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Composition : ETOPOSIDE-20MG/5ML
Description : POSID INJ 100MG 5ML INJ
Route Of Administration : PARENTERAL
Pack : 1

Drug Ingredient Information



Information for patients
Drug Information The name of your medicine is Etoposide . Etoposide contains the active ingredient etoposide phosphate. Etoposide phosphate belongs to a group of medicines called anti-cancer agents which are used in the treatment of cancer.Etoposide is used to treat certain types of cancer, in particular small cell lung cancer and testicular cancer.
Drug Alert
Alert -are allergic (hypersensitive) to etoposide , etoposide phosphate or any other ingredients of Etoposide -have severe liver problems
Before Consuming the Medicine
Avoid Drug -are allergic (hypersensitive) to etoposide , etoposide phosphate or any other ingredients of Etoposide -have severe liver problems
Drug Special Care -have any infection
Drug Drug Interactions Always tell your doctor or pharmacist about other medicines you may be taking or have recently taken including those obtained without a prescription.This is especially important if you are taking a medicine called: -ciclosporin used following organ transplant -cisplatin used to treat certain forms of cancer or if you are taking any medicines to treat: -cancer -immune diseases
Drug Pregnancy Interaction Do not receive Etoposide if you are pregnant, think you may be pregnant, or if you are breast-feeding.
Drug Breast feeding Interaction Do not receive Etoposide if you are pregnant, think you may be pregnant, or if you are breast-feeding
Drug Machinery Interaction You can drive and operate machinery while receiving Etoposide , but do not do so if you feel dizzy or light-headed
Drug More Information Effective anti-cancer treatment can destroy cancer cells rapidly in large numbers. On very rare occasions this may cause harmful amounts of substances from these cancer cells to be released into the blood. If this happens it can cause problems with the liver, kidney, heart or blood, which may result in death if not treated. In order to prevent this, your doctor will need to do regular blood tests to monitor the level of these substances during treatment with this medicine
How to take the Medicine
Consumption Info Etoposide will be given to you by a doctor or nurse. It may be given as a slow infusion into a vein from an intravenous drip. This may take up to 3½ hours.The dose you receive will be based on your body surface area and worked out by your doctor.Etoposide is usually given once daily for five consecutive days. This will be repeated every 3 weeks. This may vary depending on the results of regular blood tests.
Drug quanitty Immediately prior to administration, the content of each vial must be reconstituted with either 5 ml or 10 ml Water for Injection B.P., 5% Glucose Intravenous Infusion B.P. or 0.9% Sodium Chloride Intravenous Infusion BP to a concentration equivalent to 20 mg/ml or 10 mg/ml etoposide (22.7 mg/ml or 11.4 mg/ml etoposide phosphate), respectively. This produces a clear colourless to pale yellow solution.Following reconstitution the solution may be administered without further dilution or it can be further diluted to concentrations as low as 0.1 mg/mL etoposide (0.14 mg/ml etoposide phosphate) with either 5% Glucose Intravenous Infusion BP or 0.9% Sodium Chloride Intravenous Infusion BP. Chemical and physical in-use stability has been demonstrated for 7 days at 2-8°C.From a microbiological point of view, the product should be used immediately. If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 7 days at 2-8°C, unless dilution has taken place in controlled and validated aseptic conditions. When reconstituted as directed, Etoposide solutions can be stored in glass or plastic containers under refrigeration (2-8°C) for 7 days; at controlled room temperature 20-25°C for 24 hours following reconstitution with Sterile Water for Injection, USP, 5% Dextrose Injection, USP, or 0.9% Sodium Chloride Injection, USP; or at controlled room temperature 20-25°C for 48 hours following reconstitution with Bacteriostatic Water for Injection with Benzyl Alcohol or Bacteriostatic Sodium Chloride for Injection with Benzyl Alcohol. Etoposide solutions further diluted as directed can be stored under refrigeration (2-8°C) or at controlled room temperature 20-25°C for 24 hours. Etoposide should not be physically mixed with any other drug. Guidelines for the safe handling of anti-neoplastic agents: 1.Trained personnel should reconstitute the drug. 2.This should be performed in a designated area. 3.Adequate protective gloves should be worn. 4.Precautions should be taken to avoid the drug accidentally coming into contact with the eyes. In the event of contact with the eyes, irrigate with large amounts of water and/or saline. 5.The cytotoxic preparation should not be handled by pregnant staff. 6.Adequate care and precautions should be taken in the disposal of items (syringes, needles etc) used to reconstitute cytotoxic drugs. Excess material and body waste may be disposed of by placing in double sealed polythene bags and incinerating at a temperature of 1,000°C. Liquid waste may be flushed with copious amounts of water. 7.The work surface should be covered with disposable plastic backed absorbent paper. 8.Use Luer-Lock fittings on all syringes and sets. Large bore needles are recommended to minimise pressure and the possible formation of aerosols. The latter may also be reduced by the use of a venting needle
Drug Dose no data available
Excess Drug Consumption As Etoposide is given to you by a doctor or nurse, overdose is unlikely. If this does occur, your doctor will treat any symptoms that follow
Forgot Drug Consumption Contact Your doctor
Stop Drug Consumption Do not stop the drug untill your doctor says you to do so.
Possible Side Effects
General Information -swelling of the face, lips, or tongue -skin rash -difficulty breathing
Common Drug Side Effects -feeling sick and/or being sick -loss of appetite -soreness and swelling of the mouth and tongue -weakness and generally feeling unwell -temporary hair loss -chills and/or fever
Rare Drug Side Effects -constipation -diarrhoea -abdominal pain -a change in the way things taste -dizziness -pain or swelling at the injection site;
Very Rare Drug Side Effects -high blood pressure -flushing -irregular breathing -coughing -liver or kidney problems -tiredness or sleepiness -itching, rash or colouration of the skin -difficulty in swallowing -temporary blindness -local soft tissue damage at the injection site in case of leakage into tissue
Drug Side Effects Symptoms no data available
How to Store the Medicine
How to Store the Medicine This medicine will be stored in the pharmacy and made up in a special area before the doctor or nurse gives it to you.It should be stored between 2-8°C. The vial should be kept in the outer carton. Do not use after the expiry date shown on the packaging of Etoposide Injection

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