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Bortirel 3.5mg Injection
Bortirel 3.5mg Injection is used to treat cancers like multiple myeloma and mantle cell lymphoma. It contains Bortezomib which works by preventing the cancer cells from growing and eventually killing them. In some cases, this medicine may cause side effects such as constipation, vomiting, low white blood cell count, and low platelet count. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Bortirel 3.5mg Injection
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Nourish your body with a balanced diet with protein-rich foods like fish, eggs, and beans. Fruits, vegetables, and nuts provide essential vitamins and minerals. If necessary, consider vitamin B12 and folate supplements.
  • Practice good hygiene to protect yourself from infections. Wash your hands often, stay up-to-date on vaccinations, avoid crowded areas, and take care when handling food, pets, and diapers.
  • Aim for a good night's sleep, targeting 8 hours of sleep. Find calm through stress-reducing practices like yoga, meditation, or deep breathing. Regular physical activity can also help.
  • Stay healthy by drinking plenty of water, eating probiotic-rich foods like yoghurt, and limiting processed foods and sugars. Consult your doctor, if you are having difficulties or concerns.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Drug-Drug Interactions

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BortezomibBCG vaccine
Severe
BortezomibLomitapide
Severe

Drug-Drug Interactions

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BortezomibBCG vaccine
Severe
How does the drug interact with Bortirel 3.5mg Injection:
Coadministration of the BCG vaccine and Bortirel 3.5mg Injection can increase the risk of infection or decrease the vaccine response.

How to manage the interaction:
Taking Bortirel 3.5mg Injection with the BCG vaccine together can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.
BortezomibLomitapide
Severe
How does the drug interact with Bortirel 3.5mg Injection:
Coadministration of lomitapide and Bortirel 3.5mg Injection can increases the risk of liver problems.

How to manage the interaction:
Although using Bortirel 3.5mg Injection and Lomitapide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, joint pain or swelling, skin rash, itching, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes. Do not stop taking any medications without consulting a doctor.
BortezomibRifabutin
Severe
How does the drug interact with Bortirel 3.5mg Injection:
Coadministration of Bortirel 3.5mg Injection and rifabutin may reduce the blood levels of Bortirel 3.5mg Injection.

How to manage the interaction:
Although using Bortirel 3.5mg Injection and Rifabutin together can possibly result in an interaction, they can be taken together if prescribed by a doctor. Do not stop taking any medications without consulting a doctor.
BortezomibLeflunomide
Severe
How does the drug interact with Bortirel 3.5mg Injection:
Coadministration of leflunomide and Bortirel 3.5mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortirel 3.5mg Injection and Leflunomide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibTofacitinib
Severe
How does the drug interact with Bortirel 3.5mg Injection:
Taking tofacitinib and Bortirel 3.5mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortirel 3.5mg Injection and Tofacitinib together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibGolimumab
Severe
How does the drug interact with Bortirel 3.5mg Injection:
Coadministration of golimumab and Bortirel 3.5mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortirel 3.5mg Injection and Golimumab together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, discomfort, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibFingolimod
Severe
How does the drug interact with Bortirel 3.5mg Injection:
Coadministration of fingolimod and Bortirel 3.5mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortirel 3.5mg Injection and Fingolimod together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibClozapine
Severe
How does the drug interact with Bortirel 3.5mg Injection:
Coadministration of clozapine with Bortirel 3.5mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortirel 3.5mg Injection and Clozapine together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhoea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibVoclosporin
Severe
How does the drug interact with Bortirel 3.5mg Injection:
Coadministration of voclosporin and Bortirel 3.5mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortirel 3.5mg Injection and Voclosporin together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibTalimogene laherparepvec
Severe
How does the drug interact with Bortirel 3.5mg Injection:
Taking Bortirel 3.5mg Injection together with talimogene laherparepvec increases the risk of developing infection.

How to manage the interaction:
Although using Bortirel 3.5mg Injection and Talimogene laherparepvec together can possibly result in an interaction, they can be taken together if advised by your doctor. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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BORTEZOMIB-3.5MGCaffeine containing foods/drinks, Fiber rich foods
Moderate

Drug-Food Interactions

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BORTEZOMIB-3.5MGCaffeine containing foods/drinks, Fiber rich foods
Moderate
Common Foods to Avoid:
Green Tea, Oranges

How to manage the interaction:
Vitamin C or vitamin-containing foods and green tea diminish the effectiveness of Bortirel 3.5mg Injection Avoid or limit the consumption of Vitamin C or vitamin-containing foods and green tea.

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