POLYCAP CAPSULE

Manufacturer : CAD-CADILA PHARMACEUTICALS LTD
Composition : SIMVASTATIN-20MG+RAMIPRIL-5MG+ATENOLOL-50MG+ASPIRIN-100MG+HYDROCHLOROTHIAZIDE-12.5MG
Dose Form : CAPSULE
Description : POLYCAP CAP
Route Of Administration : ORAL
Pack : 10
In stock
SKU
POL0082
₹324.00
Manufacturer : CAD-CADILA PHARMACEUTICALS LTD
Composition : SIMVASTATIN-20MG+RAMIPRIL-5MG+ATENOLOL-50MG+ASPIRIN-100MG+HYDROCHLOROTHIAZIDE-12.5MG
Dose Form : CAPSULE
Description : POLYCAP CAP
Route Of Administration : ORAL
Pack : 10

Drug Ingredient Information

SIMVASTATIN-20MG+RAMIPRIL-5MG+ATENOLOL-50MG+ASPIRIN-100MG+HYDROCHLOROTHIAZIDE-12.5MG

SIMVASTATIN

Information for patients
Drug Information SIMVASTATIN is a medicine used to lower levels of total cholesterol, “bad” cholesterol (LDL cholesterol), and fatty substances called triglycerides in the blood. In addition, SIMVASTATIN raises levels of “good” cholesterol (HDL cholesterol). You should stay on a cholesterol-lowering diet while taking this medicine. SIMVASTATIN is a member of the class of drugs called statins. SIMVASTATIN is used along with diet if you have: •a raised cholesterol level in your blood (primary hypercholesterolaemia) or elevated fat levels in your blood (mixed hyperlipidaemia) •a hereditary illness (homozygous familial hypercholesterolaemia) that increases the cholesterol level in your blood. You may also receive other treatments. •coronary heart disease (CHD) or are at high risk of CHD (because you have diabetes, history of stroke, or other blood vessel disease). SIMVASTATIN may prolong your life by reducing the risk of heart disease problems, regardless of the amount of cholesterol in your blood. In most people, there are no immediate symptoms of high cholesterol. Your doctor can measure your cholesterol with a simple blood test. Visit your doctor regularly, keep track of your cholesterol, and discuss your goals with your doctor
Drug Alert
Alert •if you are allergic (hypersensitive) to simvastatin or any of the other ingredients of SIMVASTATIN Tablets. •if you currently have liver problems •if you are pregnant or breast-feeding •if you are taking one or more of the following drugs at the same time oitraconazole, ketoconazole, or posaconazole (medicines for fungal infections) oerythromycin, clarithromycin, or telithromycin (antibiotics for infections) oHIV protease inhibitors such as indinavir, nelfinavir, ritonavir, and saquinavir (HIV protease inhibitors are used for HIV infections) onefazodone (a medicine for depression).
Before Consuming the Medicine
Avoid Drug •if you are allergic (hypersensitive) to simvastatin or any of the other ingredients of SIMVASTATIN Tablets. •if you currently have liver problems •if you are pregnant or breast-feeding •if you are taking one or more of the following drugs at the same time oitraconazole, ketoconazole, or posaconazole (medicines for fungal infections) oerythromycin, clarithromycin, or telithromycin (antibiotics for infections) oHIV protease inhibitors such as indinavir, nelfinavir, ritonavir, and saquinavir (HIV protease inhibitors are used for HIV infections) onefazodone (a medicine for depression).
Drug Special Care •Tell your doctor about all your medical conditions including allergies. •Tell your doctor if you drink large amounts of alcohol. •Tell your doctor if you have ever had liver disease. SIMVASTATIN may not be right for you. •Tell your doctor if you are due to have an operation. You may need to stop taking SIMVASTATIN tablets for a short time. •Your doctor should do a blood test before you start taking SIMVASTATIN. This is to check how well your liver is working. •Your doctor may also want you to have blood tests to check how well your liver is working after you start taking SIMVASTATIN. •Tell your doctor if you have severe lung disease. Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness. This is because on rare occasions, muscle problems can be serious, including muscle breakdown resulting in kidney damage; and very rare deaths have occurred. The risk of muscle breakdown is greater at higher doses of SIMVASTATIN and is greater in certain patients. Talk with your doctor if any of the following applies: •you consume large amounts of alcohol •you have kidney problems •you have thyroid problems •you are 65 years or older •you are female •you have ever had muscle problems during treatment with cholesterol-lowering medicines called “statins” or fibrates •you or a close family member have a hereditary muscle disorder
