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  3. Prexorise 0.125 Tablet 10's

Prexorise 0.125 Tablet 10's, Pack of 10
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Prexorise 0.125 Tablet 10's is used to treat the symptoms of Parkinson's disease and moderate to severe Willis-Ekbom disease (restless legs syndrome) in adults. It contains Pramipexole, which works by mimicking the action of dopamine (acting in place of dopamine), a natural substance found in the brain needed to control body movement. This triggers the nerve impulses in the brain that control body movements. In some cases, you may experience certain common side effects such as sleepiness, nausea, constipation, dizziness, fatigue, hallucinations, dry mouth, muscle spasms, and peripheral oedema (leg swelling due to fluid overload). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Side effects of Prexorise 0.125 Tablet
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Uncontrolled and involuntary movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
  • Hallucination is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control hallucinations. You can share what is being seen with a therapist to know whether they are real or imaginary.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your imagination.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of hallucinations.
  • Talk to your dietician and consume food that can improve your mental health.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Do not stand up suddenly. Lie down and get up slowly only when you feel better.
  • Avoid alcohol and large meals.
  • Drink enough water before standing for long periods.
  • Exercise regularly; however, avoid exercising in extreme heat.
  • Eat small, low-carb meals.
  • Wear compression stockings.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Drug-Drug Interactions

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PramipexoleOlanzapine
Critical
PramipexoleRisperidone
Critical

Drug-Drug Interactions

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PramipexoleOlanzapine
Critical
How does the drug interact with Prexorise 0.125 Tablet:
Taking Olanzapine with Prexorise 0.125 Tablet can increase the risk and severity of side effects and reduce the effectiveness of Prexorise 0.125 Tablet.

How to manage the interaction:
Co-administration of Olanzapine and Prexorise 0.125 Tablet is not recommended as it leads to an interaction, it can be taken if advised by a doctor. If you experience any symptoms such as drowsiness, dizziness, and lightheadedness, contact a doctor immediately. Avoid driving or operating dangerous machinery, and be careful while getting up from a sitting or lying position. Do not discontinue any medications without consulting a doctor.
PramipexoleRisperidone
Critical
How does the drug interact with Prexorise 0.125 Tablet:
Taking Risperidone with Prexorise 0.125 Tablet may reduce the effectiveness of Prexorise 0.125 Tablet.

How to manage the interaction:
Taking Risperidone with Prexorise 0.125 Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, and lightheadedness contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PramipexoleSodium oxybate
Severe
How does the drug interact with Prexorise 0.125 Tablet:
Taking Sodium oxybate with Prexorise 0.125 Tablet may increase he risk of side effects.

How to manage the interaction:
Taking Prexorise 0.125 Tablet with Sodium oxybate together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, lightheadedness, confusion, depression, low blood pressure, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination, consult a doctor. Do not discontinue any medications without a doctor's advice.
PramipexoleEsketamine
Severe
How does the drug interact with Prexorise 0.125 Tablet:
Combining Esketamine with Prexorise 0.125 Tablet may increase side effects

How to manage the interaction:
Although taking Prexorise 0.125 Tablet and Esketamine together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience any symptoms like drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination, consult a doctor. Do not discontinue the medication without consulting a doctor.
PramipexoleAmisulpride
Severe
How does the drug interact with Prexorise 0.125 Tablet:
Taking Amisulpride with Prexorise 0.125 Tablet may decrease the efficacy of both medications.

How to manage the interaction:
Although taking amisulpride along with Prexorise 0.125 Tablet can result in an interaction, it can be taken if a doctor has advised it. Avoid jobs that demand mental awareness and exercise caution while rising from a sitting or sleeping posture. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:35 AM IST

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