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  3. Maxi 500mg Tablet

Maxi 500mg Tablet, Pack of 1
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Maxi 500mg Tablet is used to provide relief from mild to moderate pain and inflammation associated with muscular, rheumatic, and arthritic disorders, headache, trauma, dental pain, and pain after surgery or childbirth. Additionally, it is used to relieve period pain and premenstrual syndrome symptoms (PMS) and manage excessively heavy periods. It contains Mefenamic acid, which works by blocking the effect of chemical messengers that cause pain and inflammation. In some cases, you may experience certain common side effects such as abdominal pain, nausea, vomiting, diarrhoea, heartburn and indigestion. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Side effects of Maxi 500mg Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Drug-Drug Interactions

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Mefenamic acidKetorolac
Critical
Mefenamic acidMeloxicam
Critical

Drug-Drug Interactions

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Mefenamic acidKetorolac
Critical
How does the drug interact with Maxi 500mg Tablet:
Coadministration of Maxi 500mg Tablet with Ketorolac can increase the risk or severity of gastric bleeding and ulcers.

How to manage the interaction:
Taking Maxi 500mg Tablet with Ketorolac together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidMeloxicam
Critical
How does the drug interact with Maxi 500mg Tablet:
Co-administration of Maxi 500mg Tablet with Meloxicam together can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Maxi 500mg Tablet with Meloxicam together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking a doctor.
Mefenamic acidEtodolac
Severe
How does the drug interact with Maxi 500mg Tablet:
Coadministration of Maxi 500mg Tablet with Etodolac can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Maxi 500mg Tablet with Etodolac together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact the doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidCelecoxib
Severe
How does the drug interact with Maxi 500mg Tablet:
Coadministration of Maxi 500mg Tablet with Celecoxib can increase the risk or severity of bleeding and ulcers of the stomach.

How to manage the interaction:
Taking Maxi 500mg Tablet with Celecoxib together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, loos stools, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidTenofovir disoproxil
Severe
How does the drug interact with Maxi 500mg Tablet:
Coadministration of Maxi 500mg Tablet with Tenofovir disoproxil can show additive effect and increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Maxi 500mg Tablet with Tenofovir Disoproxil together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, red or black tarry stools, vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidBaricitinib
Severe
How does the drug interact with Maxi 500mg Tablet:
Using Maxi 500mg Tablet and baricitinib together may increase the risk of gastrointestinal perforation (a serious health condition where a hole develops through the stomach or intestine).

How to manage the interaction:
Co-administration of Maxi 500mg Tablet with Baricitinib can result in an interaction, but it can be taken if your doctor has advised it. If you notice any signs like severe stomach pain, fever, or vomiting, consult a doctor. Do not stop using any medications without talking to a doctor.
Mefenamic acidDasatinib
Severe
How does the drug interact with Maxi 500mg Tablet:
Co-administration of Maxi 500mg Tablet with Dasatinib can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Maxi 500mg Tablet with Dasatinib together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, lightheadedness, red or black tarry stools, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidDanaparoid
Severe
How does the drug interact with Maxi 500mg Tablet:
Using danaparoid together with Maxi 500mg Tablet can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possibility of interaction between Maxi 500mg Tablet and Danaparoid, but it can be taken if prescribed by a doctor. If you notice any of these signs - bruising, swelling, vomiting, headache, dizziness, weakness, bleeding, or blood in your urine or stools, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
Mefenamic acidIbrutinib
Severe
How does the drug interact with Maxi 500mg Tablet:
Co-administration of Maxi 500mg Tablet with Ibrutinib can increase the risk or severity of bleeding, leading to serious blood loss.

How to manage the interaction:
Taking Maxi 500mg Tablet with Ibrutinib together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any symptoms of unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidApixaban
Severe
How does the drug interact with Maxi 500mg Tablet:
Maxi 500mg Tablet and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Maxi 500mg Tablet and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without first consulting your doctor, never stop taking any medications.

Drug-Food Interactions

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MEFENAMIC ACID-500MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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MEFENAMIC ACID-500MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Taking Maxi 500mg Tablet with caffeine-containing foods or drinks can show an interaction. Taking Maxi 500mg Tablet with caffeine-containing foods or drinks can reduce the effectiveness of Maxi 500mg Tablet. Avoid or limit your caffeine consumption while taking Maxi 500mg Tablet dose. Do not stop using any medications without talking to a doctor.

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:41 AM IST

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