Drug Ingredient Information
METOPROLOL-25MG+AMLODIPINE-5MG
METOPROLOL
| Information for
patients
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| Drug Information |
Metoprolol tartrate, the active ingredient in Metoprolol tartrate Tablets, is one of a group of medicines called beta-blockers. Beta-blockers slow the heart beat, lessen the force with which the heart muscle contracts and reduce blood vessel contraction in the heart, brain, and throughout the body.
•Metoprolol tartrate Tablets are used to treat a number of different conditions including:
High blood pressure
Angina (chest pain)
Some heart disorders, for example, heart attack or irregular heart beats.
•They can also be used as part of the treatment for an overactive thyroid gland.
•Metoprolol tartrate Tablets can be taken to help prevent migraine attacks. |
| Drug Alert |
| Alert |
•you think you may be allergic to metoprolol or to any of the other ingredients of Metoprolol tartrate.
•you are allergic to any other beta-blocker drugs,
•you have severe asthma or severe attacks of wheezing
•you have certain serious heart or blood vessel disorders which shouldn’t be treated with beta-blockers (your doctor should be aware of these),
•you have low blood pressure,
•you been told that you have high blood pressure due to a tumour near your kidney (phaeochromocytoma),
•you have been told that your blood is more acidic than normal (a condition called metabolic acidosis). |
| Before Consuming
the Medicine
|
| Avoid Drug |
•you think you may be allergic to metoprolol or to any of the other ingredients of Metoprolol tartrate.
•you are allergic to any other beta-blocker drugs,
•you have severe asthma or severe attacks of wheezing
•you have certain serious heart or blood vessel disorders which shouldn’t be treated with beta-blockers (your doctor should be aware of these),
•you have low blood pressure,
•you been told that you have high blood pressure due to a tumour near your kidney (phaeochromocytoma),
•you have been told that your blood is more acidic than normal (a condition called metabolic acidosis). |
| Drug Special Care |
•Do you suffer from asthma, bronchitis or any similar lung disorder?
•Do you have problems with your heart (such as slow heart rate) or circulation?
•Do you have diabetes?
•Do you suffer from any serious liver disease?
•Are you pregnant or breast-feeding?
•Have you ever had a severe allergic reaction to anything?
•Do you suffer from a rare form of angina called Prinzmetal''''s angina?
•Will you be having an operation which requires a general anaesthetic?
•Do you have psoriasis? |
| Drug Drug Interactions |
Metoprolol tartrate interacts with a large number of other medicines.Make sure your doctor knows if you are taking any of the following because you may need to change your treatment:
•Medicines for high blood pressure (including prazosin, clonidine and drugs called calcium channel blockers such as verapamil or diltiazem)
•Other beta-blockers (including those used in the form of eye drops)
•Drugs which affect the peripheral circulation (fingers and toes) such as ergotamine which can be used to treat migraine
•Medicines to treat depression
•Medicines to treat other mental illnesses
•Antiretroviral drugs used to treat AIDS and some other conditions
•Antihistamines (including medicines that you can buy without a prescription for hayfever and other allergies, colds and other conditions)
•Drugs to prevent malaria
•Medicines to treat fungal infections
•Medicines which affect liver enzymes, such as cimetidine used to treat stomach ulcers and rifampicin used to treat tuberculosis
•Medicines for heart problems including angina, such as amiodarone, digoxin, nitrates and anti-arrhythmic drugs
•Insulin and other drugs to treat diabetes
•Drugs called NSAIDs used to treat pain and inflammation
•A local anaesthetic called lignocaine.
Always tell your doctor or pharmacist about all the medicines you are taking. This means medicines you have bought yourself as well as medicines on prescription from your doctor. |
| Drug Pregnancy Interaction |
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| Drug Breast feeding Interaction |
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| Drug Machinery Interaction |
If you feel dizzy or sleepy, or if you have problems with your eyes when you start to take these tablets, do not drive or use machinery until these effects have worn off. |
| Drug More Information |
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| How to take the
Medicine
|
| Consumption Info |
•Be careful when drinking alcohol - it may affect you more than usual.
•If you are going to have a general anaesthetic, tell the doctor or dentist in charge that you are taking Metoprolol tartrate.
•If you are diabetic, take particular care with your blood sugar control since Metoprolol tartrate may make you less aware of low blood sugar levels.
•The doctor will want to keep an eye on your heart and thyroid function while you are taking Metoprolol tartrate.You might also need regular eye examinations. |
| Drug quanitty |
The usual doses are:
High blood pressure
The usual starting dose is 100 mg a day. This can be increased by your doctor if necessary.
