| Information for
patients
|
| Drug Information |
Mild to moderate pain and fever |
| Drug Alert |
| Alert |
no data available |
| Before Consuming
the Medicine
|
| Avoid Drug |
no data available |
| Drug Special Care |
Renal or hepatic impairment; alcohol-dependent patients; G6PD deficiency. |
| Drug Drug Interactions |
Reduced absorption of cholestyramine within 1 hr of admin. Accelerated absorption with metoclopramide. Decreased effect with barbiturates, carbamazepine, hydantoins, rifampicin and sulfinpyrazone. Paracetamol may increase effect of warfarin.
Potentially Fatal: Paracetamol increases the risk of liver damage in chronic alcoholics. Increased risk of toxicity with other hepatotoxic drugs or drugs which induce microsomal enzymes e.g. barbiturates, carbamazepine, hydantoins, rifampicin and sulfinpyrazone. |
| Drug Pregnancy Interaction |
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters). |
| Drug Breast feeding Interaction |
no data available |
| Drug Machinery Interaction |
no data available |
| Drug More Information |
St John's Wort may decrease effect. |
| How to take the
Medicine
|
| Consumption Info |
no data available |
| Drug quanitty |
Adult: Admin over 15 minutes. Wt >50 kg: 1 g 4-6 hrly (max 4 g daily); <50 kg: 15 mg/kg 4-6 hrly (max 60 mg/kg daily).
Child: Admin over 15 min. Wt <10 kg: 7.5 mg/kg 4-6 hrly (max 30 mg/kg daily); 10-50 kg: 15 mg/kg 4-6 hrly (max 60 mg/kg daily); >50 kg: 1 g 4-6 hrly (max 4 g daily). |
| Drug Dose |
May be taken with or without food. |
| Excess Drug Consumption |
Overdosage: Consult local protocols. Early symptoms: nausea and vomiting (normally settle within 24 hr of ingestion). After 24 hr symptoms may include right subcostal pain and tenderness, usually indicates development of hepatic necrosis. Liver damage is greatest 3-4 days after ingestion and may lead to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema and death. Treatment: based on plasma concentration. Acetylcysteine protects the liver if administered within 24 hr after ingestion (most effective if given within 8 hr). Dose: 140 mg/kg orally (loading) followed by 70 mg/kg every 4 hr for 17 doses. Parenteral acetylcysteine is given to those unable to take oral dosing. Activated charcoal may be given if paracetamol is 150 mg/kg or 12 g (whichever is smaller) if it is thought that the paracetamol has been ingested within the previous hr. |
| Forgot Drug Consumption |
Contact Your doctor |
| Stop Drug Consumption |
Do not stop the drug untill your doctor says you to do so. |
| Possible Side
Effects
|
| General Information |
no data available |
| Common Drug Side Effects |
Nausea, allergic reactions, skin rashes, acute renal tubular necrosis.
Potentially Fatal: Very rare, blood dyscrasias (e.g. thrombocytopenia, leucopenia, neutropenia, agranulocytosis); liver damage. |
| Rare Drug Side Effects |
no data available |
| Very Rare Drug Side Effects |
no data available |
| Drug Side Effects Symptoms |
no data available |
| How to Store the
Medicine
|
| How to Store the Medicine |
Do not store above 30°C; do not freeze or refrigerate; if parenteral solution is diluted: use within an hr (infusion time included). |
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