Drug Drug Interactions It is particularly important to tell your doctor if you are taking any of the following drugs. Taking SIMVASTATIN with any of these drugs can increase the risk of muscle problems (some of these have already been listed in the above section “Do not take SIMVASTATIN”). •ciclosporin (a medicine often used in organ transplant patients) •danazol (a man-made hormone used to treat endometriosis) •medicines like itraconazole, ketoconazole, floconazole, or posaconazole (medicines for fungal infections) •fibrates like gemfibrozil and bezafibrate (medicines for lowering cholesterol) •erythromycin, clarithromycin, telithromycin, or fusidic acid (medicines for bacterial infections) •HIV protease inhibitors such as indinavir, nelfinavir, ritonavir, and saquinavir (medicines for AIDS) •nefazodone (a medicine for depression) •amiodarone (a medicine for an irregular heartbeat) •verapamil, diltiazem or amlodipine (medicines for high blood pressure, chest pain associated with heart disease, or other heart conditions) •colchicine (a medicine used to treat gout). As well as the medicines listed above, tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including those obtained without a prescription. In particular, tell your doctor if you are taking any of the following: •medicines to prevent blood clots, such as warfarin, phenprocoumon or acenocoumarol (anticoagulants) •fenofibrate (another medicine for lowering cholesterol) •niacin (another medicine for lowering cholesterol) •rifamapicin (a medicine used to treat tuberculosis). Also tell your doctor if you are taking niacin (nicotinic acid) or a niacin-containing product and are Chinese.
Drug Pregnancy Interaction Do not take SIMVASTATIN if you are pregnant, trying to get pregnant or think you may be pregnant. If you get pregnant while taking SIMVASTATIN, stop taking it immediately and contact your doctor. Do not take SIMVASTATIN if you are breast-feeding, because it is not known if the medicine is passed into breast milk. Ask your doctor or pharmacist for advice before taking any medicine
Drug Breast feeding Interaction Do not take SIMVASTATIN if you are pregnant, trying to get pregnant or think you may be pregnant. If you get pregnant while taking SIMVASTATIN, stop taking it immediately and contact your doctor. Do not take SIMVASTATIN if you are breast-feeding, because it is not known if the medicine is passed into breast milk. Ask your doctor or pharmacist for advice before taking any medicine
Drug Machinery Interaction SIMVASTATIN is not expected to interfere with your ability to drive or to use machinery. However, it should be taken into account that some people get dizzy after taking SIMVASTATIN
Drug More Information Grapefruit juice contains one or more components that alter how the body uses some medicinal products, including SIMVASTATIN. Consuming grapefruit juice should be avoided Safety and effectiveness have been studied in 10-17 year old boys and in girls who had started their menstrual period at least one year before (see HOW TO TAKE SIMVASTATIN). SIMVASTATIN has not been studied in children under the age of 10 years. For more information, talk to your doctor
How to take the Medicine
Consumption Info SIMVASTATIN tablets contain a sugar called lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product
