PRODUCTIVE M TABLET

Manufacturer : WAB-WANBURY LTD
Composition : CLOMIPHENE-25MG+UBIQUINONE-60MG+SELENIUM-200MCG+LEVOCARNITINE-50MG+PYRIDOXINE (VITB6)-1.5MG+L-ARGININE-20MG+FOLIC ACID-5MG+METHYLCOBALAMIN-1500MCG+ZINC-66MG
Dose Form : TABLET
Description : PRODUCTIVE M TAB
Route Of Administration : ORAL
Pack : 10
Out of stock
SKU
PRO0609
₹856.50
Manufacturer : WAB-WANBURY LTD
Composition : CLOMIPHENE-25MG+UBIQUINONE-60MG+SELENIUM-200MCG+LEVOCARNITINE-50MG+PYRIDOXINE (VITB6)-1.5MG+L-ARGININE-20MG+FOLIC ACID-5MG+METHYLCOBALAMIN-1500MCG+ZINC-66MG
Dose Form : TABLET
Description : PRODUCTIVE M TAB
Route Of Administration : ORAL
Pack : 10

Drug Ingredient Information

CLOMIPHENE-25MG+UBIQUINONE-60MG+SELENIUM-200MCG+LEVOCARNITINE-50MG+PYRIDOXINE (VITB6)-1.5MG+L-ARGININE-20MG+FOLIC ACID-5MG+METHYLCOBALAMIN-1500MCG+ZINC-66MG

