PIOGLUCORED FORTE TABLET

Manufacturer : SUN-SUN PHARMACEUTICALS
Composition : GLIBENCLAMIDE-5MG+METFORMIN-500MG+PIOGLITAZONE-15MG
Dose Form : TABLET
Description : PIOGLUCORED FORTE TAB
Route Of Administration : ORAL
Pack : 10
Out of stock
SKU
PIO0104
₹67.00
Manufacturer : SUN-SUN PHARMACEUTICALS
Composition : GLIBENCLAMIDE-5MG+METFORMIN-500MG+PIOGLITAZONE-15MG
Dose Form : TABLET
Description : PIOGLUCORED FORTE TAB
Route Of Administration : ORAL
Pack : 10

Drug Ingredient Information

GLIBENCLAMIDE-5MG+METFORMIN-500MG+PIOGLITAZONE-15MG

GLIBENCLAMIDE

Information for patients
Drug Information Glibenclamide is used to control blood glucose levels in patients with type 2 diabetes mellitus. This type of diabetes is also known as noninsulin-dependent diabetes (NIDDM) or maturity onset diabetes. It is used in conjunction with diet control and exercise to control blood sugar. Glibenclamide can be used alone, or in combination with insulin or other anti-diabetes medicines. How Glibenclamide works Glibenclamide lowers high blood glucose by increasing the amount of insulin released by your pancreas. It belongs to a group of medicines called sulphonylureas. This medicine is available only with a doctor’s prescription. Glibenclamide is not addictive.
Drug Alert
Alert no data available
Before Consuming the Medicine
Avoid Drug Do not take Glibenclamide if: - You have an allergy to: • Glibenclamide or related medicines (such as sulphur antibiotics or sulphonylureas) • any of the ingredients listed in the contents Symptoms of an allergic reaction to this medicine may include itching or rash. If you are not sure if you have or have had an allergic reaction to Glibenclamide check with your doctor. - You have any of the following conditions: • type 1 diabetes mellitus (insulin-dependent diabetes mellitus, also known as IDDM, or juvenile or growth onset diabetes) • unstable diabetes • diabetic ketoacidosis • diabetic coma or pre-coma • severe kidney disease • severe liver disease • you are taking bosentan • glucose-6-phosphate dehydrogenase (G6PD) deficiency If you are not sure if you have any of the above, ask your doctor. - The packaging is torn or shows signs of tampering (or the tablets do not look quite right). - The expiry date on the pack has passed. If you take this medicine after the expiry date has passed, it may not work as well. If you are not sure whether you should start taking Glibenclamide, talk to your doctor. Do not give Glibenclamide to children. There is not enough information to recommend the use of Glibenclamide in children.
Drug Special Care Tell your doctor if: - You have any allergies to any other medicines or any other substances such as foods, preservatives or dyes. - You have or have had any of the following medical conditions: • kidney problems • liver problems • a history of diabetic coma • adrenal, pituitary (or thyroid) problems • heart failure - You drink alcohol in any amount. - You do not eat regular meals. - You do a lot of exercise or heavy work. - You are feeling ill or unwell. Diet, exercise, alcohol and your general health all strongly affect the control of your diabetes. Discuss these things with your doctor. - You are taking any other antidiabetic treatment. If you have not told your doctor about any of the above, tell them before you start to take Glibenclamide. Things you must do ? If you become pregnant while you are taking Glibenclamide tell your doctor. ? If you are about to start taking any new medicine, tell your doctor and pharmacist that you are taking Glibenclamide. ? Tell all the doctors, dentists and pharmacists who are treating you that you are taking Glibenclamide. ? Make sure you, your friends, family and work colleagues can recognise the symptoms of hypoglycaemia and hyperglycaemia and know how to treat them. If you experience any of the symptoms of low blood sugar (hypoglycaemia), you need to raise your blood glucose urgently. You can do this by taking one of the following: • 5-7 jelly beans • 3 teaspoons of sugar or honey • ½ can of ordinary (non-diet) soft drink • 2-3 concentrated glucose tablets ? Unless you are within 10 to 15 minutes of your next meal or snack, follow up with extra carbohydrates eg. plain biscuits, fruit or milk – when over the initial symptoms. Taking this extra carbohydrate will prevent a second drop in your blood ? glucose level. ? If you are elderly or are taking other medicines for diabetes such as insulin or metformin, the risk of hypoglycaemia is increased. ? The risk of hypoglycaemia is also increased in the following situations: • too much Glibenclamide • too much or unexpected exercise • delayed meal or snack • too little food ? If you experience any of the signs of high blood glucose (hyperglycaemia), contact your doctor immediately. The risk of hyperglycaemia is increased in the following situations: • undiagnosed or uncontrolled diabetes • illness, infection or stress • too little Glibenclamide • certain other medicines • too little exercise • eating more carbohydrate than normal ? If you become ill or