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THYROUP 12.5MG TABLET are synthetic thyroid hormones which work by replacing the thyroid hormone in the body when the natural production of thyroid hormones is not sufficient to meet the needs of the body. THYROUP 12.5MG TABLET is primarily taken for treatment of hypothyroidism or low secretion of thyroid hormone. It comprises levothyroxine which is a synthetic thyroid hormone that is chemically similar to thyroxine produced by our thyroid gland. Levothyroxine helps to replace missing thyroid hormone and/or to relieve stress on the thyroid gland.

Hypothyroidism is a chronic condition in which our thyroid gland (located below the throat in the neck) is not able to produce enough thyroid hormone. Thyroid hormones are composed of triiodothyronine (T3) and thyroxine (T4) which controls the body's metabolism. In the condition of underactive thyroid body’s metabolism slows down and the person feels less energetic. Other symptoms include easy fatigability, constipation, weight gain, feeling cold even in warm weathers, dry skin or too much or too less menses (in women) or even low mood. Treatment of hypothyroid is essential to restore the normal body metabolism (basal metabolic rate).

If you are experiencing any of the above symptoms, your doctor will advise you to undertake a blood test called 'thyroid function test' which checks three hormones related to thyroid - TSH, T3, T4. High TSH and low T3/T4 indicates that your thyroid gland is not functioning normally. The dose of THYROUP 12.5MG TABLET is adjusted by your doctor on the basis of your body weight and thyroid function test report. It may take some weeks for the medicine to fully show its effects. Regular monitoring of thyroid function is advised to ensure that you receive the optimum dose of THYROUP 12.5MG TABLET.

Take THYROUP 12.5MG TABLET as prescribed by your doctor once daily, on an empty stomach, one-half to one hour before breakfast with a full glass of water. THYROUP 12.5MG TABLET usually does not have major side effects when taken regularly in the prescribed dosage but, overdosage may cause headache, nervousness, sleeplessness, irritability, diarrhoea, muscle spasm, weight loss, feeling hot even in cool environments, menstrual irregularities (in women) and skin rash. If you missed a dose do not take a double dose as it may produce serious side effects.

Your doctor may prescribe calcium or vitamin D supplements alongside THYROUP 12.5MG TABLET for your bone health. THYROUP 12.5MG TABLET should not be used for the purpose of weight loss alone. People affected with diabetes taking THYROUP 12.5MG TABLET may have altered blood glucose control that may result in increased antidiabetic agents or insulin requirements. Hence, it is recommended that people with diabetes should contact a doctor and carefully monitor their glucose level after starting, changing or discontinuing thyroid hormone therapy.


Hypothyroidism (underactive thyroid)

Directions for Use

You can take this medicine once daily in the morning, on an empty stomach, 1/2 to 1 hour before breakfast with a full glass of water. However, if you have any doubt regarding the intake of THYROUP 12.5MG TABLET you can consult a doctor for this.


Store in a cool and dry place away from sunlight

Side Effects of THYROUP 12.5MG TABLET

Like all medicines, THYROUP 12.5MG TABLET can cause side effects, although not everybody gets them. Side effects are usually due to inappropriate dosage or irregular consumption. Some people may experience irregular heartbeat (palpitations), muscle spasm, headache, nervousness, irritability, sleeplessness, tremors, muscle weakness, increased appetite, weight loss, diarrhoea, heat intolerance, menstrual irregularities and skin rash. If taken in the right dosage as prescribed by your doctor, these unpleasant side effects are usually not seen. However, in case these symptoms become bothersome, speak with your doctor.

In-Depth Precautions and Warning

Drug Warning

Foods like soybean flour, cottonseed meal, cabbage, cauliflower, walnuts, dietary fibre, calcium and calcium-fortified juices may affect the working of THYROUP 12.5MG TABLET. Hence, avoid the intake of these foods within several hours of dosing if possible. THYROUP 12.5MG TABLET should not be administered to patients with acute myocardial infarction and high blood pressure patients. So, close clinical monitoring of heart function is recommended before taking THYROUP 12.5MG TABLET.