CLOMIPHENE

Information for patients
Drug Information Clomifene citrate contains a medicine called clomifene citrate.This belongs to a group of medicines called ovulation stimulants.It works by stimulating the release of eggs from the ovary(ovulation). Clomifene citrate is used for some types of in fertility,inWomen who are not ovulating properly.
Drug Alert
Alert ? Be coming pregnant with more than one child Atthesametime (multiplepregnancies) ? Pregnancies where the baby grows outside Of the womb(ectopic) ? Apossible increased risk of ovarian cancer Anypregnancy could lead to birth defectsor miscarriage.This can happen even if you are not taking Clomifene citrate.You should talk to your doctor about the possible risks before you take Clomifene citrate
Before Consuming the Medicine
Avoid Drug × You are allergic (hypersensitive) toclomifene Or any of the other ingredients of Clomifene citrate (listed in Section 6 below). Signs of an allergic reaction include:a rash, Swallowing or breathing problems, swelling Of your lips,face,throat or tongue × You have or ever had liver disease × You have unusual menstrual bleeding where The cause is not known × You have a type of cancer that is made worse By hormones You have acyston your ovary × You are pregnant. You should have atestto Make sure you are not pregnant before you Take Clomifene citrate Do not take this medicine if any of the above Apply to you.
Drug Special Care ? You are having a nearly menopause or have Been told you are infertile ? You have stopped having periods because You are under-weight ? You have had fits or seizures in the past ? You have‘fibroids’in your womb ? You have ‘polycystic’ ovaries ? Your ovaries are swollen Your doctor should check for any other causes Offertility problems before starting treatment With Clomifene citrate. Ifyou are not sure if any of the above apply to you,talk to your doctor or pharmacist before taking Clomifene citrate.
Drug Drug Interactions Please tell your doctor or pharmacist if you Are taking or have recently taken anyother medicines.This includes medicines you buy without a prescription, including herbal medicines.This is because Clomifene citrate can affect the way some other medicines work. Also some medicines can affect the way Clomifene citrate works.
Drug Pregnancy Interaction Do not take this medicine if you are Pregnant or think you may be pregnant
Drug Breast feeding Interaction Talk to your doctor before taking this medicine If you are breast-feeding or planning to breast-feed.Clomifene citrate can lower the amount of milk produced Ask your doctor or pharmacist for advice before Taking any medicine if you are pregnant or breast-feeding.
Drug Machinery Interaction You may notice problems with your eyesight Such as blurred vision while taking this medicine. Ifth is happens, do not drive or use any tools ormachines.
Drug More Information This medicine contains lactose and sucrose, Which are types of sugar.If you have been told Byyour doctor that you cannot tolerate some sugars,talk to your doctor before taking Clomifene citrate.
How to take the Medicine
Consumption Info Always take Clomifene citrate exactly as your doctor has Told you.You should check with your doctor or Pharmacist if you are not sure.
Drug quanitty Your doctor will tell you when in your Menstrual cycle to start taking the tablets •For the first course of treatment, Take one tablet a day for five days •If you do not have a period after the First course of treatment your doctor will Increase your dose to two tablets a day for fivedays •You should start this second course atleast 30days after the first course •You will not usually take more than three Courses of treatment.If ovulation does not Happen after three courses talk to your doctor
Drug Dose Take this medicine by mouth • Swallow the tablets whole with a drink of water.Do not crush or chew your tablets • Do not take more than two tablets in one day • Do not take the tablets for more than five Days at a time • If you feel the effect of your medicine is not working,do not change the dose yourself, but ask your doctor
Excess Drug Consumption If you take more Clomifene citrate than you should, tell a Doctor or go to a hospital casualty department Straight away.Take the medicine pack with you.This is so the doctor knows what you have taken.You are likely to get over-stimulation of your ovary
