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Drug-Drug Interactions
Critical
Severe
Drug-Drug Interactions
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Critical
How does the drug interact with Defen MR 250mg/50mg/500mg Tablet:
Co-administration of Defen MR 250mg/50mg/500mg Tablet with Meloxicam can increase the risk or severity of gastrointestinal side effects.
How to manage the interaction:
Taking Meloxicam with Defen MR 250mg/50mg/500mg Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medication without doctor's advise.
Co-administration of Defen MR 250mg/50mg/500mg Tablet with Meloxicam can increase the risk or severity of gastrointestinal side effects.
How to manage the interaction:
Taking Meloxicam with Defen MR 250mg/50mg/500mg Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medication without doctor's advise.
Severe
How does the drug interact with Defen MR 250mg/50mg/500mg Tablet:
Co-administration of Defen MR 250mg/50mg/500mg Tablet and Leflunomide may increase the risk of liver problems.
How to manage the interaction:
Although there is a possible interaction between Defen MR 250mg/50mg/500mg Tablet and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Co-administration of Defen MR 250mg/50mg/500mg Tablet and Leflunomide may increase the risk of liver problems.
How to manage the interaction:
Although there is a possible interaction between Defen MR 250mg/50mg/500mg Tablet and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolValdecoxib
Severe
How does the drug interact with Defen MR 250mg/50mg/500mg Tablet:
Co-administration of Defen MR 250mg/50mg/500mg Tablet and Valdecoxib may increase the risk or severity of adverse effects.
How to manage the interaction:
Although there is a possible interaction between Defen MR 250mg/50mg/500mg Tablet and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
Co-administration of Defen MR 250mg/50mg/500mg Tablet and Valdecoxib may increase the risk or severity of adverse effects.
How to manage the interaction:
Although there is a possible interaction between Defen MR 250mg/50mg/500mg Tablet and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
Severe
How does the drug interact with Defen MR 250mg/50mg/500mg Tablet:
Co-administration of Teriflunomide with Defen MR 250mg/50mg/500mg Tablet may increase the risk or severity of Liver problems.
How to manage the interaction:
Taking Defen MR 250mg/50mg/500mg Tablet with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
Co-administration of Teriflunomide with Defen MR 250mg/50mg/500mg Tablet may increase the risk or severity of Liver problems.
How to manage the interaction:
Taking Defen MR 250mg/50mg/500mg Tablet with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
ParacetamolMipomersen
Severe
How does the drug interact with Defen MR 250mg/50mg/500mg Tablet:
Co-administration of Mipomersen with Defen MR 250mg/50mg/500mg Tablet may increase the risk or severity of liver injury.
How to manage the interaction:
There may be a possibility of interaction between Defen MR 250mg/50mg/500mg Tablet and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
Co-administration of Mipomersen with Defen MR 250mg/50mg/500mg Tablet may increase the risk or severity of liver injury.
How to manage the interaction:
There may be a possibility of interaction between Defen MR 250mg/50mg/500mg Tablet and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
Severe
How does the drug interact with Defen MR 250mg/50mg/500mg Tablet:
Co-administration of Defen MR 250mg/50mg/500mg Tablet may decrease the excretion rate of Oxazepam which could result in a higher serum level.
How to manage the interaction:
Although there is a possible interaction between Oxazepam and Defen MR 250mg/50mg/500mg Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
Co-administration of Defen MR 250mg/50mg/500mg Tablet may decrease the excretion rate of Oxazepam which could result in a higher serum level.
How to manage the interaction:
Although there is a possible interaction between Oxazepam and Defen MR 250mg/50mg/500mg Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Defen MR 250mg/50mg/500mg Tablet:
Co-administration of ketamine and Defen MR 250mg/50mg/500mg Tablet may decrease the effectiveness of Ketamine which could result in a higher blood level.
How to manage the interaction:
Although taking Ketamine and Defen MR 250mg/50mg/500mg Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
Co-administration of ketamine and Defen MR 250mg/50mg/500mg Tablet may decrease the effectiveness of Ketamine which could result in a higher blood level.