experience extra stress, injury, fever, infection or need surgery, tell your doctor. Your blood glucose may become difficult to control at these times. ? Your doctor may decide to change your treatment and use insulin instead of Glibenclamide. Make sure you check your blood glucose levels regularly. This is the best way to tell if your diabetes is being controlled properly. Your doctor or diabetes educator will show you how and when to do this. ? Visit your doctor for regular checks of your eyes, feet, kidneys, heart, circulation, blood and blood pressure. ? Carefully follow your doctor’s and your dietician’s advice on diet, drinking alcohol and exercise. If you drink alcohol while taking Glibenclamide, you may get flushing, headache, breathing difficulties, rapid heart beat, stomach pains or ? feel sick and vomit. ? Tell your doctor immediately if you notice the return of any symptoms you had before starting Glibenclamide. These may include lethargy or tiredness, headache, thirst, passing large amounts of urine and blurred vision. ? These may be signs that Glibenclamide is no longer working effectively, even though you may have been taking it ? successfully for some time. Things you must not do ? Do not give Glibenclamide to anyone else, even if they have the same condition as you. ? Do not skip meals while taking Glibenclamide. Things to be careful of ? Protect your skin when you are in the sun, especially between 10am and 3pm. ? Glibenclamide may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight may ? cause a skin rash, itching, redness or severe sunburn. If outdoors, wear protective clothing and use a highly effective sunscreen. If you experience sunburn, tell your doctor immediately. ? If you have to be alert, for example when driving, be especially careful not to let your blood glucose levels fall too low. ? If you are travelling, it is a good idea to: • wear some form of identification showing you have diabetes • carry some form of sugar to treat hypoglycaemia if it occurs eg, sugar sachets or jelly beans. • carry emergency food rations in case of a delay eg. dried fruit, biscuits or muesli bars • keep some Glibenclamide readily available ? If you become sick with a cold, fever or flu, it is very important to continue taking Glibenclamide. If you have trouble eating solid food, use sugar-sweetened drinks as a carbohydrate substitute or eat small amounts of bland food. ? Your diabetes educator or dietician can give you a list of foods to use for sick days.
Drug Drug Interactions Tell your doctor if you are taking any other medicines, including medicines that you buy without a prescription from your pharmacy, supermarket or health food shop. Some medicines may lead to low blood glucose (hypoglycaemia) by increasing the blood glucose lowering effect of Glibenclamide. These include: • alcohol • some medicines used to treat high blood pressure • some medicines used to treat arthritis, pain and inflammation • (anabolic) steroids • some cholesterol-lowering medicines • other medicines used to treat diabetes • some antibiotics • medicines used to prevent blood clots • disopyramide; a medicine used to treat irregular heart rhythms • some medicines used to treat depression • oxpentifylline, a medicine used to treat blood vessel problems • some medicines used to treat cancer • some medicines used to treat gout • cimetidine and ranitidine, medicines used to treat reflux and ulcers Some medicines may lead to loss of control of your diabetes (resulting in high blood glucose) by weakening the blood glucose-lowering effect of Glibenclamide. These include: • alcohol • some medicines used to treat glaucoma • some medicines used to treat high blood pressure • corticosteroids such as prednisone and cortisone • glucagon, a medicine used to treat low blood glucose • some medicines used to treat tuberculosis • (high dose) nicotinic acid used for the lowering of blood fats • oestrogens and oral contraceptives • some medicines used to treat mental illness or psychotic disorders • phenytoin, a medicine used to treat epilepsy (convulsions) • cimetidine and ranitidine, medicines used to treat reflux and ulcers • ritodrine, a medicine used to prevent premature labour • diuretics, also known as fluid tablets • some asthma medicines, preparations for coughs and colds and weight-reducing medicines • thyroid hormones • large doses of laxatives • indomethacin, a medicine used to treat arthritis (an inflammatory condition) • barbiturates, medicines used for sedation Some medicines may hide the symptoms of low blood sugar (hypoglycaemia). These include: • alcohol • some medicines used to treat high blood pressure You may need different amounts of your medicine or you may need to take different medicines. Your doctor, pharmacist or diabetes educator can tell you what to do if you are taking any of these medicines. They also have a more complete list of medicines to be careful with or avoid while taking Glibenclamide. Ask your doctor or pharmacist if you are not sure if you are taking any of these medicines.