Forgot Drug Consumption If you forget a dose, talk to your doctor as you May need to change your treatment cycle. Do not take a double dose to make up for a Forgotten tablet
Stop Drug Consumption Keep taking Clomifene citrate until your doctor tells you to stop.If you stop,the treatment may not work.
Possible Side Effects
General Information • You have an allergic reaction.The signs may include:a rash,swallowing or breathing problems,swelling of your lips,face,throat or tongue • You have numbness,weakness or paralysis on Oneside of your body,slurred speech,sudden Blurred vision,confusion or unsteadiness. These could be signs of a stroke
Common Drug Side Effects • Over-stimulation of the ovary.This can Lead to pain in the pelvis,stomach or calf, Swelling or feeling bloated, passing less urine,difficulty in breathing or an increase in weight.If this happens,your doctor may lower your dose of Clomifene citrate • Blurring of vision or spots or flashes inFront of the eyes.These symptoms usually Get better but in some cases they may be permanent.Your doctor may send you for any examination. • Liverproblemsthatmaycausetheeyesor skintogoyellow(jaundice) • Suddenandsevereheadaches • Mentalillnesssuchas‘psychosis’
Rare Drug Side Effects
Very Rare Drug Side Effects
Drug Side Effects Symptoms • Increased pain with periods,heavy periods Or bleeding between periods • Pain in the lower part of the stomach. Worsening of endometriosis,ovarian cancer Or enlarged ovaries • Cloudylenses in the eye(cataracts) • Fits,feeling faint,dis-orientated or more Tense than normal.Also,balance problems Or feeling dizzy (vertigo) • Feeling tired or difficulty in sleeping (insomnia),depression or change in moods Or behaviour • Speech problems • Skin rash or itching • Feeling or being sick • Flushing of the skin • Headaches • Swelling of the face,around the eyes,lips Or tongue • Painful breasts • Hairloss or thinning There have been rarere ports of ovarian cancer With fertility drugs.Some studies suggest that Prolonged use of clomifene may increase this risk.There fore there commended duration of treatment should not be exceeded. Talk to your doctor or pharmacist if any of the Side effects gets serious or lasts longer than a Few days or if you notice any side effects not Listed in this leaflet
How to Store the Medicine
How to Store the Medicine Keep out of the reach and sigh to Of children. Store in original container below 25ºC. Do not use Clomifene citrate after the expiry datewhich Is state don the carton.The expiry date refers To the last day of that month. Medicines should not be disposed of via Waste water or household waste.Ask your Pharmacist how to dispose of medicines no longer required.The semeasures will help to protect the environment.

UBIQUINONE

Information for patients
Drug Information Heart failure Angina Periodontal disease
Drug Alert
Alert no data available
Before Consuming the Medicine
Avoid Drug no data available
Drug Special Care Avoid intense exercise during ubidecarenone therapy.
Drug Drug Interactions Decreased serum levels with statins. Possible decrease in INR with warfarin.
Drug Pregnancy Interaction no data available
Drug Breast feeding Interaction no data available
Drug Machinery Interaction no data available
Drug More Information Should be taken with food. (Take after meals.)
How to take the Medicine
Consumption Info no data available
Drug quanitty no data available
Drug Dose Heart failure Adult: 50-150 mg daily in 2-3 divided doses. Angina Adult: 150-600 mg daily in divided doses. Periodontal disease Adult: 25 mg bid.
Excess Drug Consumption Call 1066 Or contact your near emergency
Forgot Drug Consumption Contact your doctor
Stop Drug Consumption Do not stop taking drug untill your doctor ask you to do so.
Possible Side Effects
General Information no data available
Common Drug Side Effects Gastric discomfort, anorexia, diarrhoea, nausea, skin rash, heart burn. Increase in LFT with doses >300 mg/day.
Rare Drug Side Effects no data available
Very Rare Drug Side Effects no data available
Drug Side Effects Symptoms no data available
How to Store the Medicine
How to Store the Medicine Store in a cool and dry place

