NEXAVAR 200MG TABLET

Manufacturer : BAY-BAYERS CORPORATION
Composition : SORAFENIB-200MG
Dose Form : TABLET
Description : NEXAVAR 200MG TAB
Route Of Administration : ORAL
Pack : 6
Out of stock
SKU
NEX0024
₹140,214.60
Manufacturer : BAY-BAYERS CORPORATION
Composition : SORAFENIB-200MG
Dose Form : TABLET
Description : NEXAVAR 200MG TAB
Route Of Administration : ORAL
Pack : 6

Drug Ingredient Information

SORAFENIB-200MG

SORAFENIB

Information for patients
Drug Information Sorafenib is used to treat liver cancer (hepatocellular carcinoma). Sorafenib is also used to treat kidney cancer (advanced renal cell carcinoma) at an advanced stage when standard therapy has not helped to stop your disease or is considered unsuitable. Sorafenib is a so-called multikinase inhibitor. It works by slowing down the rate of growth of cancer cells and cutting off the blood supply that keeps cancer cells growing.
Drug Alert
Alert
Before Consuming the Medicine
Avoid Drug If you are allergic (hypersensitive) to sorafenib or any of the other ingredients of Sorafenib. The ingredients are listed at the end of this leaflet. Take special care with Sorafenib If you experience skin problems. Sorafenib can cause rashes and skin reactions, especially on the hands and feet. These can usually be treated by your doctor. If not, your doctor may interrupt treatment or stop it altogether. If you have high blood pressure. Sorafenib can raise blood pressure, and your doctor will usually monitor your blood pressure and may give you a medicine to treat your high blood pressure. If you get any bleeding problems, or are taking warfarin or phenprocoumon. Treatment with Sorafenib may lead to a higher risk of bleeding. If you are taking warfarin or phenprocoumon, medicines which thin the blood to prevent blood clots, there may be a greater risk of bleeding. If you get chest pain or heart problems. Your doctor may decide to interrupt treatment or stop it altogether. If you have a heart disorder, such as an abnormal electrical signal called "prolongation of the QT interval". If you are going to have surgery, or if you had an operation recently. Sorafenib might affect the way your wounds heal. You will usually be taken off Sorafenib if you are having an operation. Your doctor will decide when to start with Sorafenib again. If you are taking irinotecan or are given docetaxel, which are also medicines for cancer. Sorafenib may increase the effects and, in particular, the side effects of these medicines. If you are taking Neomycin or other antibiotics. The effect of Sorafenib may be decreased. If you have severe liver impairment. You may experience more severe side effects when taking this medicine. If you have poor kidney function. Your doctor will monitor your fluid and electrolyte balance. Fertility. Sorafenib may reduce fertility in both men and women. If you are concerned, talk to a doctor. Holes in the gut wall (gastrointestinal perforation) may occur during treatment (see Possible Side Effects, section 4). In this case your doctor will interrupt the treatment. Tell your doctor if any of these affect you. You may need treatment for them, or your doctor may decide to change your dose of Sorafenib, or stop treatment altogether.
Drug Special Care
Drug Drug Interactions Some medicines may affect Sorafenib, or be affected by it. Tell your doctor or pharmacist if you are taking anything in this list: Rifampicin, Neomycin or other antibiotics St John’s wort, a herbal treatment for depression Phenytoin, carbamazepine or phenobarbital, treatments for epilepsy and other conditions Dexamethasone, a corticosteroid used for various conditions Warfarin or phenprocoumon, anticoagulants used to prevent blood clots Doxorubicin, capecitabine, docetaxel, paclitaxel and irinotecan, which are other cancer treatments Digoxin, a treatment for mild to moderate heart failure Tell your doctor or pharmacist if you are taking these or any other medicines (or have taken anything recently) – even those not prescribed.
Drug Pregnancy Interaction Avoid becoming pregnant while being treated with Sorafenib. If you could become pregnant use adequate contraception during treatment. If you become pregnant while being treated with Sorafenib, immediately tell your doctor who will decide if the treatment should be continued.