How to manage the interaction:
Although taking Ketamine and Defen MR 250mg/50mg/500mg Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ParacetamolLomitapide
Severe
How does the drug interact with Defen MR 250mg/50mg/500mg Tablet:
Co-administration of Lomitapide and Defen MR 250mg/50mg/500mg Tablet may increase the risk of severity of liver injury.
How to manage the interaction:
Although there is a possible interaction between Defen MR 250mg/50mg/500mg Tablet and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
Co-administration of Lomitapide and Defen MR 250mg/50mg/500mg Tablet may increase the risk of severity of liver injury.
How to manage the interaction:
Although there is a possible interaction between Defen MR 250mg/50mg/500mg Tablet and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Defen MR 250mg/50mg/500mg Tablet:
Co-administration of Defen MR 250mg/50mg/500mg Tablet and Ketoconazole may increase the risk of liver injury.
How to manage the interaction:
Although there is a possible interaction between Defen MR 250mg/50mg/500mg Tablet and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
Co-administration of Defen MR 250mg/50mg/500mg Tablet and Ketoconazole may increase the risk of liver injury.
How to manage the interaction:
Although there is a possible interaction between Defen MR 250mg/50mg/500mg Tablet and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
ChlorzoxazoneMorphine
Severe
How does the drug interact with Defen MR 250mg/50mg/500mg Tablet:
Using Morphine together with Defen MR 250mg/50mg/500mg Tablet can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).
How to manage the interaction:
Co-administration of Morphine with Defen MR 250mg/50mg/500mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.
Using Morphine together with Defen MR 250mg/50mg/500mg Tablet can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).
How to manage the interaction:
Co-administration of Morphine with Defen MR 250mg/50mg/500mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.
Drug-Food Interactions
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.
Drug-Food Interactions
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Product Substitutes
शराब
सावधानी
डेफेन एमआर 250mg/50mg/500mg टैबलेट के साथ शराब का सेवन नहीं करना चाहिए क्योंकि इससे अत्यधिक उनींदापन होता है
गर्भावस्था
सावधानी
केवल डेफेन एमआर 250mg/50mg/500mg टैबलेट का सेवन करें, यदि आपको डॉक्टर द्वारा निर्धारित किया गया है
स्तनपान
सावधानी
डेफेन एमआर 250mg/50mg/500mg टैबलेट स्तन के दूध के माध्यम से बच्चे को महत्वपूर्ण रूप से नहीं जाता है, डेफेन एमआर 250mg/50mg/500mg टैबलेट का उपयोग करने से पहले अपने चिकित्सक से परामर्श करें।
ड्राइविंग
सावधानी
डेफेन एमआर 250mg/50mg/500mg टैबलेट ड्राइविंग क्षमता को प्रभावित कर सकता है क्योंकि इससे चक्कर आते हैं।
जिगर
सावधानी
डेफेन एमआर 250mg/50mg/500mg टैबलेट सावधानी के साथ लेना है, खासकर यदि आपको जिगर की बीमारियों/स्थितियों का इतिहास रहा है। आपके डॉक्टर द्वारा खुराक को समायोजित करना पड़ सकता है।
गुर्दा
सावधानी
डेफेन एमआर 250mg/50mg/500mg टैबलेट सावधानी के साथ लेना है, खासकर यदि आपको गुर्दे की बीमारियों/स्थितियों का इतिहास रहा है। आपके डॉक्टर द्वारा खुराक को समायोजित करना पड़ सकता है।
बच्चे
सावधानी
डॉक्टर की सहमति के बिना 12 साल से कम उम्र के बच्चों के लिए डेफेन एमआर 250mg/50mg/500mg टैबलेट की सिफारिश नहीं की जाती है। 12 वर्ष से ऊपर के बच्चों के लिए, खुराक को केवल एक बाल रोग विशेषज्ञ द्वारा समायोजित और अनुशंसित किया जाना है।
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