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Combither Forte Tablet is used to treat and prevent malaria. It contains Artemether and Lumefantrine, which interfere with the Plasmodium parasite's growth in the red blood cells of the human body. It is a combination medicine used to treat non-severe malaria caused by a parasite called Plasmodium falciparum. It may cause common side effects, such as headache, dizziness, loss of appetite, weakness, fever, chills, tiredness, muscle or joint pain, nausea, vomiting, abdominal pain, cough, and trouble sleeping. Before using this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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Drug-Drug Interactions

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Drug-Drug Interaction: Combither Forte Tablet may interact with other anti-malarial drugs (mefloquine, quinine, quinidine), drugs treating abnormal heart rhythms (flecainide, amiodarone, sotalol, procainamide, disopyramide), antipsychotics (pimozide, ziprasidone), macrolide antibiotics (erythromycin), antibiotics (ciprofloxacin, moxifloxacin, rifabutin, rifampin), fits medicines (carbamazepine, phenobarbital, phenytoin), antifungals (ketoconazole, itraconazole), HIV drugs (delavirdine, efavirenz, nelfinavir, ritonavir), antidepressants (clomipramine, amitriptyline, imipramine), blood pressure drugs (metoprolol), depression medicines (St. John's wort) and birth control pills.

Drug-Food Interaction: Avoiding alcohol may improve the side effects of Combither Forte Tablet. Grapefruit juice may affect the efficacy of Combither Forte Tablet; hence please avoid it during treatment with Combither Forte Tablet.

Drug-Disease Interaction: Before using Combither Forte Tablet, let your doctor know if have any heart diseases, liver or kidney problems, malarial infection of the brain, lungs or kidneys, severe heart diseases, and electrolyte imbalance.

Critical

Drug-Drug Interactions

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How does the drug interact with Combither Forte Tablet:
Taking lumefantrine together with Cisapride can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking lumefantrine together with Cisapride can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Critical
How does the drug interact with Combither Forte Tablet:
Taking lumefantrine together with Enzalutamide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking lumefantrine together with Enzalutamide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Critical
How does the drug interact with Combither Forte Tablet:
Taking artemether together with fosphenytoin can reduce the blood levels of artemether, which may make the medication less effective in treating malaria.

How to manage the interaction:
The combined use of artemether and fosphenytoin is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. If you experience any symptoms, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Combither Forte Tablet:
Using Carbamazepine with Artemether may decrease the blood levels of Artemether.

How to manage the interaction:
Taking Carbamazepine with Artemether is not recommended, but can be taken if prescribed by the doctor. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Combither Forte Tablet:
Taking lumefantrine together with Clomipramine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking lumefantrine together with Clomipramine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Combither Forte Tablet:
Taking lumefantrine together with Doxepin can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking lumefantrine together with Doxepin can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Combither Forte Tablet:
Taking lumefantrine together with Astemizole can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking lumefantrine together with Astemizole can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Combither Forte Tablet:
Taking lumefantrine together with Dasatinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking lumefantrine together with Dasatinib can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Combither Forte Tablet:
Taking lumefantrine together with Citalopram can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking lumefantrine together with Citalopram can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Combither Forte Tablet:
Taking Artemether together with Amprenavir can increase the blood levels of artemether and increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Artemether together with Amprenavir can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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ARTEMETHER-80MG+LUMEFANTRINE-480MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ARTEMETHER-80MG+LUMEFANTRINE-480MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Coadministration with grapefruit juice may increase the plasma concentrations of artemether and lumefantrine. Avoid consumption of grapefruit juice and grape fruit.

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