SELENIUM

Information for patients
Drug Information Selenium is a mineral. It is taken into the body in water and foods.Selenium is used for diseases of the heart and blood vessels, including stroke and “hardening of the arteries” (atherosclerosis). It is also used for preventing various cancers including cancer of the prostate, stomach, lung, and skin.
Drug Alert
Alert
Before Consuming the Medicine
Avoid Drug no data
Drug Special Care no data
Drug Drug Interactions following drugs interact with selenium: Medications that decrease the immune system Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) Medications used for lowering cholesterol (Statins)
Drug Pregnancy Interaction Selenium use is POSSIBLY SAFE during pregnancy and breast-feeding when used short-term in amounts that are not above 400 mcg daily. Selenium is POSSIBLY UNSAFE in pregnancy and breastfeeding when taking by mouth in doses above 400 mcg daily, as this might cause toxicity.
Drug Breast feeding Interaction Selenium use is POSSIBLY SAFE during pregnancy and breast-feeding when used short-term in amounts that are not above 400 mcg daily. Selenium is POSSIBLY UNSAFE in pregnancy and breastfeeding when taking by mouth in doses above 400 mcg daily, as this might cause toxicity.
Drug Machinery Interaction no data
Drug More Information Selenium is an essential trace element and functions as a defensive mechanism for oxidative stress, for regulation of thyroid hormone activity and redox status of vitamin C and other molecules. In food, selenium is often found as the amino acids selenomethionine and selenocysteine and derivatives. There are several forms of supplemental selenium e.g. high selenium yeast, L-selenomethionine, sodium selenate, sodium selenite and selenious acid. Absorption: Readily absorbed from GI tract Distribution: Stored in RBC, liver, spleen, heart and nails. Excretion: Excreted in urine as methylated metabolites and faeces (lesser extent).
How to take the Medicine
Consumption Info Selenium is used for diseases of the heart and blood vessels, including stroke and “hardening of the arteries” (atherosclerosis). It is also used for preventing various cancers including cancer of the prostate, stomach, lung, and skin.
Drug quanitty Oral Selenium deficiency Adult: 100-500 mcg of selenium daily.
Drug Dose to be taken orally..
Excess Drug Consumption overdosage may cause Nail or hair brittleness, hair or nail loss, diarrhoea, metallic taste, garlic-like breath odour, dermatitis, irritability, peripheral neuropathy.
Forgot Drug Consumption no data
Stop Drug Consumption no data
Possible Side Effects
General Information Selenium is POSSIBLY UNSAFE when taken by mouth in high doses or for long-term. Taking doses above 400 mcg can increase the risk of developing selenium toxicity. Taking lower doses long-term can increase the risk of developing diabetes. High doses of selenium can cause significant side effects including nausea, vomiting, nail changes, loss of energy, and irritability. Poisoning from long-term use is similar to arsenic poisoning, with symptoms including hair loss, white horizontal streaking on fingernails, nail inflammation, fatigue, irritability, nausea, vomiting, garlic breath odor, and a metallic taste.
Common Drug Side Effects Selenium can also cause muscle tenderness, tremor, lightheadedness, facial flushing, blood clotting problems, liver and kidney problems, and other side effects.
Rare Drug Side Effects no data
Very Rare Drug Side Effects no data
Drug Side Effects Symptoms no data
How to Store the Medicine
How to Store the Medicine no data

