Drug Ingredient Information
VOGLIBOSE-0.3MG+METFORMIN-500MG
VOGLIBOSE
| Information for
patients
|
| Drug Information |
Improvement of postprandial hyperglycemia in diabetes mellitus when sufficient effect has not been obtained in patients who have been using oral hypoglycemic drugs or insulin preparations, in addition to dietary treatment and/ or exercise therapy
evere ketosis or in a state of Diabetic coma or precoma, severe infections, before or after operation or with serious trauma, Hypersensitivity |
| Drug Alert |
| Alert |
Follow a routine of proper diet, regular exercise, and regular blood sugar testing given by your doctor while on Voglibose.
Voglibose may cause low blood sugar level (hypoglycemia) when used in combination with sulfonylurea drugs or insulin. If such an event occurs, your healthcare provider may need to decrease the dose of medicine that you are taking. Voglibose prevents the breakdown of table sugar. In case of low blood sugar, use glucose (dextrose), not sugar or fruits, to treat symptoms of low blood sugar.
Gas, diarrhea, upset stomach, or stomach pain may occur initially during the first few weeks of treatment with Voglibose. These will improve with time. Your doctor may prescribe special diet to help lessen these side effects. If any of these effects continue or worsen, tell your doctor or pharmacist at once.
Tell your doctor or dentist that you take Voglibose before undergoing any medical, dental or surgical care.
Lab tests, including fasting blood glucose, glycosylated hemoglobin and liver function tests may be performed to monitor whether your blood sugar is under control or for side effects. Be sure to keep all doctor and lab appointments.
Do not use Voglibose in CHILDREN.
PREGNANCY and BREAST-FEEDING: Voglibose should be used only when clearly needed during pregnancy. Do not breast-feed while taking Voglibose.
Some MEDICINES MAY INTERACT with Voglibose. The following medicines should be used with caution while taking Voglibose: Insulin or sulfonylureas (eg, glyburide) may cause low blood sugar when used with Voglibose. Digoxin’s, Propranolol’s and ranitidine’s effectiveness may be decreased by Voglibose. |
| Before Consuming
the Medicine
|
| Avoid Drug |
Inflammatory bowel disease; GI obstruction or patients predisposed to it; conditions which may deteriorate as a result of increased gas formation eg, hernia; severe ketosis; diabetic coma or pre-coma; severe infection; hypersensitivity; pregnancy; lactation. Not to be used as monotherapy in IDDM.
You are allergic to any ingredient in Voglibose Tablet.
You have an obstruction of the stomach or intestine, or you are at risk for these problems.
You have long-term (chronic) intestinal inflammation, colon ulcers, or other problems that interfere with digestion or nutrient absorption.
You are suffering from diabetic ketoacidosis or severe kidney problems. Contact your doctor immediately if any of these apply to you. |
| Drug Special Care |
History of laparotomy or ileus. Roemheld's syndrome, stenosis, severe hepatic or renal impairment. Child <18 years; elderly. Monitor LFT. Treat hypoglycaemic episodes with glucose (not with sucrose). |
| Drug Drug Interactions |
May enhance effects of other antidiabetics including insulin. |
| Drug Pregnancy Interaction |
Contraindicated in pregnancy |
| Drug Breast feeding Interaction |
Contraindicated in lactation |
| Drug Machinery Interaction |
no data available |
| Drug More Information |
Should be taken with food. (Take just before meals.) |
| How to take the
Medicine
|
| Consumption Info |
no data available |
| Drug quanitty |
Oral
Diabetes mellitus
Adult: 200-300 mcg tid.
Elderly: Initiate at lower doses. |
| Drug Dose |
Take Voglibose by mouth as soon as you have the first bite of your meal.
The dosage chosen by your doctor is based on your medical condition and response to treatment.
Adopt a routine to take Voglibose at the same time each day. This will help you remember to take it and provide you maximum benefit from the medicine.
Continue to take Voglibose even if you feel well. Do not miss any doses.
If you miss a dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.
