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Comcapsy 400 mg/20 mg Tablet 7's
Comcapsy 400 mg/20 mg Tablet 7's
Comcapsy 400 mg/20 mg Tablet 7's

Comcapsy 400 mg/20 mg Tablet is an antineoplastic (anticancer) medication used to treat metastatic breast cancer. It contains Capecitabine and Cyclophosphamide, which work by damaging the genetic material of cancer cells and stopping their growth and multiplication. It may sometimes cause common side effects, such as nausea, vomiting, loss of appetite, diarrhoea, stomach pain, skin rash, weakness, tiredness, fever, mouth sores, and hair loss. Before taking this medication, inform your doctor if you are allergic to any of its ingredients or other cancer medicines, are pregnant or breastfeeding, or have any pre-existing medical conditions.

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Written By ,
Reviewed By Praneetha Akunuri , M.Pharmacy
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Side effects of Comcapsy 400 mg/20 mg Tablet
  • Apply fragrance-free, thick moisturizing creams to your hands and feet, gently pat the skin and dry instead of rubbing.
  • Use ice packs wrapped in a towel to soothe irritated areas on your palms and soles.
  • Wash your hands and feet with mild, unperfumed soap and avoid using harsh cleaning products.
  • Wear loose-fitting, well-cushioned shoes that provide ample space for your feet.
  • Practice wearing cotton gloves when doing chores that may irritate your hands.
  • Avoid hot baths or showers, instead opt for lukewarm water.
  • Wear sunscreen with a high SPF on exposed skin and limit sun exposure.
  • Don't expose your hands and feet to direct heat like or fireplaces.
  • Reduce pressure by avoiding activities that put pressure on your hands and feet, like jogging or heavy lifting.
  • If required, go for low-impact exercises like walking or swimming.
  • To reduce swelling elevate your feet when resting.
  • Consult your doctor if redness or blistering on your palms or soles, severe pain or discomfort in your hands and feet, open sores or bleeding on your skin or if significant worsening of symptoms.
  • Consult your doctor or healthcare provider before making any changes to your treatment plan or lifestyle modifications related to hand-foot syndrome.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • High levels of bilirubin in blood leads to yellow discolouration of skin and eyes which is a significant liver issue that needs immediate medical attention.
  • Eating a balanced diet can help manage such side effects and must be taken as a dietician suggests.
  • Exercise regularly to maintain a good metabolism in your body.
  • Avoid alcohol consumption as it can affect liver functioning and worsen if there is a yellow discolouration of the skin and eyes.
  • Prevent toxins from chemicals that can be touched and inhaled. Ensure to manage your medications carefully.
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
  • Bladder infection needs immediate medical attention when you observe blood in urine or have any abnormal changes in your body.
  • Get a physical examination and blood tests to identify factors that led to infection and initiate the treatment process immediately.
  • Avoid anxiety and stress, as it can worsen your condition.
  • Follow your doctor's instructions, and there can be medication with antibiotics and other supportive vitamins.
  • Take a balanced diet to prevent negative changes in your body.
  • Stay hydrated to support kidney and bladder health.
  • Rest on your back as advised by your doctor.
  • Limit physical strain for 1-2 weeks.
  • Avoid strenuous activities like running and contact sports.
  • Quit smoking to improve overall health.
  • Use pain medication responsibly.
  • Avoid foods that can irritate the urinary track, such as spicy or acidic foods.
  • Remember to consult your doctor for personalized advice and guidance on managing your symptoms and developing a treatment plan.

Drug-Drug Interactions

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CyclophosphamideCidofovir
Critical
CyclophosphamideNalidixic acid
Critical

Drug-Drug Interactions

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CyclophosphamideCidofovir
Critical
How does the drug interact with Comcapsy 400 mg/20 mg Tablet:
Co-administration of Comcapsy 400 mg/20 mg Tablet and Cidofovir may increase the risk of kidney problems.

