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Ketol-200 Tablet is an antifungal medicine used in the treatment of fungal infections such as blastomycosis, coccidioidomycosis, paracoccidioidomycosis, and histoplasmosis (lung infection caused by Histoplasma fungus). This medicine works by inhibiting the growth and multiplication of fungal cells that are responsible for the growth of infection-causing fungi.

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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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Side effects of Ketol-200 Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

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Drug-Drug Interactions

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Drug-Drug Interaction: Ketol-200 Tablet may interact with antiarrhythmic agents (quinidine, dofetilide), antipsychotic drugs (pimozide), drugs used to treat heartburn and acidity (omeprazole, cisapride), cholesterol-lowering medicines (simvastatin, lovastatin), medicines used to treat migraine (dihydroergotamine, ergotamine), high blood pressure lowering drugs (nisoldipine, eplerenone) and benzodiazepines (alprazolam, triazolam, midazolam).

Drug-Food Interaction: Ketol-200 Tablet may interact with caffeine. Therefore, avoid foods containing chocolate and caffeine such as cocoa beans, tea, coffee, cola, and energy drinks as it may increase the adverse effects of caffeine. Do not take marijuana with Ketol-200 Tablet as it may worsen the adverse effects of marijuana. Also, avoid consumption of alcohol with Ketol-200 Tablet as it may increase the risk of liver damage and cause adverse effects.

Drug-Disease Interaction: If you have adrenal insufficiency, heart or liver problems, inform your doctor before taking Ketol-200 Tablet .

Drug-Drug Interactions

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How does the drug interact with Ketol-200 Tablet:
Co-administration of Ketol-200 Tablet and Midazolam may increase the risk of side effects.

How to manage the interaction:
Although taking Ketol-200 Tablet and Midazolam together is not recommended as it may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Ketol-200 Tablet:
Using Lurasidone together with Ketol-200 Tablet may increase the risk of side effects like Parkinson's disease(It is a brain disorder that produces uncontrollable movements).

How to manage the interaction:
While lurasidone and Ketol-200 Tablet is not recommended as it may lead to an interaction, they can be used if prescribed by a doctor. However, consult a doctor if you have any abnormal muscle activity, fits, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
KetoconazoleConivaptan
Critical
How does the drug interact with Ketol-200 Tablet:
Using conivaptan together with Ketol-200 Tablet may significantly increase the blood levels of conivaptan, which may increase the risk of side effects.

How to manage the interaction:
Taking Ketol-200 Tablet with Conivaptan is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures(fits), consult the doctor immediately. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Ketol-200 Tablet:
When Nimodipine is taken with Ketol-200 Tablet, it can increase the blood levels of Nimodipine which may lead to serious side effects .

How to manage the interaction:
Taking Ketol-200 Tablet with Nimodipine is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience -irregular heart rhythm, swelling, and low blood pressure, consult the doctor. Do not discontinue any medications without consulting the doctor.
KetoconazoleVenetoclax
Critical
How does the drug interact with Ketol-200 Tablet:
When Venetoclax is taken with Ketol-200 Tablet, it can increase the risk of side effects.

How to manage the interaction:
Taking Ketol-200 Tablet with Venetoclax is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. if you experience nausea, vomiting, diarrhea, fatigue, bleeding problems, and infections, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Ketol-200 Tablet:
Coadministration of Lovastatin with Ketol-200 Tablet can increase the risk of liver damage, rhabdomyolysis (the breakdown of skeletal muscle tissue) which may lead to kidney damage.

How to manage the interaction:
Taking Ketol-200 Tablet with Lovastatin is not recommended as it can cause an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms like unexplained muscular pain, tenderness, weakness, accompanied by fever, dark urine or unexpected bruising or bleeding, skin rash, itching, vomiting, yellowing of the skin or eyes, chills, joint pain, swelling, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Ketol-200 Tablet:
When Pimozide is taken with Ketol-200 Tablet, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Ketol-200 Tablet with Pimozide is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
KetoconazoleHalofantrine
Critical
How does the drug interact with Ketol-200 Tablet:
Using Ketol-200 Tablet with Halofantrine can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Ketol-200 Tablet with Halofantrine is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
How does the drug interact with Ketol-200 Tablet:
When Regorafenib is taken with Ketol-200 Tablet, it can increase the levels of Regorafenib, which may lead to side effects.

How to manage the interaction:
Taking Regorafenib with Ketol-200 Tablet is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Ketol-200 Tablet:
Taking Ketol-200 Tablet and Disopyramide together can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Ketol-200 Tablet with Disopyramide is not recommended as it can cause an interaction, it can be taken if a doctor has advised it. However, if you experience any symptoms like dizziness, irritation, confusion, chest pain or tightness, swelling, fatigue, palpitations, shortness of breath, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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KETOCONAZOLE-200MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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KETOCONAZOLE-200MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grapefruit or its juice with Ketol-200 Tablet may result in side effects such as joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, dark urine, light colored stools, and yellowing of the skin or eyes. Avoid consuming grapefruit, grapefruit juice, or any supplements that include grapefruit extract while taking Ketol-200 Tablet.

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