LEVOCARNITINE

Information for patients
Drug Information L-carnitine tablets contain L-carnitine which is a type of protein. They are used to treat primary and secondary carnitine deficiency in adults and children over 12 years of age. Carnitine deficiency occurs when the body has a shortage of L-carnitine L-carnitine tablets make up for your bodies lack of L-carnitine and help give your body more energy.
Drug Alert
Alert no data available
Before Consuming the Medicine
Avoid Drug - if you are allergic to L-carnitine or any of the other ingredients in L-carnitine tablets. If this applies to you, do not take L-carnitine tablets.
Drug Special Care - you have severe kidney problems or kidney disease and are having dialysis - you are diabetic and taking insulin, or any other drug to treat your diabetes - you are on a diet to reduce calorie intake - you have an intolerance to some sugars. If any of the above apply to you, talk to your doctor or pharmacist.
Drug Drug Interactions Tell your doctor if you are taking or have recently taken any other medicines, including those obtained without a prescription
Drug Pregnancy Interaction Tell your doctor if you are pregnant, think you may be pregnant or if you become pregnant while taking L-carnitine tablets. Your doctor will decide whether or not you should continue to take your medicine. If you wish to breastfeed, ask your doctor for advice.
Drug Breast feeding Interaction Tell your doctor if you are pregnant, think you may be pregnant or if you become pregnant while taking L-carnitine tablets. Your doctor will decide whether or not you should continue to take your medicine. If you wish to breastfeed, ask your doctor for advice.
Drug Machinery Interaction You can drive or use machines whilst taking L-carnitine tablets.
Drug More Information no data available
How to take the Medicine
Consumption Info no data available
Drug quanitty Your doctor will carefully calculate the number of tablets you should take and may change it depending on your response to treatment. Your doctor may take blood and urine samples to check the amount of the drug in your body.
Drug Dose L-carnitine tablets are for oral use.They should be chewed, not swallowed whole. Primary and secondary Carnitine deficiency The usual dose of L-carnitine tablets is 200 mg per kg of your body weight per day.This should be taken over 2-4 doses. Higher doses of up to 400 mg per kg of your body weight per day may be necessary. Your doctor will tell you exactly how many tablets to take and when to take them. Maintenance therapy for haemodialysis patients If significant clinical benefit was gained by a first course of L-carnitine injection, then on going therapy of one L-carnitine tablet per day may be taken. On the day of dialysis, the tablet should be taken at the end of the session.
Excess Drug Consumption If you take too many L-carnitine tablets, contact your doctor or immediately go to the nearest hospital casualty department
Forgot Drug Consumption Do not take a double dose to make up for the forgotten dose. Simply continue with the next dose as planned.
Stop Drug Consumption Do not stop taking this medicine without first talking to your doctor. If you have any further questions about the use of this medicine, ask your doctor or pharmacist
Possible Side Effects
General Information no data available
Common Drug Side Effects - Mild stomach upsets such as stomach cramps and diarrhoea, or you may feel or be sick for a short time. - Drug-related body odour. Your doctor may reduce your dose to help lessen or stop the odour.
Rare Drug Side Effects no data available
Very Rare Drug Side Effects no data available
Drug Side Effects Symptoms no data available
How to Store the Medicine
How to Store the Medicine Keep out of the reach and sight of children. Do not use L-carnitine tablets after the expiry date on the carton. The expiry date refers to the last day of that month. Store below 25°C. Medicines should not be thrown away in waste wastewater or household waste. Return any medicine you no longer need to your pharmacist.

PYRIDOXINE (VITB6)

