| Information for
patients
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| Drug Information |
Therapeutic group* Carboprost belongs to a group of medicines called prostaglandins.Prostaglandins are produced naturally in your body and are very important for a variety of activities, including childbirth. After childbirth they make the womb contract and to help it stay contracted, which stops heavy bleeding from the womb. Carboprost given after childbirth increases the contraction of your womb which helps to control bleeding after delivery.
Therapeutic indications
•Carboprost is a sterile solution for injection. It is available in ampoules and contains 250mcg of the active ingredient, carboprost, per ml of solution.
•Carboprost is used to stop excessive bleeding in women who have just given birth, when bleeding is due to the womb failing to return to its normal size.
*A therapeutic group is one in which a drug is classified depending on its actions and the part(s) of the body it affects |
| Drug Alert |
| Alert |
?Do not take Carboprost:
Carboprost is not suitable for all women. Your doctor may decide to give you a different medicine if any of these apply to you.
You should not be given Carboprost if you:
•have ever had an allergic reaction to Carboprost or to any of the other ingredients of the medicine, in particular benzyl alcohol which can cause problems in some people.
•currently have an infection of your womb, ovaries or fallopian tubes (this may be causing pain in your pelvis or vaginal discharge). |
| Before Consuming
the Medicine
|
| Avoid Drug |
?Do not take Carboprost:
Carboprost is not suitable for all women. Your doctor may decide to give you a different medicine if any of these apply to you.
You should not be given Carboprost if you:
•have ever had an allergic reaction to Carboprost or to any of the other ingredients of the medicine, in particular benzyl alcohol which can cause problems in some people.
•currently have an infection of your womb, ovaries or fallopian tubes (this may be causing pain in your pelvis or vaginal discharge). |
| Drug Special Care |
Tell your doctor if you currently have, or have had in the past any of the following, as Carboprost will have to be used more carefully;
•glaucoma (raised pressure in your eyes)
•high or low blood pressure (including high blood pressure in pregnancy)
•heart disease or anaemia (low blood count)
•lung disease, including asthma
•kidney or liver disease (including jaundice)
•diabetes or epilepsy
•a caesarean section or any other operation on your womb
In very rare cases heart and circulation failure have been reported following the use of prostaglandins (the active ingredient of this medicine).
It is possible that this medicine may lower the oxygen levels in your blood. If you have previously suffered from conditions affecting your heart and lungs your doctor will monitor you and may give you additional oxygen as necessary.Your doctor may give you other medicines to reduce the side effects of being sick or having diarrhoea as these are the common side effects of all prostaglandins (the active ingredient of this medicine).Raised temperature has been observed with treatment from Carboprost. This will usually return to normal several hours after the last injection. |
| Drug Drug Interactions |
Treatments that strengthen contraction of the womb, including oxytocin and ergometrine, can be affected by Carboprost. Medical staff will watch over you very carefully if you have had these treatments as well as Carboprost.
Tell your midwife or doctor if you are taking any other medicines |
| Drug Pregnancy Interaction |
Carboprost will only be given shortly after you have delivered your baby and not while you are still pregnant.
It is not known if carboprost is excreted in human breast milk. As your own body produces prostaglandins during childbirth, Carboprost is not expected to cause any harm to your baby.Ask your doctor or pharmacist for advice before taking any medicine. |
| Drug Breast feeding Interaction |
Carboprost will only be given shortly after you have delivered your baby and not while you are still pregnant.
It is not known if carboprost is excreted in human breast milk. As your own body produces prostaglandins during childbirth, Carboprost is not expected to cause any harm to your baby.Ask your doctor or pharmacist for advice before taking any medicine. |
| Drug Machinery Interaction |
Do not drive because it is unlikely that you will be well enough to drive.Do not use any tools or operate machinery soon after receiving Carboprost. |
| Drug More Information |
Carboprost contains less than 1 mmol sodium (23mg) per dose and is essentially‘sodium free.Carboprost also contains benzyl alcohol which may cause allergic reactions |
| How to take the
Medicine
|
| Consumption Info |
If you continue to bleed heavily after being given Carboprost you may be given other medicines to help control the bleeding. Your doctor or midwife will be watching you closely to help them decide whether Carboprost is working for you. |
| Drug quanitty |
•The first dose is usually 1 ml of solution (250 micrograms of carboprost).Your doctor may give you more doses of 1 ml if you need them. You should not have doses more often than once every 15 minutes. Usually you would have them less often, about once in one-and-a-half hours.
•You should not be given more than 8 doses (2 mg of carboprost) altogether. Carboprost is not indicated for use in children. |
| Drug Dose |
This product should be used only in hospitals and clinics with specialised units for pregnancy and childbirth. Medical staff should be available in the hospital at all times.Carboprost may be given by a doctor or a midwife.
The staff will make sure that this medicine is used in the right way and at the right time. You should never be given Carboprost while you are pregnant, only after the birth. It must never be given by injection into a vein.
•Carboprost is given by injection deep into a muscle |
| Excess Drug Consumption |
If you get very bad sickness and diarrhoea, your doctor may delay the next injection of Carboprost, or may not give you any more doses. Your doctor will treat the symptoms that the Carboprost has caused |
| Forgot Drug Consumption |
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| Stop Drug Consumption |
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| Possible Side
Effects
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| General Information |
•Effects on your respiratory system and immune system: Carboprost can very occasionally cause serious breathing difficulties as well as asthma and wheezing. If you have any difficulty breathing after receiving Carboprost tell your doctor or midwife immediately.
•The benzyl alcohol in Carboprost solution can cause an allergic reaction in some people. If you suffer from wheezing together with any itching or swelling of the face or tongue tell your doctor or midwife immediately.
The following side effects are listed by frequency. |
| Common Drug Side Effects |
Diarrhoea, nausea, vomiting, increased body temperature. |
| Rare Drug Side Effects |
These include: headache, hot flushes, chills, coughing, bleeding from the uterus, retained placenta or membranes, and inflammation of the uterus. |
| Very Rare Drug Side Effects |
These include: septic shock, vomiting blood, urinary tract infection, irregular sleep patterns or general feeling of drowsiness, muscle contractions affecting your posture and positioning of the head, general muscle pain, pins and needles, abnormal taste, increased levels of sweating, chest discomfort, severe shortness of breath, asthma and
general breathing difficulties such as rapid breathing or wheezing, general pain especially in regions such as the upper abdomen, back and pelvis, tenderness of the breasts, blurred vision, dizziness, eye pain, dry mouth, hiccups, vertigo, ringing in the ears, increased heart rate, uterine rupture, uterine cervical laceration, fluid retention, general feeling of being unwell and injection site pain. |
| Drug Side Effects Symptoms |
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| How to Store the
Medicine
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| How to Store the Medicine |
Keep out of the reach and site of children.Do not use Carboprost after the expiry date which is stated on the box and on the ampoule. Your pharmacist will check this before the injection is given. The expiry date refers to the last day of the month.The vial must be stored at in a refrigerator at 0 - 6°C. Ampoules should be stored in a refrigerator between 2 – 8°C. Your pharmacist will check the ampoules are still clear and colourless before use.Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment |
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