Drug Pregnancy Interaction You are pregnant or intend to become pregnant. Insulin is more suitable for controlling blood sugar during pregnancy. Your doctor will replace Glibenclamide with insulin while you are pregnant.
Drug Breast feeding Interaction You are breastfeeding or plan to breastfeed. It is not known whether glibenclamide is excreted in milk or whether it has a harmful effect on the newborn. Therefore it is not recommended for nursing mothers unless the expected benefits outweigh any potential risks.
Drug Machinery Interaction Low blood glucose levels may slow your reaction time and affect your ability to drive or operate machinery.Drinking alcohol can make this worse. However, Glibenclamide by itself is unlikely to affect how you drive or operate machinery.
Drug More Information no data available
How to take the Medicine
Consumption Info Your doctor will decide what is the best dose for you and your condition. Follow all directions given to you by your doctor, pharmacist and diabetes educator carefully. They may differ from the information contained in this leaflet.
Drug quanitty Your doctor will tell you how many tablets to take each day. Your doctor may increase or decrease the dose depending on your blood glucose levels. If you do not understand the instructions on the pack, ask your doctor or pharmacist for help.
Drug Dose When to take it Take your tablet immediately before breakfast. If you only eat a very light breakfast then this dose should be put off until lunchtime. Swallow the tablets with a glass of water. Do not skip meals whilst using Glibenclamide. Take your dose at the same times each day. How long to take it Continue taking Glibenclamide for as long as your doctor recommends. Make sure that you have enough Glibenclamide to last over weekends and holidays. Glibenclamide will help control your diabetes but will not cure it. Therefore, you may have to take it for a long time. Currently there is no cure for diabetes.
Excess Drug Consumption Immediately telephone your doctor or Poisons Information Centre, or go to Accident and Emergency at your nearest hospital, if you think that you or anyone else may have taken too much Glibenclamide. Do this even if there are no signs of discomfort or poisoning. If you take too much Glibenclamide you may experience symptoms of hypoglycaemia (low blood sugar). If not treated quickly, these symptoms may progress to loss of co-ordination, slurred speech, confusion, loss of consciousness and the occurrence of fits. At the first signs of hypoglycaemia, raise your blood glucose quickly by taking jelly beans, sugar or honey, soft drink (non-diet) or glucose tablets. If you experience any of the symptoms of an overdose, immediately get medical help.
Forgot Drug Consumption If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, take it as soon as you remember, and then go back to taking your tablets as you would normally. Missed doses can cause high blood sugar (hyperglycaemia). If you are not sure whether to skip the dose, talk to your doctor or pharmacist. Do not take a double dose to make up for the dose that you missed. If you double a dose this may cause low blood sugar (hypoglycaemia). If you have trouble remembering to take your tablets, ask your pharmacist for some hints.
Stop Drug Consumption Do not stop the drug untill your doctor says you to do so.
