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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Linezolid Tablet is an antibiotic medication used to treat bacterial infections of the skin and lungs (pneumonia). It is also used to treat infections that are resistant to other antibiotics, such as vancomycin-resistant enterococcal infections. It contains Linezolid, which works by stopping the growth of infection-causing bacteria. Thus, it helps treat the bacterial infection. In some cases, you may experience common side effects, such as thrush (a fungal infection), headache, a metallic taste, diarrhoea, nausea, vomiting, dizziness, constipation, and indigestion. Before taking this medicine, inform your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and any pre-existing medical conditions.

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Drug-Drug Interactions

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LinezolidCaffeine
Critical

Drug-Drug Interactions

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How does the drug interact with Linezolid Tablet Tablet:
Using Linezolid Tablet together with Paroxetine can increase the risk of a serious condition called serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is a chemical that plays a role in overall wellbeing and especially a mood stabilizer).

How to manage the interaction:
Taking Paroxetine with Linezolid Tablet is not recommended but should be taken if advised by a doctor. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LinezolidCaffeine
Critical
How does the drug interact with Linezolid Tablet Tablet:
Taking these two together can cause your blood pressure to rise, a condition known as a hypertensive crisis.

How to manage the interaction:
Taking Caffeine with Linezolid Tablet is not recommended, please consult your doctor before taking it. It can be taken if your doctor prescribes it. Do not stop taking any medication without consulting your doctor.
How does the drug interact with Linezolid Tablet Tablet:
Taking Linezolid Tablet with Methylphenidate together may increase the risk or severity of high blood pressure.

How to manage the interaction:
Taking Linezolid Tablet with Methylphenidate is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden and severe headaches, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting, contact a doctor immediately. You may use methylphenidate only after you have been off Linezolid Tablet for at least 14 days. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Linezolid Tablet Tablet:
Using Linezolid Tablet together with mirtazapine might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Linezolid Tablet with Mirtazapine can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Linezolid Tablet Tablet:
Using Linezolid Tablet with Trazodone can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Trazodone with Linezolid Tablet is not recommended but can be taken if prescribed by a doctor. However, consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Linezolid Tablet Tablet:
Coadministration of Nortriptyline with Linezolid Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Nortriptyline with Linezolid Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Linezolid Tablet Tablet:
Taking Linezolid Tablet with Amitriptyline can increase the risk of serotonin syndrome (increased serotonin hormone).

How to manage the interaction:
Although using Linezolid Tablet and Amitriptyline together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Linezolid Tablet Tablet:
Using Linezolid Tablet together with atomoxetine can cause high blood pressure.

How to manage the interaction:
Taking Linezolid Tablet with Atomoxetine is not recommended, consult a doctor before taking it. You should seek immediate medical attention if you experience sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting. Do not stop using any medications without talking to a doctor.
How does the drug interact with Linezolid Tablet Tablet:
Using Carbamazepine with Linezolid Tablet can cause serotonin syndrome(a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Carbamazepine and Linezolid Tablet together is not recommended, but it can be taken if prescribed by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, stomach pain, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Linezolid Tablet Tablet:
Co-administration of Linezolid Tablet with Tramadol can increase the risk of serotonin syndrome and seizures.

How to manage the interaction:
Taking Linezolid Tablet with Tramadol is not recommended, consult a doctor before taking it. Consult a doctor if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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LINEZOLID-600MGTyramine-containing food
Severe

Drug-Food Interactions

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LINEZOLID-600MGTyramine-containing food
Severe
Common Foods to Avoid:
Pepperoni, Miso Soup, Natto, Ricotta, Salami, Shoyu, Shrimp, Stilton Cheese, Swiss Cheese, Tamari, Tempeh, Fish, Farm Cheese, Fava Beans, Fermented Seafood, Fermented Tofu, Gorgonzola Cheese, Chicken Liver, Chocolates, Cottage Cheese, Cream Cheese, Dried Sausage, Dry-Type Summer Sausages, Cheddar Cheese, Cashews, Camembert, Beef Liver, American Cheese, Almonds, Avocado

How to manage the interaction:
Taking high tyramine-containing food along with Linezolid Tablet can cause blood pressure to rise to exceedingly high levels, a condition known as a hypertensive crisis (Severely elevated blood pressure). Avoid high tyramine-containing food while taking Linezolid Tablet. Consult a doctor, if you experience severe headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, convulsions, and sudden numbness or weakness (especially on one side of the body).

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