Prasugrel is used to prevent blood cells from clotting. It is used by people who have had a PCI (percutaneous coronary intervention) because of unstable angina or a heart attack. PCI is a procedure where a balloon-tipped tube is used to open a blocked artery, with or without a stent being placed in the artery.
Prasugrel belongs to the group of medicines called antiplatelet agents. It works by reducing the ability of blood cells to clot. By preventing blood cells from clumping, it reduces the chances of blood clots forming (a process called thrombosis), thereby decreasing or even stopping blood supply to the heart muscle.
Prasugrel is always taken with aspirin.
Ask your doctor if you have any questions about why this medicine has been prescribed for you.
Your doctor may have prescribed this medicine for another use. If you want more information, ask your doctor.
This medicine is available only with a doctor''s prescription.
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||Do not take Prasugrel
1. if you have an allergy to Prasugrel or any of the ingredients listed at the end of this leaflet:
Symptoms of an allergic reaction may include:
• shortness of breath
• wheezing or difficulty breathing
• swelling of the face, lips, tongue or other parts of the body
If you are not sure if you have an allergy to Prasugrel , check with your doctor.
2. if you have had any of the following medical conditions:
• bleeding caused by a stomach ulcer
• bleeding inside your head
• transient ischaemic attack (TIA) which resulted in a temporary paralysis, numbness, speech difficulty or other symptoms affecting your nervous system which happened suddenly and disappeared within 24 hours
• severe liver disease
• the packaging is torn or shows signs of tampering (or the tablets do not look quite right)
• the expiry date on the pack has passed. If you take this medicine after the expiry date has passed, it may not work as well.
Do not give this medicine to children.
There is no experience with the use of this medicine in children.
|Drug Special Care
||Before you start to take it
Tell your doctor if:
you have any allergies to any other medicines or any other substances such as foods, preservatives or dyes
you are already taking aspirin
you are pregnant or plan to become pregnant
you are breast-feeding or plan to breast-feed
you have or have had any of the following medical conditions:
bleeding disorders or blood clotting problems
a tendency to bleed as a result of a recent trauma, recent surgery (including dental surgery), recent or recurrent gastrointestinal bleeding, active peptic ulcer disease
a history of kidney or liver problems
a history of stroke or TIA
weigh less than 60 kg
are more than 75 years old
a history of tumours or cancer
If you have not told your doctor or pharmacist about any of the above, tell them before you start taking prasugrel.
|Drug Drug Interactions
||Tell your doctor or pharmacist if you are taking any other medicines, including medicines you buy without a prescription from a pharmacy, supermarket or health food shop.
You will be prescribed aspirin at a low dose with Prasugrel. Aspirin works together with Prasugrel.
Some medicines and Prasugrel may interfere with each other. These are:
• medicines that "thin the blood" such as warfarin and heparin.
• non steroidal anti-inflammatory drugs (NSAIDs) - medicines used to treat arthritis, period pain, aches and pain
• fibrinolytics - a group of medicines used to dissolve a blood clot that has formed in an artery or a vein
• some medicines used to treat HIV (e.g. efavirenz).
• some medicines used to treat cancer (e.g. cyclophosphamide).
These medicines may be affected by Prasugrel or may affect how well it works. You may need different amounts of your medicine or you may need to take different medicines.
Your doctor or pharmacist can tell you what to do if you are taking any of these medicines. They also have a more complete list of medicines to be careful with or avoid while taking Prasugrel .
Ask your doctor or pharmacist if you are not sure if you are taking any of these medicines.
|Drug Pregnancy Interaction
||Your doctor will discuss the possible risks and benefits of taking this medicine during pregnancy.
|Drug Breast feeding Interaction
||Prasugrel is not recommended while you are breast-feeding. It is not known whether it passes into breast-milk.
|Drug Machinery Interaction
||Be careful driving or operating machinery until you know how it affects you.
Make sure you know how you react to it before you drive a car, operate machinery or do anything else that could be dangerous if you are dizzy or light-headed. If this does occur, do not drive.
If you drink alcohol, faintness or dizziness may be worse.
|Drug More Information
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|How to take the
||While you are taking Prasugrel
Things you must do
Take it every day exactly as your doctor has prescribed.
If you become pregnant while you are taking it, tell your doctor.
If you decide to breast-feed your baby, tell your doctor.