Possible Side Effects
General Information Check with your doctor as soon as possible if you have any problems while taking Glibenclamide, even if you do not think the problems are connected with the medicine or are not listed in this leaflet. Like other medicines, Glibenclamide can cause some side effects. If they occur, most are likely to be minor and temporary. However, some may be serious and need medical attention. Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Glibenclamide. Ask your doctor or pharmacist to answer any questions you may have.
Common Drug Side Effects Tell your doctor if you notice any of the following and they worry you: • signs of hypoglycaemia which may include weakness, trembling or shaking, sweating, light headedness, headache, dizziness, lack of concentration, tearfulness or crying, irritability, hunger and numbness around the lips and fingers • stomach upset including nausea (feeling sick), vomiting, heartburn, indigestion, cramps • diarrhoea, constipation or a feeling of fullness in the stomach • loss of appetite • headache • weakness • eye problems including blurred or double vision • unusual weight gain
Rare Drug Side Effects Tell your doctor immediately or go to Accident and Emergency at your nearest hospital if you notice any of the following: • convulsions or fits • deafness • blindness • severe pain or tenderness in the stomach • sudden onset of abnormal thoughts or delusions • swelling of the face, lips or tongue which may cause difficulty in swallowing or breathing • symptoms of lactic acidosis (too much acid in the blood) which may include loss of appetite, unexplained weight loss, nausea, vomiting, stomach pain, trouble breathing, feeling weak, tired or uncomfortable, unusual muscle pain, slow heart beat • rash, sores, redness or itching of the skin, itchy hives-like rash or spots • symptoms of sunburn such as redness, itching, swelling or blistering which may occur more quickly than normal • bleeding or bruising more easily than normal, reddish or purplish blotches under the skin • yellowing of the skin or eyes, also called jaundice • signs of frequent or worrying infections such as fever, severe chills, sore throat or mouth ulcers • signs of anaemia such as tiredness, being short of breath and looking pale • a change in the colour or amount of urine passed, blood in the urine
Very Rare Drug Side Effects In very rare cases, intolerance to alcohol may occur. Drinking large amounts of alcohol may interfere with the way Glibenclamide works. It may not work at all or it may take much longer than usual to work.
Drug Side Effects Symptoms If your blood glucose is not properly controlled, you may experience hypoglycaemia (low blood glucose) or hyperglycaemia (high bloodglucose). High blood glucose can lead to serious problems with your heart, eyes, circulation or kidneys. Low blood glucose can occur suddenly. Signs may include: • weakness, trembling, shaking • sweating • light headedness, dizziness, headache or lack of concentration • tearfulness, crying or depression • irritability • hunger • numbness around the lips and tongue • restlessness or disturbed sleep If not treated promptly, these may progress to: • loss of co-ordination • slurred speech • confusion • loss of consciousness or seizures High blood glucose usually occurs more slowly than low blood glucose. Signs of high blood glucose may include: • lethargy or tiredness • headache • severe thirst • passing large amounts of urine and more often • blurred vision • dry mouth or dry skin
How to Store the Medicine
How to Store the Medicine Storage Keep your tablets in the pack until it is time to take them. If you take the tablets out the pack they may not keep as well. Keep it in a cool dry place where the temperature stays below 25oC. Do not store it or any other medicine in the bathroom or near a sink. Do not leave it in the car or on window sills. Heat and dampness can destroy some medicines. Keep it where children cannot reach it. A locked cupboard at least one-and a-half metres above the ground is good place to store medicines. Disposal If your doctor tells you to stop taking the tablets or the tablets have passed their expiry date, ask your pharmacist what to do with any tablets that are left over.

METFORMIN

Information for patients
Drug Information Metformin is used alone or with other medications, including insulin, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Metformin helps to control the amount of glucose (sugar) in your blood. It decreases the amount of glucose you absorb from your food and the amount of glucose made by your liver. Metformin also increases your body's response to insulin, a natural substance that controls the amount of glucose in the blood. Metformin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood).
Drug Alert
Alert no data available
Before Consuming the Medicine
Avoid Drug Tell your doctor if you regularly drink alcohol or sometimes drink large amounts of alcohol in a short time (binge drinking). Drinking alcohol increases your risk of developing lactic acidosis or may cause a decrease in blood sugar. Ask your doctor how much alcohol is safe to drink while you are taking metformin.