Information for patients
Drug Information Pyridoxine is vitamin B6. Vitamins occur naturally in foods such as meat, poultry, nuts, whole grains, bananas, and avocados. Vitamin B6 is important for many processes in the body. Pyridoxine is used to treat or prevent vitamin B6 deficiency. It is also used to treat a certain type of anemia (lack of red blood cells). Pyridoxine injection is also used to treat some types of seizure in babies. Pyridoxine taken by mouth (oral) is available without a prescription. Injectable pyridoxine must be given by a healthcare professional.
Drug Alert
Alert do not exceed stated dose
Before Consuming the Medicine
Avoid Drug Many drugs may alter the metabolism or bioavailability of pyridoxine, including isoniazid, penicillamine and oral contraceptives, which may increase the requirements for pyridoxine. Pyridoxine hydrochloride may reduce the effect of levodopa, a drug used in the treatment of Parkinsons Disease unless a dopa decarboxylase inhibitor is also given.
Drug Special Care You should not use pyridoxine if you have ever had an allergic reaction to it.
Drug Drug Interactions Many drugs may alter the metabolism or bioavailability of pyridoxine, including isoniazid, penicillamine and oral contraceptives, which may increase the requirements for pyridoxine. Pyridoxine hydrochloride may reduce the effect of levodopa, a drug used in the treatment of Parkinsons Disease unless a dopa decarboxylase inhibitor is also given.
Drug Pregnancy Interaction Data on exposed pregnancies indicate no adverse effects of pyridoxine in therapeutic doses on pregnancy or the health of the foetus or newborn child, or during lactation. Animal studies are insufficient with respect to effects on pregnancy, embryonal/foetal development, parturition or postnatal development. Caution should be exercised when prescribing to pregnant women.
Drug Breast feeding Interaction Data on exposed pregnancies indicate no adverse effects of pyridoxine in therapeutic doses on pregnancy or the health of the foetus or newborn child, or during lactation.
Drug Machinery Interaction no data
Drug More Information Long term administration of large doses of pyridoxine is associated with the development of severe peripheral neuritis.
How to take the Medicine
Consumption Info Pyridoxine Hydrochloride is used for isoniazid-induced peripheral neuritis, idiopathic sideroblastic anaemia and Vitamin B6 deficiency states.
Drug quanitty 50mg three times a day
Drug Dose no data
Excess Drug Consumption a) Symptoms – None reported b) Treatment – no treatment necessary
Forgot Drug Consumption no data
Stop Drug Consumption no data
Possible Side Effects
General Information As well as its needed effects, pyridoxine may cause unwanted side effects that require medical attention
Common Drug Side Effects With large doses Clumsiness numbness of hands or feet
Rare Drug Side Effects Nervous system side effects have included sensory neuropathy with axonal degeneration. The adverse neurologic side effects have been reported following a single large dose (10 g) administered intravenously. It may rarely occur following chronic administration of lower doses. Peripheral sensory neuropathy has also been reported
Very Rare Drug Side Effects Dermatologic side effects have included allergic contact dermatitis. Photosensitivity has been confirmed in a female patient taking pyridoxine 100 mg orally daily
Drug Side Effects Symptoms no data
How to Store the Medicine
How to Store the Medicine Store below 25°C Protect from light and moisture.

L

Information for patients
Drug Information
Drug Alert
Alert
Before Consuming the Medicine
Avoid Drug
Drug Special Care
Drug Drug Interactions
Drug Pregnancy Interaction
Drug Breast feeding Interaction
Drug Machinery Interaction
Drug More Information
How to take the Medicine
Consumption Info
Drug quanitty
Drug Dose
Excess Drug Consumption
Forgot Drug Consumption
Stop Drug Consumption
Possible Side Effects
General Information
Common Drug Side Effects
Rare Drug Side Effects
Very Rare Drug Side Effects
Drug Side Effects Symptoms
How to Store the Medicine
How to Store the Medicine

FOLIC ACID

Information for patients
Drug Information The name of your medicine is Folic acid. It contains folic acid. This belongs to a group of vitamins called ‘B vitamins’. Folic acid is used to help prevent babies being born with Neural Tube Defects such as Spina Bifida. n You should use this medicine if you are trying to become pregnant and also during the first three months of your pregnancy. n You should also use this when you know you are pregnant or you think you are pregnant and continue to use it for the first three months of your pregnancy.
Drug Alert
Alert You are allergic (hypersensitive) to folic acid or any other ingredients in this liquid (listed in Section 6) Signs of an allergic reaction include a rash, itching or shortness of breath n You have a tumour or cancer
Before Consuming the Medicine
Avoid Drug You are allergic (hypersensitive) to folic acid or any other ingredients in this liquid (listed in Section 6) Signs of an allergic reaction include a rash, itching or shortness of breath n You have a tumour or cancer
Drug Special Care You have been told that you have something called ‘pernicious anaemia’ or a ‘vitamin B12 deficiency’.
Drug Drug Interactions Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines you buy without a prescription, including herbal medicines. This is because Folic acid can affect the way some other medicines work. Also, some medicines can affect the way Folic acid works. In particular, tell your doctor if you are taking any of the following: n Medicines for epilepsy and fits such as phenytoin or primidone. Your doctor may need to change the amount you are taking. This is because Folic acid may make these medicines work less well.
Drug Pregnancy Interaction Talk to your doctor before taking this medicine if you are pregnant, planning to become pregnant or are breastfeeding. If you are a woman and you are pregnant, this medicine is unlikely to cause any harm to you or your unborn child.
Drug Breast feeding Interaction Talk to your doctor before taking this medicine if you are pregnant, planning to become pregnant or are breastfeeding. If you are a woman and you are pregnant, this medicine is unlikely to cause any harm to you or your unborn child.
Drug Machinery Interaction Folic acid is not likely to affect you being able to drive or use any tools or machines
Drug More Information
How to take the Medicine
Consumption Info to be taken orally
Drug quanitty as per the requirement
Drug Dose as per the requirement
Excess Drug Consumption There have been no cases of people taking an overdose with this medicine. However, if you think you have taken more than you should, talk to your doctor or go to a hospital straight away.
Forgot Drug Consumption If you forget a dose, take it as soon as you remember it. However, if it is nearly time for the next dose, skip the missed dose. Do not take a double dose (two doses at the same time) to make up for a forgotten dose.
Stop Drug Consumption Do not stop the drug untill your doctor says you to do so.
Possible Side Effects
General Information no data available
Common Drug Side Effects An allergic reaction may include: n Any kind of skin rash, flaking skin, boils or sore lips and mouth n Sudden wheezing, fluttering or tightness of the chest or collapse. Tell your doctor if you get any of these side effects: n Feeling sick (nausea), being sick (vomiting) or an upset stomach.
Rare Drug Side Effects no data available
Very Rare Drug Side Effects no data available
Drug Side Effects Symptoms
How to Store the Medicine
How to Store the Medicine Keep out of the reach and sight of children n Do not store above 25°C n Take back to the pharmacy 1 month after opening. n Do not use after the expiry date which is stated on the label and carton (Exp: month, year) n The expiry date refers to the last day of that month n Do not use Folic acid if you notice a change in the appearance or smell of the medicine. Talk to your pharmacist n Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment

METHYLCOBALAMIN

Information for patients
Drug Information Vitamin B12, is used to treat vitamin B12 deficiency, cyanide poisoning, and hereditary deficiency of transcobalamin II.[3] It is also given as part of the schilling test for detecting pernicious anemia.[3] For cyanide poisoning, large amount may be given intravenously, and sometimes in combination with sodium thiosulfate.[4] The mechanism of action is straightforward: the hydroxycobalamin hydroxide ligand is displaced by the toxic cyanide ion, and the resulting harmless B12 complex is excreted in urine. In the United States, the Food and Drug Administration approved (in 2006) the use of hydroxocobalamin for acute treatment of cyanide poisoning.[5] High vitamin B12 level in elderly individuals may protect against brain atrophy or shrinkage, associated with Alzheimer's disease and impaired cognitive function.[6] High-dose administration of Vitamin B12 has been additionally validated to stimulate the activity of the body's TH1 suppressor T-Cells, which then down-regulates the over-production of the allagen antibody 1gE in allergic individuals.
Drug Alert
Alert no data available
Before Consuming the Medicine
Avoid Drug no data available
Drug Special Care Vitamin B12 supplements in theory should be avoided in people sensitive or allergic to cobalamin, cobalt, or any other product ingredients. However, direct allergy to a vitamin or nutrient is extremely rare, and if reported, other causes should be sought.
Drug Drug Interactions Aminosalicylic acid (para-aminosalicylic acid, PAS, Paser): Aminosalicylic acid can reduce oral vitamin B12 absorption, possibly by as much as 55%, as part of a general malabsorption syndrome. Megaloblastic changes, and occasional cases of symptomatic anemia have occurred, usually after doses of 8 to 12 g/day for several months. Vitamin B12 levels should be monitored in people taking aminosalicylic acid for more than one month. Antibiotics: An increased bacterial load can bind significant amounts of vitamin B12 in the gut, preventing its absorption. In people with bacterial overgrowth of the small bowel, antibiotics such as metronidazole (Flagyl) can actually improve vitamin B12 status. The effects of most antibiotics on gastrointestinal bacteria are unlikely to have clinically significant effects on vitamin B12 levels. Hormonal contraception: The data regarding the effects of oral contraceptives on vitamin B12serum levels are conflicting. Some studies have found reduced serum levels in oral contraceptive users, but others have found no effect despite use of oral contraceptives for up to 6 months. When oral contraceptive use is stopped, normalization of vitamin B12 levels usually occurs. Lower vitamin B12serum levels seen with oral contraceptives probably are not clinically significant. Chloramphenicol (Chloromycetin): Limited case reports suggest that chloramphenicol can delay or interrupt the reticulocyte response to supplemental vitamin B12 in some patients. Blood counts should be monitored closely if this combination cannot be avoided. Cobalt irradiation: Cobalt irradiation of the small bowel can decrease gastrointestinal (GI) absorption of vitamin B12. Colchicine: Colchicine in doses of 1.9 to 3.9 mg/day can disrupt normal intestinal mucosal function, leading to malabsorption of several nutrients, including vitamin B12. Lower doses do not seem to have a significant effect on vitamin B12 absorption after 3 years of colchicine therapy. The significance of this interaction is unclear. Vitamin B12 levels should be monitored in people taking large doses of colchicine for prolonged periods. Colestipol (Colestid), cholestyramine (Questran): These resins used for sequestering bile acids to decrease cholesterol, can decrease gastrointestinal (GI) absorption of vitamin B12. It is unlikely this interaction will deplete body stores of vitamin B12 unless there are other factors contributing to deficiency. In a group of children treated with cholestyramine for up to 2.5 years, there was not any change in serum vitamin B12 levels. Routine supplements are not necessary. H2-receptor antagonists: include cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), and ranitidine (Zantac). Reduced secretion of gastric acid and pepsin produced by H2 blockers can reduce absorption of protein-bound (dietary) vitamin B12, but not of supplemental vitamin B12. Gastric acid is needed to release vitamin B12 from protein for absorption. Clinically significant vitamin B12 deficiency and megaloblastic anemia are unlikely, unless H2 blocker therapy is prolonged (2 years or more), or the person's diet is poor. It is also more likely if the person is rendered achlorhydric(with complete absence of gastric acid secretion), which occurs more frequently with proton pump inhibitors than H2 blockers. Vitamin B12 levels should be monitored in people taking high doses of H2 blockers for prolonged periods. Metformin (Glucophage): Metformin may reduce serum folic acid and vitamin B12 levels. These changes can lead to hyperhomocysteinemia, adding to the risk of cardiovascular disease in people with diabetes.[citation needed] There are also rare reports of megaloblastic anemia in people who have taken metformin for five years or more. Reduced serum levels of vitamin B12 occur in up to 30% of people taking metformin chronically.[20][21] However, clinically significant deficiency is not likely to develop if dietary intake of vitamin B12 is adequate. Deficiency can be corrected with vitamin B12 supplements even if metformin is continued. The metformin-induced malabsorption of vitamin B12 is reversible by oral calcium supplementation.[22] The general clinical significance of metformin upon B12 levels is as yet unknown.[23] Neomycin: Absorption of vitamin B12 can be reduced by neomycin, but prolonged use of large doses is needed to induce pernicious anemia. Supplements are not usually needed with normal doses. Nicotine: Nicotine can reduce serum vitamin B12 levels. The need for vitamin B12 supplementation in smokers has not been adequately studied. Nitrous oxide: Nitrous oxide inactivates the cobalamin form of vitamin B12 by oxidation. Symptoms of vitamin B12 deficiency, including sensory neuropathy, myelopathy, and encephalopathy, can occur within days or weeks of exposure to nitrous oxide anesthesia in people with subclinical vitamin B12 deficiency. Symptoms are treated with high doses of vitamin B12, but recovery can be slow and incomplete. People with normal vitamin B12 levels have sufficient vitamin B12 stores to make the effects of nitrous oxide insignificant, unless exposure is repeated and prolonged (such as recreational use). Vitamin B12 levels should be checked in people with risk factors for vitamin B12 deficiency prior to using nitrous oxide anesthesia. Chronic nitrous oxide B12 poisoning (usually from use of nitrous oxide as a recreational drug), however, may result in B12 functional deficiency even with normal measured blood levels of B12.