Safety Advice

  • Alcohol

    You are recommended not to consume alcohol along with THYROUP 12.5MG TABLET to avoid unpleasant side-effects.

  • Pregnancy

    Only consume THYROUP 12.5MG TABLET, if you are prescribed by a doctor. However, the need for levothyroxine may increase during pregnancy due to increased blood levels of oestrogen (female sex hormone) hence, monitoring of thyroid function should be done regularly both during and after pregnancy. In this case, thyroid hormone dose can be adjusted by your doctor.

  • Breast Feeding

    Even during high dose levothyroxine therapy, the amount of THYROUP 12.5MG TABLET passing into the breast milk during lactation is very low and therefore harmless. However, if you have any doubt consult a doctor.

  • Driving

    THYROUP 12.5MG TABLET does not interfere with your ability to drive.

  • Liver

    THYROUP 12.5MG TABLET can be taken in the prescribed dose as it does not affect the liver.

  • Kidney

    THYROUP 12.5MG TABLET can be taken in the prescribed dose as it does not affects the kidney. However patient with adrenal gland complication or problem should consult a doctor before its intake.

Other Information (THY0062)

This item is Not Returnable.

Expires on or after - September 2021

Patients Concern


No. THYROUP 12.5MG TABLET is only indicated for hypothyroidism and not for weight loss.

No. THYROUP 12.5MG TABLET should be not be taken with food. Please take it empty stomach at least half an hour before tea/coffee/breakfast in the morning.

If you observe symptoms like sudden weight gain, fatigue, increased sensitivity to cold, dry skin, constipation, puffy face, muscle weakness, anxiety or voice hoarseness. You should consult an Endocrinologist/Physician for further treatment.

You need to have a thyroid profile test which includes parameters like T3, T4 and TSH every month. You will observe a decrease in your TSH level after regular intake of THYROUP 12.5MG TABLET as prescribed by your doctor.

Your thyroid hormone may vary depending on your age, sex, and condition (like pregnancy, chronic condition or complication). For example, a 30-year-old woman may have normal TSH around 4.2 mU/L, while a 90-year-old man may reach 8.9 mU/L at their upper limits. Besides this, your level of stress, diet, and medications and menses period can fluctuate your level of thyroid hormone.

Yes. Limit salt intake less than 2300 mg daily. Too much salt intake can increase your blood pressure especially when you have an underactive thyroid.

Yes. Based on the thyroid profile test, an Endocrinologist may advise a pregnant woman to take a high dose of THYROUP 12.5MG TABLET to meet the high-level thyroid hormone requirement. Treatment of underactive thyroid is vital during pregnancy, as low levels of thyroid hormone in the mother may harm both mother and baby.

A TSH test can be done once a year in case of hypothyroidism or under active thyroid to check whether your thyroid hormone levels are in normal range or not.

Do not take double doses in case you missed the dose of THYROUP 12.5MG TABLET. If accidentally you have taken too much of THYROUP 12.5MG TABLET, it may cause side effects like nervousness, insomnia, mild elevation of temperature, blood pressure elevation or loose stools. In this case immediately contact the doctor and take only when your doctor has allowed to take it.

Pregnant women with uncontrolled hypothyroidism or underactive thyroid can get low haemoglobin (anaemia), high blood pressure, muscle pain and weakness. Besides this, it can also cause an increased risk of miscarriage, premature birth (before 37 weeks of pregnancy) or even stillbirth. Also, untreated hypothyroidism during pregnancy can cause hypothyroid even in the baby. So, it is advisable to consult an endocrinologist if you are diagnosed with hypothyroidism.

Hair loss may occur during the first few months of treatment. This effect is usually temporary as your body adjusts to this medication. If this effect persists or worsens, tell your doctor for further treatment.

Long term use of THYROUP 12.5MG TABLET may cause decreases bone mineral density. Consult your doctor for further advice.

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. IndianCountry of Origin: India



MRP: 71.10


1 Tablet in 1 Strip