Drug Special Care Before taking metformin, tell your doctor and pharmacist if you are allergic to metformin or any other medications. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: amiloride (Midamor, Moduretic); antihistamines; beta-blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Lexxel, Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular), and verapamil (Calan, Isoptin, Verelan); cimetidine (Tagamet); digoxin (Lanoxin, Lanoxicaps); furosemide (Lasix); hormone replacement therapy; insulin or other medications for diabetes; isoniazid (INH, Nydrazid); medications for asthma and colds; medications for mental illness and nausea such as fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), promethazine (Phenergan), thioridazine (Mellaril), thiothixene (Navane), trifluoperazine (Stelazine), and triflupromazine (Vesprin); medications for thyroid disease; morphine (MS Contin, Roxanol, others); nicotinic acid; oral contraceptives ('birth control pills'); oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); phenytoin (Dilantin, Phenytek); procainamide (Procanbid); quinidine (Quinidex); quinine; ranitidine (Zantac); triamterene (Dyazide, Maxzide, others); or trimethoprim (Proloprim, Trimpex). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor if you have or have ever had any medical condition, especially those mentioned in the IMPORTANT WARNING section. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking metformin, call your doctor. if you are using the extended-release tablets, you should know that sometimes the tablet shell may appear in your stool. If this occurs, it is not harmful and will not affect the way the medication works. tell your doctor if you eat less or exercise more than usual. This can affect your blood sugar. Your doctor will give you instructions if this happens.
Drug Drug Interactions acyclovir (Zovirax); acetaminophen (Tylenol); aminoglycoside antibiotics such as amikacin (Amikin), gentamicin (Garamycin), Kanamycin (Kantrex), Neomycin (Neo-Fradin, Neo-Rx), netilmicin (Netromycin), paromomycin (Humatin), streptomycin and tobramycin (Nebcin, Tobi); amphotericin B (Abelcet, Amphocin, others); angiotensin converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinvil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); cancer chemotherapy medications; cyclosporine (Sandimmune, Neoral); dapsone (Avlosulfon); diuretics (water pills); foscarnet (Foscavir); gold compounds such as auranofin (Ridaura), aurothioglucose (Aurolate, Solganol), and gold sodium thiomalate (Myochrysine); hydralazine (Hydra-Zide); lithium (Eskalith, Lithobid); medications to treat human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS); methicillin (Staphcillin); nitrates; penicillin and sulfa antibiotics; penicillamine (Cuprimine, Depen); primaquine; propranolol (Inderal); rifampin (Rifadin, Rimactane); tacrolimus (Prograf); vancomycin (Vancocin); or if you have ever taken the Chinese weight-loss herb Aristolochia.
Drug Pregnancy Interaction no data available
Drug Breast feeding Interaction no data available
Drug Machinery Interaction no data available
Drug More Information In addition to describing the cardiovascular risks, the drug labels have been revised to state that rosiglitazone and rosiglitazone-containing medicines should only be used: In patients already being treated with these medicines In patients whose blood sugar cannot be controlled with other anti-diabetic medicines and who, after consulting with their healthcare professional, do not wish to use pioglitazone-containing medicines
How to take the Medicine
Consumption Info If you are having surgery, including dental surgery, any x-ray procedure in which dye is injected, or any major medical procedure, tell the doctor that you are taking metformin. You may need to stop taking metformin before the procedure and wait 48 hours to restart treatment. Your doctor will tell you exactly when you should stop taking metformin and when you should start taking it again.
Drug quanitty no data available
Drug Dose Metformin comes as a liquid, a tablet and an extended-release (long-acting) tablet to take by mouth. The liquid is usually taken with meals one or two times a day. The regular tablet is usually taken with meals two or three times a day. The extended-release tablet is usually taken once daily with the evening meal. To help you remember to take metformin, take it around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take metformin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Swallow metformin extended-release tablets whole; do not split, chew, or crush them. Your doctor may start you on a low dose of metformin and gradually increase your dose not more often than once every 1 to 2 weeks. You will need to monitor your blood sugar carefully so your doctor will be able to tell how well metformin is working. Metformin controls diabetes but does not cure it. Continue to take metformin even if you feel well. Do not stop taking metformin without talking to your doctor.