If you take digestive enzyme preparations, do not take them within 2 to 4 hours before or after taking Voglibose. Check with your doctor to get more information. |
| Excess Drug Consumption |
Voglibose competitively and reversibly inhibits the alpha glucosidase enzymes in
the brush border in the small intestine, which delays the hydrolysis of complex
carbohydrates. It appears unlikely to produce hypoglycaemia in overdose, but
abdominal discomfort and diarrhea may occur. |
| Forgot Drug Consumption |
Contact Your doctor |
| Stop Drug Consumption |
Do not stop the drug untill your doctor says you to do so. |
| Possible Side
Effects
|
| General Information |
no data available |
| Common Drug Side Effects |
Flatulence; abdominal distension; diarrhoea; pain; skin reactions; hypoglycemia; increased LFT.Potentially Fatal: Hepatotoxicity. |
| Rare Drug Side Effects |
no data available |
| Very Rare Drug Side Effects |
no data available |
| Drug Side Effects Symptoms |
no data available |
| How to Store the
Medicine
|
| How to Store the Medicine |
Store below 30°C. |
METFORMIN
| Information for
patients
|
| Drug Information |
Metformin is used alone or with other medications, including insulin, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Metformin helps to control the amount of glucose (sugar) in your blood. It decreases the amount of glucose you absorb from your food and the amount of glucose made by your liver. Metformin also increases your body's response to insulin, a natural substance that controls the amount of glucose in the blood. Metformin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). |
| Drug Alert |
| Alert |
no data available |
| Before Consuming
the Medicine
|
| Avoid Drug |
Tell your doctor if you regularly drink alcohol or sometimes drink large amounts of alcohol in a short time (binge drinking). Drinking alcohol increases your risk of developing lactic acidosis or may cause a decrease in blood sugar. Ask your doctor how much alcohol is safe to drink while you are taking metformin. |
| Drug Special Care |
Before taking metformin,
tell your doctor and pharmacist if you are allergic to metformin or any other medications.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: amiloride (Midamor, Moduretic); antihistamines; beta-blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Lexxel, Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular), and verapamil (Calan, Isoptin, Verelan); cimetidine (Tagamet); digoxin (Lanoxin, Lanoxicaps); furosemide (Lasix); hormone replacement therapy; insulin or other medications for diabetes; isoniazid (INH, Nydrazid); medications for asthma and colds; medications for mental illness and nausea such as fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), promethazine (Phenergan), thioridazine (Mellaril), thiothixene (Navane), trifluoperazine (Stelazine), and triflupromazine (Vesprin); medications for thyroid disease; morphine (MS Contin, Roxanol, others); nicotinic acid; oral contraceptives ('birth control pills'); oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); phenytoin (Dilantin, Phenytek); procainamide (Procanbid); quinidine (Quinidex); quinine; ranitidine (Zantac); triamterene (Dyazide, Maxzide, others); or trimethoprim (Proloprim, Trimpex). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor if you have or have ever had any medical condition, especially those mentioned in the IMPORTANT WARNING section.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking metformin, call your doctor.
if you are using the extended-release tablets, you should know that sometimes the tablet shell may appear in your stool. If this occurs, it is not harmful and will not affect the way the medication works.
tell your doctor if you eat less or exercise more than usual. This can affect your blood sugar. Your doctor will give you instructions if this happens. |
| Drug Drug Interactions |
acyclovir (Zovirax); acetaminophen (Tylenol); aminoglycoside antibiotics such as amikacin (Amikin), gentamicin (Garamycin), Kanamycin (Kantrex), Neomycin (Neo-Fradin, Neo-Rx), netilmicin (Netromycin), paromomycin (Humatin), streptomycin and tobramycin (Nebcin, Tobi); amphotericin B (Abelcet, Amphocin, others); angiotensin converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinvil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); cancer chemotherapy medications; cyclosporine (Sandimmune, Neoral); dapsone (Avlosulfon); diuretics (water pills); foscarnet (Foscavir); gold compounds such as auranofin (Ridaura), aurothioglucose (Aurolate, Solganol), and gold sodium thiomalate (Myochrysine); hydralazine (Hydra-Zide); lithium (Eskalith, Lithobid); medications to treat human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS); methicillin (Staphcillin); nitrates; penicillin and sulfa antibiotics; penicillamine (Cuprimine, Depen); primaquine; propranolol (Inderal); rifampin (Rifadin, Rimactane); tacrolimus (Prograf); vancomycin (Vancocin); or if you have ever taken the Chinese weight-loss herb Aristolochia. |
| Drug Pregnancy Interaction |
no data available |
| Drug Breast feeding Interaction |
no data available |
| Drug Machinery Interaction |
no data available |
| Drug More Information |
In addition to describing the cardiovascular risks, the drug labels have been revised to state that rosiglitazone and rosiglitazone-containing medicines should only be used:
In patients already being treated with these medicines
In patients whose blood sugar cannot be controlled with other anti-diabetic medicines and who, after consulting with their healthcare professional, do not wish to use pioglitazone-containing medicines |
| How to take the
Medicine
|
| Consumption Info |
If you are having surgery, including dental surgery, any x-ray procedure in which dye is injected, or any major medical procedure, tell the doctor that you are taking metformin. You may need to stop taking metformin before the procedure and wait 48 hours to restart treatment. Your doctor will tell you exactly when you should stop taking metformin and when you should start taking it again. |
| Drug quanitty |
no data available |
| Drug Dose |
Metformin comes as a liquid, a tablet and an extended-release (long-acting) tablet to take by mouth. The liquid is usually taken with meals one or two times a day. The regular tablet is usually taken with meals two or three times a day. The extended-release tablet is usually taken once daily with the evening meal. To help you remember to take metformin, take it around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take metformin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow metformin extended-release tablets whole; do not split, chew, or crush them.