Your doctor may want to discuss this and change your medicine.
If you are about to start taking any new medicines, tell your doctor and pharmacist that you are taking Prasugrel .
Tell all doctors, dentists and pharmacists who are treating you that you are taking Prasugrel .
Tell your doctor, dentist or pharmacist that you are taking Prasugrel before you have any surgery.
It may increase the risk of bleeding during an operation or some dental work. Therefore, treatment may need to be stopped before surgery.
Your doctor will decide whether to stop Prasugrel and if so, for how long.
Ask your doctor whether there are any activities you should avoid while taking this medicine, for example, certain sports.
Sometimes after an injury, bleeding may occur inside your body without you knowing about it.
Tell your doctor immediately if you are injured while taking this medicine.
It may take longer than usual to stop bleeding while you are taking Prasugrel.
Tell your doctor immediately if you notice the return of any of the symptoms you had before starting Prasugrel.
Things you must not do
Do not give this medicine to anyone else, even if they have the same condition as you
||Take this medicine only as prescribed by your doctor and follow his/her directions carefully.
These may differ from the information contained in this leaflet.
Your doctor will tell you how many tablets to take each day.
Prasugrel is available as a 5 and 10 mg tablet. It is usual for your doctor to start you on a single dose of six 10 mg tablets and then continue with a 10 mg or 5 mg once daily dose. Your doctor will also prescribe a daily dose of aspirin to take with this medicine.
||You should swallow the tablets with a glass of water.
The tablets can be taken before or after meals.
Do not break the tablet in half. Talk to your doctor or pharmacist if you have trouble swallowing tablets.
Take it at the same time each day.
Taking your tablets at the same time will have the best effect. It will also help you to remember when to take it.
How long to take it
Continue taking Prasugrel for as long as your doctor recommends.
|Excess Drug Consumption
||Immediately telephone your doctor, or Poisons Information Centre for advice if you think that you or anyone else may have taken too much Prasugrel. Do this even if there are no signs of discomfort or poisoning.
You may need urgent attention.
|Forgot Drug Consumption
||If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, take it as soon as you remember, then go back to taking your tablets as you would normally.
Do not take a double dose to make up for the dose you have missed.
This may increase the chance of you getting an unwanted side effect.
If you are not sure what to do, ask your doctor or pharmacist.
If you have trouble remembering to take your medicine, ask your pharmacist for some hints.
|Stop Drug Consumption
||Do not stop taking this medicine without informing your doctor as it may increase the chance of a heart attack or stroke or a blood clot forming.
||Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking prasugrel.
It helps most people, but it may have unwanted side effects in a few people. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.
Ask your doctor or pharmacist to answer any questions you may have.
|Common Drug Side Effects
||Tell your doctor if you notice any of the following:
cuts that take longer than usual to stop bleeding
|Rare Drug Side Effects
||Tell your doctor immediately, or go to Accident and Emergency if you notice any of the following:
signs of anaemia (being tired and looking pale)
severe or uncontrollable bleeding, including after surgery
coughing up blood (a sign of bleeding from the stomach)
pink or brown urine
red or black stools
diarrhoea with blood, mucus, stomach pain and fever (a sign of bleeding from the intestine)
unusual bruising (bruises that develop without known cause or grow in size)
red or purple spots visible through your skin
unusually heavy bleeding or bruising from cuts or wounds
blood in the eyes
swelling of the face, lips, mouth, tongue or throat which may cause difficulty in swallowing or breathing .
The above list includes serious side effects. You may need urgent medical attention.
Tell your doctor if you notice any other effects.
Other side effects not listed above may also occur in some people.
Do not be alarmed by this list of possible side effects.
You may not experience any of them.
|Very Rare Drug Side Effects
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|Drug Side Effects Symptoms
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|How to Store the
|How to Store the Medicine
Keep your tablets in the blister pack until it is time to take them.
If you take the tablets out of the blister pack, they may not keep well.
Keep them in a cool, dry place where it stays below 30°C. Do not store them, or any other medicine, in a bathroom or near a sink. Do not leave them in the car or on window sills.
Heat and dampness can destroy some medicines.
Keep them where children cannot reach them.
A locked cupboard at least one and a half metres above the ground is a good place to store medicines.
If your doctor tells you to stop taking this medicine, or the tablets have passed their expiry date, ask your pharmacist what to do with any tablets left over.