Composition : NEVIRAPINE-200MG
Dose Form : TABLET
Description : NEVIR TABS
Route Of Administration : ORAL
Pack : 10
Out of stock
Composition : NEVIRAPINE-200MG
Dose Form : TABLET
Description : NEVIR TABS
Route Of Administration : ORAL
Pack : 10

Drug Ingredient Information



Information for patients
Drug Information NEVIRAPINE belongs to a group of medicines called antiretrovirals, used in the treatment of Human Immunodeficiency Virus (HIV-1) infection. The active ingredient of your medicine is called nevirapine. The active ingredient is the substance in this medicine that reduces the amount of viruses in the blood thus improving your medical condition. Nevirapine belongs to a class of anti-HIV medicines called non-nucleoside reverse transcriptase inhibitors (NNRTIs). Reverse transcriptase is an enzyme that HIV needs in order to multiply. Nevirapine stops reverse transcriptase from working. By stopping reverse transcriptase from working, NEVIRAPINE helps control HIV-1 infection. You must take NEVIRAPINE together with other antiretroviral medicines. Your doctor will recommend the best medicines for you.
Drug Alert
Alert - if you are allergic (hypersensitive) to nevirapine or any of the other ingredients of NEVIRAPINE. See Section 6 of this leaflet for a list of other ingredients (“What NEVIRAPINE contains”). - if you have taken NEVIRAPINE before and had to stop the treatment because you suffered from: - severe skin rash
Before Consuming the Medicine
Avoid Drug - if you are allergic (hypersensitive) to nevirapine or any of the other ingredients of NEVIRAPINE. See Section 6 of this leaflet for a list of other ingredients (“What NEVIRAPINE contains”). - if you have taken NEVIRAPINE before and had to stop the treatment because you suffered from: - severe skin rash - skin rash with other symptoms for example: - fever - blistering - mouth sores - inflammation of the eye - swelling of the face - general swelling - shortness of breath - muscle or joint pain - general feelings of illness - abdominal pain - hypersensitivity (allergic) reactions - inflammation of the liver (hepatitis) - if you have severe liver disease - if you have had to stop NEVIRAPINE treatment in the past because of changes in your liver function - if you are taking a medicine containing the herbal substance St John’s Wort (Hypericum perforatum). This herbal substance may stop NEVIRAPINE from working properly.
Drug Special Care During the first 18weeks of treatment with NEVIRAPINE It is very important that you and your doctor watchout For signs of liver or skin reactions.These can be come Severe and even life threatening.You are at greatest risk Of such areation during the first 6weeks of treatment. If you experience sever erashor hypersensitivity (allergic reactions that may appear in the form of rash) accompanied by other sideeffects such as - fever, - blistering, - mouthsores, - inflammation of the eye, - swelling of the face, - general swelling, - shortness of breath, - muscle or jointpain, - general feelings of illness, - or abdominal pain YOU SHOULD DISCONTINUE TAKING NEVIRAPINEAND YOU MUST CONTACT your doctor IMMEDIATELY as such reaction scan be potentially life-threatening or leadtodeath. If you ever have only mild rash symptoms without Any other reaction please inform your doctor immediately,who will advise you whether you should stoptaking NEVIRAPINE.
Drug Drug Interactions Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Inform your doctor about all other medicines you are taking before you start taking NEVIRAPINE. Your doctor might need to monitor whether your other medicines are still working and adjust doses. Carefully read the package leaflet of all other HIV medicinal products you are taking in combination with NEVIRAPINE. It is particularly important that you tell your doctor if you are taking or have recently taken: - St John’s Wort (Hypericum perforatum, medicine to treat depression) - rifampicin (medicine to treat tuberculosis) - rifabutin (medicine to treat tuberculosis) - macrolides e.g. clarithromycin (medicine to treat bacterial infections) - fluconazole (medicine to treat fungal infections) - ketoconazole (medicine to treat fungal infections) - itraconazole (medicine to treat fungal infections) - methadone (medicine used for treatment of opiate addicts) - warfarin (medicine to reduce blood clotting) - hormonal contraceptives (e.g. the “pill”) - atazanavir (another medicine to treat HIV-infection) - lopinavir/ritonavir (another medicine to treat HIV-infection) - fosamprenavir (another medicine to treat HIV-infection) - efavirenz (another medicine to treat HIV-infection) Your doctor will carefully monitor the effect of NEVIRAPINE and any of these medicines if you are taking them together. If you are undergoing kidney dialysis, your doctor may consider a dose adjustment of NEVIRAPINE. This is because NEVIRAPINE can be partly washed out of your blood by dialysis
Drug Pregnancy Interaction Ask your doctor or pharmacist for advice before taking any medicine.
Drug Breast feeding Interaction You should stop breast-feeding if you are taking NEVIRAPINE. It is in general recommended that you do not breast-feed if you have HIV infection because it is possible that your baby can become infected with HIV through your breast milk
Drug Machinery Interaction There are no specific studies on the ability to drive vehicles and use machinery. If you feel that your ability to drive or use machines may be affected you should not drive or use machines.
Drug More Information NEVIRAPINE tablets contain lactose (milk sugar). If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking NEVIRAPINE
How to take the Medicine
Consumption Info If you experience symptoms suggesting damage of The liver,such as - lossofappetite, - feelingsick(nausea), - vomiting, - yellowskin(jaundice), - abdominalpain youshoulddiscontinuetakingNEVIRAPINEandmust contactyourdoctorimmediately. If you develop severe liver, skin or hypersensitivity Reactions whilst taking NEVIRAPINE ,NEVER TAKE NEVIRAPINE again without referring to your doctor. You must take the dosage of Nevirapine as prescribed By your doctor. This is especially important within The first 14 days of treatment (see more information in“How to take NEVIRAPINE”). Taking NEVIRAPINE with food and drink There are no restrictions on taking NEVIRAPINE with food and drink
