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About TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN

TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN belongs to the class of medications called ‘analgesics’ used to treat pain associated with various conditions. It is used in the treatment of pain, swelling and inflammation associated with chronic (long-term) conditions such as osteoarthritis (joint pain, especially in the knees, hip, hands, neck, and lower back) and rheumatoid arthritis (joint pain, especially in the hands and feet). It can also relieve acute (short-term) pain such as toothache, ear pain, throat pain, muscle ache, and backache.

TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN combines four medicines: Trypsin, Bromelains, Rutoside, and Papain. Trypsin, Papain and Bromelain are enzymes and have antiseptic and anti-inflammatory properties. They reduce pain, swelling, and inflammation by increasing the blood supply to the affected area. It can also promote healing. Rutoside is an antioxidant and anti-inflammatory agent. It prevents further swelling and inflammation by neutralizing the chemicals (free radicals) that cause cell damage. 

TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN should be taken exactly as prescribed by your doctor. In some cases, TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN may cause side effects such as nausea, vomiting, stomach pain, indigestion, heartburn, stomach upset, diarrhoea, headache, flushing (skin reddening), and skin rash. These side effects are usually mild and temporary. However, if any of these side effects persist or worsen, consult a doctor immediately.

Do not take TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN if you are allergic to NSAIDs or any other contents of it. TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN should not be used in patients with a history of stomach ulcers, active stomach ulcers or bleeding, or stomach problems due to NSAIDs, heart, liver, kidney disease, and poor blood circulation. TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN should be used with caution in patients with ulcerative colitis (inflammation of the large intestine), other bowel disorders, porphyria ( an inherited blood disorder), bleeding disorders, asthma, other respiratory infections, hypertension (high blood pressure), history of blood clots, high cholesterol, diabetes, history of smoking, and systemic lupus erythematosus (a skin disease). TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN should also be used with caution in pregnant and breastfeeding women. TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN is not recommended for children below 12 years of age. TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN may require dose adjustments when used in elderly people. Alcohol may increase the risk of liver damage and side effects, such as nausea, vomiting, and diarrhoea. TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN may cause dizziness, so do not drive or operate heavy machinery if you are dizzy.

Uses of TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN

Management of pain and swelling

Medicinal Benefits

TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN is a combination of four medicines: Trypsin, Bromelains, Rutoside, and Papain. Trypsin, Papain and Bromelain are enzymes and have antiseptic and anti-inflammatory properties. They reduce pain, swelling, and inflammation by increasing the blood supply to the affected area. It can also promote healing. Rutoside is an antioxidant and anti-inflammatory agent. It prevents further swelling and inflammation by neutralizing the chemicals (free radicals) that cause cell damage. TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN can be used to treat pain associated with osteoarthritis, rheumatoid arthritis, toothache, ear pain, throat pain, and muscle pain. It can provide quick relief from the pain and also promote faster healing of the affected tissue. It helps you to do your daily activities by decreasing the interference of pain and improving quality-of-life.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN

  • Nausea
  • Vomiting
  • Stomach pain
  • Indigestion
  • Heartburn
  • Stomach upset
  • Diarrhoea
  • Headache
  • Flushing (skin reddening)
  • Skin rash

In-Depth Precautions and Warning

Drug Warnings

TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN should be used with caution in patients with heart diseases as it may increase heart rate. TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN may cause liver damage, so regular monitoring of liver function is required if this medicine is taken for longer durations. If you are scheduled for surgery of the stomach or intestine, inform your doctor that you are taking the TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN, as this medicine may delay wound healing. Do not overdose on medicine, as TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN in higher doses may increase heart attack or stroke risk.

Drug Interactions

Drug-Drug Interactions: TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN may interact with other painkillers (aspirin and ibuprofen), antibiotic (amoxicillin), blood thinners (warfarin), an antidepressant (lithium), anticancer agents (methotrexate), drugs that suppress the immune system (ciclosporin and tacrolimus), a medicine used to treat urinary tract infections (trimethoprim), abortion drug (mifepristone), a medication used to heart problems (digoxin), oral steroids, a medicine used to treat fits (phenytoin), antifungal agent (voriconazole), and medicines used to reduce cholesterol levels (colestipol and cholestyramine).