Drug quanitty The dose is 1 SIMVASTATIN tablet by mouth once a day. For children (10-17 years old), the recommended usual starting dose is 10 mg a day in the evening. The maximum recommended dose is 40 mg a day. The 80 mg dose is only recommended for adult patients with very high cholesterol levels and at high risk of heart disease problems who have not reached their cholesterol goal on lower doses
Drug Dose Always take SIMVASTATIN exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. You should stay on a cholesterol-lowering diet while taking SIMVASTATIN Your doctor will determine the appropriate tablet strength for you, depending on your condition, your current treatment and your personal risk status. Take SIMVASTATIN in the evening. You can take it with or without food. The usual starting dose is 10, 20 or, in some cases, 40 mg a day. Your doctor may adjust your dose after at least 4 weeks to a maximum of 80 mg a day. Do not take more than 80 mg a day. Your doctor may prescribe lower doses, particularly if you are taking certain medicinal products listed above or have certain kidney conditions. Keep taking SIMVASTATIN unless your doctor tells you to stop. If your doctor has prescribed SIMVASTATIN along with any bile acid sequestrant (medicines for lowering cholesterol), you should take SIMVASTATIN at least 2 hours before or 4 hours after taking the bile acid sequestrant.
Excess Drug Consumption •please contact your doctor or pharmacist
Forgot Drug Consumption •do not take an extra dose, just take your normal amount of SIMVASTATIN at the usual time the next day.
Stop Drug Consumption •your cholesterol may rise again. If you have any further questions on the use of this product, ask your doctor or pharmacist.
Possible Side Effects
General Information •muscle pain, tenderness, weakness, or cramps. On rare occasions, these muscle problems can be serious, including muscle breakdown resulting in kidney damage; and very rare deaths have occurred. •hypersensitivity (allergic) reactions including: •swelling of the face, tongue and throat which may cause difficulty in breathing •severe muscle pain usually in the shoulders and hips •rash with weakness of limbs and neck muscles •pain or inflammation of the joints •inflammation of the blood vessels •unusual bruising, skin eruptions and swelling, hives, skin sensitivity to the sun, fever, flushing •shortness of breath and feeling unwell •lupus-like disease picture (including rash, joint disorders, and effects on blood cells) •inflammation of the liver with yellowing of the skin and eyes, itching, dark-coloured urine or pale-coloured stool, liver failure (very rare) •inflammation of the pancreas often with severe abdominal pain. The following side effects have also been reported rarely: •low red blood cell count (anaemia) •numbness or weakness of the arms and legs •headache, tingling sensation, dizziness •digestive disturbances (abdominal pain, constipation, flatulence, indigestion, diarrhoea,nausea, vomiting) •rash, itching, hair loss •weakness •trouble sleeping (very rare) •poor memory (very rare). The following side effects have also been reported but the frequency cannot be estimated from the available information (frequency not known): •erectile dysfunction •depression •inflammation of the lungs causing breathing problems including persistent cough and/or shortness of breath or fever. Additional possible side effects reported with some statins: • sleep disturbances, including nightmares • memory loss • sexual difficulties
Common Drug Side Effects no data available
Rare Drug Side Effects no data available
Very Rare Drug Side Effects no data available
Drug Side Effects Symptoms Elevations in some laboratory blood tests of liver function and a muscle enzyme (creatine kinase) have been observed. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist
How to Store the Medicine
How to Store the Medicine Keep out of the reach and sight of children. Do not use SIMVASTATIN after the expiry date which is stated on the container. Do not store above 25oC. Keep the blister in outer carton in order to protect from moisture. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

