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Profen 400mg Tablet

Profen 400mg Tablet is used to relieve mild to moderate pain, inflammation, and fever in adults and paediatrics above 6 months of age. It helps to treat conditions such as menstrual cramps, headache, neuralgia (nerve-related pain), migraine, back pain, dental pain, swelling and stiffness in joints and muscles, cold, and flu symptoms. It contains Ibuprofen, which works by reducing the production of chemicals prostaglandins that are produced at injury sites and cause pain and swelling. Thus, it reduces mild to moderate pain, inflammation, and fever. In some cases, you may experience certain common side effects such as indigestion, diarrhoea, constipation, flatulence (gas), general weakness, and dizziness. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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Side effects of Profen 400mg Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Eosinophil levels can be lowered by eating fruits and vegetables, avoiding smoking, and consuming alcohol in moderation.
  • Several foods, such as ginger, garlic, pepper, turmeric, and honey, might boost immunity.
  • Avoid dairy products, including cheese, yoghurt, and milk.
  • Drink water and keep yourself hydrated.

Drug-Drug Interactions

verifiedApollotooltip
IbuprofenMeloxicam
Critical
IbuprofenKetorolac
Critical

Drug-Drug Interactions

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IbuprofenMeloxicam
Critical
How does the drug interact with Profen 400mg Tablet:
Combining Meloxicam and Profen 400mg Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.

How to manage the interaction:
Taking Meloxicam and Profen 400mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenKetorolac
Critical
How does the drug interact with Profen 400mg Tablet:
Taking Ketorolac and Profen 400mg Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding and ulceration.

How to manage the interaction:
Taking Ketorolac and Profen 400mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenRivaroxaban
Severe
How does the drug interact with Profen 400mg Tablet:
Co-administration of Rivaroxaban and Profen 400mg Tablet can increase the risk of bleeding problems.

How to manage the interaction:
Co-administration of Rivaroxaban and Profen 400mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenCidofovir
Severe
How does the drug interact with Profen 400mg Tablet:
Taking cidofovir and Profen 400mg Tablet can increase the risk of Kidney problems.

How to manage the interaction:
Taking Cidofovir and Profen 400mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss , swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenSirolimus
Severe
How does the drug interact with Profen 400mg Tablet:
Co-administration of Sirolimus and Profen 400mg Tablet together increases the risk or severity of kidney problems.

How to manage the interaction:
Co-administration of Sirolimus and Profen 400mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, irregular heart rhythm, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenDiclofenac
Severe
How does the drug interact with Profen 400mg Tablet:
Taking diclofenac and Profen 400mg Tablet can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Co-administration of Diclofenac and Profen 400mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenBromfenac
Severe
How does the drug interact with Profen 400mg Tablet:
using Bromfenac and Profen 400mg Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.

How to manage the interaction:
Taking bromfenac and Profen 400mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness,ightheadedness,red or black, tarry stools,coughing up or vomiting fresh or dried blood that looks like coffee grounds,severe headache,and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenMetrizamide
Severe
How does the drug interact with Profen 400mg Tablet:
The combined use of Metrizamide and Profen 400mg Tablet can cause kidney damage.

How to manage the interaction:
Co-administration of Metrizamide and Profen 400mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, irregular heart rhythm, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenDanaparoid
Severe
How does the drug interact with Profen 400mg Tablet:
The combined use of Danaparoid and Profen 400mg Tablet can increase the risk of bleeding complications.

How to manage the interaction:
Taking Danaparoid and Profen 400mg Tablet together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness during treatment with these medications, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenMethotrexate
Severe
How does the drug interact with Profen 400mg Tablet:
Coadministration of methotrexate with Profen 400mg Tablet can increase the effect and side effects of methotrexate.

How to manage the interaction:
Although there is a possible interaction between methotrexate and Profen 400mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Nov 18, 2025 | 7:34 AM IST

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