Excess Drug Consumption In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911. Symptoms of overdose may include: extreme tiredness weakness discomfort vomiting nausea stomach pain decreased appetite deep, rapid breathing shortness of breath dizziness lightheadedness abnormally fast or slow heartbeat flushing of the skin muscle pain feeling cold
Forgot Drug Consumption Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Stop Drug Consumption Do not stop the drug untill your doctor says you to do so.
Possible Side Effects
General Information extreme tiredness, weakness, or discomfort; nausea; vomiting; stomach pain; decreased appetite; deep and rapid breathing or shortness of breath; dizziness; lightheadedness; fast or slow heartbeat; flushing of the skin; muscle pain; or feeling cold.
Common Drug Side Effects Metformin may rarely cause a serious, life-threatening condition called lactic acidosis. Tell your doctor if you have or have ever had a heart attack; stroke; high blood pressure; diabetic ketoacidosis (blood sugar that is high enough to cause severe symptoms and requires emergency medical treatment) or coma; surgery to remove part of your small intestine; anemia (not enough red blood cells), or heart, kidney, lung, or liver disease.
Rare Drug Side Effects no data available
Very Rare Drug Side Effects no data available
Drug Side Effects Symptoms This medication may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms. You may experience hypoglycemia (low blood sugar) while you are taking this medication. Your doctor will tell you what you should do if you develop hypoglycemia. He or she may tell you to check your blood sugar, eat or drink a food or beverage that contains sugar, such as hard candy or fruit juice, or get medical care. Follow these directions carefully if you have any of the following symptoms of hypoglycemia: shakiness dizziness or lightheadedness sweating nervousness or irritability sudden changes in behavior or mood headache numbness or tingling around the mouth weakness pale skin hunger clumsy or jerky movements If hypoglycemia is not treated, severe symptoms may develop. Be sure that your family, friends, and other people who spend time with you know that if you have any of the following symptoms, they should get medical treatment for you immediately: confusion seizures loss of consciousness Call your doctor immediately if you have any of the following symptoms of hyperglycemia (high blood sugar): extreme thirst frequent urination extreme hunger weakness blurred vision If high blood sugar is not treated, a serious, life-threatening condition called diabetic ketoacidosis could develop. Call your doctor immediately if you have any of these symptoms: dry mouth nausea and vomiting shortness of breath breath that smells fruity decreased consciousness Metformin may cause side effects. Tell your doctor if any of these symptoms are severe, do not go away, go away and come back, or do not begin for some time after you begin taking metformin: diarrhea bloating stomach pain gas constipation unpleasant metallic taste in mouth heartburn headache sneezing cough runny nose flushing of the skin nail changes muscle pain Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them or those listed in the IMPORTANT WARNING section, call your doctor immediately: chest pain rash Some female laboratory animals given high doses of metformin developed non-cancerous polyps (abnormal growths of tissue) in the uterus (womb). It is not known if metformin increases the risk of polyps in humans. Talk to your doctor about the risks of taking this medication. Metformin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
How to Store the Medicine
How to Store the Medicine Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

PIOGLITAZONE

Information for patients
Drug Information PIOGLITAZONE is a tablet that is used to improve the action of the body?s naturally produced insulin. It is used in the management of type 2 diabetes not controlled by diet. It helps to control the level of glucose in your blood when you have type 2 diabetes. This is the „adult onset? type of diabetes and is controlled by diet, certain oral medications and occasionally insulin. This medicine is available as pioglitazone hydrochloride and belongs to a group of medicines called glitazones. Glitazones decrease insulin resistance. Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed it for another reason. PIOGLITAZONE can be used alone (when diet and exercise is not enough to treat your diabetes) or together with other anti-diabetic medicines. This medicine is available only with a doctor?s prescription. The use of PIOGLITAZONE has not been studied in children.
