Composition : IMIPRAMINE-50MG
Dose Form : TABLET
Description : NILDEP 50MG TAB
Route Of Administration : ORAL
Pack : 10
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Composition : IMIPRAMINE-50MG
Dose Form : TABLET
Description : NILDEP 50MG TAB
Route Of Administration : ORAL
Pack : 10

Drug Ingredient Information



Information for patients
Drug Information Imipramine Hydrochloride contains the active ingredient imipramine. This belongs to a class of medicines called tricyclic antidepressants and is used to treat: n the symptoms of depression n night-time bed-wetting in children.
Drug Alert
Alert no data available
Before Consuming the Medicine
Avoid Drug n are allergic (hypersensitive) to imipramine or any other tricyclic antidepressant, or to any of the other ingredients of Imipramine Hydrochloride (see Section 6, and end of Section 2) n have serious heart or liver disease n have narrow angle glaucoma (increased pressure in the eye) n have difficulty in passing water n suffer from mania n have had a heart attack in the past 3 months n are taking (now or recently) any other medicines for depression (particularly monoamine oxidase inhibitors [MAOIs] such as moclobemide within the last 3 weeks). Children under 6 years old should not take this medicine.
Drug Special Care n epilepsy (fits) or brain damage n severe kidney disease n a history of low blood pressure n a tumour of the adrenal gland (called phaeochromocytoma or neuroblastoma) n an overactive thyroid n constipation, especially if you are elderly or bedridden n an intolerance to some sugars n a withdrawal from alcohol or any anticonvulsive drugs n electroconvulsive therapy (ECT) treatment and are taking Imipramine Hydrochloride – you will be carefully supervised. If you think that any of the above apply to you then tell your doctor before taking Imipramine Hydrochloride.
Drug Drug Interactions n you will need routine tests (blood, heart and liver tests) from time to time. These will be carried out by your doctor n you will be closely monitored as improvement may not occur for the first 2 – 4 weeks of treatment n if you already suffer from a panic disorder, you may experience an increase in your feeling of anxiety when you start treatment with Imipramine Hydrochloride . This is usually worse in the first few days and should go away in the first 2 weeks n have regular dental check-ups as long term treatment may increase the risk of tooth decay n if you need an operation tell your doctor that you are taking the n contact lens wearers may notice reduced production of tears n if you have suicidal thoughts or want to harm yourself tell your doctor immediately; it may be necessary to reduce or stop the dose. Always speak to your doctor first in order to avoid possible side effects. Children taking Imipramine Hydrochloride may have behavioural changes n medications for depression called MAOIs (monoamine oxidase inhibitors) such as moclobemide – see Section n medication for depression called SSRIs (Selective serotonin reuptake inhibitors) such as fluoxetine and fluvoxamine n a medication used to treat depression and to help stop smoking called amfebutamone n medications for high blood pressure such as guanethidine, betanidine, reserpine, clonidine or alpha-methyldopa n medication for irregular heartbeat such as those containing quinidine n medication for colds, sinus problems, containing decongestants such as ephedrine, phenylephrine or phenylpropanolamine n antihistamines for hay fever or allergies n isoprenaline used to treat asthma n contraceptives or oestrogens (e.g. hormone replacement therapy [HRT]) n cimetidine (an anti-ulcer drug) n methylphenidate (used to treat behavioural disorders in children) n disulfiram or alprazolam (for alcohol abuse) n barbiturates, tranquillizers (such as phenothiazines, thioridazine or benzodiazepines), general or local anaesthetics n treatments for Parkinson’s disease such as biperiden n medication to treat epilepsy such as carbamazepine or phenytoin n antifungal medication such as terbinafine n noradrenaline, mainly used to treat low blood pressure in emergencies n nicotine found in cigarettes or in medications used to help stop smoking n blood-thinning tablets (anticoagulants) e.g. warfarin.
Drug Pregnancy Interaction Ask your doctor for advice before taking any medicine. Treatment with Imipramine Hydrochloride should be avoided during pregnancy unless your doctor considers it necessary.
Drug Breast feeding Interaction If you are breastfeeding, you may be advised to stop taking Imipramine Hydrochloride gradually, or to stop breastfeeding, because imipramine passes into breast milk.
