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Prehal-D21 Tablet 21's

Prehal-D21 Tablet 21's is used for contraception and in the treatment of dysmenorrhea (irregular and painful periods). It contains Desogestrel and Ethinylestradiol, which help to prevent pregnancy in multiple ways. It prevents the release of an egg from the ovaries and makes the fluid present in the cervix thick, making it difficult for sperm to enter the womb. In addition to this, it prevents the thickening of the uterus's inner wall, which is necessary for an egg to grow and multiply. It may cause side effects such as headache, weight increase or decrease, acne, abdominal pain, cramps, and depression. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Prehal-D21 Tablet
  • Eat a healthy balanced diet.
  • Reduce stress with relaxation techniques such as yoga or meditation.
  • Keep track of your menstrual cycle any irregularities.
  • Have regular check ups to exclude other health problems.
  • Exercise but do not exercise to the extent of overheating.
  • Hydrate well, eat well (particularly iron and vitamins).
  • Use hot or cold packs on your breasts to help alleviate discomfort.
  • Choose a supportive, well-fitting bra, preferably one that has been professionally fitted.
  • Practice relaxation techniques to manage stress and anxiety that may accompany severe breast pain.
  • Limit or avoid caffeine consumption.
  • Eat a low-fat diet and focus on foods rich in complex carbohydrates.
  • Rubbing evening primrose oil on your breasts may help balance fatty acids in the cells and reduce pain.
  • Keep track of when your breast pain occurs and any other symptoms to determine if the pain is regular or not.
  • Vitamin E supplements may help reduce pain for women who experience pain linked to their menstrual cycle.
  • Over-the-counter pain relievers like acetaminophen or ibuprofen can provide relief, but be sure to consult your doctor for the correct dosage, as prolonged use may cause side effects.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Lie down or take a nap in dark and quiet room.
  • To avoid dehydration, drink plenty of fluids.
  • In case of mild to moderate migraine, you can take over-the-counter pain relievers like paracetamol or ibuprofen.
  • Apply an ice pack or cool cloth on your forehead.
  • Try relaxation techniques such as yoga, meditation, or deep breathing to reduce stress and relax.
  • Avoid foods and drinks that trigger migraine such as chocolate, alcohol, cheese, caffeine, processed meats, artificial sweeteners and dried fruits.
  • Manage your stress by eating healthy, exercising and a regular sleep schedule.

Drug-Drug Interactions

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EthinylestradiolTranexamic acid
Critical
DesogestrelDantrolene
Critical

Drug-Drug Interactions

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EthinylestradiolTranexamic acid
Critical
How does the drug interact with Prehal-D21 Tablet:
Taking Prehal-D21 Tablet with Tranexamic acid may increase the risk of blood clot formation.

How to manage the interaction:
Taking Prehal-D21 Tablet with Tranexamic acid is not recommended, as it can lead to an interaction, but can be taken if a doctor has prescribed it. However, if you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult doctor immediately. Do not stop using any medications without talking to a doctor.
DesogestrelDantrolene
Critical
How does the drug interact with Prehal-D21 Tablet:
Using ethinyl estradiol and dantrolene can cause serious side effects that may affect your liver.

How to manage the interaction:
Taking Prehal-D21 Tablet with Dantrolene is not recommended, please consult your doctor before taking it. Call a doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or eyes. Do not stop using any medication without consulting a doctor.
EthinylestradiolOxcarbazepine
Severe
How does the drug interact with Prehal-D21 Tablet:
When coupled with oxcarbazepine, the blood levels of Prehal-D21 Tablet can be reduced.

How to manage the interaction:
Although taking oxcarbazepine and Prehal-D21 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you use hormone replacement therapy(Prehal-D21 Tablet) for menopause, consult the doctor if your symptoms are no longer controlled or if you deal with unusual bleeding. Do not discontinue any medications without consulting a doctor.
EthinylestradiolCarfilzomib
Severe
How does the drug interact with Prehal-D21 Tablet:
Carfilzomib can cause serious blood clots and taking it with ethinyl estradiol may enhance the risk.

How to manage the interaction:
There may be a possibility of interaction between Carfilzomib and Prehal-D21 Tablet, but it can be taken if prescribed by a doctor. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, you should consult a doctor. Do not stop using any medications without a doctor's advice.
EthinylestradiolPomalidomide
Severe
How does the drug interact with Prehal-D21 Tablet:
Pomalidomide can cause serious blood clots, and taking it with Ethinyl estradiol may enhance the risk.

How to manage the interaction:
Although there is a possible interaction between Pomalidomide and Prehal-D21 Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience chest pain, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
EthinylestradiolTopiramate
Severe
How does the drug interact with Prehal-D21 Tablet:
When Prehal-D21 Tablet and Topiramate are taken together, Prehal-D21 Tablet is less effective as a form of birth control.

How to manage the interaction:
Co-administration of Topiramate with Prehal-D21 Tablet can result in an interaction, but it can be taken if a doctor has advised it. If you are taking hormone replacement therapy for menopause, and you notice an increase in the frequency or severity of your symptoms, such as hot flashes, vaginal dryness, or irregular bleeding contact a doctor Do not stop using any medications without a doctor's advice.
EthinylestradiolLetrozole
Severe
How does the drug interact with Prehal-D21 Tablet:
When taken together ethinyl estradiol may interfere with letrozole's activity and make it less effective in treating the condition.

How to manage the interaction:
Although taking Letrozole and Prehal-D21 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Do not stop using any medications without a doctor's advice.
EthinylestradiolRifabutin
Severe
How does the drug interact with Prehal-D21 Tablet:
Taking rifabutin with ethinyl estradiol it may significantly reduces the blood levels.

How to manage the interaction:
There may be a possibility of interaction between Prehal-D21 Tablet and Rifabutin, but it can be taken if prescribed by a doctor. If you use hormone replacement therapy for menopause, inform a doctor if experience any unusual symptoms or if you develop unusual bleeding. Do not stop using any medications without talking to a doctor.
EthinylestradiolMycophenolic acid
Severe
How does the drug interact with Prehal-D21 Tablet:
Coadministration of Prehal-D21 Tablet with Mycophenolic acid may lower the blood levels and effects of Prehal-D21 Tablet, making it less effective as a form of birth control.

How to manage the interaction:
There could be a possible interaction between Mycophenolic acid and Prehal-D21 Tablet, but they can be taken together if a doctor has prescribed them. However, if you are taking hormone replacement therapy for menopause, and you notice an increase in the frequency or severity of your symptoms, such as hot flashes, vaginal dryness, or irregular bleeding, consult a doctor. Do not discontinue any medications without a doctor's advice.
EthinylestradiolDabrafenib
Severe
How does the drug interact with Prehal-D21 Tablet:
When coupled with Dabrafenib, the blood level of Prehal-D21 Tablet can be reduced.

How to manage the interaction:
There may be a possibility of interaction between Dabrafenib and Prehal-D21 Tablet, but it can be taken if prescribed by a doctor. If you are taking hormone replacement therapy for menopause, you should notify your doctor if you notice an increase in the frequency or severity of your symptoms, such as hot flashes, vaginal dryness, or irregular bleeding. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Nov 21, 2025 | 11:23 AM IST

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