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Gefzest-250 Tablet 10's
Gefzest-250 Tablet 10's is used to treat non-small cell lung cancer. It contains Gefitinib which works by inhibiting the growth and multiplication of cancer cells. In some cases, this medicine may cause side effects such as itching or skin rash, acne, nail problems, vomiting, diarrhoea, and loss of appetite. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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Side effects of Gefzest-250 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Increased protein levels indicate the body is dehydrated and when blood plasma is concentrated.
  • Consume water and stay hydrated. Talk to your doctor and take an oral rehydrating salt (ORS).
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding hydration.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Using a cold compress may help relieve itching and inflammation associated with conjunctivitis.
  • A warm compress and washing the eyes with water can help with crusting on the eyelids.
  • Avoid wearing contact lens until you feel better; use spectacles instead.
  • Do not rub the eyes.
  • Practise good hand hygiene and avoid touching the eyes to prevent the spread of infection.

Drug-Drug Interactions

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GefitinibThioridazine
Critical
GefitinibRifampicin
Severe

Drug-Drug Interactions

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GefitinibThioridazine
Critical
How does the drug interact with Gefzest-250 Tablet:
When Gefzest-250 Tablet is taken with Thioridazine it can increase the levels of Thioridazine in the body. This increases the risk or severity of side effects in the body.

How to manage the interaction:
Co-administration of Gefzest-250 Tablet with Thioridazine is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any symptoms, such as sudden dizziness, lightheadedness, fainting, trouble breathing, or experiencing heart palpitations, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
GefitinibRifampicin
Severe
How does the drug interact with Gefzest-250 Tablet:
Coadministration of Gefzest-250 Tablet with Rifampicin can decrease the blood levels of Gefzest-250 Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Gefzest-250 Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
GefitinibCarbamazepine
Severe
How does the drug interact with Gefzest-250 Tablet:
Taking carbamazepine and Gefzest-250 Tablet may significantly reduce the blood levels of Gefzest-250 Tablet, which may make the medication less effective

How to manage the interaction:
Although taking carbamazepine and Gefzest-250 Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
GefitinibTeriflunomide
Severe
How does the drug interact with Gefzest-250 Tablet:
Gefzest-250 Tablet can cause higher levels of Teriflunomide in the blood by reducing its excretion rate.

How to manage the interaction:
Co-administration of Gefzest-250 Tablet with Teriflunomide can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away: fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, liver damage, or bleeding. Do not discontinue any medications without consulting a doctor.
GefitinibCalcium carbonate
Severe
How does the drug interact with Gefzest-250 Tablet:
Co-administration of Calcium carbonate may interfere with the absorption of Gefzest-250 Tablet and reduce its effectiveness.

How to manage the interaction:
Although there is an interaction, Calcium carbonate can be taken with Gefzest-250 Tablet if prescribed by the doctor. However, Gefzest-250 Tablet and Calcium carbonate should not be taken orally at the same time. Maintain a gap of 2-6 hours between both medicines. Do not discontinue using any medications without consulting a doctor.
GefitinibPrimidone
Severe
How does the drug interact with Gefzest-250 Tablet:
Coadministration of Gefzest-250 Tablet with primidone may decrease the blood levels of Gefzest-250 Tablet and reduce its effectiveness.

How to manage the interaction:
Co-administration of Gefzest-250 Tablet with Primidone can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
GefitinibEnzalutamide
Severe
How does the drug interact with Gefzest-250 Tablet:
Coadministration of Gefzest-250 Tablet with Enzalutamide can alter the blood levels of Gefzest-250 Tablet which can lead to poor treatment outcomes.

How to manage the interaction:
Taking Gefzest-250 Tablet with Enzalutamide together can possibly result in an interaction, it can be taken if your doctor has advised it. Do not stop using any medications without talking to a doctor.
GefitinibNizatidine
Severe
How does the drug interact with Gefzest-250 Tablet:
Nizatidine can make Gefzest-250 Tablet less effective by reducing its absorption and lowering its concentration in the blood. This decreases the treatment outcomes.

How to manage the interaction:
Although there is a possible interaction between Gefzest-250 Tablet and Nizatidine, you can take these medicines together if prescribed by your doctor. It is recommended that you take Gefzest-250 Tablet 6 hours before or 6 hours after nizatidine to help minimize the impact of the interaction. Do not stop using any medications without talking to a doctor.
GefitinibMagnesium carbonate
Severe
How does the drug interact with Gefzest-250 Tablet:
Magnesium carbonate can make Gefzest-250 Tablet less effective by reducing its absorption and lowering its concentration in the blood.

How to manage the interaction:
Although there is a possible interaction between Gefzest-250 Tablet and Magnesium carbonate, you can take these medicines together if prescribed by your doctor. It's important to keep an eye on how well your treatment is working. Your doctor can help you find other options that won't interfere with your current medication. Do not discontinue any medications without consulting a doctor.
GefitinibRabeprazole
Severe
How does the drug interact with Gefzest-250 Tablet:
Taking Rabeprazole together with Gefzest-250 Tablet results in decreased levels of Gefzest-250 Tablet in your blood. This can result in a decreased effectiveness of Gefzest-250 Tablet in treating the disease.

How to manage the interaction:
Although taking Rabeprazole and Gefzest-250 Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. To lessen the effects of the interaction, it is advised that you take Gefzest-250 Tablet 12 hours before or 12 hours after rabeprazole. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Dec 24, 2025 | 7:50 AM IST

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