Drug Machinery Interaction You may feel dizzy or sleepy or have blurred vision when you take this medicine. DO NOT drive or operate machinery without advice from your doctor or pharmacist.
Drug More Information DO NOT DRINK alcohol while you are taking this medicine.
How to take the Medicine
Consumption Info Keep taking your medicine until your doctor tells you to stop. Do not stop suddenly because you do not feel any better – the may take up to 4 weeks to work.
Drug quanitty Depression: Adults: At first, one 5ml spoonful (25mg) one to three times a day. Your doctor may increase your dose gradually as needed. However, the dose is usually not more than 6 to 8 spoonfuls (150-200mg) a day unless you are in hospital. Elderly: Your doctor may prescribe lower doses of Imipramine Hydrochloride , particularly when you first start taking this medicine. Night-time Bed-wetting Children over 6 years: 1 to 3 spoonfuls (25mg-75mg) a day at bedtime depending on the age and weight of the child.Treatment with Imipramine Hydrochloride must be checked after 3 months.
Drug Dose Always take Imipramine Hydrochloride exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.
Excess Drug Consumption If you (or a child) accidentally take too much Imipramine Hydrochloride , tell your doctor at once or contact your hospital casualty department. Overdosage in children is serious and could be potentially fatal.
Forgot Drug Consumption It is important to take your medicine at the right times. If you forget to take a dose, take the next dose at the usual time DO NOT take a double dose to make up for the forgotten dose.
Stop Drug Consumption Keep taking your medicine until your doctor tells you to stop. Do not stop suddenly because you do not feel any better. If you need to stop treatment, your doctor will tell you how to reduce the dose gradually. This is to help prevent unwanted effects such as headache, sickness, stomach upset, diarrhoea, sleeplessness, nervousness and anxiety. If you have any further questions on the use of this product, ask your doctor or pharmacist.
Possible Side Effects
General Information no data available
Common Drug Side Effects n trembling n weight gain n fast heartbeat n light headedness (especially when getting up from lying or sitting position). n drowsiness, tiredness n dizziness n restlessness, anxiety n nausea (feeling sick) n any yellowing of your skin or the whites of your eyes n sore throat or fever n glaucoma (increased pressure in the eye) n difficulty in passing water n hair loss n swelling of the breasts and discharge of milk n dilation of the pupils n increased sensitivity to sunlight n sexual difficulties n ringing in the ears n mood changes, aggression n activation of psychotic symptoms n vomiting, loss of appetite, weight loss n paralytic ileus (no bowel movement) n diarrhoea n stomach pain n any general swelling n tingling or numbness n poor blood circulation which makes the toes and fingers numb and pale n skin rash or itching n darkening of skin n loss of balance n muscle weakness or stiffness, muscle spasm n difficulty in controlling movements n changes to the electrical waves in your brain n difficulty in speaking n inflammation of the lungs which causes breathlessness, cough and raised temperature n feeling your heartbeat or irregular heartbeat n heart failure n red or brownish spots on skin n fits, confusion or delirium n sleep disturbances or difficulty in sleeping n raised blood pressure n low blood pressure n hallucinations n change in blood sugar levels n a condition called ‘syndrome of inappropriate antidiuretic hormone secretion’ which will cause a lowering of salt in your body n severe reduction in number of white blood cells which makes infections more likely n reduction in blood platelets, which increases risk of bleeding or bruising n other blood disorders n raised levels of enzymes in your liver n inflammation of the mouth or sores on the tongue. n dry mouth n blurred vision n headache n hot flushes, sweating n constipation
Rare Drug Side Effects no data available
Very Rare Drug Side Effects no data available
Drug Side Effects Symptoms no data available
How to Store the Medicine
How to Store the Medicine Keep the medicine in a cool place (below 25°C). Keep the bottle tightly closed and in its carton when not in use. Do not use for more than 1 month after first opening. Do not use Imipramine Hydrochloride after the expiry date which is stated on the carton as {EXP MM/YYYY}. The expiry date refers to the last day of that month. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

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