RAMIPRIL

Information for patients
Drug Information Ramipril is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Ramipril is also used to improve survival after a heart attack. It may also be used in high risk patients (such as patients with heart disease/diabetes) to help prevent heart attacks and strokes. Ramipril is an ACE inhibitor and works by relaxing blood vessels so that blood can flow more easily. This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. This medication may also be used to treat heart failure or to help protect the kidneys from harm due to diabetes.
Drug Alert
Alert This drug can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. Therefore, it is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication. If you are planning pregnancy, become pregnant, or think you may be pregnant, contact your doctor immediately.
Before Consuming the Medicine
Avoid Drug Before taking ramipril, tell your doctor or pharmacist if you are allergic to it; or to other ACE inhibitors (such as benazepril); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Drug Special Care Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of an allergic reaction which included swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (such as LDL apheresis, dialysis), high level of potassium in the blood, collagen vascular disease (such as lupus, scleroderma). This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Too much sweating, diarrhea, or vomiting may cause loss of too much body water (dehydration) and increase your risk of lightheadedness. Report prolonged diarrhea or vomiting to your doctor. Be sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). This product may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist. Older adults may be more sensitive to the effects of this product, especially dizziness.
Drug Drug Interactions Before taking ramipril, tell your doctor if you are taking any of the following drugs: a diuretic (water pill); gold injections to treat arthritis; lithium (Lithobid, Eskalith); a potassium supplement such as K-Dur, Klor-Con; salt substitutes that contain potassium; or aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), naproxen (Aleve, Naprosyn), and others. This list is not complete and there may be other drugs that can interact with ramipril. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Drug Pregnancy Interaction This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details.
Drug Breast feeding Interaction It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.
Drug Machinery Interaction
Drug More Information
How to take the Medicine
Consumption Info Avoid drinking alcohol. It can further lower your blood pressure and may increase some of the side effects of ramipril. Do not use salt substitutes or potassium supplements while taking ramipril, unless your doctor has told you to. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Drug quanitty
Drug Dose Take this medication by mouth with or without food as directed by your doctor, usually once or twice daily. If you are taking the capsule form of ramipril, swallow it whole. If you have difficulty swallowing the capsule, the capsule may be opened and the contents sprinkled onto cool applesauce (about 4 ounces) or mixed in half a glass of water or apple juice (4 ounces/120 milliliters). Swallow or drink the whole mixture. The dosage is based on your medical condition and response to treatment. Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time(s) each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. For the treatment of high blood pressure, it may take several weeks before you get the full benefit of this medication. Tell your doctor if your condition does not improve or if it worsens (such as your blood pressure readings remain high or increase).
Excess Drug Consumption Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include feeling extremely dizzy or light-headed, or fainting.
Forgot Drug Consumption If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Stop Drug Consumption
Possible Side Effects
General Information Dizziness, lightheadedness, or tiredness may occur as your body adjusts to the medication. Dry cough may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Common Drug Side Effects fainting, muscle weakness, signs of infection (such as fever, chills, persistent sore throat), change in the amount of urine.
Rare Drug Side Effects serious (possibly fatal) liver problems yellowing eyes/skin, dark urine, severe stomach/abdominal pain, persistent nausea/vomiting.
Very Rare Drug Side Effects
Drug Side Effects Symptoms rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
How to Store the Medicine
How to Store the Medicine Store at room temperature away from light and moisture. If you are taking the capsule form of ramipril and have opened the capsule and mixed the contents with food or liquid, then the mixture can be kept at room temperature for up to 24 hours or refrigerated for up to 48 hours. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

