POLY B 500000I.U INJECTION

Manufacturer : SAM-SAMARTH PHARMA PVT LTD
Composition : POLYMYXIN B-500000I.U
Dose Form : INJECTION
Description : POLY B 500000 I.U INJ
Route Of Administration : PARENTERAL
Pack : 1
In stock
SKU
POL0010
₹1,566.00
Manufacturer : SAM-SAMARTH PHARMA PVT LTD
Composition : POLYMYXIN B-500000I.U
Dose Form : INJECTION
Description : POLY B 500000 I.U INJ
Route Of Administration : PARENTERAL
Pack : 1

Drug Ingredient Information

POLYMYXIN B-500000I.U

POLYMYXIN B

Information for patients
Drug Information Polymyxin B is an antibiotic primarily used for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa.
Drug Alert
Alert should not be used in patients who are Hypersensitivity to polymyxins; perforated ear drums (otic). Concurrent use w/ nephrotoxic and/or neurotoxic drugs and neuromuscular blockers.
Before Consuming the Medicine
Avoid Drug Aminoglycoside antibiotics (eg, gentamicin), nondepolarizing muscle relaxants (eg, vecuronium), or medicines that may harm the kidney (eg, ether, succinylcholine, gallamine, sodium citrate, bacitracin, streptomycin, neomycin, kanamycin, tobramycin, amikacin, cephaloridine, paromomycin, viomycin, colistin) because the risk of their side effects may be increased by polymyxin b sulfate
Drug Special Care no data
Drug Drug Interactions Potentially Fatal: Additive neurotoxic or nephrotoxic effect w/ bacitracin, streptomycin, neomycin, kanamycin, gentamicin, tobramycin, amikacin, cephaloridine, paromomycin, viomycin, colistin. Increased risk of resp paralysis w/ neuromuscular blockers (e.g. anaesthetics, muscle relaxants).
Drug Pregnancy Interaction Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Drug Breast feeding Interaction no data
Drug Machinery Interaction Counselling Eye drop/oint may cause temporary blurred vision or other visual disturbances which may affect ability to drive or operate machinery.
Drug More Information Polymyxin B binds to phospholipids, alters permeability and disrupts the bacterial cytoplasmic membrane of mostly gm-ve organisms allowing leakage of intracellular constituents by binding to membrane phospholipids. Absorption: Minimal from the GI tract except in infants (=10% of a dose). Time to peak plasma concentration: W/in 2 hr (IM). Distribution: Widely distributed; extensively bound to cell membranes in the tissues. Plasma protein binding: Low. Excretion: Via urine (approx 60% as unchanged drug). Half-life: 6 hr.;
How to take the Medicine
Consumption Info Polymyxin B is an antibiotic primarily used for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa.
Drug quanitty Intramuscular Susceptible infections Adult: 25,000-30,000 U/kg daily in divided doses 4-6 hrly. Max: 2,000,000 U/day. Child: <2 yr 40,000 U/kg daily in divided doses 6 hrly (not routinely recommended due to pain at injection sites); =2 yr Same as adult dose but not routinely recommended due to pain at injection sites. Renal impairment: Reduce dose. Max: 15,000 U/kg/day. Reconstitution: Dissolve 500,000 U in 2 mL sterile water for inj or NaCl 0.9% inj or 1% procaine HCl inj. Incompatibility: Cloxacillin. Intravenous Susceptible infections Adult: 15,000-25,000 U/kg daily by continuous IV drip or intermittent infusion 12 hrly at 60-120 min duration. Max: 2,000,000 U/day. Child: <2 yr 40,000 U/kg daily in divided doses 12 hrly; =2 yr Same as adult dose. Renal impairment: Reduce dose. Max: 15,000 U/kg/day. Reconstitution: Dissolve 500,000 U in 300-500 mL of D5W for continuous IV drip, or intermittent infusion. Incompatibility: Cloxacillin.
Drug Dose parenteral route i.m or i.v
Excess Drug Consumption no data
Forgot Drug Consumption no data
Stop Drug Consumption no data
Possible Side Effects
General Information Facial flushing, fever, rash, pruritus, urticaria, skin exanthema, eosinophilia, dizziness, ataxia; severe pain at inj sites (IM), thrombophlebitis (IV) at inj sites. Ophth: ocular discomfort, keratitis, eye irritation. Potentially Fatal: Nephrotoxicity, neurotoxicity (higher doses or in patients w/ renal impairment); resp paralysis, anaphylaxis, Clostridium difficile-associated diarrhoea and pseudomembranous colitis.
Common Drug Side Effects Nephrotoxicity, neurotoxicity (higher doses or in patients w/ renal impairment); resp paralysis, anaphylaxis, Clostridium difficile-associated diarrhoea and pseudomembranous colitis.
Rare Drug Side Effects no data
Very Rare Drug Side Effects no data
Drug Side Effects Symptoms no data
How to Store the Medicine
How to Store the Medicine Intramuscular: Store between 20-25°C. Protect from light. Reconstituted soln: Store between 2-8°C, stable for 72 hr. Do not store in alkaline soln. Intrathecal: Store between 20-25°C. Protect from light. Reconstituted soln: Store between 2-8°C, stable for 72 hr. Do not store in alkaline soln. Intravenous: Store between 20-25°C. Protect from light. Reconstituted soln: Store between 2-8°C, stable for 72 hr. Do not store in alkaline soln.

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