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Bonitar 100 Tablet 10's
Bonitar 100 Tablet 10's
Bonitar 100 Tablet 10's
Bonitar 100 Tablet 10's

Bonitar 100 Tablet is used to treat certain cancers such as Philadelphia chromosome-positive chronic myeloid leukaemia. It contains Bosutinib, which belongs to the class of kinase inhibitors. It works by inhibiting the action of abnormal proteins that cause the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduces the spread of cancer to other parts of the body.

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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Bonitar 100 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

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Drug-Drug Interactions

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Drug-Drug Interactions: Bonitar 100 Tablet may interact with vaccines, proton pump inhibitors (pantoprazole, esomeprazole), CYP3A inhibitors (ritonavir, itraconazole, ketoconazole, clarithromycin, erythromycin), CYP3A inducers (rifampin, phenytoin, phenobarbitone, carbamazepine).

Drug-Food Interactions: Avoid alcohol consumption and smoking. 

Drug-Disease Interactions: Inform your doctor if you have kidney or liver disease, gastrointestinal disorders, diabetes, hepatotoxicity, and cardiac disorders before taking Bonitar 100 Tablet .

BosutinibYellow fever vaccine
Critical
BosutinibIdelalisib
Severe

Drug-Drug Interactions

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BosutinibYellow fever vaccine
Critical
How does the drug interact with Bonitar 100 Tablet:
Combining Yellow fever vaccine with Bonitar 100 Tablet can increase the risk of infection.

How to manage the interaction:
Taking Yellow fever vaccine with Bonitar 100 Tablet can result in an interaction, but it can be taken if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
BosutinibIdelalisib
Severe
How does the drug interact with Bonitar 100 Tablet:
Taking Bonitar 100 Tablet with idelalisib can increase the blood levels of Bonitar 100 Tablet. This can increase side effects such as nausea, vomiting, abdominal pain, and diarrhea.

How to manage the interaction:
Although there is an interaction between Bonitar 100 Tablet and idelalisib, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
BosutinibAmprenavir
Severe
How does the drug interact with Bonitar 100 Tablet:
Taking Bonitar 100 Tablet with amprenavir may increase the blood levels of Bonitar 100 Tablet, which can raise the risk and severity of side effects.

How to manage the interaction:
Although there is an interaction between Bonitar 100 Tablet and Amprenavir, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience abdominal pain, diarrhea, fatigue, dizziness, fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
BosutinibMibefradil
Severe
How does the drug interact with Bonitar 100 Tablet:
Taking Bonitar 100 Tablet with Mibefradil can increase the blood levels of Bonitar 100 Tablet, which can increase the risk of side effects such as nausea, vomiting, abdominal pain, diarrhea, and liver problems.

How to manage the interaction:
Although there is an interaction between Bonitar 100 Tablet and Mibefradil, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, pain or burning during urination. Do not discontinue any medications without consulting a doctor.
BosutinibFosphenytoin
Severe
How does the drug interact with Bonitar 100 Tablet:
Taking Bonitar 100 Tablet with fosphenytoin can lower blood levels of Bonitar 100 Tablet, which could decrease its effectiveness in treating your condition.

How to manage the interaction:
Although there is an interaction between Bonitar 100 Tablet and Fosphenytoin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
BosutinibIbutilide
Severe
How does the drug interact with Bonitar 100 Tablet:
Taking Bonitar 100 Tablet and ibutilide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between Bonitar 100 Tablet with ibutilide, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
BosutinibCeritinib
Severe
How does the drug interact with Bonitar 100 Tablet:
Coadministration of Bonitar 100 Tablet and ceritinib may significantly increase the blood levels of Bonitar 100 Tablet.

How to manage the interaction:
Although there is an interaction between Bonitar 100 Tablet and Ceritinib, it can be taken together if prescribed by a doctor. However, consult your doctor if you experience abdominal pain, diarrhea, dizziness, fainting, loose stools, muscle aches, red or inflamed skin. Do not discontinue any medications without consulting a doctor.
BosutinibRibociclib
Severe
How does the drug interact with Bonitar 100 Tablet:
Taking Bonitar 100 Tablet and Ribociclib together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between Bonitar 100 Tablet and ribociclib, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, or fainting. Do not discontinue any medications without consulting a doctor.
BosutinibVandetanib
Severe
How does the drug interact with Bonitar 100 Tablet:
Taking vandetanib with Bonitar 100 Tablet can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between Bonitar 100 Tablet and vandetanib, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, or fainting. Do not discontinue any medications without consulting a doctor.
BosutinibCitalopram
Severe
How does the drug interact with Bonitar 100 Tablet:
Taking Bonitar 100 Tablet with citalopram may increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is an interaction between Bonitar 100 Tablet and Citalopram, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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BOSUTINIB-100MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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BOSUTINIB-100MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking grapefruit or grapefruit juice with Bonitar 100 Tablet can increase the blood levels and effects of Bonitar 100 Tablet, which may increase the risk of side effects. Avoid the consumption of grapefruit and grapefruit juice.

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

  • Dr Aneela Siddabathuni

    MPharma., PhD

Last Updated

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