Onbort 2 mg Injection का उपयोग, फायदे ,साइड इफेक्ट,कीमत in Hindi

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Onbort 2 mg Injection is used to treat cancers like multiple myeloma and mantle cell lymphoma. It contains Bortezomib which works by preventing the cancer cells from growing and eventually killing them. In some cases, this medicine may cause side effects such as constipation, vomiting, low white blood cell count, and low platelet count. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

Written By Bayyarapu Mahesh Kumar , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

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Side effects of Onbort 2 mg Injection

Low Platelet Count

Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
If you experience severe bleeding or bruising, seek emergency medical attention immediately.

Increased Risk Of Infection Due To Low Neutrophil Count

Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
Avoid contact with people who are sick.
Wash your hands regularly with soap and water.
Avoid unpasteurized dairy products.

Anemia

Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
Consume vitamin C-rich foods as they aid iron absorption.
Limit tea, cocoa, and coffee as these can slow iron absorption.
Exercise regularly; however, do not overdo it.

Low White Blood Cell Count

Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
Get sufficient sleep and manage stress which helps in improving white blood cell count.
Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.

Low Levels Of Lymphocytes (A Type Of White Blood Cells)

Nourish your body with a balanced diet with protein-rich foods like fish, eggs, and beans. Fruits, vegetables, and nuts provide essential vitamins and minerals. If necessary, consider vitamin B12 and folate supplements.
Practice good hygiene to protect yourself from infections. Wash your hands often, stay up-to-date on vaccinations, avoid crowded areas, and take care when handling food, pets, and diapers.
Aim for a good night's sleep, targeting 8 hours of sleep. Find calm through stress-reducing practices like yoga, meditation, or deep breathing. Regular physical activity can also help.
Stay healthy by drinking plenty of water, eating probiotic-rich foods like yoghurt, and limiting processed foods and sugars. Consult your doctor, if you are having difficulties or concerns.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

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Drug-Drug Interactions

Drug-Drug Interactions: Onbort 2 mg Injection interacts with antifungal medication (ketoconazole), HIV medication (ritonavir), antibiotic medication (rifampicin), epilepsy medications (carbamazepine, phenytoin or phenobarbital), depression medication (St. John’s Wort), and oral antidiabetics.

Drug-Food Interactions: No food interaction was found.

Drug-Disease Interactions: Inform your doctor before taking Onbort 2 mg Injection; it requires close monitoring if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), and hepatic disorders.

BortezomibTalimogene laherparepvec

Severe

BortezomibPhenytoin

Severe

Drug-Drug Interactions

BortezomibTalimogene laherparepvec

Severe

How does the drug interact with Onbort 2 mg Injection:
Taking Onbort 2 mg Injection together with talimogene laherparepvec increases the risk of developing infection.

How to manage the interaction:
Although using Onbort 2 mg Injection and Talimogene laherparepvec together can possibly result in an interaction, they can be taken together if advised by your doctor. Do not stop taking any medications without consulting a doctor.

BortezomibPhenytoin

Severe

How does the drug interact with Onbort 2 mg Injection:
Coadministration of phenytoin and Onbort 2 mg Injection can lower the levels of Onbort 2 mg Injection, which could decrease its effectiveness.

How to manage the interaction:
Although using Onbort 2 mg Injection and Phenytoin together can result in an interaction, they can be taken together if advised by a doctor. However, consult a doctor if your condition worsens. Do not stop taking any medications without consulting a doctor.

BortezomibAdalimumab

Severe

How does the drug interact with Onbort 2 mg Injection:
Coadministration of adalimumab and Onbort 2 mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Onbort 2 mg Injection and Adalimumab together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience any symptoms of infection, such as fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, discomfort, or burning during urination. Do not stop taking any medications without consulting a doctor.

BortezomibPhenobarbital

Severe

How does the drug interact with Onbort 2 mg Injection:
Coadministration of Onbort 2 mg Injection and phenobarbital may reduce the blood levels of Onbort 2 mg Injection, which may make the medication less effective in treating a condition.

How to manage the interaction:
Although using Onbort 2 mg Injection and Phenobarbital together can result in an interaction, they can be taken together if advised by a doctor. However, consult a doctor if your condition worsens. Do not stop taking any medications without consulting a doctor.

BortezomibClozapine

Severe

How does the drug interact with Onbort 2 mg Injection:
Coadministration of clozapine with Onbort 2 mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Onbort 2 mg Injection and Clozapine together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhoea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.

BortezomibVoclosporin

Severe

How does the drug interact with Onbort 2 mg Injection:
Coadministration of voclosporin and Onbort 2 mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Onbort 2 mg Injection and Voclosporin together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.

BortezomibCertolizumab

Severe

How does the drug interact with Onbort 2 mg Injection:
Coadministration of certolizumab and Onbort 2 mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Onbort 2 mg Injection and Certolizumab together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhoea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.

BortezomibInfliximab

Severe

How does the drug interact with Onbort 2 mg Injection:
Coadministration of infliximab and Onbort 2 mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Onbort 2 mg Injection and Infliximab together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, discomfort or burning during urination. Do not stop taking any medications without consulting a doctor.

BortezomibSamarium (153sm) lexidronam

Severe

How does the drug interact with Onbort 2 mg Injection:
Using samarium (153sm) lexidronam together with Onbort 2 mg Injection may increase the risk of side effects

How to manage the interaction:
Co-administration of Onbort 2 mg Injection with Samarium (153sm) lexidronam can possibly result in an interaction; they can be taken if your doctor has advised it. However, consult a doctor if you experience fatigue, dizziness, fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, and pain or burning during urination. Do not stop using any medications without a doctor's advice.

BortezomibGolimumab

Severe

How does the drug interact with Onbort 2 mg Injection:
Coadministration of golimumab and Onbort 2 mg Injection may increase the risk of infections.

How to manage the interaction:
Although using Onbort 2 mg Injection and Golimumab together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, discomfort, or burning during urination. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

BORTEZOMIB-2MGCaffeine containing foods/drinks, Fiber rich foods

Moderate

Drug-Food Interactions

BORTEZOMIB-2MGCaffeine containing foods/drinks, Fiber rich foods

Moderate

Common Foods to Avoid:
Green Tea, Oranges

How to manage the interaction:
Vitamin C or vitamin-containing foods and green tea diminish the effectiveness of Onbort 2 mg Injection Avoid or limit the consumption of Vitamin C or vitamin-containing foods and green tea.

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