - Dispose of your used syringe in a safe container. If any liquid remains in the vial after an injection, the vial should be properly disposed of and not reused.
Excess Drug Consumption Tell the doctor or nurse immediately if you think too much EPOETIN ALFA has been injected. Side effects from an overdose of EPOETIN ALFA are unlikely.
Forgot Drug Consumption Make the next injection as soon as you remember. If you are within a day of your next injection, forget the missed one and carry on with your normal schedule. Do not double up the injections.
Stop Drug Consumption Do not stop the drug untill your doctor says you to do so.
Possible Side Effects
General Information Flu-like symptoms, such as headache, aches and pains in the joints, feeling of weakness, tiredness and dizziness. These may be more common at the start of treatment. If you have these symptoms during intravenous injection, a slower delivery of the injection may help to avoid them in future.
Common Drug Side Effects Increased blood pressure in people with cancer and in people with symptomatic anaemia caused by kidney disease. Headaches, particularly sudden, stabbing migraine-like headaches, feeling confused or having fits may be signs of a sudden increase in blood pressure. This requires urgent treatment . Raised blood pressure may require treatment with drugs (or adjustment to any drugs you already take for high blood pressure).Chest pain, breathlessness, painful swelling in the leg which may be symptoms of blood clots (thrombosis). Skin rashes and swelling around the eyes (oedema), which may result from an allergic reaction. If you are receiving haemodialysis: Blood clots (thrombosis) may form in your dialysis shunt. This is more likely if you have low blood pressure or if your fistula has complications. Blood clots may also form in your haemodialysis system. Your doctor may decide to increase your heparin dose during dialysis.
Rare Drug Side Effects no data available
Very Rare Drug Side Effects Symptoms of pure red cell aplasia (PRCA) PRCA means the inability to produce enough red blood cells in the bone marrow. PRCA can result in sudden and severe anaemia. The symptoms are: unusual tiredness, feeling dizzy, breathlessness. PRCA has been very rarely reported after months to years of treatment with EPOETIN ALFA and other products that stimulate red blood cell production in patients with chronic renal failure. If you are receiving haemodialysis an increase in levels of small blood cells (called platelets), which are normally involved in the formation of a blood clot may occur, particularly when starting treatment. Your doctor will check on this. You may experience redness, burning and pain at the site of injection. Tell your doctor or nurse immediately if you are aware of any of these effects, or if you notice any other effects while you are receiving treatment with EPOETIN ALFA.
Drug Side Effects Symptoms no data available
How to Store the Medicine
How to Store the Medicine Keep out of the reach and sight of children. Do not use EPOETIN ALFA after the expiry date, which is stated on the box and on the label after the letters EXP. The expiry date refers to the last day of that month. Store in a refrigerator (2C-8C). You may take EPOETIN ALFA out of the refrigerator and keep it at room temperature (up to 25C) for no longer than 3 days. Once a syringe or vial has been removed from the refrigerator and has reached room temperature (up to 25C) it must either be used within 3 days or disposed of. Do not freeze or shake. Store in the original package in order to protect from light. Do not use EPOETIN ALFA if you notice that the seal is broken or if the liquid is coloured or you can see particles floating in it. Don’t use the EPOETIN ALFA syringes or vials if any of these applies. Talk to a doctor or pharmacist.Medicines should not be disposed of via waste water or in household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

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