[24] Phenytoin (Dilantin), phenobarbital, primidone (Mysoline): These anticonvulsants have been associated with reduced vitamin B12 absorption, and reduced serum and cerebrospinal fluidlevels in some patients. This may contribute to the megaloblastic anemia, primarily caused by folate deficiency, associated with these drugs. It is also suggested that reduced vitamin B12 levels may contribute to the neuropsychiatric side effects of these drugs. Patients should be encouraged to maintain adequate dietary vitamin B12 intake. Folate and vitamin B12 status should be checked if symptoms of anemia develop. Proton pump inhibitors (PPIs): The PPIs include omeprazole (Prilosec, Losec), lansoprazole(Prevacid), rabeprazole (Aciphex), pantoprazole (Protonix, Pantoloc), and esomeprazole (Nexium). The reduced secretion of gastric acid and pepsin produced by PPIs can reduce absorption of protein-bound (dietary) vitamin B12, but not supplemental vitamin B12. Gastric acid is needed to release vitamin B12 from protein for absorption. Reduced vitamin B12 levels may be more common with PPIs than with H2-blockers, because they are more likely to produce achlorhydria (complete absence of gastric acid secretion). However, clinically significant vitamin B12 deficiency is unlikely, unless PPI therapy is prolonged (2 years or more) or dietary vitamin intake is low. Vitamin B12 levels should be monitored in people taking high doses of PPIs for prolonged periods. Zidovudine (AZT, Combivir, Retrovir): Reduced serum vitamin B12 levels may occur when zidovudine therapy is started. This adds to other factors that cause low vitamin B12 levels in people with HIV, and might contribute to the hematological toxicity associated with zidovudine. However, the data suggest vitamin B12 supplements are not helpful for people taking zidovudine.[citation needed] Folic acid: Folic acid, particularly in large doses, can mask vitamin B12 deficiency by completely correcting hematological abnormalities. In vitamin B12 deficiency, folic acid can produce complete resolution of the characteristic megaloblastic anemia, while allowing potentially irreversible neurological damage (from continued inactivity of methylmalonyl mutase) to progress. Thus, vitamin B12 status should be determined before folic acid is given as monotherapy. Potassium: Potassium supplements can reduce absorption of vitamin B12 in some people. This effect has been reported with potassium chloride and, to a lesser extent, with potassium citrate. Potassium might contribute to vitamin B12 deficiency in some people with other risk factors, but routine supplements are not necessary.[
Drug Pregnancy Interaction no data available
Drug Breast feeding Interaction no data available
Drug Machinery Interaction no data available
Drug More Information Alcohol (ethanol): Excessive alcohol intake lasting longer than two weeks can decrease vitamin B12 absorption from the gastrointestinal tract.[c
How to take the Medicine
Consumption Info no data available
Drug quanitty The dietary reference intake for an adult ranges from 2 to 3 µg per day.[9] Vitamin B12 is believed to be safe when used orally in amounts that do not exceed the recommended dietary allowance (RDA). There have also been studies that showed no adverse consequences of doses above the RDA.[10] The RDA for vitamin B12 in pregnant women is 2.6 µg per day and 2.8 µg during lactation periods.[citation needed] There is insufficient reliable information available about the safety of consuming greater amounts of vitamin B12 during pregnancy. The Vegan Society, the Vegetarian Resource Group, and the Physicians Committee for Responsible Medicine, among others, recommend that vegans either consistently eat foods fortified with B12 or take a daily or weekly B12 supplement.[11][12][13] Fortified breakfast cereals are a particularly valuable source of vitamin B12 for vegetarians and vegans. In addition, adults age 51 and older are recommended to consume B12 fortified food or supplements to meet the RDA, because they are a population at an increased risk of deficiency
Drug Dose Can you take too much? No. Unlike other supplements which you can overdose on, your body doesn’t store excess vitamin B12. But you don’t want to waste it. I usually go with ~1cc every week or so.
Excess Drug Consumption no data available
Forgot Drug Consumption contact your doctor
Stop Drug Consumption do not stop the medicine untill adviced by your doctor
Possible Side Effects
General Information no data available
Common Drug Side Effects Vitamin B12 has extremely low toxicity and even taking it in enormous doses appears not to be harmful to healthy individuals.[17][18] Hematologic: Peripheral vascular thrombosis has been reported. Treatment of vitamin B12 deficiency can unmask polycythemia vera, which is characterized by an increase in blood volume and the number of red blood cells. The correction of megaloblastic anemia with vitamin B12 can result in fatal hypokalemia and gout in susceptible individuals, and it can obscure folate deficiency in megaloblastic anemia. Caution is warranted. Leber's disease: Vitamin B12 in the form of cyanocobalamin is contraindicated in early Leber's disease, which is hereditary optic nerve atrophy. Cyanocobalamin can cause severe and swift optic atrophy, but other forms of vitamin B12 are available. However, the sources of this statement are not clear, while an opposing view[19] concludes: "The clinical picture of optic neuropathy associated with vitamin B12 deficiency shows similarity to that of Leber's disease optic neuropathy. Both involve the nerve fibres of the papillomacular bundle. The present case reports suggest that optic neuropathy in patients carrying a primary LHON mtDNA mutation may be precipitated by vitamin B12 deficiency. Therefore, known carriers should take care to have an adequate dietary intake of vitamin B12 and malabsorption syndromes like those occurring in familial pernicious anaemia or after gastric surgery should be excluded."
Rare Drug Side Effects no data available
Very Rare Drug Side Effects no data available
Drug Side Effects Symptoms no data available
How to Store the Medicine
How to Store the Medicine Precautions: Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents. Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area.

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