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Regestrone 5 mg Tablet is used to treat heavy, painful, or irregular periods, premenstrual syndrome (PMS), and endometriosis. Additionally, it may be used in the treatment of breast cancer. It contains Norethisterone, which works by restoring the hormone levels in the body. In some cases, this medicine may cause side effects such as unusual vaginal bleeding or spotting, dizziness, dry mouth, constipation, nausea, and diarrhoea. Let the doctor know if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Regestrone 5 mg Tablet:
Taking griseofulvin with Regestrone 5 mg Tablet may reduce blood levels and the effects of Regestrone 5 mg Tablet.

How to manage the interaction:
Although there is a possible interaction between Griseofulvin and Regestrone 5 mg Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience any of these symptoms like unexpected bleeding or abnormal bleeding, it's important to contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Regestrone 5 mg Tablet:
The combined use of Regestrone 5 mg Tablet and phenobarbital can reduce the blood levels and effects of Regestrone 5 mg Tablet.

How to manage the interaction:
Although taking phenobarbital and Regestrone 5 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience any symptoms like abnormal bleeding, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
NorethisteroneFosphenytoin
Severe
How does the drug interact with Regestrone 5 mg Tablet:
Coadministration of Regestrone 5 mg Tablet with Fosphenytoin can reduces the blood levels and effects of Regestrone 5 mg Tablet .

How to manage the interaction:
Taking Regestrone 5 mg Tablet with Fosphenytoin together can result in an interaction, but it can be taken if your doctor has advised it. If you experience symptoms of abnormal bleeding while using birth control, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Regestrone 5 mg Tablet:
Coadministration of Phenytoin and Regestrone 5 mg Tablet may decrease the blood levels of Regestrone 5 mg Tablet, which may make Regestrone 5 mg Tablet less effective.

How to manage the interaction:
Although taking Phenytoin and Regestrone 5 mg Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. If you experience any symptoms, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Regestrone 5 mg Tablet:
Coadministration of Regestrone 5 mg Tablet and primidone can reduce the blood levels and effects of Regestrone 5 mg Tablet and increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Regestrone 5 mg Tablet and Primidone, they can be taken together if prescribed by a doctor. However, if you experience abnormal bleeding, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NorethisteroneFosamprenavir
Severe
How does the drug interact with Regestrone 5 mg Tablet:
Using norethindrone together with fosamprenavir may decrease the effects of fosamprenavir.

How to manage the interaction:
Taking Regestrone 5 mg Tablet with Fosamprenavir together can result in an interaction, but it can be taken if your doctor has advised it. If you're taking birth control and experiencing any symptoms, it's important to reach out to a doctor right away. They can recommend other options that won't interfere with your medication. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Regestrone 5 mg Tablet:
Coadministration of Regestrone 5 mg Tablet with Rifabutin can reduce the blood levels and effects of norethindrone.This increases the risk of severe bleeding and unintended pregnancy.

How to manage the interaction:
Taking Regestrone 5 mg Tablet with Rifabutin together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of abnormal bleeding, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NorethisteroneBexarotene
Severe
How does the drug interact with Regestrone 5 mg Tablet:
Coadministration of Bexarotene and Regestrone 5 mg Tablet together can decrease the effectiveness of norethindrone and increase the risk of unintended pregnancy.

How to manage the interaction:
Combining Bexarotene with Regestrone 5 mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Regestrone 5 mg Tablet:
Coadministration of Regestrone 5 mg Tablet with Topiramate can reduce the blood levels and effects of norethindrone in the body. This increases the risk of severe bleeding and unintended pregnancy.

How to manage the interaction:
Taking Regestrone 5 mg Tablet and topiramate together can result in an interaction; it can be taken if your doctor has advised it. However, if you notice any symptoms of abnormal bleeding, hot flashes or vaginal dryness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Regestrone 5 mg Tablet:
Eslicarbazepine may reduce the effects of Regestrone 5 mg Tablet and its blood levels.

How to manage the interaction:
Although taking Eslicarbazepine and Regestrone 5 mg Tablet results in an interaction, they can be taken together if prescribed by your doctor. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Consuming Grapefruit juice may increase the blood levels of Regestrone 5 mg Tablet. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Regestrone 5 mg Tablet dose. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Regestrone 5 mg Tablet dose.

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