ATENOLOL

Information for patients
Drug Information Atenolol contains a medicine called atenolol. This belongs to a group of medicines called beta blockers. Atenolol is used to: •Treat high blood pressure (hypertension). •Treat uneven heart beats (arrhythmias). •Help prevent chest pain (angina). •Protect the heart in the early treatment after a heart attack (myocardial infarction). It works by making your heart beat more slowly and with less force.
Drug Alert
Alert Do not take Atenolol if: •You are allergic (hypersensitive) to atenolol. •You have ever had any of the following heart problems: -heart failure which is not under control (this usually makes you breathless and causes your ankles to swell) - second- or third-degree heart block (a condition which may be treated by a pacemaker) - very slow or very uneven heart beats, very low blood pressure or very poor circulation. • You have a tumour called phaeochromocytoma that is not being treated. This is usually near your kidney and can cause high blood pressure. If you are being treated for phaeochromocytoma, your doctor will give you another medicine, called an alpha-blocker, to take as well as your Atenolol. •You have been told that you have higher than normal levels of acid in your blood (metabolic acidosis). Do not take Atenolol if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before taking Atenolol.
Before Consuming the Medicine
Avoid Drug Do not take Atenolol if: •You are allergic (hypersensitive) to atenolol. •You have ever had any of the following heart problems: -heart failure which is not under control (this usually makes you breathless and causes your ankles to swell) - second- or third-degree heart block (a condition which may be treated by a pacemaker) - very slow or very uneven heart beats, very low blood pressure or very poor circulation. • You have a tumour called phaeochromocytoma that is not being treated. This is usually near your kidney and can cause high blood pressure. If you are being treated for phaeochromocytoma, your doctor will give you another medicine, called an alpha-blocker, to take as well as your Atenolol. •You have been told that you have higher than normal levels of acid in your blood (metabolic acidosis). Do not take Atenolol if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before taking Atenolol.
Drug Special Care Check with your doctor or pharmacist before taking Atenolol if: •You have asthma, wheezing or any other similar breathing problems, or you get allergic reactions, for example to insect stings. If you have ever had asthma or wheezing, do not take this medicine without first checking with your doctor. •You have a type of chest pain (angina) called Prinzmetal’s angina. •You have poor blood circulation or controlled heart failure. •You have first-degree heart block. •You have diabetes. Your medicine may change how you respond to having low blood sugar. You may feel your heart beating faster. •You have thyrotoxicosis (a condition caused by an overactive thyroid gland). Your medicine may hide the symptoms of thyrotoxicosis. •You have problems with your kidneys. You may need to have some check-ups during your treatment. If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Atenolol.
Drug Drug Interactions Please tell your doctor or pharmacist if you are taking, or have recently taken, any other medicines. This includes medicines that you buy without a prescription and herbal medicines. This is because Atenolol can affect the way some other medicines work and some medicines can have an effect on Atenolol. In particular, tell your doctor if you are taking any of the following medicines: •Clonidine (for high blood pressure or migraine). If you are taking clonidine and Atenolol together, do not stop taking clonidine unless your doctor tells you to do so. If you have to stop taking clonidine, your doctor will give you careful instructions about how to do it. •Verapamil, diltiazem and nifedipine (for high blood pressure or chest pain). •Disopyramide, quinidine or amiodarone (for an uneven heart beat). •Digoxin (for heart problems). •Adrenaline, also known as epinephrine (a medicine that stimulates the heart). •Ibuprofen or indometacin (for pain and inflammation). •Insulin or medicines that you take by mouth for diabetes. •Medicines to treat nose or sinus congestion or other cold remedies (including those you can buy in the pharmacy). Operations If you go into hospital to have an operation, tell the anaesthetist or medical staff that you are taking Atenolol. This is because you can get low blood pressure (hypotension) if you are given certain anaesthetics while you are taking Atenolol.