Drug quanitty The dose is one 200 mg tablet per day for the first 14 days of treatment (“lead-in” period). After 14 days, the usual dose is one 200 mg tablet twice a day. It is very important that you take only one NEVIRAPINE tablet a day for the first 14 days (“lead-in” period). If you have any rash during this period, do not increase the dose but consult your doctor. The 14-day ”lead-in” period has been shown to lower the risk of skin rash
Drug Dose You should not use NEVIRAPINE on its own. You must take it with at least two other antiretroviral medicines. Your doctor will recommend the best medicines for you Always take NEVIRAPINE exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. Only take NEVIRAPINE tablets by mouth. Do not chew your tablets. You may take NEVIRAPINE with or without food.As NEVIRAPINE must always be taken together with other HIV antiretroviral medicines, you should follow the instructions for your other medicines carefully. These are supplied in the package leaflets for those medicines. NEVIRAPINE is also available in liquid form as an oral suspension. This is particularly suitable if: - you have problems swallowing tablets - or you are a child weighing less than 50 kg - or you are a child having a body surface area less than 1.25 square metres (your doctor will work out your surface area). You should continue to take NEVIRAPINE for as long as instructed by your doctor. As explained in ‘Take special care with NEVIRAPINE’, above, your doctor will monitor you with liver tests or for undesirable effects such as rash. Depending on the outcome your doctor may decide to interrupt or stop your NEVIRAPINE treatment. Your doctor might then decide to restart you on a lower dose.
Excess Drug Consumption Do not take more Nevirapine than prescribed by your doctor and described in this leaflet. There is at present little information on the effects of .Nevirapine overdose. Consult your doctor if you have taken more .Nevirapine than you should.
Forgot Drug Consumption Try not to miss a dose. If you notice that you have missed a dose within 8 hours, take the next dose as soon as possible. If you notice it more than 8 hours later, take the next dose at the usual time.
Stop Drug Consumption Taking all doses at the appropriate times: - greatly increases the effectiveness of your combination antiretroviral medicines - reduces the chances of your HIV infection becoming resistant to your antiretroviral medicines. It is important that you continue taking .nevirapine correctly, as described above, unless your doctor instructs you to stop. If you stop taking .nevirapine for more than 7 days your doctor will instruct you to start the 14 day ‘lead-in’ period (described above) once again, before returning to the twice daily dose. If you have any further questions on the use of this product, ask your doctor or pharmacist
Possible Side Effects
General Information loss of appetite - feeling sick (nausea) - vomiting - yellow skin (jaundice) - abdominal pain
Common Drug Side Effects - decreased numbers of white blood cells (granulocytopenia) - allergic reactions (hypersensitivity) - headache - feeling sick (nausea) - vomiting - abdominal pain - loose stools (diarrhoea) - inflammation of the liver (hepatitis) - muscle pain (myalgia) - feeling tired (fatigue) - fever - abnormal liver function tests
Rare Drug Side Effects sudden and intense inflammation of the liver
Very Rare Drug Side Effects - drug rash with systemic symptoms (drug rash with eosinophilia and systemic symptoms) - allergic reaction characterized by rash, swelling of the face, difficulty breathing (bronchial spasm) or anaphylactic shock - decreased numbers of red blood cells (anaemia) - yellow skin (jaundice) - severe and life-threatening skin rashes (Stevens- Johnson syndrome/toxic epidermal necrolysis) - hives (urticaria) - fluid under the skin (angioedema) - joint pain (arthralgia)
Drug Side Effects Symptoms rash Abnormal liver functioning has been reported with the use of NEVIRAPINE. This includes some cases of inflammation of the liver (hepatitis), which can be sudden and intense (fulminant hepatitis), and liver failure, which can be both fatal. Combination antiretroviral therapy may cause changes in body shape due to changes in fat distribution. These may include loss of fat from legs, arms and face, increased fat in the abdomen (belly) and other internal organs, breast enlargement and fatty lumps on the back of the neck (‘buffalo hump’). The cause and long-term health effects of these conditions are not known at this time. Combination antiretroviral therapy may also cause raised lactic acid and sugar in the blood, hyperlipaemia (increased fats in the blood) and resistance to insulin. The following events have also been reported when NEVIRAPINE has been used in combination with other antiretroviral agents: - decreased numbers of red blood cells or platelets - inflammation of the pancreas - decrease in or abnormal skin sensations These events are commonly associated with other antiretroviral agents and may be expected to occur when NEVIRAPINE is used in combination with other agents; however, it is unlikely that these events are due to treatment with NEVIRAPINE. Use in children A reduction in white blood cells (granulocytopenia) can occur, which is more common in children. A reduction in red blood cells (anaemia), which may be related to nevirapine therapy, is also more commonly observed in children. As with rash symptoms, please inform your doctor of any side effects. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
How to Store the Medicine
How to Store the Medicine Keep out of the reach and sight of children. Do not use .nevirapine after the expiry date which is stated on the carton and on the blister after “EXP”. The expiry date refers to the last day of that month. This medicinal product does not require any special storage conditions. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

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