Drug Alert
Alert no data available
Before Consuming the Medicine
Avoid Drug Do not take PIOGLITAZONE if you have: heart failure requiring treatment. Talk to your doctor if you have heart failure type 1 diabetes or diabetic ketoacidosis (often caused by very high blood glucose levels) an allergy to any medicine containing pioglitazone hydrochloride or any of the ingredients listed in the contents. Some of the symptoms of an allergic reaction may include shortness of breath, wheezing or difficulty breathing; swelling of the face, lips, tongue or other parts of the body; rash, itching or hives on the skin. Do not take this medicine after the date printed on the pack or if the packaging is torn or shows signs of tampering. If it has expired or is damaged, return it to your pharmacist for disposal. If you are not sure whether you should start taking this medicine, talk to your doctor.
Drug Special Care Before you start to take it • Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes. • Tell your doctor if you have or have had any of the following medical conditions: • heart disease with shortness of breath after minimal physical activity • heart disease with severe symptoms at rest • swelling of hands, ankles or feet • problems with your liver • problems with your kidneys that requires dialysis. PIOGLITAZONE is not recommended for use if you are on dialysis • some women who do not have monthly periods and have not been through menopause may restart their periods when taking PIOGLITAZONE. These women may be at increased risk of pregnancy • bone fractures, usually in the hand, upper arm or foot, have been seen in some women when taking PIOGLITAZONE. Talk to your doctor for advice on how to keep your bones healthy. • Tell your doctor if you are pregnant or plan to become pregnant or are breast-feeding.Things you must do It is important that you remember to take PIOGLITAZONE daily and at the dose prescribed by your doctor. Tell any other doctors, dentists and pharmacists who treat you that you are taking PIOGLITAZONE. If you are about to be started on any new medicine, remind your doctor and pharmacist that you are taking PIOGLITAZONE. If you are going to have surgery, tell the surgeon or anaesthetist that you are taking this medicine. It may affect other medicines used during surgery. If you are about to have any blood tests, tell your doctor that you are taking this medicine. It may interfere with the results of some tests. Keep all of your doctor’s appointments so that your progress can be checked. Your doctor may do some tests from time to time to make sure the medicine is working and to prevent unwanted side effects. Tell your doctor if you have gained weight since taking PIOGLITAZONE. Weight gain can be associated with improved blood sugar control however; it may also be a symptom of heart failure. Things you must not do Do not take PIOGLITAZONE to treat any other complaints unless your doctor tells you to. Do not give your medicine to anyone else, even if their symptoms seem similar to yours or they have the same condition as you.
Drug Drug Interactions Tell your doctor if you are using another medicine for diabetes. PIOGLITAZONE can enhance the action of other medicines. You may be at risk of low blood sugar (hypoglycaemia). If this happens, your doctor may need to adjust the dose of your other medicines. Tell your doctor if you suffer from lactose intolerance (because PIOGLITAZONE tablets contain lactose). If you have not told your doctor about any of the above, tell him/her before you start taking PIOGLITAZONE. Taking other medicines Tell your doctor or pharmacist if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop. Some medicines and PIOGLITAZONE may interfere with each other. These include: chlorpropamide gemfibrozil glibenclamide gliclazide insulin metformin oral contraceptives rifampicin tolbutamide These medicines may be affected by PIOGLITAZONE or may affect how well it works. You may need different amounts of your medicines, or you may need to take different medicines. Your doctor or pharmacist has more information on medicines to be careful with or to avoid while taking this medicine.
Drug Pregnancy Interaction It is not recommended for use during pregnancy. If there is a need to consider PIOGLITAZONE during your pregnancy, your doctor will discuss with you the benefits and risks of taking PIOGLITAZONE.
Drug Breast feeding Interaction It is recommended that you do not breast-feed while taking PIOGLITAZONE, as it is not known whether this drug passes into breast milk.
Drug Machinery Interaction PIOGLITAZONE alone is unlikely to affect your ability to drive or operate machinery. However, be careful to avoid hypoglycaemia whilst driving or operating machinery if using PIOGLITAZONE combination with other diabetes medicines.