Drug Pregnancy Interaction Talk to your doctor before taking Atenolol if you are pregnant, may become pregnant or are breast-feeding.
Drug Breast feeding Interaction Talk to your doctor before taking Atenolol if you are pregnant, may become pregnant or are breast-feeding.
Drug Machinery Interaction •Your medicine is not likely to affect you being able to drive or use any tools or machines. However, it is best to wait to see how your medicine affects you before trying these activities. •If you feel dizzy or tired when taking this medicine, do not drive or use any tools or machines. Important information about some of the ingredients of Atenolol
Drug More Information no data available
How to take the Medicine
Consumption Info no data available
Drug quanitty Adults •High blood pressure (hypertension): the usual dose is 50 mg to 100 mg (two to four 5 ml spoonfuls) a day. •Chest pain (angina): the usual dose is 100 mg (four 5 ml spoonfuls) a day or 50 mg (two 5 ml spoonfuls) twice a day. •Uneven heart beats (arrhythmias): the usual dose is 50 mg to 100 mg (two to four 5 ml spoonfuls) a day. •The early treatment of a heart attack (myocardial infarction): the usual dose is 50 mg to 100 mg (two to four 5 ml spoonfuls) a day. Elderly people If you are an elderly person, your doctor may decide to give you a lower dose, particularly if you have problems with your kidneys. People with kidney problems If you have severe kidney problems your doctor may decide to give you a lower dose. Children Your medicine must not be given to children.
Drug Dose Always take Atenolol exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. •Your doctor will tell you how much to take each day and when to take it. Read the label on the container to remind you what the doctor said. •Atenolol should be swallowed. •Try to take your medicine at the same time each day
Excess Drug Consumption If you take more Atenolol than prescribed by your doctor, talk to a doctor or go to a hospital straight away. Take along any left over , as well as the container and label, so that the can be identified.
Forgot Drug Consumption If you forget to take a dose, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose. Do not take a double dose to make up for a forgotten dose.
Stop Drug Consumption Do not stop taking Atenolol without talking to your doctor. In some cases, you may need to stop taking it gradually
Possible Side Effects
General Information If you have an allergic reaction, see a doctor straight away. The signs may include raised lumps on your skin (weals) or swelling of your face, lips, mouth, tongue or throat.
Common Drug Side Effects •You may notice that your pulse rate becomes slower while you are taking Atenolol. This is normal, but if you are concerned please tell your doctor about it. •Cold hands and feet. •Diarrhoea. •Feeling sick (nausea). •Feeling tired.
Rare Drug Side Effects •Heart block (which may cause an abnormal heart beat, dizziness, tiredness or fainting). •Numbness and spasm in your fingers which is followed by warmth and pain (Raynaud’s disease). •Mood changes. •Nightmares. •Feeling confused. •Changes in personality (psychoses). •Hallucinations. •Headache. •Dizziness, particularly when standing up. •Tingling of your hands. •Being unable to get an erection (impotence). •Dry mouth. •Dry eyes. •Disturbances of vision. •Thinning of your hair. •Skin rash. •Reduced numbers of platelets in your blood (this may make you bruise more easily). •Purplish marks on your skin. •Jaundice (causing yellowing of your skin or the whites of your eyes).
Very Rare Drug Side Effects •Changes to some of the cells or other parts of your blood. Your doctor may take blood samples every so often to check whether Atenolol has had any effect on your blood. Conditions that may get worse If you have any of the following conditions, they may get worse when you start to take your medicine: •Psoriasis (a skin condition). •Being short of breath or having swollen ankles (if you have heart failure). •Asthma or breathing problems. •Poor circulation. Do not be concerned by this list of side effects. You may not get any of them. If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
Drug Side Effects Symptoms •Disturbed sleep.
How to Store the Medicine
How to Store the Medicine •Keep your medicine in a safe place where children cannot see or reach it. Your medicine could harm them. •Do not store above 25oC. Store in the original container. •Do not use your medicine after the expiry date which is stated on the label. The expiry date refers to the last day of that month. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines that are no longer required. These measures will help to protect the environment.