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN may interact with disease conditions including stomach ulcers, active stomach ulcers or bleeding, or stomach problems due to NSAIDs, heart, liver, kidney disease, and poor blood circulation. TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN should be used with caution in patients with ulcerative colitis (inflammation of the large intestine), other bowel disorders, porphyria ( an inherited blood disorder), bleeding disorders, asthma, other respiratory infections, hypertension (high blood pressure), history of blood clots, high cholesterol, diabetes, and systemic lupus erythematosus (a skin disease).

Drug-Drug Interactions Checker List:

  • ASPIRIN
  • IBUPROFEN
  • AMOXICILLIN
  • WARFARIN
  • LITHIUM
  • METHOTREXATE
  • CICLOSPORIN
  • TACROLIMUS
  • TRIMETHOPRIM
  • MIFEPRISTONE
  • DIGOXIN
  • PHENYTOIN
  • VORICONAZOLE
  • COLESTIPOL
  • CHOLESTYRAMINE
  • Safety Advice

    • Safety Warning

      Alcohol

      caution

      Alcohol may cause further liver damage and worsen side-effects of TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN. So, limit the consumption of alcohol while using TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN.

    • Safety Warning

      Pregnancy

      unsafe

      TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN may cause harmful effects to the unborn baby. So, it is used in pregnant women only if the doctor thinks the benefits outweigh the risks.

    • Safety Warning

      Breast Feeding

      caution

      TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN should be used with caution in breastfeeding mothers as there is not enough research to establish the safe use of TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN during breastfeeding.

    • Safety Warning

      Driving

      caution

      TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN may cause headaches and dizziness. So, you should not drive or operate heavy machinery if you feel dizzy.

    • Safety Warning

      Liver

      caution

      TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN may alter liver function. So, it should be used with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.

    • Safety Warning

      Kidney

      caution

      TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN should be used with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.

    • Safety Warning

      Children

      caution

      TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN is not recommended for children below 12 years of age.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercises like walking on the treadmill, bike riding, and swimming. You can also strengthen your muscles by lifting light weights.
    • In chronic arthritis or joint pain, try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimize levels of chemicals called cytokines, which ramp up inflammation.
    • Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible, and only for a short duration of time. Long-term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel to minimise pain at the back of your spine curve. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.

    Special Advise

    • TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN may increase the heart rate. Inform your doctor about any such symptoms.
    • Long-term use of TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN may cause liver damage, and your doctor may advise liver function for regular monitoring of liver function.

    Patients Concern

    Disease/Condition Glossary

    Pain: Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. It can be temporary (acute) or lifelong (chronic) in nature. Acute pain is, for a short time, caused by damage to the tissues of the muscle, bone, or organs. While chronic pain lasts lifelong and can occur due to severe inflammation or tissue damage, such as osteoarthritis and rheumatoid arthritis. Extreme tissue pain and inflammation caused due to sprains, strains, trauma, or post-surgery may require prolonged healing time.

    Osteoarthritis: It is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering of cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms include pain, stiffness, inflammation, and tenderness.

    Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities, and loss of joint function.

    FAQs

    How does TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN work?

    TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN combines four medicines: Trypsin, Bromelains, Rutoside, and Papain. Trypsin, Papain and Bromelain are enzymes that reduce pain, swelling, and inflammation by increasing the blood supply to the affected area. Rutoside is an antioxidant and prevents further swelling and inflammation by neutralizing the chemicals (free radicals) that cause cell damage. Together, TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN can effectively treat pain associated with various conditions.

    Can TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN treat period pain?

    TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN should not be used to treat period pain. You should discuss with your doctor before taking TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN for any indication to avoid unwanted effects.

    What are the common side-effects of TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN?

    The common side-effects of TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN are nausea, vomiting, stomach pain, indigestion, heartburn, stomach upset, diarrhoea, headache, flushing (skin reddening), and skin rash. These side effects are usually mild and temporary. However, if any of these side effects persist or get worse, consult a doctor immediately.

    Can I take TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN with aspirin?

    TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN should not be taken with aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen and aceclofenac. It may increase the risk of gastrointestinal (stomach and intestine) side effects.

    Is TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN safe for hypertensive patients?

    TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN is usually well-tolerated in most patients. However, it should be used with caution in patients with high blood pressure and high cholesterol as it increases the risk of a heart attack in higher doses. So, inform your doctor about your illnesses before taking this medicine.

    Does TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN have any effect on stools?

    TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN may cause a change in the consistency and colour of the stools. Consult a doctor if the condition persists.

    Available Medicines for

    TRYPSIN+BROMELAINS+RUTOSIDE+PAPAIN

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