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Proluton Depot Injection 2 ml
Proluton Depot Injection 2 ml
Proluton Depot Injection 2 ml
Proluton Depot Injection 2 ml
Proluton Depot Injection 2 ml

Proluton Depot Injection 2 ml is used to prevent premature labour. It contains Hydroxyprogesterone, which modulates the immune response of pregnant women to prevent rejection of the embryo and allow its attachment to the uterus. It prevents miscarriage and helps lower the risk of premature birth in pregnant women who have had past premature labour. In some cases, you may experience certain common side effects such as nausea, vomiting, itching, hives (skin rashes), swelling in the face, lips, tongue, or throat, and diarrhea.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Proluton Depot Injection 2 ml
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

Health Queries

I am 30 weeks pregnant with a cervical length of 2.38 cm, with internal os opening and mild funneling seen on ultrasound. I have been advised bed rest and given Proluton Depot weekly and Endogest daily. Is this the correct management?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

At 30 weeks of pregnancy, a short cervix (2.38 cm) with internal opening and funnelling suggests a risk of preterm labour, and the management you have been advised, reduced activity/modified bed rest along with progesterone support using Proluton Depot weekly and Endogest daily, is commonly used and considered appropriate to help relax the uterus and reduce the risk of early delivery. It is important to follow your doctor's advice closely, avoid heavy work or long standing, stay well hydrated, and attend regular follow-ups to monitor your condition. Watch for warning signs like lower abdominal pain, tightening of the uterus, vaginal discharge or leaking fluid, and report them immediately. Your care plan may be adjusted based on how you progress, but overall, this is a standard and reasonable approach for your situation.

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Drug-Drug Interactions

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Drug-Drug interaction: This Proluton Depot Injection 2 ml interacts with pain killers (acetaminophen) anti-epilepsy medicines (primidone, phenytoin, carbamazepine), antidiabetics (metformin, glimepiride, glipizide, canagliflozin), medicines used to treat HIV (efavirenz) medicine used to treat fungal infections (griseofulvin, ketoconazole, itraconazole, posaconazole).

Drug-Food Interaction: Proluton Depot Injection 2 ml may interact with grapefruit and alcohol.

Drug-Disease Interaction: Proluton Depot Injection 2 ml should be taken with caution in breast cancer, thromboembolism (blood clot form in blood vessels), depression, diabetes, fluid retention (excess fluid builds up within the body), and kidney or liver disease.

HydroxyprogesteroneRifabutin
Severe
HydroxyprogesteroneItraconazole
Severe

Drug-Drug Interactions

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HydroxyprogesteroneRifabutin
Severe
How does the drug interact with Proluton Depot Injection 2 ml:
Coadministration of Rifabutin and Proluton Depot Injection 2 ml may reduce the blood levels and effects of Proluton Depot Injection 2 ml.

How to manage the interaction:
Using Rifabutin and Proluton Depot Injection 2 ml together can lead to an interaction; they can be taken if your doctor advises. However, if you experience any abnormal bleeding, or pain, swelling, itching, bruising, or a lump at the injection site, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
HydroxyprogesteroneItraconazole
Severe
How does the drug interact with Proluton Depot Injection 2 ml:
Coadministration of Itraconazole and Proluton Depot Injection 2 ml can cause an increase in the levels of Proluton Depot Injection 2 ml.

How to manage the interaction:
Using Itraconazole and Proluton Depot Injection 2 ml together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, or vaginal bleeding, consult the doctor . Do not stop using any medications without a doctor's advice.
HydroxyprogesteroneNicotine
Severe
How does the drug interact with Proluton Depot Injection 2 ml:
Coadministration of Nicotine and Proluton Depot Injection 2 ml may reduce the blood levels and effects of nicotine.

How to manage the interaction:
Using Nicotine and Proluton Depot Injection 2 ml together can lead to an interaction, they can be taken if advised by your doctor. Consult your doctor if your symptoms do not improve or worsen. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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HYDROXYPROGESTERONE-500MGCaffeine containing foods/drinks, Grapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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HYDROXYPROGESTERONE-500MGCaffeine containing foods/drinks, Grapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu, Grapefruit Juice, Grapefruit

How to manage the interaction:
Proluton Depot Injection 2 ml may reduce the blood levels and effects of caffeine. Grapefruit juice may increase the blood levels of Proluton Depot Injection 2 ml. Avoid or limit taking caffeine and grape juice while taking Proluton Depot Injection 2 ml as it can lead to interaction.

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