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  3. Isordril-5 Tablet 10's

Isordril-5 Tablet 10's, Pack of 10
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Isordril-5 Tablet 10's is used in the prevention of angina (heart-related chest pain) or heart failure. It contains Isosorbide dinitrate, which works by dilating, relaxing, and widening the constricted blood vessels, thereby increasing the blood and oxygen supply to the heart. Thus, it effectively helps prevent the risk of future heart attack and stroke in the future, especially in high blood pressure patients. It may cause common side effects such as headache (during initial days of therapy) and flushing (reddening of the skin, especially the face). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Side effects of Isordril-5 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Drug-Drug Interactions

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Isosorbide dinitrateAvanafil
Critical
Isosorbide dinitrateTadalafil
Critical

Drug-Drug Interactions

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Isosorbide dinitrateAvanafil
Critical
How does the drug interact with Isordril-5 Tablet:
Taking Avanafil with Isordril-5 Tablet can cause low blood pressure.

How to manage the interaction:
Taking Isordril-5 Tablet with Avanafil is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, priapism in males (persistent and painful erection unrelated to sexual activity). Do not discontinue any medications without consulting a doctor.
Isosorbide dinitrateTadalafil
Critical
How does the drug interact with Isordril-5 Tablet:
Taking Tadalafil with Isordril-5 Tablet can increase the risk or severity of low blood pressure.

How to manage the interaction:
Taking Isordril-5 Tablet with Tadalafil is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, or heart palpitations. Do not discontinue any medications without consulting a doctor.
Isosorbide dinitrateRiociguat
Critical
How does the drug interact with Isordril-5 Tablet:
Taking Riociguat with Isordril-5 Tablet may lead to excessively low blood pressure.

How to manage the interaction:
Taking Isordril-5 Tablet with Riociguat is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, priapism in males (persistent and painful erection unrelated to sexual activity). Do not discontinue any medications without consulting a doctor.
Isosorbide dinitrateSildenafil
Critical
How does the drug interact with Isordril-5 Tablet:
Coadministration of Isordril-5 Tablet and Sildenafil can increase the risk of low blood pressure.

How to manage the interaction:
Taking Isordril-5 Tablet and Sildenafil together is generally avoided as it can lead to an interaction, it can be taken only if advised by your doctor. However, if you experience dizziness, lightheadedness, fainting, headache, flushing, heart palpitations, and priapism (prolonged and painful erection unrelated to sexual activity) contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
Isosorbide dinitrateSodium nitrite
Severe
How does the drug interact with Isordril-5 Tablet:
Taking Isordril-5 Tablet with sodium nitrite may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking Isordril-5 Tablet and sodium nitrite together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
Isosorbide dinitrateLidocaine
Severe
How does the drug interact with Isordril-5 Tablet:
Taking Isordril-5 Tablet with lidocaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking Isordril-5 Tablet and lidocaine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
Isosorbide dinitrateBupivacaine
Severe
How does the drug interact with Isordril-5 Tablet:
Combining Bupivacaine with Isordril-5 Tablet can increase the risk of methemoglobinemia(a rare condition that can lead to oxygen deprivation in tissues and vital organs due to reduced oxygen-carrying capacity of the blood).

How to manage the interaction:
Co-administration of Bupivacaine with Isordril-5 Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like grey discolouration of the skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, confusion, consult a doctor right away. Do not stop using any medications without a doctor's advice.
Isosorbide dinitrateCabergoline
Severe
How does the drug interact with Isordril-5 Tablet:
Coadministration of Isordril-5 Tablet and cabergoline may decrease your blood pressure.

How to manage the interaction:
Co-administration of Isordril-5 Tablet with Cabergoline can result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these signs - headache, dizziness, feeling lightheaded, or fainting, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
Isosorbide dinitrateCabergoline
Severe
How does the drug interact with Isordril-5 Tablet:
Taking Isordril-5 Tablet with cabergoline can increase the effects of Cabergoline.

How to manage the interaction:
Although taking Isordril-5 Tablet and cabergoline together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. Do not stop using any medications without consulting doctor.
Isosorbide dinitrateRopivacaine
Severe
How does the drug interact with Isordril-5 Tablet:
Taking Isordril-5 Tablet with ropivacaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking Isordril-5 Tablet and ropivacaine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Aug 6, 2025 | 10:58 AM IST

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