ASPIRIN

Information for patients
Drug Information Aspirin belong to a group of medicines which have analgesic (pain relieving), anti-inflammatory (inflammation reducing) and antipyretic (temperature reducing) properties. These may be used for the relief of: •headache, toothache, migraine, neuralgia (nerve pain), sore throat or period pains. •symptoms of influenza, feverishness, rheumatic pains, sciatica (nerve pain of the leg/back), lumbago (lower back pain), fibrositis (muscular rheumatism), muscular aches and pains. The may also be used to prevent blood clots especially after a heart attack or in patients with unstable angina or reduced blood flow in the brain.
Drug Alert
Alert Do not take Aspirin and tell your doctor if you have: •an allergy (hypersensitivity) to aspirin, salicylates or non-steroidal anti-inflammatory drugs (NSAIDs) or other ingredients in the product. You may have developed difficulty breathing, a runny nose, itchy skin or swelling after taking aspirin or a NSAID previously •a stomach ulcer or a history of ulcers or indigestion •nasal polyps associated with asthma •haemophilia or other blood clotting disorder or are taking medicines to thin the blood •severe liver, kidney or heart failure •are in the third trimester of pregnacy •the patient is a child under 16 years old.
Before Consuming the Medicine
Avoid Drug Do not take Aspirin and tell your doctor if you have: •an allergy (hypersensitivity) to aspirin, salicylates or non-steroidal anti-inflammatory drugs (NSAIDs) or other ingredients in the product. You may have developed difficulty breathing, a runny nose, itchy skin or swelling after taking aspirin or a NSAID previously •a stomach ulcer or a history of ulcers or indigestion •nasal polyps associated with asthma •haemophilia or other blood clotting disorder or are taking medicines to thin the blood •severe liver, kidney or heart failure •are in the third trimester of pregnacy •the patient is a child under 16 years old.
Drug Special Care •asthma or allergies •heart, liver or kidney problems or gout •an overactive thyroid gland •dehydration •anaemia or suffer from a deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD) this can cause episodes of anaemia after eating certain foods such as fava beans (favism) •systemic lupus erythematosus (SLE) or other connective tissue disease •elderly •had any disorders affecting blood vessels in the brain •received a varicella (chickenpox) vaccination within the last 6 weeks •planning to become pregnant.
Drug Drug Interactions Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Especially: •medicines to prevent blood clotting such as warfarin, dipyridamole and heparin •metoclopramide or domperidone (to prevent sickness) •diuretics (“water ”) e.g. spironolactone, frusemide, acetazolamide (to treat high blood pressure) •medicines which make your urine more alkaline such as antacids, citrates •probenecid, sulphinpyrazone (to treat gout) •methotrexate (to treat some cancers, psoriasis and rheumatic disease) •antidiabetics •phenytoin or sodium valproate (to treat epilepsy) •corticosteroids (to suppress the immune system) •mifepristone (to induce abortion) •other non-steroidal anti-inflammatory drugs - NSAIDs (eg ibuprofen or naproxen) •medicines which can cause hearing problems (vancomycin) •medicines to treat high blood pressure (ACE inhibitors, Calcium channel blockers) •medicines to treat depression (SSRIs) •varicella (chickenpox) vaccine. Aspirin should be avoid for 6 weeks after vaccination •herbal medicines containing ginkgo biloba
Drug Pregnancy Interaction Avoid taking Aspirin during pregnancy especially in the last 3 months of pregnancy or whilst breast-feeding. Ask your doctor or pharmacist for advice before taking this medicine.
Drug Breast feeding Interaction Avoid taking Aspirin during pregnancy especially in the last 3 months of pregnancy or whilst breast-feeding. Ask your doctor or pharmacist for advice before taking this medicine.
Drug Machinery Interaction
Drug More Information There is a possible association between aspirin and Reye’s Syndrome when given to children. Reye’s syndrome is a very rare disease, which can be fatal. For this reason aspirin should not be given to children aged under 16 years, unless on the advice of a doctor.
How to take the Medicine
Consumption Info If you need to have an operation including having your teeth removed or blood and urine tests, tell your doctor or dentist you are taking this medicine.
Drug quanitty Adults, including the elderly: 1 or 2 every 3 to 4 hours as required. No more than 12 in any 24 hour period. Children under 16 years old: Not recommended. For prevention of blood clots: 1 once a day
Drug Dose Always take Aspirin exactly as your doctor has told you. If you are not sure, check with your doctor or pharmacist. Avoid alcohol whilst taking this medicine. Swallow the with a glass of water.
Excess Drug Consumption If you (or someone else) swallow a lot of at the same time, or you think a child may have swallowed any contact your nearest hospital casualty department or tell your doctor immediately. Symptoms of an overdose include ringing in the ears, spinning sensation, fast breathing rate, changes in some of the chemicals in the body, heart or kidney failure, fever or coma.
Forgot Drug Consumption Do not take a double dose to make up for a forgotten dose. If you forget to take a dose take it as soon as you remember it and then take the next dose at the right time. Do not take more than one dose in any 4 hour period.
Stop Drug Consumption
Possible Side Effects
General Information
Common Drug Side Effects Allergic reactions - runny nose, itchy, red, blotchy, blistered skin, swelling of the face, lips, throat or tongue, difficulty breathing, worsening of asthma. Gastrointestinal system - stomach ulcers or bleeding which can be severe (you may develop bloody or black tarry stools, severe stomach pain and vomit blood), stomach irritation (mild stomach pain, heartburn and feeling or being sick) and inflammation of the liver. Deaths have occurred. Blood - anaemia, changes in numbers and types of blood cells and enzymes seen in blood tests. If you have an increase in number of nose bleeds, longer bleeding time or notice that you bruise more easily or have more infections talk to your doctor. Kidney - changes in the amount or need to urinate. Ears - ringing or buzzing in the ear. Salicylism - if you take large doses for a long time you may develop symptoms of salicylism, these include: dizziness, ringing or buzzing in the ear, deafness, sweating, feeling or being sick, headache and confusion.
Rare Drug Side Effects
Very Rare Drug Side Effects
Drug Side Effects Symptoms
How to Store the Medicine
How to Store the Medicine Keep out of the reach and sight of children. Store the below 25°C in a dry place. Do not use Aspirin after the expiry date stated on the label/carton/bottle. The expiry date refers to the last day of that month. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