Angina (Chest pain)
The usual dose is 50-100 mg taken two or three times a day.
For other conditions, the usual total daily dose is between 100 and 200 mg. Your doctor will
choose a suitable starting dose and monitor your progress.
•Swallow your tablets whole with a drink of water.
•Do not stop taking your tablets suddenly as this may cause your condition to get worse. Ask your doctor first.
•Metoprolol tartrate is not recommended for children.
•People with liver problems may be told to take a lower dose. |
| Drug Dose |
The doctor will tell you how many Metoprolol tartrate Tablets to take and when to take them.The dose
you are prescribed will depend on the condition you have and how severe it is. Always follow
the doctor’s instructions carefully. The dose will be on the pharmacist’s label. Check the label
carefully. If you are not sure, ask your doctor or pharmacist. Keep taking your tablets for as
long as you have been told, unless you have any problems. In that case, check with your doctor. |
| Excess Drug Consumption |
If you accidentally take too many Metoprolol tartrate tablets, tell your doctor at once or contact your nearest hospital casualty department.Take your medicine pack with you so that people can see what you have taken |
| Forgot Drug Consumption |
If you forget to take a dose, take it when you remember and then take your next dose at the usual time.However, it is important not to take two doses at the same time |
| Stop Drug Consumption |
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| Possible Side
Effects
|
| General Information |
•Headache, dizziness, or unusual tiredness.
•Slow heart beat.
•Low blood pressure which might make you faint or dizzy.
•Feeling short of breath when exercising.
•Feeling or being sick, stomach ache |
| Common Drug Side Effects |
•Sleep disorders such as sleepiness, sleeplessness or nightmares.
•Feeling less alert.
•Coldness, numbness or tingling in your hands and feet.
•Depression.
•Muscle cramps
•Heart failure or irregular heart beat.
•Water retention (oedema).
•Breathlessness or wheeziness (bronchospasm).
•Diarrhoea or constipation.
•Skin rash and/or itching |
| Rare Drug Side Effects |
•Weight gain.
•Hallucinations or personality disorders.
•Dry or sore eyes or problems with vision.
•Tinnitus or hearing problems.
•Gangrene.
•Runny nose, dry mouth.
•Changes in the results of liver function tests.
•Bruising or increased sensitivity of the skin to sunlight, worsening of psoriasis.
•Increased sweating, loss of hair.
•Impotence or loss of libido.
•Painful joints.
•Chest pain. |
| Very Rare Drug Side Effects |
•Confusion
•Abnormal levels of certain types of fats such as cholesterol or triglycerides in the blood.
•Abnormal curvature of the penis with painful erections (known as Peyronie’s disease)
•Retroperitoneal fibrosis where abnormal scar tissue occurs behind the membrane that lines the cavity of the abdomen. This may present with pain in the back, groin or the lower abdomen.
•Hepatitis |
| Drug Side Effects Symptoms |
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| How to Store the
Medicine
|
| How to Store the Medicine |
Store in a dry place. Keep out of the reach and sight of children. Do not take Metoprolol tartrate Tablets after the expiry date which is printed on the outside of the pack. If your doctor tells you to stop taking the tablets, please take any unused tablets back to your pharmacist to be destroyed.Do not throw them away with your normal household water or waste.This will help to protect the environment |
AMLODIPINE
| Information for
patients
|
| Drug Information |
Amlodipine is one of a group of medicines called calcium antagonists.
Your medicine is used to treat high blood pressure (hypertension) or a certain type of chest pain called angina, a rare form of which is Prinzmetal’s or variant angina.
In patients with high blood pressure your medicine works by relaxing blood vessels, so that blood passes through them more easily. In patients with angina Amlodipine works by
improving blood supply to the heart muscle which then receives more oxygen and as a result chest pain is prevented. Your medicine does not provide immediate relief of chest
pain from angina |
| Drug Alert |
| Alert |
•if you are allergic (hypersensitive) to Amlodipine, or any of the other ingredients of your medicine, or to any other calcium antagonists. This may be itching, reddening of the skin or difficulty in breathing;
•if you have narrowing of the aortic heart valve (aortic stenosis), unstable angina or cardiogenic shock |
| Before Consuming
the Medicine
|
| Avoid Drug |
Do not take Amlodipine:
•if you are allergic (hypersensitive) to Amlodipine, or any of the other ingredients of your medicine , or to any other calcium antagonists. This may be itching, reddening of the skin or difficulty in breathing;
•if you have narrowing of the aortic heart valve (aortic stenosis), unstable angina or cardiogenic shock;
•if you are pregnant or breast feeding |
| Drug Special Care |
You should inform your Doctor if you have or have had any of the following conditions:
•Recent heart attack (within the last month).