Your doctor may start you on a low dose of metformin and gradually increase your dose not more often than once every 1 to 2 weeks. You will need to monitor your blood sugar carefully so your doctor will be able to tell how well metformin is working.
Metformin controls diabetes but does not cure it. Continue to take metformin even if you feel well. Do not stop taking metformin without talking to your doctor. |
| Excess Drug Consumption |
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
extreme tiredness
weakness
discomfort
vomiting
nausea
stomach pain
decreased appetite
deep, rapid breathing
shortness of breath
dizziness
lightheadedness
abnormally fast or slow heartbeat
flushing of the skin
muscle pain
feeling cold |
| Forgot Drug Consumption |
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. |
| Stop Drug Consumption |
Do not stop the drug untill your doctor says you to do so. |
| Possible Side
Effects
|
| General Information |
extreme tiredness, weakness, or discomfort; nausea; vomiting; stomach pain; decreased appetite; deep and rapid breathing or shortness of breath; dizziness; lightheadedness; fast or slow heartbeat; flushing of the skin; muscle pain; or feeling cold. |
| Common Drug Side Effects |
Metformin may rarely cause a serious, life-threatening condition called lactic acidosis. Tell your doctor if you have or have ever had a heart attack; stroke; high blood pressure; diabetic ketoacidosis (blood sugar that is high enough to cause severe symptoms and requires emergency medical treatment) or coma; surgery to remove part of your small intestine; anemia (not enough red blood cells), or heart, kidney, lung, or liver disease. |
| Rare Drug Side Effects |
no data available |
| Very Rare Drug Side Effects |
no data available |
| Drug Side Effects Symptoms |
This medication may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.
You may experience hypoglycemia (low blood sugar) while you are taking this medication. Your doctor will tell you what you should do if you develop hypoglycemia. He or she may tell you to check your blood sugar, eat or drink a food or beverage that contains sugar, such as hard candy or fruit juice, or get medical care. Follow these directions carefully if you have any of the following symptoms of hypoglycemia:
shakiness
dizziness or lightheadedness
sweating
nervousness or irritability
sudden changes in behavior or mood
headache
numbness or tingling around the mouth
weakness
pale skin
hunger
clumsy or jerky movements
If hypoglycemia is not treated, severe symptoms may develop. Be sure that your family, friends, and other people who spend time with you know that if you have any of the following symptoms, they should get medical treatment for you immediately:
confusion
seizures
loss of consciousness
Call your doctor immediately if you have any of the following symptoms of hyperglycemia (high blood sugar):
extreme thirst
frequent urination
extreme hunger
weakness
blurred vision
If high blood sugar is not treated, a serious, life-threatening condition called diabetic ketoacidosis could develop. Call your doctor immediately if you have any of these symptoms:
dry mouth
nausea and vomiting
shortness of breath
breath that smells fruity
decreased consciousness
Metformin may cause side effects. Tell your doctor if any of these symptoms are severe, do not go away, go away and come back, or do not begin for some time after you begin taking metformin:
diarrhea
bloating
stomach pain
gas
constipation
unpleasant metallic taste in mouth
heartburn
headache
sneezing
cough
runny nose
flushing of the skin
nail changes
muscle pain
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them or those listed in the IMPORTANT WARNING section, call your doctor immediately:
chest pain
rash
Some female laboratory animals given high doses of metformin developed non-cancerous polyps (abnormal growths of tissue) in the uterus (womb). It is not known if metformin increases the risk of polyps in humans. Talk to your doctor about the risks of taking this medication.
Metformin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. |
| How to Store the
Medicine
|
| How to Store the Medicine |
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication. |
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