Drug Breast feeding Interaction You must not breast-feed your baby during Sorafenib treatment, as this medicine may interfere with the growth and development of your baby.
Drug Machinery Interaction There is no evidence that Sorafenib will affect the ability to drive or to operate machines.
Drug More Information
How to take the Medicine
Consumption Info
Drug quanitty The usual dose of Sorafenib in adults is 2 x 200 mg tablets, twice daily. This is equivalent to a daily dose of 800 mg or four tablets a day.
Drug Dose Tell your doctor straight away if you (or anyone else) have taken more than your prescribed dose. Taking too much Sorafenib makes side effects more likely or more severe, especially diarrhoea and skin reactions. Your doctor may tell you to stop taking Sorafenib.
Excess Drug Consumption Tell your doctor straight away if you (or anyone else) have taken more than your prescribed dose. Taking too much Sorafenib makes side effects more likely or more severe, especially diarrhoea and skin reactions. Your doctor may tell you to stop taking Sorafenib.
Forgot Drug Consumption If you have missed a dose, take it as soon as you remember. If it is nearly time for the next dose, forget about the missed one and carry on as normal. Do not take a double dose to make up for forgotten individual doses.
Stop Drug Consumption
Possible Side Effects
General Information diarrhoea feeling sick (nausea) feeling weak or tired pain (including mouth pain, abdominal pain, headache, bone pain, tumour pain) hair loss flushing flushed or painful palms or soles (hand foot syndrome) itching or rash throwing up (vomiting) bleeding (including bleeding in the brain, gut wall and respiratory tract; haemorrhage) high blood pressure, or increases in blood pressure
Common Drug Side Effects flu-like illness fever indigestion constipation difficulty swallowing inflamed or dry mouth, tongue pain weight loss loss of appetite joint or muscle pain (arthralgia) disturbed sensations in fingers and toes, including tingling or numbness depression erection problems (impotence) hoarseness acne inflamed, dry or scaly skin that sheds heart failure heart attack (myocardial infarction) or chest pain tinnitus (ringing sound in the ear) kidney failure
Rare Drug Side Effects allergic reaction with swelling of the skin (e. g. face, tongue) that may cause difficulty in breathing or swallowing (angioedema) a sudden, severe allergic reaction that occurs when you are exposed to a substance that your body was sensitised to during a previous exposure (anaphylactic reaction) abnormal heart rhythm (QT prolongation) - inflammation of the liver, which may lead to nausea, vomiting, abdominal pain, and jaundice (drug induced hepatitis) a sunburn-like rash that may occur on skin that has previously been exposed to radiotherapy and can be severe (radiation recall dermatitis) serious reactions of the skin and/or mucous membranes which may include painful blisters and fever (Stevens-Johnson syndrome) If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
Very Rare Drug Side Effects inflamed stomach lining (gastritis) and heartburn (gastrooesophageal reflux disease) pain in the tummy (abdomen) caused by pancreatitis, inflammation of the gall bladder and/or bile ducts yellow skin or eyes (jaundice) caused by high levels of bile pigments (hyperbilirubinaemia) allergic like reactions (including skin reactions and hives) infections of hair follicles (folliculitis) general infections dehydration enlarged breasts persistent runny nose breathing difficulty (lung disease) eczema underactive or overactive thyroid multiple skin eruptions (erythema multiforme) abnormally high blood pressure holes in the gut wall (gastrointestinal perforation) reversible swelling in the rear part of the brain that can be associated with headache, altered consciousness, fits and visual symptoms including visual loss (reversible posterior leukoencephalopathy) benign localised skin growth (keratoacanthoma)/skin cancer
Drug Side Effects Symptoms
How to Store the Medicine
How to Store the Medicine Keep out of the reach and sight of children. Do not use the tablets after the expiry date which is stated on the carton and on each blister after EXP. The expiry date refers to the last day of that month. Do not store above 25°C. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

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