Drug More Information no data available
How to take the Medicine
Consumption Info Follow all directions given to you by your doctor or pharmacist carefully. They may differ from the information contained in this leaflet. If you do not understand the instructions on the carton, ask your doctor or pharmacist for help.
Drug quanitty Your doctor will tell you how many PIOGLITAZONE tablets you should take. The dose your doctor will prescribe for you will usually be in the range of 15 mg to 45 mg per day. PIOGLITAZONE tablets should be taken once a day as advised by your doctor. Your doctor may increase or decrease your dose in order to find the appropriate dose for your condition.
Drug Dose PIOGLITAZONE tablets should be swallowed whole with a glass of water. When to take it Take your medicine at about the same time each day. Taking it at the same time each day will have the best effect. It will also help you remember when to take it. It does not matter if you take this medicine before or after food. How long to take it Continue taking your medicine for as long as your doctor tells you. This medicine helps to control your condition, but does not cure it. It is important to keep taking your medicine even if you feel well.
Excess Drug Consumption Immediately telephone your doctor or the Poisons Information Centre or go to Accident and Emergency at the nearest hospital, if you think that you or anyone else may have taken too much PIOGLITAZONE. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.
Forgot Drug Consumption If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally. Do NOT take a double dose to make up for the dose that you missed. If you are not sure what to do, ask your doctor or pharmacist. If you have trouble remembering to take your medicine, ask your pharmacist for some hints.
Stop Drug Consumption Do not stop taking your medicine or lower the dosage without checking with your doctor. If you stop taking it suddenly, your condition may worsen or you may have unwanted side effects.
Possible Side Effects
General Information Tell your doctor or pharmacist as soon as possible if you experience any undesirable effect or feel unwell while you are taking PIOGLITAZONE. This medicine helps most people with type 2 diabetes not controlled by diet, but it may have unwanted side effects in some people. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical attention if you get some of the side effects. Some side effects may be related to the dose of PIOGLITAZONE. Accordingly, it is important that you tell your doctor as soon as possible about any unwanted effects. Your doctor may then decide to adjust the dose of PIOGLITAZONE you are taking. Do not be alarmed by the following list of side effects. You may not experience any of them. Ask your doctor or pharmacist to answer any questions you may have.
Common Drug Side Effects A few patients have experienced the following side effects whilst taking PIOGLITAZONE: a small increase in weight low blood sugar levels (hypoglycaemia). This occurs more often when PIOGLITAZONE is taken with a sulfonylurea or insulin heart failure which may show as localised swelling of the ankles, feet and hands (oedema) and/or fluid in the lungs (pulmonary oedema). This has been reported in clinical trials mainly in patients who are taking PIOGLITAZONE in combination with insulin increased risk of fracture in women macular oedema (an eye disorder that can affect vision) altered or impaired liver function.
Rare Drug Side Effects dark urine or pale stools, yellowing of the skin or eyes, severe cramps of the stomach, nausea or vomiting, loss of weight, tiredness shortness of breath when at rest or after minimal physical activity with swelling of legs, feet and hands, rapid increase in weight The above list includes serious side effects, which may require medical attention. Serious side effects are rare.
Very Rare Drug Side Effects no data available
Drug Side Effects Symptoms weight gain signs of hypoglycaemia which may include weakness, trembling or shaking, sweating, light-headedness, headache, dizziness, lack of concentration, tearfulness or crying, irritability, hunger, numbness around the lips and fingers eye problems including blurred or double vision.
How to Store the Medicine
How to Store the Medicine Storage Keep your tablets in the aluminium blister pack until it is time to take them. Keep your tablets in a cool, dry place where the temperature stays below 30 degree celcius. Do not store PIOGLITAZONE or any other medicine in the bathroom or near a sink. Do not leave it on a window sill or in the car. Heat and dampness can destroy some medicines. Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines. Disposal If your doctor tells you to stop taking PIOGLITAZONE or the expiry date has passed, ask your pharmacist what to do with any medicine that is left over.

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