•Severe increase in blood pressure (Hypertensive crisis).
•Liver disease |
| Drug Drug Interactions |
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription |
| Drug Pregnancy Interaction |
If you think you might be pregnant, or are planning to get pregnant, tell your doctor before you take Amlodipine
Women of child bearing potential should ensure that they use effective contraception |
| Drug Breast feeding Interaction |
You should not take Amlodipine if you are breast-feeding
Ask your doctor or pharmacist for advice before taking any medicine |
| Drug Machinery Interaction |
Amlodipine is unlikely to affect your ability to drive or use machines. |
| Drug More Information |
Your medicine can be used before or after food. Grapefruit juice and grapefruit should not be consumed by people who are taking Amlodipine. This is because grapefruit and grapefruit juice can lead to an increase in the blood levels of the active ingredient amlodipine, which can cause an unpredictable increase in the blood pressure lowering effect of Amlodipine.
Children
Safety and effectiveness have been studied in 6-17 year old boys and in girls. Amlodipine has not been
studied in children under the age of 6 years. For more information, talk to your doctor. |
| How to take the
Medicine
|
| Consumption Info |
|
| Drug quanitty |
The usual dose of Amlodipine is one tablet daily. |
| Drug Dose |
The usual dose of Amlodipine is one tablet daily. |
| Excess Drug Consumption |
Taking too may tablets at once may make you unwell. If you take too may Amlodipine tablets contact your doctor at once or go to the nearest hospital casualty department |
| Forgot Drug Consumption |
Do not worry. If you forget to take a tablet, leave out that dose completely. Take your next dose at the right time. Do not take a double dose to make up for a missed dose |
| Stop Drug Consumption |
Your doctor will advise you how long to take your medicine. Your condition may return if you stop using your medicine before you are advised.
If you have any further questions on how to take this product, ask your doctor or pharmacist |
| Possible Side
Effects
|
| General Information |
|
| Common Drug Side Effects |
•Headache, dizziness, sleepiness.
•Palpitations (awareness of your heart beat), flushing.
•Abdominal pain, feeling sick (nausea).
•Ankle swelling (oedema), tiredness.
Other side-effects that have been reported include the following list. If any of these get serious, or
if you notice any side-effects not listed in this leaflet, please tell your doctor or pharmacist |
| Rare Drug Side Effects |
•Unusual bruising and bleeding (red blood cell damage).
•Severe skin reactions.
•Excess sugar in blood (diabetes).
•Increased sensitivity of the skin, pins and needles, loss of pain sensation.
•Heart attack.
•Hives.
•Abdominal bloating (gastritis).
•Cough.
•Inflamed pancreas.
•Abnormal liver function, inflammation of the liver, yellowing of the skin (jaundice), liver enzyme increases.
If any of the side effects gets serious, or if you notice any side effects not listed in this , please tell your doctor or pharmacist |
| Very Rare Drug Side Effects |
•Mood changes, sleeplessness.
•Trembling, taste abnormalities, fainting, weakness.
•Visual disturbances, ringing in the ears.
•Low blood pressure.
•Shortness of breath, sneezing/running nose.
•Altered bowel habit, indigestion, dry mouth, vomiting (being sick).
•Hair loss, increased sweating, itchy skin, red patches on skin.
•Increased need to urinate especially at night, inability to obtain an erection.
•Chest pain, weakness, pain, feeling unwell.
•Joint or muscle pain, muscle cramps, back pain.
•Weight increase or decrease.
•Enlargening of male breasts |
| Drug Side Effects Symptoms |
Like all medicines, Amlodipine can cause side effects, although not everybody gets them. Tell your doctor immediately if you experience any of the following symptoms after taking this medicine.
Although they are very rare, the symptoms can be severe.
•Sudden wheeziness, difficulty in breathing, swelling of eyelids, face or lips, rash or itching (especially affecting the whole body).
The following Common side-effects have been reported. If any of these cause you problems or if they last for more than one week, you should contact your doctor |
| How to Store the
Medicine
|
| How to Store the Medicine |
Keep out of the reach and sight of children.
Do not store above 25oC.
Do not use your medicine after the expiry date which is stamped on the pack. The expiry date
refers to the last day of that month.
Medicines should not be disposed of via wastewater of household waste. Ask your
pharmacist how to dispose of medicines no longer required. These measures will help to
protect the environment |
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