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Is Syndopa Plus Effective Against Parkinson's Disease?

By Apollo Pharmacy, Published on- 06 September 2023

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Parkinson's Disease is a neurodegenerative disorder that primarily affects the motor system. While there is no known cure for Parkinson's Disease, medication plays a crucial role in managing its symptoms and improving the quality of life for patients. One such medication commonly prescribed is Syndopa Plus. Let us explore how Syndopa Plus works to manage the symptoms of Parkinson's Disease.

What is Parkinson's Disease?

Parkinson's disease is a progressive neurological disorder that affects movement and coordination. It occurs due to the loss of dopamine-producing cells in the brain, primarily in an area called the substantia nigra.

The exact cause of Parkinson's disease is still unknown, but researchers believe it is a combination of genetic and environmental factors.

Symptoms of Parkinson's Disease

The symptoms of Parkinson's disease vary from person to person but commonly include:

  • Tremors
  • Stiffness
  • Slowness of movement
  • Balance problems
  • Changes in speech
  • Difficulty in writing
  • Impaired sense of smell

Diagnosis of Parkinson's disease is based on medical history, physical examination, and the presence of specific motor symptoms for a significant period.

How Does Syndopa Plus Work in Parkinson's Disease?

Syndopa Plus is a combination medication commonly used for the management of symptoms associated with Parkinson's disease. It consists of two main components which work synergistically to alleviate the motor symptoms of this progressive neurological disorder.

1. Levodopa

Levodopa, also known as L-DOPA, is a precursor of dopamine, a neurotransmitter that plays a crucial role in regulating movement and coordination. In Parkinson's disease, there is a deficiency of dopamine in certain regions of the brain. It works by:

  • increasing dopamine levels in the brain
  • helping to restore normal functioning
  • providing relief from motor symptoms

However, Levodopa has limited efficacy on its own as it can also be converted into dopamine outside the brain, causing side effects like nausea and vomiting.

2. Carbidopa

Carbidopa is added to Syndopa Plus to enhance the effectiveness of Levodopa. The process through which it works is:

  • Carbidopa inhibits an enzyme called dopa decarboxylase, which is responsible for converting Levodopa into dopamine outside the brain
  • By preventing this conversion in the peripheral tissues, Carbidopa allows more Levodopa to reach the brain, improving its efficacy and reducing side effects

Benefits of Syndopa Plus

Here are some of the benefits and therapeutic effects of Syndopa Plus:

1. Symptom Relief

One of the primary benefits of Syndopa Plus is its ability to alleviate motor symptoms associated with Parkinson's disease. As dopamine levels decline, individuals with Parkinson's disease experience a range of motor symptoms. By replenishing the levels of dopamine in the brain, Syndopa Plus leads to improved motor function and a reduction in symptoms.

2. Quality of Life

The relief provided by Syndopa Plus allows patients to regain control over their movements and engage more actively in daily activities.

Consequently, this can lead to:

  • Improved independence
  • Increased social interactions
  • Greater sense of well-being

3. Long-Term Management and Disease Progression

One of the potential benefits of using Syndopa Plus over an extended period is its ability to slow down the progression of the disease in some cases. Research suggests that Levodopa, the primary component of Syndopa Plus, may have neuroprotective properties.

By reducing oxidative stress and inflammation in the brain, it has the potential to delay the degeneration of dopaminergic neurons responsible for Parkinson's disease.

Administration and Dosage Guidelines

When it comes to taking Syndopa Plus for Parkinson's disease, it is important to follow the right administration technique.

  • Timing: Take Syndopa Plus exactly as prescribed by your healthcare provider. It is usually recommended to take the medication at a fixed time every day such as about 30 minutes before a meal, to maximize its effectiveness as advised by your doctor.
  • Dosage: The dosage of Syndopa Plus may vary depending on individual needs and response to treatment. However, it is recommended not to take more than one dose (two capsules) daily.
  • Dietary Considerations: Certain protein-rich foods such as meat, poultry, eggs, nuts, and seeds can interfere with the absorption of levodopa, the main component of Syndopa Plus. To ensure optimal effectiveness, it is recommended to take the medication on an empty stomach. However, if you experience nausea or stomach upset, your doctor may advise you to take it with food.
  • Swallowing: Take Syndopa Plus tablets whole with a glass of water. Do not crush, chew, or break them unless instructed otherwise by your doctor.
  • Storage: Keep Syndopa Plus in a cool, dry place away from direct sunlight and moisture. Follow the instructions on the packaging regarding proper storage conditions.

Precautions to Take while Using Syndopa Plus

Preexisting conditions or certain medications may interfere with Syndopa Plus. They include:

1. Pre-existing Medical Condition

  • Glaucoma: Individuals with glaucoma should exercise caution while using Syndopa Plus. This medication can potentially increase intraocular pressure, which may worsen the condition.
  • Cardiovascular Disorders: Patients with cardiovascular disorders, such as hypertension or arrhythmias, should be closely monitored while taking Syndopa Plus. The medication can cause fluctuations in blood pressure and heart rate.
  • Psychiatric Disorders: Individuals with a history of psychiatric disorders, including depression or psychosis, should be carefully evaluated before starting Syndopa Plus. The medication may exacerbate these conditions.

2. Interaction with other Medications

  • Monoamine Oxidase Inhibitors (MAOIs): Syndopa Plus should not be taken concurrently with MAOIs or within two weeks after discontinuing MAOIs. The combination can result in a dangerous increase in blood pressure.
  • Iron Supplements: Iron supplements should be avoided while taking Syndopa Plus as they can decrease the absorption of levodopa, the main active ingredient in the medication.


Syndopa Plus is a widely used medication for the management of Parkinson's disease. Its combination of levodopa and carbidopa helps to alleviate the symptoms of the condition, allowing individuals to maintain a better quality of life. With proper management and ongoing care, individuals living with Parkinson's disease can lead fulfilling lives and maintain their independence for as long as possible.

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Q. What are the common side effects of Syndopa Plus?

The most common side effects of Syndopa Plus include nausea, vomiting, dizziness, headache, and dry mouth. These side effects are usually mild and temporary. In some cases, patients may also experience hallucinations or sleep disturbances.

Q. How should Syndopa Plus be taken?

Syndopa Plus should be taken exactly as prescribed by your doctor. It is usually taken multiple times a day, with or without food. The dosage may vary depending on your individual needs and response to the medication.

Q. Are there any new technologies or advancements in the treatment of Parkinson's disease?

Yes, there are ongoing advancements in the treatment of Parkinson's disease. Deep brain stimulation (DBS) is a surgical procedure that involves implanting electrodes in specific areas of the brain to help control movement. Additionally, researchers are exploring the use of stem cell therapy and gene therapy as potential treatments for Parkinson's disease.

Q. Are there any lifestyle factors that can affect the effectiveness of Syndopa Plus?

Yes, certain lifestyle factors can affect the effectiveness of Syndopa Plus. It is important to avoid high-protein meals as they can interfere with the absorption of levodopa in the body. Additionally, alcohol and certain medications can interact with Syndopa Plus and worsen side effects.

Q. How long does it take for Syndopa Plus to start working?

The onset of action varies from person to person. Some individuals may start experiencing improvements in their symptoms within a few days, while others may take several weeks.


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