HYDROCHLOROTHIAZIDE

Information for patients
Drug Information Hydrochlorothiazide, a 'water pill,' is used to treat high blood pressure and fluid retention caused by various conditions, including heart disease. It causes the kidneys to get rid of unneeded water and salt from the body into the urine. This medicine is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.Hydrochlorothiazide may also be used to treat patients with diabetes insipidus and certain electrolyte disturbances and to prevent kidney stones in patients with high levels of calcium in their blood. Talk to your doctor about the possible risks of using this medicine for your condition.
Drug Alert
Alert You should not use this medication if you are allergic to hydrochlorothiazide or if you are unable to urinate. Before using hydrochlorothiazide, tell your doctor if you have liver disease, kidney disease, glaucoma, asthma or allergies, gout, diabetes, or if you are allergic to sulfa drugs or penicillin. Avoid drinking alcohol, which can increase some of the side effects of hydrochlorothiazide. Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough. There are many other drugs that can interact with hydrochlorothiazide. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you. If you are being treated for high blood pressure, keep using hydrochlorothiazide even if you feel fine. High blood pressure often has no symptoms.
Before Consuming the Medicine
Avoid Drug You should not use this medication if you are allergic to hydrochlorothiazide, or if you are unable to urinate. To make sure you can safely take hydrochlorothiazide, tell your doctor if you have any of these other conditions: kidney disease; liver disease; glaucoma; asthma or allergies; gout; diabetes; or an allergy to sulfa drugs. FDA pregnancy category B. Hydrochlorothiazide is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Hydrochlorothiazide can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Drug Special Care tell your doctor and pharmacist if you are allergic to hydrochlorothiazide, sulfa drugs, or any other drugs. tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially other medicines for high blood pressure, anti-inflammatory medications such as ibuprofen (Motrin, Nuprin) or naproxen (Aleve), corticosteroids (e.g., prednisone), lithium (Eskalith, Lithobid), medications for diabetes, probenecid (Benemid), and vitamins. If you also are taking cholestyramine or colestipol, take it at least 1 hour after hydrochlorothiazide. tell your doctor if you have or have ever had diabetes, gout, or kidney, liver, thyroid, or parathyroid disease. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking hydrochlorothiazide, call your doctor immediately. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking hydrochlorothiazide. you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you. remember that alcohol can add to the drowsiness caused by this drug. plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Hydrochlorothiazide may make your skin sensitive to sunlight.
Drug Drug Interactions lithium (Eskalith, Lithobid); digoxin (Lanoxin); cholestyramine (Prevalite, Questran) or colestipol (Colestid); steroids (prednisone and others); other blood pressure medications; NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others; or insulin or oral diabetes medication.
Drug Pregnancy Interaction
Drug Breast feeding Interaction
Drug Machinery Interaction
Drug More Information Follow your doctor's directions. They may include following a daily exercise program or a low-salt or low-sodium diet, potassium supplements, and increased amounts of potassium-rich foods (e.g., bananas, prunes, raisins, and orange juice) in your diet.
How to take the Medicine
Consumption Info Drinking alcohol can increase certain side effects of hydrochlorothiazide. Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Drug quanitty Usual Adult Hydrochlorothiazide Dose for Edema: 25 to 100 mg orally as a single or divided dose. Usual Adult Dose for Hypertension: Initial dose: 25 mg orally once a day. Maintenance dose: May increase to 50 mg orally as a single or 2 divided doses. Usual Adult Hydrochlorothiazide Dose for Nephrocalcinosis: Initial: 25 mg orally once a day Maintenance dose: May increase to 50 mg twice a day Usual Adult Dose for Osteoporosis: Initial: 25 mg orally once a day Maintenance dose: May increase to 50 mg per day Usual Adult Hydrochlorothiazide Dose for Diabetes Insipidus: Initial: 50 mg orally once a day Maintenance dose: May increase to 100 mg per day
Drug Dose Hydrochlorothiazide comes as a tablet and liquid to take by mouth. It usually is taken once or twice a day. If you are to take it once a day, take it in the morning; if you are to take it twice a day, take it in the morning and in the late afternoon to avoid going to the bathroom during the night. Take this medication with a meal or snack. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take hydrochlorothiazide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Hydrochlorothiazide controls high blood pressure but does not cure it. Continue to take hydrochlorothiazide even if you feel well. Do not stop taking hydrochlorothiazide without talking to your doctor.
Excess Drug Consumption Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Forgot Drug Consumption Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Stop Drug Consumption
Possible Side Effects
General Information sore throat with fever unusual bleeding or bruising severe skin rash with peeling skin difficulty breathing or swallowing
Common Drug Side Effects muscle weakness dizziness cramps thirst stomach pain nausea vomiting diarrhea loss of appetite headache hair loss
Rare Drug Side Effects
Very Rare Drug Side Effects
Drug Side Effects Symptoms
How to Store the Medicine
How to Store the Medicine Keep this medicine in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not allow the liquid to freeze. Throw away any medicine that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medicine.

Substitute Drugs

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