How to manage the interaction:
Taking Cyclophosphamine with Cidofovir is not recommended, please consult your doctor before taking it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor
CyclophosphamideNalidixic acid
Critical
How does the drug interact with Comcapsy 400 mg/20 mg Tablet:
Co-administration of Nalidixic acid with Comcapsy 400 mg/20 mg Tablet may cause an increase in the risk of side effects.

How to manage the interaction:
Co-administration of Comcapsy 400 mg/20 mg Tablet and Nalidixic acid can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like bruising or bleeding, unusual weakness, nausea, stomach pain, low fever, or loss of appetite, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CyclophosphamideTenofovir disoproxil
Severe
How does the drug interact with Comcapsy 400 mg/20 mg Tablet:
Coadministration of Tenofovir disoproxil with Comcapsy 400 mg/20 mg Tablet may increase the risk of developing kidney problems.

How to manage the interaction:
Although there is a possible interaction, Comcapsy 400 mg/20 mg Tablet can be taken with Tenofovir disoproxil if prescribed by the doctor. Consult the doctor if you experience signs and symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medication without consulting a doctor.
CyclophosphamideTenofovir alafenamide
Severe
How does the drug interact with Comcapsy 400 mg/20 mg Tablet:
Co-administration of Tenofovir alafenamide may cause kidney problems, and combining it with Comcapsy 400 mg/20 mg Tablet may increase the risk.

How to manage the interaction:
Although there is a possible interaction, Comcapsy 400 mg/20 mg Tablet can be taken with Tenofovir alafenamide if prescribed by the doctor. Consult the doctor if you develop signs and symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop any medication without consulting a doctor.
CyclophosphamideBaricitinib
Severe
How does the drug interact with Comcapsy 400 mg/20 mg Tablet:
Using baricitinib together with Comcapsy 400 mg/20 mg Tablet may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction, Baricitinib can be taken with Comcapsy 400 mg/20 mg Tablet if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue the medication without consulting a doctor.
CyclophosphamideRopivacaine
Severe
How does the drug interact with Comcapsy 400 mg/20 mg Tablet:
Co-administration of Ropivacaine with Comcapsy 400 mg/20 mg Tablet can cause methemoglobinemia (low levels of oxygen in the blood).

How to manage the interaction:
Although there is a possible interaction between Ropivacaine and Comcapsy 400 mg/20 mg Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
CyclophosphamideTofacitinib
Severe
How does the drug interact with Comcapsy 400 mg/20 mg Tablet:
Taking Comcapsy 400 mg/20 mg Tablet with Tofacitinib may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Comcapsy 400 mg/20 mg Tablet can be taken with Tofacitinib if prescribed by the doctor. Consult the doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
CyclophosphamideGolimumab
Severe
How does the drug interact with Comcapsy 400 mg/20 mg Tablet:
Co-administration of Golimumab with Comcapsy 400 mg/20 mg Tablet may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Comcapsy 400 mg/20 mg Tablet with Golimumab can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away: fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination. Do not stop using any medications without a doctor's advice.
CyclophosphamideVoclosporin
Severe
How does the drug interact with Comcapsy 400 mg/20 mg Tablet:
Co-administration of Comcapsy 400 mg/20 mg Tablet with Voclosporin can increase the risk of kidney damage.

How to manage the interaction:
Although there is a possible interaction between Comcapsy 400 mg/20 mg Tablet and Voclosporin, you can take these medicines together if prescribed by a doctor. It's important to keep an eye on how much you pee. Some other signs to watch out for are feeling sick, throwing up, not wanting to eat, gaining or losing weight suddenly, holding onto fluids, having a fever or chills, having diarrhea or a sore throat, feeling weak or dizzy, being confused, having trouble breathing, feeling pain or a burning sensation when you pee, or having an irregular heartbeat. Do not stop using any medications without talking to a doctor.
CyclophosphamideThiotepa
Severe
How does the drug interact with Comcapsy 400 mg/20 mg Tablet:
When Thiotepa is taken with Comcapsy 400 mg/20 mg Tablet, can increase the blood levels or add to the medication side effects of Comcapsy 400 mg/20 mg Tablet.

How to manage the interaction:
Although taking Thiotepa and Comcapsy 400 mg/20 mg Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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